Standout Papers
Citation Impact
Citing Papers
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
2006
Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
2004 StandoutScience
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
2004 StandoutScience
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
2008
Regulation of Insulin Secretion by SIRT4, a Mitochondrial ADP-ribosyltransferase
2007
Sirtuins as regulators of metabolism and healthspan
2012 Standout
Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression
2003
Hallmarks of Cancer: The Next Generation
2011 Standout
Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
2008
Nuclear Trapping of the Forkhead Transcription Factor FoxO1 via Sirt-dependent Deacetylation Promotes Expression of Glucogenetic Genes
2005
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation
2003
Metabolism and cancer: the circadian clock connection
2009
Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells
2008
SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
2007
Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
2005
Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1
2002
Paradigms and pitfalls of yeast longevity research
2002
Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
2010
Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State
2003
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1
1993 StandoutNobel
The Sir2 family of protein deacetylases
2005
Transformation of Different Human Breast Epithelial Cell Types Leads to Distinct Tumor Phenotypes
2007
The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences.
1993
New light on Myc and Myb. Part I. Myc.
1990
DNA binding specificity of homeodomains
1991
DBC1 is a negative regulator of SIRT1
2008 Nature
The generation of diversity and pattern in animal development
1992 StandoutNobel
SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons
2008
NAD+ as a Signaling Molecule Modulating Metabolism
2011
E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation
2006
1p36: Every subband a suppressor?
1995
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
2007
Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1
2007
Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses
2005
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
2002
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
2003 Nature
Interaction of goosecoid and brachyury in Xenopus mesoderm patterning
1997
Transcriptional targets of sirtuins in the coordination of mammalian physiology
2008
Tissue-specific regulation of SIRT1 by calorie restriction
2008
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
2005 StandoutNobel
Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis
1994
CD44+/CD24-breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis
2006
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
2007 StandoutNature
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Acetylation and deacetylation of non-histone proteins
2005
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Hydration and DNA Recognition by Homeodomains
1996 StandoutNobel
SIRT1: recent lessons from mouse models
2010
Comparative biology of mouse versus human cells: modelling human cancer in mice
2003
Recent progress in the biology and physiology of sirtuins
2009 Nature
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
2003
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
2005
New light on Myc and Myb. Part II. Myb.
1990
Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
2010
FOXO4 Is Acetylated upon Peroxide Stress and Deacetylated by the Longevity Protein hSir2
2004
Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
2009
AMP-activated protein kinase and its downstream transcriptional pathways
2010
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase
2003
Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
1995 StandoutNobel
Homeobox genes and axial patterning
1992 Standout
SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
2010
Mitochondrial sirtuins
2010
Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions
1994 StandoutNatureNobel
Negative regulation of the deacetylase SIRT1 by DBC1
2008 Nature
DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
2010
Homeodomain-DNA recognition
1994 StandoutNobel
Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?
2011
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
2005 StandoutNature
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
2004 Standout
The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation
1993
SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells
2006
Active Regulator of SIRT1 Cooperates with SIRT1 and Facilitates Suppression of p53 Activity
2007
Are Complex Behaviors Specified by Dedicated Regulatory Genes? Reasoning from Drosophila
2001 StandoutNobel
Shaping animal body plans in development and evolution by modulation of Hox expression patterns
1998
Sirtuin Catalysis and Regulation
2012
SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
2009
Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
2011
Mouse gastrulation: the formation of a mammalian body plan
1997
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
2003 StandoutNature
Deformed autoregulatory element from Drosophila functions in a conserved manner in transgenic mice
1992 Nature
Involvement of the Histone Deacetylase SIRT1 in Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF)-interacting Protein 2-mediated Transcriptional Repression
2003
Post-translational modification of p53 in tumorigenesis
2004
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
2006
PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
2009
The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein
1994
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
2001 Standout
SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
2010
Eomesodermin is required for mouse trophoblast development and mesoderm formation
2000 StandoutNatureNobel
Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39
1993 StandoutNobel
Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer
2011
Mammalian SIRT1 Represses Forkhead Transcription Factors
2004
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Functional differences between HOX proteins conferred by two residues in the homeodomain N-terminal arm.
