Citation Impact
Citing Papers
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
2003 StandoutNobel
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints
2002
Functional specialization of β-arrestin interactions revealed by proteomic analysis
2007 StandoutNobel
Circadian oscillation of nucleotide excision repair in mammalian brain
2009 StandoutNobel
Identification of a Human Homologue of theSchizosaccharomyces pombe rad17+ Checkpoint Gene
1998
A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage
1995 StandoutNobel
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine
2001
Checkpoints in the cell cycle of fission yeast
1995 StandoutNobel
Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p
1998
Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9‐1‐1 and Rad17‐RFC
2002
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase
1995 StandoutNobel
Atm-dependent interactions of a mammalian Chk1 homolog with meiotic chromosomes
1997
Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
1999 Nature
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe
1998
Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway
1997
The S / M checkpoint at 37°C and the recovery of viability of the mutant polδts3 require the crb2 +/rhp9 + gene in fission yeast
1999
Meiotic DNA replication checkpoint control in fission yeast
1999 StandoutNobel
The novel DNA damage checkpoint protein Ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast
1997
Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint
1997
Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1
2001
Human Homologs of Schizosaccharomyces pombe Rad1, Hus1, and Rad9 Form a DNA Damage-responsive Protein Complex
1999
DNA damage checkpoints in mammals
2005
Feedback controls and G2 checkpoints: Fission yeast as a model system
1993
The Human Checkpoint Protein hRad17 Interacts with the PCNA-like Proteins hRad1, hHus1, and hRad9
2000
When Checkpoints Fail
1997 StandoutNobel
ATR: an essential regulator of genome integrity
2008
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation
1997
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability
2008 Nature
The Drosophila grapes gene is related to checkpoint gene chk1/rad27 and is required for late syncytial division fidelity
1997
Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1
1997
Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage
1999
Biochemical Characterization of DNA Damage Checkpoint Complexes: Clamp Loader and Clamp Complexes with Specificity for 5′ Recessed DNA
2003
Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses
1998
A kinase from fission yeast responsible for blocking mitosis in S phase
1995 Nature
The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding
2002
The genetics of cell cycle checkpoints
1995
A unified view of the DNA-damage checkpoint
2002
Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1
1998 Nature
Identification and functional analysis of TopBP1 and its homologs
2005
DNA structure checkpoints in fission yeast
1995
Cell Cycle Control in Fission Yeast and Mammals: Identification of New Regulatory Mechanisms
1996
Comprehensive Proteomic Analysis of Interphase and Mitotic 14-3-3-binding Proteins
2004
Repair of UV damage in the fission yeast Schizosaccharomyces pombe
2000
Checkpoint Pathways Come of Age
1997 StandoutNobel
Physical Interactions among Human Checkpoint Control Proteins HUS1p, RAD1p, and RAD9p, and Implications for the Regulation of Cell Cycle Progression
2000
A Human Homologue of the Schizosaccharomyces pombe rad1+ Checkpoint Gene Encodes an Exonuclease
1998
The chk1 pathway is required to prevent mitosis following cell-cycle arrest at ‘start’
1995
The phosphorylated C‐terminal domain of Xenopus Cut5 directly mediates ATR‐dependent activation of Chk1
2006
Human and Mouse Homologs of theSchizosaccharomyces pombe rad17Cell Cycle Checkpoint Control Gene
1999
Mitotic DNA damage and replication checkpoints in yeast
1998
Sensing and responding to DNA damage
2000
The Rad9–Hus1–Rad1 (9–1–1) clamp activates checkpoint signaling via TopBP1
2007
Reconstitution and Molecular Analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA Damage Responsive Checkpoint Complex
2001
Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage
1998
Retention of the Human Rad9 Checkpoint Complex in Extraction-resistant Nuclear Complexes after DNA Damage
2000
DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts
2000 StandoutNobel
