Scott Lovell

Lipid Rafts As a Membrane-Organizing Principle

Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility

Distinct Populations of Primary and Secondary Effectors During RNAi in C. elegans

Structural Mechanisms of QacR Induction and Multidrug Recognition

Surfing biological surfaces: exploiting the nucleoid for partition and transport in bacteria

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

Expansive discovery of chemically diverse structured macrocyclic oligoamides

Function and Structure of a Prokaryotic Formylglycine-generating Enzyme

Comparison of Hydride, Hydrogen Atom, and Proton-Coupled Electron Transfer Reactions

Intracellular sterol dynamics

A route to high surface area, porosity and inclusion of large molecules in crystals

Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis

Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor

Isolation and Characterization of the Osmium(V)–Imido Complex [OsV(Tp)(Cl)2(NH)] We are grateful to the National Science Foundation under Grant number CHE-9503738, the Los Alamos National Laboratory (DOE) under Grant Number 10730-001-00-2C, and the Laboratory Directed Research and Development Program for support of this research. M. H. V. Huynh gratefully acknowledges postdoctoral fellowship support from the Directorapos;s Office of Los Alamos National Laboratory. Los Alamos National Laboratory is operated by the University of California for the U.S. Department of Energy under Contract W-7405-ENG-36. We also thank Dr. Paul R. Sharp (Professor of Chemistry, University of Missouri, Columbia, MO, 65211) for the information on transition metal parent imido complexes.

The Possible Role of Proton‐Coupled Electron Transfer (PCET) in Water Oxidation by Photosystem II

Fluoro amino acids: A rarity in nature, yet a prospect for protein engineering

Proton-Coupled Electron Transfer from Phosphorus: A P−H/P−D Kinetic Isotope Effect of 178

Accurate design of co-assembling multi-component protein nanomaterials

Thermodynamics and kinetics of proton-coupled electron transfer: stepwise vs. concerted pathways

Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution

A three-dimensional view of the molecular machinery of RNA interference

Main-group elements as transition metals

Theoretical studies of proton-coupled electron transfer reactions

Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

Purified Argonaute2 and an siRNA form recombinant human RISC

Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase

The catalytic pathway of horseradish peroxidase at high resolution

Ribosomal synthesis and folding of peptide-helical aromatic foldamer hybrids

The outs and ins of transposition: from Mu to Kangaroo

Models for Proton-coupled Electron Transfer in Photosystem II

The ParA/MinD family puts things in their place

Phosphoramidites: Privileged Ligands in Asymmetric Catalysis

Lock-Arm Supramolecular Ordering: A Molecular Construction Set for Cocrystallizing Organic Charge Transfer Complexes

The Common Structural Architecture of Shigella flexneri and Salmonella typhimurium Type Three Secretion Needles

Effect of metal ions on radical type and proton‐coupled electron transfer channel: σ‐Radical vs π‐radical and σ‐channel vs π‐channel in the imide units

Emerging themes in the computational design of novel enzymes and protein–protein interfaces

Crystal Structure of the Non-heme Iron Dioxygenase PtlH in Pentalenolactone Biosynthesis

Regulation of proteasome assembly and activity in health and disease

Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor

Therapeutic suppression of premature termination codons: Mechanisms and clinical considerations (Review)

Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity

Computational design of ligand-binding proteins with high affinity and selectivity

Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression

Separating water isotopologues using diffusion-regulatory porous materials

Small RNAs are modified with N-glycans and displayed on the surface of living cells

Direct observation of kinesin stepping by optical trapping interferometry

The crystal structure of SdsA1, an alkylsulfatase from Pseudomonas aeruginosa , defines a third class of sulfatases

Theoretical Perspectives on Proton-Coupled Electron Transfer Reactions

Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains

Application of the Marcus Cross Relation to Hydrogen Atom Transfer Reactions

Distinct Mechanisms of Bridging-Oxo Exchange in Di-μ-O Dimanganese Complexes with and without Water-Binding Sites:  Implications for Water Binding in the O₂-Evolving Complex of Photosystem II

Norbornene Oxidation by Chiral Complexes Encapsulated in NaY Zeolite

Porous Crystalline Olefin-Linked Covalent Organic Frameworks

Electron Transfer Driven by Proton Fluctuations in a Hydrogen-Bonded Donor−Acceptor Assembly

Evidence that the Head of Kinesin Is Sufficient for Force Generation and Motility in Vitro

Reversible Osmium(VI) Nitrido to Osmium(II) Ammine Interconversion in Complexes Containing Polypyrazolyl Ligands

