Citation Impact
Citing Papers
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
2006 StandoutNobel
Neutralizing antibody response during acute and chronic hepatitis C virus infection
2004 StandoutNobel
Complete Replication of Hepatitis C Virus in Cell Culture
2005 StandoutScienceNobel
The use of mRNA display to select high-affinity protein-binding peptides
2001 StandoutNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130
2002 StandoutNobel
Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity.
1996
Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target
2010
Hepatitis C Virus NS5A Is a Direct Substrate of Casein Kinase I-α, a Cellular Kinase Identified by Inhibitor Affinity Chromatography Using Specific NS5A Hyperphosphorylation Inhibitors
2006
Intrabody construction and expression III: Engineering hyperstable VH domains
1999
Challenges and successes in developing new therapies for hepatitis C
2005 Nature
Structures of MLSBK Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance
2005 StandoutNobel
Nucleoside Analog Inhibitors of Hepatitis C Virus Replication
2006
Antiviral interactions of an HCV polymerase inhibitor with an HCV protease inhibitor or interferon in vitro
2006
In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance
2006
In Vitro Studies of Cross-resistance Mutations against Two Hepatitis C Virus Serine Protease Inhibitors, VX-950 and BILN 2061
2005
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
The therapeutic potential of interleukin-6 hyperagonists and antagonists
1997
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3
2001
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Circulating Endothelial Progenitor Cells and Cardiovascular Outcomes
2005 Standout
Ribosome-inactivating proteins from plants
1993
Dynamic Hepatitis C Virus Genotypic and Phenotypic Changes in Patients Treated With the Protease Inhibitor Telaprevir
2007
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Crystal Structure of HEL4, a Soluble, Refoldable Human VH Single Domain with a Germ-line Scaffold
2004 StandoutNobel
Architects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesis
2008 StandoutNobel
Recognition of the highly conserved GTPase center of 23 S ribosomal RNA by ribosomal protein L11 and the antibiotic thiostrepton
1991
High Resolution Structure of the Large Ribosomal Subunit from a Mesophilic Eubacterium
2001 StandoutNobel
The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coli
2005 StandoutNobel
The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism
1999
The hepatitis C virus replicon system: From basic research to clinical application
2005
Streptomycin binds to the decoding center of 16 S ribosomal RNA 1 1Edited by M. Gottesman
1997
Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Å Resolution
2000 StandoutNobel
The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy
1999
An antibody single-domain phage display library of a native heavy chain variable region: isolation of functional single-domain VH molecules with a unique interface 1 1Edited by I. A. Wilson
1999
De NovoInitiation of RNA Synthesis by a Recombinant Flaviridae RNA-dependent RNA Polymerase
1999
The involvement of RNA in ribosome function
2002 StandoutNatureNobel
Prospects for a vaccine against the hepatitis C virus
2005 StandoutNatureNobel
Association of Fibrinogen, C-reactive Protein, Albumin, or Leukocyte Count With Coronary Heart Disease
1998 Standout
Relationship Between Interleukin 6 and Mortality in Patients With Unstable Coronary Artery Disease
2001
Chapter 2 Cutting the Gordian Knot-Development and Biological Relevance of Hepatitis C Virus Cell Culture Systems
2008
Definition of a Composite Binding Site for gp130 in Human Interleukin-6
1995
Dimerization of cell surface receptors in signal transduction
1995
RNA-dependent RNA Polymerase Activity of the Soluble Recombinant Hepatitis C Virus NS5B Protein Truncated at the C-terminal Region
1998
Selection by phage display of llama conventional VH fragments with heavy chain antibody VHH properties
2002
Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein
2008
Function Follows Form: The Structure of the N-Terminal Domain of HCV NS5A *
2005
