Standout Papers
Citation Impact
Citing Papers
Consistent blind protein structure generation from NMR chemical shift data
2008 StandoutNobel
Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O 2 activation
2019 StandoutNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease
2010 StandoutScienceNobel
Organization of Intracellular Reactions with Rationally Designed RNA Assemblies
2011 Science
Sculpting conducting nanopore size and shape through de novo protein design
2024 StandoutScienceNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Crystal Structure of a Cross-reaction Complex between Fab F9.13.7 and Guinea Fowl Lysozyme
1995
Conversion of monomeric protein L to an obligate dimer by computational protein design
2001 StandoutNobel
Three-dimensional structures of the free and the antigen-complexed Fab from monoclonal anti-lysozyme antibody D44.1
1994
Atomic model of the type III secretion system needle
2012 StandoutNatureNobel
Pathogenesis and Treatment of Sickle Cell Disease
1997
Hemoglobin: Structure, Function and Allostery
2020
Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia
1995 Standout
Computational Enzyme Design
2013 StandoutNobel
The type III needle and the damage done
2005
Electrostatic fields in antibodies and antibody/antigen complexes
1992
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution
2001 StandoutNatureNobel
Enhanced Expression and Purification of Fungal Galactose Oxidase in Escherichia coli and Use for Analysis of a Saturation Mutagenesis Library
2011
Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit
2013 StandoutNatureNobel
Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor
2012 StandoutNobel
Antibody framework residues affecting the conformation of the hypervariable loops
1992 StandoutNobel
Evaluation and improvement of multiple sequence methods for protein secondary structure prediction
1999
Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation
2013 StandoutNobel
The type III secretion injectisome
2006
New structural insights into the bacterial type III secretion system
2006
A role for surface hydrophobicity in protein‐protein recognition
1994
Identification of critical contact residues in the NC41 epitope of a subtype N9 influenza virus neuraminidase
1993
Reaction of nitric oxide with heme proteins and model compounds of hemoglobin
1987
Identification of the haemoglobin scavenger receptor
2001 StandoutNature
Natural Diversity to Guide Focused Directed Evolution
2010
A Randomized Trial of Bevacizumab, an Anti–Vascular Endothelial Growth Factor Antibody, for Metastatic Renal Cancer
2003 Standout
N9 Neuraminidase Complexes with Antibodies NC41 and NC10: Empirical Free Energy Calculations Capture Specificity Trends Observed with Mutant Binding Data
1994
Infrared spectra of carbonyl hemoglobins: characterization of dynamic heme pocket conformers
1990
Recombinant Human Single Chain Fv Antibodies Recognizing Human Interleukin-6
1998 StandoutNobel
Functional analysis of the interaction between HCV 5'UTR and putative subunits of eukaryotic translation initiation factor eIF3
1998
Structural repertoire of the human VH segments
1992 StandoutNobel
Distributions of enzyme residues yielding mutants with improved substrate specificities from two different directed evolution strategies
2009
Tess: A geometric hashing algorithm for deriving 3D coordinate templates for searching structural databases. Application to enzyme active sites
1997
Exploring protein fitness landscapes by directed evolution
2009 StandoutNobel
The NS5A Protein of Hepatitis C Virus Is a Zinc Metalloprotein
2004 StandoutNobel
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
2008 Standout
Aptamers come of age – at last
2006
Treatment of Sickle Cell Anemia with Hydroxyurea and Erythropoietin
1990
Solution structure of P22 transcriptional antitermination N peptide–box B RNA complex
1998
Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer
2004 Standout
VEGF in Signaling and Disease: Beyond Discovery and Development
2019 Standout
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
2013 Standout
Engineering the third wave of biocatalysis
2012 StandoutNature
Biochemistry of Nitric Oxide and Its Redox-Activated Forms
1992 StandoutScience
Prediction of the structure of symmetrical protein assemblies
2007 StandoutNobel
Advances in engineering hydrogels
2017 StandoutScience
A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q
1994 StandoutNobel
Single‐chain Fvs
1995
Molecular dynamics simulation of photodissociation of carbon monoxide from hemoglobin.
1985 StandoutNobel
Copper Active Sites in Biology
2014 Standout
Guanylate cyclase from bovine lung. Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes.
1984 StandoutNobel
Structure of carboxymyoglobin in crystals and in solution.
1979
Dynamic protein structures: infrared evidence for four discrete rapidly interconverting conformers at the carbon monoxide binding site of bovine heart myoglobin.
1981
Aptamers Selected for Higher-Affinity Binding Are Not More Specific for the Target Ligand
2006 StandoutNobel
The Energy Landscapes and Motions of Proteins
1991 StandoutScience
Classical Electrostatics in Biology and Chemistry
1995 StandoutScience
Mapping epitopes and antigenicity by site-directed masking
2006 StandoutNobel
Activation of purified soluble guanylate cyclase by protoporphyrin IX.
1982 StandoutNobel
Antigen recognition properties of mutant V beta 3+ T cell receptors are consistent with an immunoglobulin-like structure for the receptor.
1993
Localized Surface Plasmon Resonance Sensors
2011 Standout
The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 Å
1996 StandoutScience
A Hot Spot of Binding Energy in a Hormone-Receptor Interface
1995 StandoutScience
Structural basis for the conformational states of nitrosyl hemoglobins M Saskatoon and M Milwaukee. Influence of distal histidine residues on proximal histidine-iron bonds.
1980
Process of Protein Transport by the Type III Secretion System
2004
Gold Nanoparticles in Chemical and Biological Sensing
2012 Standout
Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins.
1984 StandoutNobel
"Diabodies": small bivalent and bispecific antibody fragments.
1993 StandoutNobel
Reaction of nitric oxide with heme proteins: studies on metmyoglobin, opossum methemoglobin, and microperoxidase
1983
Oxidized LDL Receptor LOX-1 Binds to C-Reactive Protein and Mediates Its Vascular Effects
2008
Protein Structure Prediction and Structural Genomics
2001 StandoutScienceNobel
Adaptive Recognition by Nucleic Acid Aptamers
2000 Science
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
Caged nitric oxide. Stable organic molecules from which nitric oxide can be photoreleased.
1994 StandoutNobel
Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.
1997
Antibody-antigen interactions
1993
Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.
1994 StandoutNobel
Role of Aromatic Side Chains in the Folding and Thermodynamic Stability of Integral Membrane Proteins
2007
Novel β-Barrel Fold in the Nuclear Magnetic Resonance Structure of the Replicase Nonstructural Protein 1 from the Severe Acute Respiratory Syndrome Coronavirus
2007 Nobel
Resonance Raman investigation of carbon monoxide bonding in (carbon monoxy)hemoglobin and -myoglobin: detection of iron-carbon monoxide stretching and iron-carbon-oxygen bending vibrations and influence of the quaternary structure change
1982
Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA
2004 StandoutNobel
Bound water molecules and conformational stabilization help mediate an antigen-antibody association.
1994
Works of S.E.V. Phillips being referenced
Structural and kinetic studies of a series of mutants of galactose oxidase identified by directed evolution
2004
Crystal structure of an RNA aptamer–protein complex at 2.8 Å resolution
1998
LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cells
2005
Physiological and x-ray studies of potential antisickling agents.
1983
Structure of hemoglobins Zürich [His E7(63)beta replaced by Arg] and Sydney [Val E11(67)beta replaced by Ala] and role of the distal residues in ligand binding.
1978
Structure of HrcQ B -C, a conserved component of the bacterial type III secretion systems
2003
Crystallographic refinement of the three-dimensional structure of the FabD1.3-lysozyme complex at 2.5-A resolution
1991