Citation Impact
Citing Papers
On the relationship between folding and chemical landscapes in enzyme catalysis
2008 StandoutNobel
Relating Protein Motion to Catalysis
2006
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Exploiting conformational dynamics to modulate the function of designed proteins
2023 StandoutNobel
Origins of catalysis by computationally designed retroaldolase enzymes
2010 StandoutNobel
Computational Thermostabilization of an Enzyme
2005 StandoutScienceNobel
The Dynamic Energy Landscape of Dihydrofolate Reductase Catalysis
2006 Science
Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
2011 StandoutNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Energetics of Pore Opening in a Voltage-Gated K+ Channel
2002 StandoutNobel
Allosteric Communication in Dihydrofolate Reductase: Signaling Network and Pathways for Closed to Occluded Transition and Back
2007
Strong and Reversible Binding of Carbon Dioxide in a Green Metal–Organic Framework
2011 StandoutNobel
Dynamic personalities of proteins
2007 StandoutNature
A conformational switch controls hepatitis delta virus ribozyme catalysis
2004 StandoutNatureNobel
Preorganization and protein dynamics in enzyme catalysis
2002
Catalysis by enzyme conformational change as illustrated by orotidine 5′-monophosphate decarboxylase
2003
Computational Enzyme Design
2013 StandoutNobel
Capture and Visualization of a Catalytic RNA Enzyme-Product Complex Using Crystal Lattice Trapping and X-Ray Holographic Reconstruction
2000
Solvation, Reorganization Energy, and Biological Catalysis
1998
Single-molecule Enzymology
1999
Protein—DNA recognition complexes: Conservation of structure and binding energy in the transition state
1997
Protein dynamics and enzyme catalysis: Insights from simulations
2010
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Evidence for a Triplex DNA Conformation at the bcl-2 Major Breakpoint Region of the t(14;18) Translocation
2005
Spectroscopic analysis of the pyrimidine(6–4)pyrimidone photoproduct: insights into the (6–4) photolyase reaction
2008
Engineering Δ9-16:0-Acyl Carrier Protein (ACP) Desaturase Specificity Based on Combinatorial Saturation Mutagenesis and Logical Redesign of the Castor Δ9-18:0-ACP Desaturase
2001
The coming of age of de novo protein design
2016 StandoutNatureNobel
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant
2011 StandoutNatureNobel
Dynamics and mechanism of repair of ultraviolet-induced (6–4) photoproduct by photolyase
2010 StandoutNatureNobel
Stretching exercises — flexibility in dihydrofolate reductase catalysis
1998
The contribution of cytosine protonation to the stability of parallel DNA triple helices 1 1Edited by D. E. Draper
1998
Dynamics of biochemical and biophysical reactions: insight from computer simulations
2001 StandoutNobel
The chemical repertoire of natural ribozymes
2002 StandoutNatureNobel
Double-mutant cycles: a powerful tool for analyzing protein structure and function
1996
Simulating enzyme reactions: Challenges and perspectives
2001
At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?
2009 StandoutNobel
Engineering the third wave of biocatalysis
2012 StandoutNature
Exploitation of binding energy for catalysis and design
2009 StandoutNatureNobel
Acinetobacter baumannii : Emergence of a Successful Pathogen
2008 Standout
Reply to Karplus: Conformational dynamics have no role in the chemical step
2010 StandoutNobel
Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase
2009
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Foldamers as Reactive Sieves: Reactivity as a Probe of Conformational Flexibility
2007
Molecular Reaction Dynamics
2005
Pillar[5]arene as a Co-Factor in Templating Rotaxane Formation
2013 StandoutNobel
Solute Solvent Dynamics and Energetics in Enzyme Catalysis: The SN2 Reaction of Dehalogenase as a General Benchmark
2004 StandoutNobel
Ketosteroid isomerase provides further support for the idea that enzymes work by electrostatic preorganization
2010 StandoutNobel
A new paradigm for electrostatic catalysis of radical reactions in vitamin B 12 enzymes
2007 StandoutNobel
An NMR Perspective on Enzyme Dynamics
2006
Attosecond physics
2009 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Apparent NAC Effect in Chorismate Mutase Reflects Electrostatic Transition State Stabilization
2003 StandoutNobel
Computer Simulation of the Chemical Catalysis of DNA Polymerases: Discriminating between Alternative Nucleotide Insertion Mechanisms for T7 DNA Polymerase
2003 StandoutNobel
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR
2020
How Much Do Enzymes Really Gain by Restraining Their Reacting Fragments?
