Citation Impact
Citing Papers
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
2007 StandoutScienceNobel
MicroRNA-155 is induced during the macrophage inflammatory response
2007 StandoutNobel
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
2009 StandoutScienceNobel
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity
2006
C/EBPβ Gene Inactivation Causes Both Impaired and Enhanced Gene Expression and Inverse Regulation of IL-12 p40 and p35 mRNAs in Macrophages
2002
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids
2003
Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
1998
TLR2: Cellular Sensor for Microbial and Endogenous Molecular Patterns
2002
Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin
2001
Mucins in cancer: function, prognosis and therapy
2009
A Toll-like receptor recognizes bacterial DNA
2000 StandoutNature
Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose
2008 Standout
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
mRNA Is an Endogenous Ligand for Toll-like Receptor 3
2004 StandoutNobel
Toll-Like Receptors and Their Ligands
2002
Cell-Type-Specific Control of Enhancer Activity by H3K9 Trimethylation
2012
Human Toll-like receptor 2 mediates induction of the antimicrobial peptide human beta-defensin 2 in response to bacterial lipoprotein
2001
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Interleukin-12 and the regulation of innate resistance and adaptive immunity
2003 Standout
Selective Transcription in Response to an Inflammatory Stimulus
2010
Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway
2000
Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity
2002
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
The p38 Mitogen-activated Kinase Pathway Regulates the Human Interleukin-10 Promoter via the Activation of Sp1 Transcription Factor in Lipopolysaccharide-stimulated Human Macrophages
2001
Synergistic Regulation of the Human Interleukin-12 p40 Promoter by NFκB and Ets Transcription Factors in Epstein-Barr Virus-transformed B Cells and Macrophages
1998
Toll signaling pathways in the innate immune response
2000
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
2001 StandoutNature
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
2001 Standout
The Toll receptor family and microbial recognition
2000
Control of NF- B-dependent Transcriptional Responses by Chromatin Organization
2009
Saturated Fatty Acid Activates but Polyunsaturated Fatty Acid Inhibits Toll-like Receptor 2 Dimerized with Toll-like Receptor 6 or 1
2004 Standout
Crohn's disease
2012 Standout
A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling
2009
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
2002 Nature
The Utility of Biomarkers in the Diagnosis and Therapy of Inflammatory Bowel Disease
2011
Inflammatory Bowel Disease
2009 Standout
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
2001 Nature
TOLL-like receptors linking innate and adaptive immune response
2002
Gram-negative Bacteria-binding Protein, a Pattern Recognition Receptor for Lipopolysaccharide and β-1,3-Glucan That Mediates the Signaling for the Induction of Innate Immune Genes in Drosophila melanogaster Cells
2000
The gut as a sensory organ
2013
Role of TLR-2 in the Activation of Nuclear Factor κB by Oxidative Stress in Cardiac Myocytes
2001
Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event
2001
Bacterial Lipopolysaccharide Activates NF-κB through Toll-like Receptor 4 (TLR-4) in Cultured Human Dermal Endothelial Cells
2000
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas
2010 StandoutNobel
IFNs activate toll-like receptor gene expression in viral infections
2001
The Role of C/EBP Isoforms in the Control of Inflammatory and Native Immunity Functions
1998
The apoptotic signaling pathway activated by Toll-like receptor-2
2000
Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner
2009 Standout
Toll-like Receptor-2 Mediates Treponema Glycolipid and Lipoteichoic Acid-induced NF-κB Translocation
2001
Toll-like receptors in the induction of the innate immune response
2000 StandoutNature
Discrimination of bacterial lipoproteins by Toll-like receptor 6
2001 Standout
CD36 is a sensor of diacylglycerides
2005 StandoutNatureNobel
Selective and antagonistic functions of SWI/SNF and Mi-2β nucleosome remodeling complexes during an inflammatory response
2006
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
Transient Cytokine-Induced Liver Injury Following Administration of the Humanized Anti-CD3 Antibody Visilizumab (HuM291) in Crohn's Disease
2009
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