1994
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
2006
Functional specificity of the homeodomain protein fushi tarazu: the role of DNA-binding specificity in vivo.
1993
Sustained expression of the human protooncogene MYCN rescues rat embryo cells from senescence.
1988 StandoutNobel
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
2003
NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein.
1992 StandoutNobel
Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila.
1995 StandoutNobel
Analysis of a fushi tarazu autoregulatory element: multiple sequence elements contribute to enhancer activity.
1993
Mapping functional specificity in the Dfd and Ubx homeo domains.
1992
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism
2002
Regulation of Telomerase by Telomeric Proteins
2004
The Biochemistry of Sirtuins
2006
Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes.
1995 StandoutNobel
Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity
1993
Telomerase maintains telomere structure in normal human cells
2006
On Acetyl-CoA as a Gauge of Cellular Metabolic State
2011
Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1
2009 Science
N-formylation of lysine in histone proteins as a secondary modification arising from oxidative DNA damage
2006
Understanding the homeodomain.
1993
Structure of the even-skipped homeodomain complexed to AT-rich DNA: new perspectives on homeodomain specificity.
1995
Down-regulation of LFA-1 Adhesion Receptors by C- myc Oncogene in Human B Lymphoblastoid Cells
1990 Science
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
miR-34a repression of SIRT1 regulates apoptosis
2008
The conserved role of Krox-20 in directing Hox gene expression during vertebrate hindbrain segmentation.
1996 StandoutNobel
The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.
1994
A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation
1999 StandoutNobel
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Diversity in the Sir2 family of protein deacetylases
2004
Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway
2004 Science
Mammalian Sirtuins: Biological Insights and Disease Relevance
2010 Standout
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Control of skin cancer by the circadian rhythm
2011 StandoutNobel
Cooperation between the activin and Wnt pathways in the spatial control of organizer gene expression
1998 StandoutNobel
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Control of expression of the homeotic labial (lab) locus of Drosophila melanogaster. evidence for both positive and negative autogenous regulation
1991
Dissection of an indirect autoregulatory response of a homeotic Drosophila gene.
1993
Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins.
1995
Deformed protein binding sites and cofactor binding sites are required for the function of a small segment-specific regulatory element in Drosophila embryos.
1994
Trapping a transition state in a computationally designed protein bottle
2015 StandoutScienceNobel
Expression of N-myc and c-src during the development of fetal human brain.
1987
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
Genetics and the Specificity of the Aging Process
2003 Science
Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway
1998 StandoutNobel
Regulation of the Twist target gene tinman by modular cis-regulatory elements during early mesoderm development
1997
Identification of a small molecule inhibitor of Sir2p
2001
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Complete sequence of the bithorax complex of Drosophila.
1995 StandoutNobel
Sirtuins — novel therapeutic targets to treat age-associated diseases
2008
Transient up-regulation of P2Y2nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes
1997 StandoutNobel
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways
2010
The Structural Basis of Sirtuin Substrate Affinity,
2006
Antimorphic goosecoids
1998
Works of Scott Dessain being referenced
Regulating the expression and function of homeotic genes scott dessain and William McGinnis
1991
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
2001 Standout
Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation
2002
A functional homologue of goosecoid in Drosophila
1996
Antp-type homeodomains have distinct DNA binding specificities that correlate with their different regulatory functions in embryos.
1992
N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma
1986
High-affinity binding sites for the Deformed protein are required for the function of an autoregulatory enhancer of the Deformed gene.
1991
Methylation of the human telomerase gene CpG island.
2000
A Mouse Model of Human Breast Cancer Metastasis to Human Bone
2005