2002 StandoutNobel
Simulations of the Large Kinetic Isotope Effect and the Temperature Dependence of the Hydrogen Atom Transfer in Lipoxygenase
2004 StandoutNobel
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Challenges in Enzyme Mechanism and Energetics
2003
Targeted Mutagenesis in Mammalian Cells Mediated by Intracellular Triple Helix Formation
1995
Direct pKa Measurement of the Active-Site Cytosine in a Genomic Hepatitis Delta Virus Ribozyme
2001 StandoutNobel
Artificial Organic Host Molecules for Anions
1997 Standout
Temperature Effects on the Catalytic Efficiency, Rate Enhancement, and Transition State Affinity of Cytidine Deaminase, and the Thermodynamic Consequences for Catalysis of Removing a Substrate “Anchor”
2000
Perspective: Defining and quantifying the role of dynamics in enzyme catalysis
2016 Nobel
Biochemical Detection of Cytidine Protonation within RNA
2000
Binding Energy and Catalysis: The Implications for Transition-State Analogs and Catalytic Antibodies
1997
A General Strategy for the Semisynthesis of Ratiometric Fluorescent Sensor Proteins with Increased Dynamic Range
2016
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase
2006
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Enzyme catalysis: over-the-barrier or through-the-barrier?
2000
Redox cycling and kinetic analysis of single molecules of solution-phase nitrite reductase
2011 StandoutNobel
Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design
2015 StandoutNobel
Enzyme millisecond conformational dynamics do not catalyze the chemical step
2009 StandoutNobel
How important are entropic contributions to enzyme catalysis?
2000 StandoutNobel
A Perspective on Enzyme Catalysis
2003 Science
Network of coupled promoting motions in enzyme catalysis
2002
Structure, Dynamics, and Catalytic Function of Dihydrofolate Reductase
2004
Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
2014 StandoutNobel
Frozen Density Functional Free Energy Simulations of Redox Proteins: Computational Studies of the Reduction Potential of Plastocyanin and Rusticyanin
2003 StandoutNobel
Exploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase
2010 StandoutNobel
pKa Perturbation in Genomic Hepatitis Delta Virus Ribozyme Catalysis Evidenced by Nucleotide Analogue Interference Mapping
2002
Structural Reorganization and Preorganization in Enzyme Active Sites: Comparisons of Experimental and Theoretically Ideal Active Site Geometries in the Multistep Serine Esterase Reaction Cycle
2008
Works of Scott F. Singleton being referenced
Influence of pH on the equilibrium association constants for oligodeoxyribonucleotide-directed triple helix formation at single DNA sites
1992
A perspective on biological catalysis
1996
Molecular Basis for Nonadditive Mutational Effects in Escherichia coli Dihydrofolate Reductase
1995
Evidence for dynamics in proteins as a mechanism for ligand dissociation
2012
Equilibrium association constants for oligonucleotide-directed triple helix formation at single DNA sites: Linkage to cation valence and concentration
1993
Facile Synthesis of a Fluorescent Deoxycytidine Analogue Suitable for Probing the RecA Nucleoprotein Filament
2001
Thermodynamics of oligodeoxyribonucleotide-directed triple helix formation: an analysis using quantitative affinity cleavage titration
1992
Thermodynamic characterization of the stability and the melting behavior of a DNA triplex: a spectroscopic and calorimetric study.
1990
A Molecular Target for Suppression of the Evolution of Antibiotic Resistance: Inhibition of the Escherichia coli RecA Protein by N6-(1-Naphthyl)-ADP
2005