2000
Frequency, phenotype, outcome, and therapeutic impact of skin reactions following initiation of adalimumab therapy: Experience from a consecutive cohort of inflammatory bowel disease patients
2011
The immune response of Drosophila
2003 StandoutNatureNobel
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
1999 Standout
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice
2002
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
The biology of Toll-like receptors
2000
Tuberculosis
2007
Murine TOLL-like Receptor 4 Confers Lipopolysaccharide Responsiveness as Determined by Activation of NFκB and Expression of the Inducible Cyclooxygenase
2000
Dendritic-cell control of pathogen-driven T-cell polarization
2003
The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management
2010
The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling
2000
The Role of Toll-like Receptors (TLRs) in Bacteria-induced Maturation of Murine Dendritic Cells (DCs)
2001
Genetics and pathogenesis of inflammatory bowel disease
2011 StandoutNature
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Class II MHC peptide loading by the professionals
2003
Toll-like receptors: critical proteins linking innate and acquired immunity
2001 Standout
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells
1999
Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway
2002 Standout
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Toll-like receptors and innate immunity
2009
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
2000
A CRISPR/Cas system mediates bacterial innate immune evasion and virulence
2013 Nature
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
2000
TRANSFAC(R): transcriptional regulation, from patterns to profiles
2003 Standout
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
An Evidence-Based Systematic Review on Medical Therapies for Inflammatory Bowel Disease
2011
Toll-like receptors and innate immunity
2001 Standout
Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells
2001
Toll-Like Receptors
2003 Standout
Innate immunity: Lipoproteins take their Toll on the host
1999
Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2
1999 StandoutScience
Human Toll-Like Receptor 2 Mediates Monocyte Activation byListeria monocytogenes, But Not by Group B Streptococci or Lipopolysaccharide
2000
Involvement of Toll-Like Receptor 4 in Innate Immunity to Respiratory Syncytial Virus
2001
Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Infliximab, a Chimeric Monoclonal Antibody to Tumor Necrosis Factor-α, in Patients With Moderate-to-Severe Heart Failure
2003 Standout
An Essential Role of the NF-κB/Toll-Like Receptor Pathway in Induction of Inflammatory and Tissue-Repair Gene Expression by Necrotic Cells
2001
Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins
2002 Standout
Monoclonal antibodies, immunogenicity, and associated infusion reactions.
2005
Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex
2000
Phagocytosis of Microbes: Complexity in Action
2002
Cutting Edge: Preferentially the R-Stereoisomer of the Mycoplasmal Lipopeptide Macrophage-Activating Lipopeptide-2 Activates Immune Cells Through a Toll-Like Receptor 2- and MyD88-Dependent Signaling Pathway
2000
Suppression of IL-12 Transcription in Macrophages Following Fcγ Receptor Ligation
2001
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Rapid Chromatin Remodeling of Toll-Like Receptor 2 Promoter During Infection of Macrophages with Mycobacterium avium
2002
Impaired Production of Proinflammatory Cytokines and Host Resistance to Acute Infection withTrypanosoma cruziin Mice Lacking Functional Myeloid Differentiation Factor 88
2004
Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible toStaphylococcus aureusInfection
2000
Cooperation of Toll-Like Receptor 2 and 6 for Cellular Activation by Soluble Tuberculosis Factor andBorrelia burgdorferiOuter Surface Protein A Lipoprotein: Role of Toll-Interacting Protein and IL-1 Receptor Signaling Molecules in Toll-Like Receptor 2 Signaling
2001
Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity
2002
Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells
2001
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
NFκB and Sp1 Elements Are Necessary for Maximal Transcription of Toll-like Receptor 2 Induced byMycobacterium avium
2001
Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite
2001
Signaling by Toll-Like Receptor 2 and 4 Agonists Results in Differential Gene Expression in Murine Macrophages
2001
Expression of Murine IL-12 Is Regulated by Translational Control of the p35 Subunit