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
2002
DNA polymerase δ is required for the replication feedback control of cell cycle progression in Schizosaccharomyces pombe
1995
The Cdt1 protein is required to license DNA for replication in fission yeast
2000 StandoutNatureNobel
Human Homologues of Yeast Vacuolar Protein Sorting 29 and 35
2000
Structures of the Human Rad17-Replication Factor C and Checkpoint Rad 9-1-1 Complexes Visualized by Glycerol Spray/Low Voltage Microscopy
2002 StandoutNobel
DNA damage checkpoints update: getting molecular
1998
CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint
1997 StandoutNobel
A Human and Mouse Homolog of theSchizosaccharomyces pombe rad1+Cell Cycle Checkpoint Control Gene
1998
Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
2000
Human DNA Damage Checkpoint Protein hRAD9 Is a 3′ to 5′ Exonuclease
2000 StandoutNobel
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
1999
Checkpoints on the road to mitosis
1998
Human and mouse homologs ofSchizosaccharomyces pombe rad1+andSaccharomyces cerevisiae RAD17:linkage to checkpoint control and mammalian meiosis
1998
The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR
2007
HRad17 Colocalizes with NHP2L1 in the Nucleolus and Redistributes after UV Irradiation
1999
The nonmutagenic repair of broken replication forks via recombination
2002
Exercising self-restraint: Discouraging illicit acts of S and M in eukaryotes
1993
Facilitative Urea Transporters
2001
The Role of Single-stranded DNA and Polymerase α in Establishing the ATR, Hus1 DNA Replication Checkpoint
2002
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Tyrosine Phosphorylation of Cdc2 Is Required for the Replication Checkpoint in Schizosaccharomyces pombe
1998
Coupling of DNA replication and mitosis by fission yeast rad4/cut5
1994
A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.
1995 StandoutNobel
Involvement of the MKK6-p38γ Cascade in γ-Radiation-Induced Cell Cycle Arrest
2000
A Ubiquitin-Conjugating Enzyme in Fission Yeast That Is Essential for the Onset of Anaphase in Mitosis
1997
The Xenopus Chk1 Protein Kinase Mediates a Caffeine-sensitive Pathway of Checkpoint Control in Cell-free Extracts
1998
A novel mutant allele of the chromatin-bound fission yeast checkpoint protein Rad17 separates the DNA structure checkpoints
2000 StandoutNobel
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering
2001 StandoutNobel
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
DNA MISMATCH REPAIR AND GENETIC INSTABILITY
2000
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
14-3-3 Protein Homologs Required for the DNA Damage Checkpoint in Fission Yeast
1994 Science
DNA Damage and Replication Checkpoints in Fission Yeast Require Nuclear Exclusion of the Cdc25 Phosphatase via 14-3-3 Binding
1999
A Novel Mutant Allele of Schizosaccharomyces pombe rad26 Defective in Monitoring S-Phase Progression To Prevent Premature Mitosis
1997
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27.
1996 StandoutNobel
Function of a Conserved Checkpoint Recruitment Domain in ATRIP Proteins
2007
The Schizosaccharomyces pombe S-Phase Checkpoint Differentiates Between Different Types of DNA Damage
1998
Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.
1994 StandoutNobel
Basis for the Checkpoint Signal Specificity That Regulates Chk1 and Cds1 Protein Kinases
1999
ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1
2001
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins.
1995
Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast.
1997
The Basic Cleft of RPA70N Binds Multiple Checkpoint Proteins, Including RAD9, To Regulate ATR Signaling
2008
Analysis of radiation-sensitive mutants of fission yeast
1997
Aberrant cell cycle checkpoint function and early embryonic death in Chk1−/− mice
2000
Schizosaccharomyces pombe Cells Lacking the Amino-Terminal Catalytic Domains of DNA Polymerase Epsilon Are Viable but Require the DNA Damage Checkpoint Control
2001
Analysis of fission yeast DNA structure checkpoints:1996 Fleming Lecture
1998
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways
2000
Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216
1997 Science
Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25
1997 Science
Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome
1999 Science
Surfing the p53 network
2000 StandoutNature
Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast.
