Standout Papers
Citation Impact
Citing Papers
Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron
2011
Highly Recurrent TERT Promoter Mutations in Human Melanoma
2013 StandoutScience
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
2004 StandoutScience
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
Hemophagocytosis causes a consumptive anemia of inflammation
2011
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
Computation and Functional Studies Provide a Model for the Structure of the Zinc Transporter hZIP4
2015 StandoutNobel
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
2011 StandoutNobel
Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis
2012
Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis
2011
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
2009 StandoutNobel
Regulation of erythropoiesis by hypoxia-inducible factors
2013
Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors
2010 StandoutNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
Diagnosis and management of anaemia of chronic disease: current status
2011
The molecular basis of hepcidin-resistant hereditary hemochromatosis
2009
2-Oxoglutarate-dependent oxygenases control hepcidin gene expression
2008
Quantification of mRNA using real-time RT-PCR
2006 Standout
Phlebotomies or erythropoietin injections allow mobilization of iron stores in a mouse model mimicking intensive care anemia
2008
Targeting Interleukin-6 Signaling in Clinic
2019
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
Iron Metabolism: Interactions with Normal and Disordered Erythropoiesis
2012
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
2007
Targeting the hepcidin–ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation
2011
Balancing Acts
2004 Standout
Iron Overload in Human Disease
2012
Targeting Interleukin-6: All the Way to Treat Autoimmune and Inflammatory Diseases
2012
Iron Deficiency and Raised Hepcidin in Idiopathic Pulmonary Arterial Hypertension
2011
Erythropoiesis Stimulatory Agent- Resistant Anemia in Dialysis Patients: Review of Causes and Management
2009
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
Molecular Architecture and Function of ZnT Transporters
2012
Mechanisms of Anemia in CKD
2012
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI
2019 StandoutNobel
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
2005
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Hepcidin and iron homeostasis
2012
Evidence for a Lack of a Direct Transcriptional Suppression of the Iron Regulatory Peptide Hepcidin by Hypoxia-Inducible Factors
2009
Two to Tango: Regulation of Mammalian Iron Metabolism
2010 Standout
IL-6 in Inflammation, Immunity, and Disease
2014 Standout
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Macrophages and Systemic Iron Homeostasis
2012
Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1
2012 StandoutNobel
Charting the travels of copper in eukaryotes from yeast to mammals
2012
Identification of erythroferrone as an erythroid regulator of iron metabolism
2014
Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice
2011
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
2009
Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin
2009
Iron regulation by hepcidin
2013
Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension
2013
TGFβ in Cancer
2008 Standout
A Red Carpet for Iron Metabolism
2017
Iron and microbial infection
2004
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
1999 StandoutNobel
Anemia of inflammation: the hepcidin link
2005
The role of iron in brain ageing and neurodegenerative disorders
2014 Standout
Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production
2009
Serum hepcidin-25 levels in patients with chronic kidney disease are independent of glomerular filtration rate
2009
Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
2009 StandoutNobel
A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication
2009
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
2007
Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development
2006 StandoutNobel
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
1998 StandoutNobel
Anaemia in kidney disease: harnessing hypoxia responses for therapy
2015
Cellular iron transport
2009
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
2017 Standout
Hepcidin: from discovery to differential diagnosis
2007
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice
2011
Pattern of resistance to erythropoietin-stimulating agents in chronic kidney disease
2011
Global quantification of mammalian gene expression control
2011 StandoutNature
Relationship between hepcidin levels and periodic limb movement disorder in patients with obstructive sleep apnea syndrome
2014
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
2006
The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression
2008
Anemia of Chronic Disease
2005 Standout
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation
2013 StandoutNobel
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Mitochondrial Mayhem: The Mitochondrion as a Modulator of Iron Metabolism and Its Role in Disease
2011
Iron Homeostasis and Its Interaction with Prolyl Hydroxylases
2009
Efficacy, safety and tolerability of tocilizumab in patients with systemic juvenile idiopathic arthritis
2012
Dissecting racial bias in an algorithm used to manage the health of populations
2019 StandoutScience
Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency
2008
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
1993 StandoutNobel
Clinical iron deficiency disturbs normal human responses to hypoxia
2016 StandoutNobel
Regulation of hepcidin expression at high altitude
2011
Hepcidin and Disorders of Iron Metabolism
2010
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1α with p300 and CBP
2002 StandoutNobel
Hepcidin is a Potential Regulator of Iron Status in Chronic Kidney Disease
2012
Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo
2010
Regulation of cellular iron metabolism
2011
Regulation of hepcidin transcription by interleukin-1 and interleukin-6
2005
Modeling hepatitis C virus infection using human induced pluripotent stem cells
2012 StandoutNobel
Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPα
2008
Interleukin-6 induces hepcidin expression through STAT3
2006
Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis
2004
Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia
2010
The distal location of the iron responsive region of the hepcidin promoter
2007
Cytokine Storm
2020 Standout
Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia
2004
Therapeutic Targeting of the Interleukin-6 Receptor
2011
Iron Homeostasis
2006
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.
1994 StandoutNobel
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Human and viral interleukin-6 and other cytokines in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease
2013
Nutritional iron deficiency
2007
Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations
2005
Hepcidin and iron regulation, 10 years later
2011
Detection, evaluation, and management of iron-restricted erythropoiesis
2010
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
1997 StandoutNobel
Immunoassay for human serum hepcidin
2008
Forging a field: the golden age of iron biology
2008
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Erythroferrone contributes to recovery from anemia of inflammation
2014
Systemic Iron Homeostasis
2013
Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis
2010
Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses
2011
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
2006
Regulation of Hepcidin by Erythropoiesis: The Story So Far
2016
Metal–Organic Frameworks in Biomedicine
2011 Standout
Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
2005
Hepcidin in iron overload disorders
2005
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression
2011
Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats
2011
Treatment of erythropoietin deficiency in mice with systemically administered siRNA
2012 StandoutNobel
Regulation of Iron Metabolism by Hepcidin
2006
Works of Seth Rivera being referenced
Hepcidin—A Potential Novel Biomarker for Iron Status in Chronic Kidney Disease
2009
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
2004 Standout
Animal Models of Anemia of Inflammation
2009
Suppression of hepcidin during anemia requires erythropoietic activity
2006
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
2004 Standout
In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2
2010
Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response
2005
In Chronic Inflammation, There Exists an IL-6 Independent Pathway for the Induction of Hepcidin.
2004
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
2005
Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
2004