Citation Impact
Citing Papers
Improvement of comparative model accuracy by free-energy optimization along principal components of natural structural variation
2004 StandoutNobel
Nature of the protein universe
2009 StandoutNobel
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The IRS‐signalling system during insulin and cytokine action
1997
The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity
1997 Standout
Signal transduction via platelet-derived growth factor receptors
1998
Oncogenic kinase signalling
2001 StandoutNature
Suppressor of Cytokine Signaling-1 Inhibits VAV Function through Protein Degradation
2000
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
SHP-2 binds to Tyr763 and Tyr1009 in the PDGF β-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis
1999
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
1999 Standout
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Prolonged Kappa Opioid Receptor Phosphorylation Mediated by G-protein Receptor Kinase Underlies Sustained Analgesic Tolerance
2004 StandoutNobel
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Phosphatidylinositol 3-Kinase Signaling Inhibits DAF-16 DNA Binding and Function via 14-3-3-dependent and 14-3-3-independent Pathways
2001 StandoutNobel
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
The ground state of embryonic stem cell self-renewal
2008 StandoutNature
SHP-2 Is a Dual-specificity Phosphatase Involved in Stat1 Dephosphorylation at Both Tyrosine and Serine Residues in Nuclei
2002
Noncanonical Tandem SH2 Enables Interaction of Elongation Factor Spt6 with RNA Polymerase II
2010
Association of Atypical Protein Kinase C Isotypes with the Docker Protein FRS2 in Fibroblast Growth Factor Signaling
1999
The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression
1997
Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2
1998
SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130
2002
Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry
2004
The Histone Chaperone Spt6 Is Required for Activation-induced Cytidine Deaminase Target Determination through H3K4me3 Regulation
2012 StandoutNobel
The COOH-terminal Tyrosine Phosphorylation Sites on IRS-1 Bind SHP-2 and Negatively Regulate Insulin Signaling
1998
Regulation of the Mitogen-activated Protein Kinase Signaling Pathway by SHP2
2002
Insulin Receptor Substrate and p55 Orthologous Adaptor Proteins Function in the Caenorhabditis elegans daf-2/Insulin-like Signaling Pathway
2002 StandoutNobel
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ
2004
A Novel Phosphotyrosine Motif with a Critical Amino Acid at Position −2 for the SH2 Domain-mediated Activation of the Tyrosine Phosphatase SHP-1
1997
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Signaling—2000 and Beyond
2000 Standout
C2-domains, Structure and Function of a Universal Ca2+-binding Domain
1998 StandoutNobel
Crystal Structure of Human Protein-tyrosine Phosphatase SHP-1
2003
Peptide–Surface Association: The Case of PDZ and PTB Domains
1996
The Generation of New Protein Functions by the Combination of Domains
2007
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Suppression of SHP-2 and ERK Signalling Promotes Self-Renewal of Mouse Embryonic Stem Cells
1999
The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p
2000
β-Arrestins Regulate Mitogenic Signaling and Clathrin-mediated Endocytosis of the Insulin-like Growth Factor I Receptor
1998 StandoutNobel
C2 domain conformational changes in phospholipase C-δ1
1996
Role of IRS-2 in insulin and cytokine signalling
1995 Nature
The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
2003
Protein Tyrosine Phosphatases in the Human Genome
2004 Standout
A Novel Protein-Protein Interaction between a G Protein-coupled Receptor and the Phosphatase SHP-2 Is Involved in Bradykinin-induced Inhibition of Cell Proliferation
2002
Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome
2001
Structure and function of theprotein tyrosine phosphatases
1996
Src-dependent Tyrosine Phosphorylation Regulates Dynamin Self-assembly and Ligand-induced Endocytosis of the Epidermal Growth Factor Receptor
2002 StandoutNobel
Molecular basis for TPR domain‐mediated regulation of protein phosphatase 5
2004
The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain
2003
Site-Specific Incorporation of a Phosphotyrosine Mimetic Reveals a Role for Tyrosine Phosphorylation of SHP-2 in Cell Signaling
2001
Protein–protein interactions define specificity in signal transduction
2000
Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3
2003
Protein tyrosine phosphatases
2002
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering
2001 StandoutNobel
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
2003 Standout
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor
2004 StandoutNobel
MODULAR PEPTIDE RECOGNITION DOMAINS IN EUKARYOTIC SIGNALING
1997
A Novel Membrane Glycoprotein, SHPS-1, That Binds the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-2 in Response to Mitogens and Cell Adhesion
1996
CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca 2+ signaling
2013
Membrane-permeant Esters of Phosphatidylinositol 3,4,5-Trisphosphate
1998 StandoutNobel
Role of CD47 as a Marker of Self on Red Blood Cells
2000 StandoutScience
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
1998 Standout
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
2004 StandoutNobel
The IRS-signalling system: A network of docking proteins that mediate insulin action
1998
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Signal Transduction of IL-6, Leukemia-Inhibitory Factor, and Oncostatin M: Structural Receptor Requirements for Signal Attenuation
2000
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
2001 StandoutNobel
Translating the Histone Code
2001 StandoutScience
PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
1997 StandoutScience
THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions
1999
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells
2001 StandoutNobel
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
2007 StandoutNobel
Vitamin B 2 -based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals
1998 StandoutNobel
The IRS-signalling system: A network of docking proteins that mediate insulin action
1998
The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling
2003
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5
2006 StandoutNobel
A C-terminal motif found in the β 2 -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na + /H + exchanger regulatory factor family of PDZ proteins
1998 StandoutNobel
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
1996 StandoutScience
Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression
1998
Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor
1999 Standout
Works of Scott Pluskey being referenced
Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2
1996 Nature
Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains
1995
Crystal Structure of the Tyrosine Phosphatase SHP-2
1998
Activated Mutants of SHP-2 Preferentially Induce Elongation of Xenopus Animal Caps
2000