Bacterial scaffold directs pole-specific centromere segregation

Slow Hydrogen Atom Self-Exchange between Os(IV) Anilide and Os(III) Aniline Complexes:  Relationships with Electron and Proton Transfer Self-Exchange

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

Engineering enzymes for noncanonical amino acid synthesis

PCET in the oxidation of ascorbate. Dramatic change of the kinetic isotope effect on the change in solvent polarity

Syntheses, structures and second-order nonlinear optical properties of octupolar compounds: 2,4,6-tri-substituted s-triazine

Complexes of tris(pentafluorophenyl)boron with nitrogen-containing compounds: Synthesis, reactivity and metallocene activation

Structure and Function of the 26S Proteasome

Effects of Sr²⁺-Substitution on the Reduction Rates of Y_z^• in PSII MembranesEvidence for Concerted Hydrogen-Atom Transfer in Oxygen Evolution

Synthetic Models for the Cysteinate-Ligated Non-Heme Iron Enzyme Superoxide Reductase:  Observation and Structural Characterization by XAS of an Fe^III−OOH Intermediate

Additions to Metal-Activated Organonitriles

Hydrogen Atom Transfer Reactions of a Ruthenium Imidazole Complex: Hydrogen Tunneling and the Applicability of the Marcus Cross Relation

Concerted Proton−Electron Transfer to Dioxygen in Water

Analysis of Kinetic Isotope Effects for Proton-Coupled Electron Transfer Reactions

The Role of Collective Solvent Coordinates and Nonequilibrium Solvation in Charge-Transfer Reactions

Electron and Hydrogen-Atom Self-Exchange Reactions of Iron and Cobalt Coordination Complexes

A bacterial Argonaute with noncanonical guide RNA specificity

Proton-Coupled Electron Transfer in Solution, Proteins, and Electrochemistry

Theoretical Investigation of Large Kinetic Isotope Effects for Proton-Coupled Electron Transfer in Ruthenium Polypyridyl Complexes

Slow Hydrogen Atom Transfer Reactions of Oxo- and Hydroxo-Vanadium Compounds: The Importance of Intrinsic Barriers

Diastereoselective Synthesis of ψ[(E)-CMeCH]- and ψ[(E)-CMeCMe]- Type Dipeptide Isosteres Based on Organocopper-Mediated anti-S_N2‘ Reaction

Concerted hydrogen-atom abstraction in photosynthetic water oxidation

Solid-Phase Synthesis of Bicyclic Dipeptide Mimetics by Intramolecular Cyclization of Alcohols, Thiols, Amines, and Amides with N-Acyliminium Intermediates

A Theory that Connects Proton-Coupled Electron-Transfer and Hydrogen-Atom Transfer Reactions

Theory of Coupled Electron and Proton Transfer Reactions

Dioxygen Activation at Mononuclear Nonheme Iron Active Sites:  Enzymes, Models, and Intermediates

In vitro reconstitution of the human RISC-loading complex

Proton-Coupled Electron Transfer in Biology: Results from Synergistic Studies in Natural and Model Systems

Quantum dynamics of proton-coupled electron transfer in model systems

Nitroxyl Radical Plus Hydroxylamine Pseudo Self-Exchange Reactions: Tunneling in Hydrogen Atom Transfer

RNA Display Methods for the Discovery of Bioactive Macrocycles

Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

The Essential Roles of Chemistry in High-Throughput Screening Triage

A Unified Perspective on the Hydrogen Atom Transfer and Proton-Coupled Electron Transfer Mechanisms in Terms of Topographic Features of the Ground and Excited Potential Energy Surfaces As Exemplified by the Reaction between Phenol and Radicals

Confined acids catalyze asymmetric single aldolizations of acetaldehyde enolates

Catalytic Asymmetric Conjugate Addition and Allylic Alkylation with Grignard Reagents

A systematic dissection of determinants and consequences of snoRNA-guided pseudouridylation of human mRNA

Quantum and dynamical effects of proton donor-acceptor vibrational motion in nonadiabatic proton-coupled electron transfer reactions

The RaPID Platform for the Discovery of Pseudo-Natural Macrocyclic Peptides

First-Principles Calculation of pK_aValues for Organic Acids in Nonaqueous Solution

Theoretical Study of Electron, Proton, and Proton-Coupled Electron Transfer in Iron Bi-imidazoline Complexes

Bioinspired Metal–Organic Framework Catalysts for Selective Methane Oxidation to Methanol

π-Bonding and the Lone Pair Effect in Multiple Bonds between Heavier Main Group Elements

De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor

Model Proton-Coupled Electron Transfer Reactions in Solution:  Predictions of Rates, Mechanisms, and Kinetic Isotope Effects