1999
Modulation of the expression of cyclooxygenase‐2 by fatty acids mediated through Toll‐like receptor 4‐derived signaling pathways 1
2001
Regulation of IL-12 p40 Promoter Activity in Primary Human Monocytes: Roles of NF-κB, CCAAT/Enhancer-Binding Protein β, and PU.1 and Identification of a Novel Repressor Element (GA-12) That Responds to IL-4 and Prostaglandin E2
2001
DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells
2002
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
2000 Standout
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
NF-κB and STAT5 Play Important Roles in the Regulation of Mouse Toll-Like Receptor 2 Gene Expression
2001
Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium
2015
Interleukin-10 and the Interleukin-10 Receptor
2001 Standout
Toll-Like Receptor 2 Is Required for Innate, But Not Acquired, Host Defense to Borrelia burgdorferi
2002
Cutting Edge: Immune Stimulation by Neisserial Porins Is Toll-Like Receptor 2 and MyD88 Dependent
2002
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
Variegation of the Immune Response with Dendritic Cells and Pathogen Recognition Receptors
2005
Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2
2000
From plankton to pathogen recognition
2004
Expression of Toll-Like Receptor 2 on γδ T Cells Bearing Invariant Vγ6/Vδ1 Induced by Escherichia coli Infection in Mice
2000
Immunobiology of Dendritic Cells
2000 Standout
Ipilimumab Plus Sargramostim vs Ipilimumab Alone for Treatment of Metastatic Melanoma
2014
Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages
1999
Gene Expressions of Toll-Like Receptor 2, But Not Toll-Like Receptor 4, Is Induced by LPS and Inflammatory Cytokines in Mouse Macrophages
2000
Regulation of interleukin-12 production in antigen-presenting cells
2001
Decreased Expression of Toll-Like Receptor-4 and MD-2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Proinflammatory Gene Expression in Response to Bacterial Lipopolysaccharide
2001
Specific Phospholipid Oxidation Products Inhibit Ligand Activation of Toll-Like Receptors 4 and 2
2003
Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors
2001 Science
Toll‐like receptors: molecular mechanisms of the mammalian immune response
2000
Innate Immune Recognition
2002 Standout
Microbial Lipopeptides Stimulate Dendritic Cell Maturation Via Toll-Like Receptor 2
2001
Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression
2000
An IFN-γ-Inducible Transcription Factor, IFN Consensus Sequence Binding Protein (ICSBP), Stimulates IL-12 p40 Expression in Macrophages
2000
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Maturation of Human Dendritic Cells by Cell Wall Skeleton ofMycobacterium bovisBacillus Calmette-Guerin: Involvement of Toll-Like Receptors
2000
Works of Scott E. Plevy being referenced
Enteroendocrine cells express functional Toll-like receptors
2007
Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis
2010
A Phase I Study of Visilizumab, a Humanized Anti-CD3 Monoclonal Antibody, in Severe Steroid-Refractory Ulcerative Colitis
2007
ANCA pattern and LTA haplotype relationship to clinical responses to anti-TNF antibody treatment in Crohn's disease
2001
Characterization of an Activation Protein-1-binding Site in the Murine Interleukin-12 p40 Promoter
2001
Infliximab for treatment of pyoderma gangrenosum associated with inflammatory bowel disease
2003
Infliximab induces potent anti‐inflammatory and local immunomodulatory activity but no systemic immune suppression in patients with Crohn’s disease
2001
Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in Murine Ileitis and Progressive Ileal Crohn's Disease
2008
Infliximab Prevents Crohn's Disease Recurrence After Ileal Resection
2008
Rapid and Selective Remodeling of a Positioned Nucleosome during the Induction of IL-12 p40 Transcription
1999
Dosage adjustment during long-term adalimumab treatment for Crohnʼs disease: Clinical efficacy and pharmacoeconomics
2010
The Incidence and Management of Infusion Reactions To Infliximab: A Large Center Experience
2003
Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1–dependent pathway
2005
Cutting Edge: Transgenic Expression of Human MUC1 in IL-10−/− Mice Accelerates Inflammatory Bowel Disease and Progression to Colon Cancer
2007
NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity
2011
A Prominent Role for Sp1 During Lipopolysaccharide- Mediated Induction of the IL-10 Promoter in Macrophages
2000
Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins
1997
Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors
1999 Science