Combining Two Mutations of Human Interleukin-6 That Affect gp130 Activation Results in a Potent Interleukin-6 Receptor Antagonist on Human Myeloma Cells
1995
Identification of Single Amino Acid Residues of Human IL-6 Involved in Receptor Binding and Signal Initiation
1996
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
1999
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
2011 Standout
Hepatitis C Virus NS5B and Host Cyclophilin A Share a Common Binding Site on NS5A
2012
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
In Vitro Resistance Studies of Hepatitis C Virus Serine Protease Inhibitors, VX-950 and BILN 2061
2004
Atherosclerosis — An Inflammatory Disease
1999 Standout
Recombinant Human Single Chain Fv Antibodies Recognizing Human Interleukin-6
1998 StandoutNobel
The many roles of histone deacetylases in development and physiology: implications for disease and therapy
2008 Standout
Directed Evolution of High-Affinity Antibody Mimics Using mRNA Display
2002
Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus†
2007
From Structure to Function: New Insights into Hepatitis C Virus RNA Replication
2005
Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity
2012
Mutations Conferring Resistance to SCH6, a Novel Hepatitis C Virus NS3/4A Protease Inhibitor
2005
C-Reactive Protein Is a Potent Predictor of Mortality Independently of and in Combination With Troponin T in Acute Coronary Syndromes: A TIMI 11A Substudy
1998
Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon
2005 StandoutNobel
Identification of Three Distinct Receptor Binding Sites of Murine Interleukin-11
1999
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
2014 Standout
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
Hepatitis C therapeutics: current status and emerging strategies
2002
Inflammation, Atherosclerosis, and Coronary Artery Disease
2005 Standout
Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
1997 Standout
A genetically humanized mouse model for hepatitis C virus infection
2011 StandoutNatureNobel
Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages
1999
C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women
2000 Standout
Ribosome Structure and the Mechanism of Translation
2002 StandoutNobel
Inhibition of Hepatitis C Virus RNA Replication by 2′-Modified Nucleoside Analogs
2003
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
2008 Standout
Potent enzyme inhibitors derived from dromedary heavy-chain antibodies
1998
The way forward in HCV treatment — finding the right path
2007 StandoutNobel
Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034
2006
Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria
2001 StandoutNatureNobel
Replication of hepatitis C virus
2007 StandoutNobel
Structure of the 80S Ribosome from Saccharomyces cerevisiae—tRNA-Ribosome and Subunit-Subunit Interactions
2001 StandoutNobel
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
2003 StandoutNobel
Elevated Levels of C-Reactive Protein at Discharge in Patients With Unstable Angina Predict Recurrent Instability
1999
Initiation of viral RNA-dependent RNA polymerization
2004
Replication of Hepatitis C Virus (HCV) RNA in Mouse Embryonic Fibroblasts: Protein Kinase R (PKR)-Dependent and PKR-Independent Mechanisms for Controlling HCV RNA Replication and Mediating Interferon Activities
2006
Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus
2006
Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.
1995
Combination of a Hepatitis C Virus NS3-NS4A Protease Inhibitor and Alpha Interferon Synergistically Inhibits Viral RNA Replication and Facilitates Viral RNA Clearance in Replicon Cells
2004
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Human VAP-B Is Involved in Hepatitis C Virus Replication through Interaction with NS5A and NS5B
2005
Increasing Levels of Interleukin (IL)-1Ra and IL-6 During the First 2 Days of Hospitalization in Unstable Angina Are Associated With Increased Risk of In-Hospital Coronary Events
1999
RNA-peptide fusions for the in vitro selection of peptides and proteins
1997 StandoutNobel
Specific Interaction between the Hepatitis C Virus NS5B RNA Polymerase and the 3′ End of the Viral RNA
1999
Development of an interleukin (IL) 6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells.