1994
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
The Schizosaccharomyces pombe rad3 checkpoint gene.
1996
Regulation of Mitotic Inhibitor Mik1 Helps to Enforce the DNA Damage Checkpoint
2000
14-3-3 Proteins: Structure, Function, and Regulation
2000 Standout
Schizosaccharomyces pombe cdc 20 + encodes DNA polymerase ɛ and is required for chromosomal replication but not for the S phase checkpoint
1997 StandoutNobel
Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control.
1994
Characterization of Schizosaccharomyces pombeHus1: a PCNA-Related Protein That Associates with Rad1 and Rad9
2000
ATM-dependent Phosphorylation of Human Rad9 Is Required for Ionizing Radiation-induced Checkpoint Activation
2001
A Fission Yeast Gene,him1+/dfp1+, Encoding a Regulatory Subunit for Hsk1 Kinase, Plays Essential Roles in S-Phase Initiation as Well as in S-Phase Checkpoint Control and Recovery from DNA Damage
1999
Aquaglyceroporin AQP9: Solute permeation and metabolic control of expression in liver
2003 StandoutNobel
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
2005
The Spd1p S phase inhibitor can activate the DNA replication checkpoint pathway in fission yeast
2000 StandoutNobel
P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks
2000
rad -Dependent Response of the chk1 -Encoded Protein Kinase at the DNA Damage Checkpoint
1996 Science
Cdc18p can block mitosis by two independent mechanisms
1998 StandoutNobel
RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae.
1996
Cdc25 Inhibited In Vivo and In Vitro by Checkpoint Kinases Cds1 and Chk1
1999
Toward Maintaining the Genome: DNA Damage and Replication Checkpoints
2002
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
2001 StandoutNobel
A Fission Yeast Homolog of CDC20/p55CDC/Fizzy Is Required for Recovery from DNA Damage and Genetically Interacts with p34cdc2
1997
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
2004 StandoutNobel
Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation
1997 StandoutScienceNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Cell cycle checkpoint control
1997
Radiation effects on DNA synthesis in a defined chromosomal replicon.
1994
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Repair of DNA–polypeptide crosslinks by human excision nuclease
2006 StandoutNobel
HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene
1998
Cell Cycle Checkpoints: Preventing an Identity Crisis
1996 StandoutScience
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
RAD1,a Human Structural Homolog of theSchizosaccharomyces pombe RAD1Cell Cycle Checkpoint Gene
1998
Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase
1997 Science
Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard.
1994 StandoutNobel
Structure-Function Analysis of Fission Yeast Hus1-Rad1-Rad9 Checkpoint Complex
2001
The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.
1996
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
1999
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
1994 Standout
Works of Scott Davey being referenced
The Fission Yeast UVDR DNA Repair Pathway Is Inducible
1997
DNA Damage-dependent and -independent Phosphorylation of the hRad9 Checkpoint Protein
2001
A Role for the Phosphorylation of hRad9 in Checkpoint Signaling
2003
Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2
1993 Nature
An Alternative Eukaryotic DNA Excision Repair Pathway
1995
Fission Yeastrad12+Regulates Cell Cycle Checkpoint Control and Is Homologous to the Bloom’s Syndrome Disease Gene
1998
The Human G2 Checkpoint Control Protein hRAD9 Is a Nuclear Phosphoprotein That Forms Complexes with hRAD1 and hHUS1
1999
Mammalian Rad9 Plays a Role in Telomere Stability, S- and G2-Phase-Specific Cell Survival, and Homologous Recombinational Repair
2006
RACH2, a novel human gene that complements a fission yeast cell cycle checkpoint mutation.
1995
hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation.
2003
A Uve1p-Mediated Mismatch Repair Pathway inSchizosaccharomyces pombe
1999
A human homolog of the Schizosaccharomyces pombe rad9 + checkpoint control gene
1996