Citation Impact
Citing Papers
Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching
2008
Chromosomal variation in neurons of the developing and adult mammalian nervous system
2001
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch
2004 StandoutScienceNobel
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
2013 StandoutScience
Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks
2012
Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism
2007
A Non-Leaky Artemis-Deficient Mouse That Accurately Models the Human Severe Combined Immune Deficiency Phenotype, Including Resistance to Hematopoietic Stem Cell Transplantation
2009
The DNA-damage response in human biology and disease
2009 StandoutNature
A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci
2004
H3K4me3 Stimulates the V(D)J RAG Complex for Both Nicking and Hairpinning in trans in Addition to Tethering in cis: Implications for Translocations
2009
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination
2004
Collateral Damage from Antigen Receptor Gene Diversification
2008
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase
2007
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
2010
The bounty of RAGs: recombination signal complexes and reaction outcomes
2004
p53: traffic cop at the crossroads of DNA repair and recombination
2005
The DNA-dependent Protein Kinase Catalytic Subunit Phosphorylation Sites in Human Artemis
2005
Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes
2009
Chromatin Modifications and Their Function
2007 Standout
IgH Class Switch Recombination to IgG1 in DNA-PKcs-Deficient B Cells
2002
H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility
2003
Cell-cycle checkpoints and cancer
2004 StandoutNature
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
The genetics of ageing
2010 StandoutNature
MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals
2006
The Mechanism and Regulation of Chromosomal V(D)J Recombination
2002
The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by Bulky Adduct-containing DNA
2011 StandoutNobel
Tying the loose ends together in DNA double strand break repair with 53BP1.
2006
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
2004
Histone H2AX
2003
Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX
2003
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 StandoutNature
The nonhomologous end joining factor Artemis suppresses multi-tissue tumor formation and prevents loss of heterozygosity
2007
Indecent Exposure
2004
Mechanism and regulation of human non-homologous DNA end-joining
2003
Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes
2003
Nonoverlapping Functions of DNA Polymerases Mu, Lambda, and Terminal Deoxynucleotidyltransferase during Immunoglobulin V(D)J Recombination In Vivo
2006
An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity
2008
The cellular response to DNA damage: A focus on MDC1 and its interacting proteins
2010
DNA Repair, Genome Stability, and Aging
2005
Nucleases of the Metallo-β-lactamase Family and Their Role in DNA and RNA Metabolism
2007
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
A DNA damage checkpoint response in telomere-initiated senescence
2003 StandoutNature
A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining
2008
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
2006 StandoutNobel
The Histone Chaperone Spt6 Is Required for Activation-induced Cytidine Deaminase Target Determination through H3K4me3 Regulation
2012 StandoutNobel
Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice
2004
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
The mechanisms of immune diversification and their disorders
2003
UV-induced Ataxia-telangiectasia-mutated and Rad3-related (ATR) Activation Requires Replication Stress
2004
Cernunnos, a Novel Nonhomologous End-Joining Factor, Is Mutated in Human Immunodeficiency with Microcephaly
2006
MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
2005
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
2003
γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
2006
Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining
2015
Stem cells, ageing and the quest for immortality
2006 StandoutNature
Lymphocyte-Specific Compensation for XLF/Cernunnos End-Joining Functions in V(D)J Recombination
2008
Replication protein A and γ-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks
2004
Requirement of Non-canonical Activity of Uracil DNA Glycosylase for Class Switch Recombination
2006 StandoutNobel
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
2009 Nature
γH2AX and cancer
2008
Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System
2014 StandoutNobel
Cdc7-Dbf4 and the Human S Checkpoint Response to UVC
2007 StandoutNobel
H2AX Prevents DNA Breaks from Progressing to Chromosome Breaks and Translocations
2006
The cellular response to general and programmed DNA double strand breaks
2004
H2AX: the histone guardian of the genome
2004
Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase
2009 StandoutNobel
MDC1 is a mediator of the mammalian DNA damage checkpoint
2003 Nature
Functional and biochemical dissection of the structure‐specific nuclease ARTEMIS
2004
A Plant Homeodomain in Rag-2 that Binds Hypermethylated Lysine 4 of Histone H3 Is Necessary for Efficient Antigen-Receptor-Gene Rearrangement
2007
Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences
2005
SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
2008
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Coordinate 5′ and 3′ endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase
2008
The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci
2010
The Hallmarks of Aging
2013 Standout
Phosphorylation of H2AX at Short Telomeres in T Cells and Fibroblasts
2004 StandoutNobel
The role of the DNA double-strand break response network in meiosis
2004
The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps
2005
Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis
2002 StandoutNobel
Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks
2006
Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations
2006
Phosphorylation and Regulation of DNA Ligase IV Stability by DNA-dependent Protein Kinase
2004
lincRNAs act in the circuitry controlling pluripotency and differentiation
2011 StandoutNature
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
The cellular response to DNA double-strand breaks: defining the sensors and mediators
2003
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
2012 StandoutNobel
Processing of 3′-Phosphoglycolate-terminated DNA Double Strand Breaks by Artemis Nuclease
2006
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
2006 Nature
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
2003 Nature
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
2013 Standout
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements
2007 StandoutNobel
γH2AX and its role in DNA double-strand break repairThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.
2006
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
2013 StandoutNobel
Telomerase core components protect Candida telomeres from aberrant overhang accumulation
2007 StandoutNobel
ATM Is Required for Efficient Recombination between Immunoglobulin Switch Regions
2004
Mechanisms of double-strand break repair in somatic mammalian cells
2009
MECHANISM AND CONTROL OF V(D)J RECOMBINATION AT THE IMMUNOGLOBULIN HEAVY CHAIN LOCUS
2006
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres
2006 StandoutNobel
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination
2007
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Following the Path of the Virus: The Exploitation of Host DNA Repair Mechanisms by Retroviruses
2006
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development
2006
The Yeast Chromatin Remodeler RSC Complex Facilitates End Joining Repair of DNA Double-Strand Breaks
2005
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation
2003
The cellular response to DNA damage: A focus on MDC1 and its interacting proteins
2010
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Targeted Disruption of the Artemis Murine Counterpart Results in SCID and Defective V(D)J Recombination That Is Partially Corrected with Bone Marrow Transplantation
2005
Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination
2019
DNA Double-Strand Breaks
2002 StandoutNobel
Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants
2008 StandoutNobel
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation
2011 StandoutNobel
Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination
2013
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination
2004 StandoutNobel
Non-homologous end-joining, a sticky affair
2007
Works of Scott Whitlow being referenced
Increased Accumulation of Hybrid V(D)J Joins in Cells Expressing Truncated versus Full-Length RAGs
2001
Leaky Scid Phenotype Associated with Defective V(D)J Coding End Processing in Artemis-Deficient Mice
2002
Vβ cluster sequences reduce the frequency of primary Vβ2 and Vβ14 rearrangements
2008
Defective DNA Repair and Increased Genomic Instability in Artemis-deficient Murine Cells
2003
Impaired V(D)J Recombination and Lymphocyte Development in Core RAG1-expressing Mice
2003
Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells
2004
Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development
2001
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
2002