Proton coupled electron transfer of galvinol in self-assembled monolayers

C−H Bond Activation by a Ferric Methoxide Complex:  Modeling the Rate-Determining Step in the Mechanism of Lipoxygenase

Quantum Mechanical Continuum Solvation Models

Proton-Coupled Electron Transfer

Mechanistic Aspects of C−H Activation by Pt Complexes

PROTON-COUPLED ELECTRON TRANSFER: A Reaction Chemist's View

C−H Bond Activations by Metal Oxo Compounds

Structural Basis for Double-Stranded RNA Processing by Dicer

A Systematic K-edge X-ray Absorption Spectroscopic Study of Cu(III) Sites

Chemistry: Chemical con artists foil drug discovery

A Solid-Phase Approach to Mouse Melanocortin Receptor Agonists Derived from a Novel Thioether Cyclized Peptidomimetic Scaffold

Solar Synthesis: Prospects in Visible Light Photocatalysis

Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy

Dyeing Crystals

Thermochemistry of Proton-Coupled Electron Transfer Reagents and its Implications

Potential-, pH-, and Isotope-Dependence of Proton-Coupled Electron Transfer of an Osmium Aquo Complex Attached to an Electrode

The Bump-and-Hole Tactic: Expanding the Scope of Chemical Genetics

Aliphatic C−H Bond Activation Initiated by a (μ-η²:η²-Peroxo)dicopper(II) Complex in Comparison with Cumylperoxyl Radical

Proton-Coupled Electron Transfer

Reversible, Metal-Free Hydrogen Activation

In Situ Formation of an Oxygen-Evolving Catalyst in Neutral Water Containing Phosphate and Co ²⁺

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

The Min Oscillator Uses MinD-Dependent Conformational Changes in MinE to Spatially Regulate Cytokinesis

The Structural Determination of an Insect Sterol Carrier Protein-2 with a Ligand-bound C16 Fatty Acid at 1.35-Å Resolution

Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases

Two-metal active site binding of a Tn5 transposase synaptic complex

Reconfiguration of the proteasome during chaperone-mediated assembly

The crystal structures of the Salmonella type III secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholate

Evidence for “Unseen” Transposase–DNA Contacts

The Designability of Protein Switches by Chemical Rescue of Structure: Mechanisms of Inactivation and Reactivation

Poppy Acid:  Synthesis and Crystal Chemistry

Effects of Trifluoromethyl Substituents in a Tris(pyrazolyl)borate Ligand:  A Structural and Spectroscopic Study of Analogous Platinum(IV) Trimethyl Complexes

Kinetic Stabilization of Biopolymers in Single-Crystal Hosts:  Green Fluorescent Protein in α-Lactose Monohydrate

Crystal violet’s shoulder

Hydrocarbon Oxidation by Bis-μ-oxo Manganese Dimers:  Electron Transfer, Hydride Transfer, and Hydrogen Atom Transfer Mechanisms

Evidence That Histidine Protonation of Receptor-Bound Anthrax Protective Antigen Is a Trigger for Pore Formation

Suppression of contractile force in muscle fibers by antibody to myosin subfragment 2.

Single-Crystal Matrix Isolation of Biopolymers

Designing Allosteric Control into Enzymes by Chemical Rescue of Structure

Modeling the Reactivity of Superoxide Reducing Metalloenzymes with a Nitrogen and Sulfur Coordinated Iron Complex

Why Is There an “Inert” Metal Center in the Active Site of Nitrile Hydratase? Reactivity and Ligand Dissociation from a Five-Coordinate Co(III) Nitrile Hydratase Model

Intrinsic Barriers for Electron and Hydrogen Atom Transfer Reactions of Biomimetic Iron Complexes

The progress of logwood extract

Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses

Chalcogen Atom Transfer to a Metal Nitrido. The First Transition Metal Selenonitrosyl Complex

Charge Transfer Interactions in Dyed Crystals of Aromatic Carboxylic Acids and Their Relevance to MALDI Mass Spectrometry

Solid-Phase Synthesis and Structural Analysis of Bicyclic β-Turn Mimetics Incorporating Functionality at theitoi+ 3 Positions

Protonation and Deprotonation of TpOs(NHPh)Cl₂:  An Unusually Inert Amido Ligand

How Do Oxidized Thiolate Ligands Affect the Electronic and Reactivity Properties of a Nitrile Hydratase Model Compound?

Oxidations of C−H and O−H Bonds by Isolated Copper(III) Complexes

C−N Bond Formation on Addition of Aryl Carbanions to the Electrophilic Nitrido Ligand in TpOs(N)Cl₂

Nitrogen Abstraction from Nitriles by Osmium(IV) Complexes