1994
Cell Culture Adaptation of Hepatitis C Virus and In Vivo Viability of an Adapted Variant
2007
Human interleukin-6 receptor super-antagonists with high potency and wide spectrum on multiple myeloma cells
1996
Increased Proinflammatory Cytokines in Patients With Chronic Stable Angina and Their Reduction By Aspirin
1999
The Hepatitis C Virus NS3 Proteinase: Structure and Function of a Zinc-Containing Serine Proteinase
1998
Enhanced Levels of Soluble and Membrane-Bound CD40 Ligand in Patients With Unstable Angina
1999
The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication
2007 StandoutNobel
Studying Hepatitis C Virus: Making the Best of a Bad Virus
2007 StandoutNobel
De Novo Initiation of RNA Synthesis by the RNA-Dependent RNA Polymerase (NS5B) of Hepatitis C Virus
2000
Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles
2008
Genetic diversity and evolution of hepatitis C virus – 15 years on
2004
The α Isoform of Protein Kinase CKI Is Responsible for Hepatitis C Virus NS5A Hyperphosphorylation
2006
Hepatitis C Virus RNA Synthesis in a Cell-Free System Isolated from Replicon-Containing Hepatoma Cells
2003 StandoutNobel
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
Monoclonal T-Cell Proliferation and Plaque Instability in Acute Coronary Syndromes
2000
Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins
1998 StandoutNobel
De Novo Initiation of RNA Synthesis by Hepatitis C Virus Nonstructural Protein 5B Polymerase
2000
Phage Display
1997
Development of a GB Virus B Marmoset Model and Its Validation with a Novel Series of Hepatitis C Virus NS3 Protease Inhibitors
2004
Characterization of Soluble Hepatitis C Virus RNA-Dependent RNA Polymerase Expressed in Escherichia coli
1999
Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men
2000 Standout
Evidence for Antigen-Driven T-Cell Response in Unstable Angina
2000
Mutations Conferring Resistance to a Potent Hepatitis C Virus Serine Protease Inhibitor In Vitro
2004
The Hepatitis C Virus NS4B Protein Can trans -Complement Viral RNA Replication and Modulates Production of Infectious Virus
2008
Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro
2005
CF2H, a Hydrogen Bond Donor
2017 Standout
Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis
1997 StandoutScienceNobel
C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction
1999 Standout
Cardiovascular Disease, Interleukin-6, and Risk of Mortality in Older Women
2001
Functional analysis of seven ribosomal systems from extremely halophilic archaea
1993
Works of Sergio Altamura being referenced
Reduction of Hepatitis C Virus NS5A Hyperphosphorylation by Selective Inhibition of Cellular Kinases Activates Viral RNA Replication in Cell Culture
2004
Affinity selection of a camelized V(H) domain antibody inhibitor of hepatitis C virus NS3 protease
1997
Biochemical characterization of a hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequence
2000
Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase
2003
Aminoglycoside-induced mistranslation in thermophilic archaebacteria
1988
A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease
2002
The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase
2004
Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture
2009
Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small Molecule Inhibitors Bound to a Novel Allosteric Site
2005
[4] RNA-dependent RNA polymerase of hepatitis C virus
1996
Monovalent phage display of human interleukin (hIL)-6: selection of superbinder variants from a complex molecular repertoire in the hIL-6 D-helix
1995
The Molecular Design of Human IL‐6 Receptor Antagonistsa
1995
Mechanismof Action and Antiviral Activity of Benzimidazole-Based AllostericInhibitors of the Hepatitis C Virus RNA-Dependent RNAPolymerase
2003
The Antibiotic Sensitivity Spectra of Ribosomes from the Thermoproteales: Phylogenetic Depth and Distribution of Antibiotic Binding Sites
1988
Discovery of α,γ-Diketo Acids as Potent Selective and Reversible Inhibitors of Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase
2003
Enhanced Inflammatory Response to Coronary Angioplasty in Patients With Severe Unstable Angina
1998
Characterization of the Inhibition of Hepatitis C Virus RNA Replication by Nonnucleosides
2003
Rational design of a receptor super-antagonist of human interleukin-6.
1994
Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.
1994
Unique antibiotic sensitivity of archaebacterial polypeptide elongation factors
1986
Review HCV Antiviral Resistance: The Impact of in vitro Studies on the Development of Antiviral Agents Targeting the Viral NS5B Polymerase
2005
Characterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoires
1997
Prime Site Binding Inhibitors of a Serine Protease: NS3/4A of Hepatitis C Virus
2002
Unique antibiotic sensitivity of an in vitro polypeptide synthesis system from the archaebacterium Thermoplasma acidophilum. Phylogenetic implications
1987
Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors
2009
Potent Peptide Inhibitors of Human Hepatitis C Virus NS3 Protease Are Obtained by Optimizing the Cleavage Products
1998
Elevated Levels of Interleukin-6 in Unstable Angina
1996
Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases
2008
In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor
2003
Cell Clones Selected from the Huh7 Human Hepatoma Cell Line Support Efficient Replication of a Subgenomic GB Virus B Replicon
2002