Citation Impact
Citing Papers
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
2007 StandoutNobel
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
2002 StandoutNobel
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
2006 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The many substrates and functions of ATM
2000
Src kinase contributes to the metastatic spread of carcinoma cells
2002
COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes
1998 StandoutNobel
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
1994
The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src
1997
Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
2008 Standout
Cancer drug resistance: an evolving paradigm
2013 Standout
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
1996 StandoutNatureNobel
When Checkpoints Fail
1997 StandoutNobel
A Functional Phosphatidylinositol 3,4,5-Trisphosphate/Phosphoinositide Binding Domain in the Clathrin Adaptor AP-2 α Subunit. IMPLICATIONS FOR THE ENDOCYTIC PATHWAY
1996
G Protein-coupled Receptors Mediate Two Functionally Distinct Pathways of Tyrosine Phosphorylation in Rat 1a Fibroblasts
1997 StandoutNobel
Epithelial Cell Plasticity in Development and Tumor Progression
1999
Recognition and specificity in protein tyrosine kinase-mediated signalling
1995
Coordination between transcription and pre‐mRNA processing
2001
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Gβγ-dependent Phosphoinositide 3-Kinase Activation in Hearts with in Vivo Pressure Overload Hypertrophy
2000
Epithelial–mesenchymal transitions in tumour progression
2002 Standout
STAM and Hrs Are Subunits of a Multivalent Ubiquitin-binding Complex on Early Endosomes
2003
When is a lipid kinase not a lipid kinase? When it is a protein kinase
1995
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion
2001
Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer
1997
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression
2009 StandoutNobel
α-Thrombin Induces Rapid and Sustained Akt Phosphorylation by β-Arrestin1-dependent and -independent Mechanisms, and Only the Sustained Akt Phosphorylation Is Essential for G1 Phase Progression
2002
Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance
2012
Insulin Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression Does Not Require Activation of the Ras/Mitogen-activated Protein Kinase Signaling Pathway
1996
Phosphatidylinositol 3‐kinase
1994
Lysophosphatidic acid: G-protein signalling and cellular responses
1997
Mitogenic Signaling via G Protein-Coupled Receptors
1996 StandoutNobel
Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement
2018 StandoutNobel
Nuclear Signaling by Endothelin-1 Requires Src Protein-tyrosine Kinases
1996
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages
1999
A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling
2006
Mitotic regulation of the human anaphase-promoting complex by phosphorylation
2003
Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM
1995
Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells
2000
Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells
1998
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Generation, Control, and Processing of Cellular Calcium Signals
2001
Mechanisms responsible for nilotinib resistance in human chronic myeloid leukemia cells and reversal of resistance
2012
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Eph receptors and ephrins in cancer: bidirectional signalling and beyond
2010
Chemokine Receptors CXCR-1/2 Activate Mitogen-activated Protein Kinase via the Epidermal Growth Factor Receptor in Ovarian Cancer Cells
2000
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Cytokine Signaling in 2002
2002 Standout
RhoB and Actin Polymerization Coordinate Src Activation with Endosome-Mediated Delivery to the Membrane
2004
Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication
2018 Standout
Cancer-related inflammation
2008 StandoutNature
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
2009 Standout
Protein kinases and phosphatases that act on histidine, lysine, or arginine residues in eukaryotic proteins: A possible regulator of the mitogen-activated protein kinase cascade
1995
ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK
1999
c-Src-mediated Phosphorylation of the Epidermal Growth Factor Receptor on Tyr845 and Tyr1101 Is Associated with Modulation of Receptor Function
1999
Cooperation of Src Homology Domains in the Regulated Binding of Phosphatidylinositol 3-Kinase
1995
Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways
2002
Loss of Hippocampal CA3 Pyramidal Neurons in Mice Lacking STAM1
2001
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast
1996
Mechanism of activation of protein kinase B by insulin and IGF-1.
1996 Standout
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
Stat1-independent regulation of gene expression in response to IFN-γ
2001
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
McsB Is a Protein Arginine Kinase That Phosphorylates and Inhibits the Heat-Shock Regulator CtsR
2009 StandoutScienceNobel
The Structure and Function of P55PIK Reveal a New Regulatory Subunit for Phosphatidylinositol 3-Kinase
1995
Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice
2002 StandoutNobel
Ataxia-telangiectasia and cellular responses to DNA damage.
1995
Targeting G βγ signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis
1999 StandoutNobel
Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation
2001 StandoutNobel
Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) Interferes with Extracellular Signal-regulated Kinase (ERK) and Jun NH2-terminal Kinase (JNK) Activation, but Does Not Affect Phosphorylation of T Cell Receptor ζ and ZAP70
1997
Protection from angiotensin II–mediated vasculotoxic and hypertensive response in mice lacking PI3Kγ
2005
β-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
2006 StandoutNobel
Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.
1995 StandoutNobel
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
1995 StandoutNobel
Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells
1998
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
2004 StandoutNobel
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
1997 Standout
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.
1996
Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure
2001 StandoutNobel
Aquaglyceroporin AQP9: Solute permeation and metabolic control of expression in liver
2003 StandoutNobel
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
2001 StandoutNobel
Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function.
1996
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways
1996 Science
THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions
1999
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.
1996
Reactive Oxygen Species as Mediators of Signal Transduction in Cardiovascular Disease
1998
Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor
1995 Science
The transmembrane protein CBP plays a role in transiently anchoring small clusters of Thy-1, a GPI-anchored protein, to the cytoskeleton
2009
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors
2000 StandoutNobel
Works of Serge Roche being referenced
Quantitative Phosphoproteomics Reveals a Cluster of Tyrosine Kinases That Mediates Src Invasive Activity in Advanced Colon Carcinoma Cells
2009
Evidence that Resistance to Nilotinib May Be Due to BCR-ABL, Pgp, or Src Kinase Overexpression
2008
Identification of a Novel Immunoreceptor Tyrosine-based Activation Motif-containing Molecule, STAM2, by Mass Spectrometry and Its Involvement in Growth Factor and Cytokine Receptor Signaling Pathways
2000
A Function for Phosphoinositide 3-Kinase β Lipid Products in Coupling βγ to Ras Activation in Response to Lysophosphatidic Acid
2002
The Src SH3 Domain Is Required for DNA Synthesis Induced by Platelet-derived Growth Factor and Epidermal Growth Factor
1996
Src and Ras are involved in separate pathways in epithelial cell scattering
1997
DNA Synthesis Induced by Some but Not All Growth Factors Requires Src Family Protein Tyrosine Kinases
1995
The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1
2008
Syntenin mediates SRC function in exosomal cell-to-cell communication
2017
A Function for Phosphatidylinositol 3-Kinase β (p85α-p110β) in Fibroblasts during Mitogenesis: Requirement for Insulin- and Lysophosphatidic Acid-Mediated Signal Transduction
1998
The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.
1994
PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.
1994
A Specific Role of Phosphatidylinositol 3–Kinase γ
2001
Src Family Tyrosine Kinase Regulates Intracellular pH in Cardiomyocytes
1998
The catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src complexes
1994
Requirement for Src Family Protein Tyrosine Kinases in G 2 for Fibroblast Cell Division
1995 Science
Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways.
1996
The Tom1L1-Clathrin Heavy Chain Complex Regulates Membrane Partitioning of the Tyrosine Kinase Src Required for Mitogenic and Transforming Activities
2007
Calcium Release at Fertilization in Starfish Eggs Is Mediated by Phospholipase Cγ
1997