Citation Impact
Citing Papers
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms
2005 Standout
CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation
1999 StandoutNobel
Cytolytic T Lymphocyte-Associated Antigen-4 and the TCRζ/CD3 Complex, But Not CD28, Interact with Clathrin Adaptor Complexes AP-1 and AP-2
1999
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
An integrated encyclopedia of DNA elements in the human genome
2012 StandoutNature
Lymphoproliferative Disorder in CTLA-4 Knockout Mice Is Characterized by CD28-Regulated Activation of Th2 Responses
1999
Cocompartmentalization of p53 and Mdm2 Is a Major Determinant for Mdm2-Mediated Degradation of p53
2001
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans
2021 Nature
The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology
2006
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
The role of B7 co‐stimulation in activation and differentiation ofCD4+and CD8+T cells
1998
The reverse stop-signal model for CTLA4 function
2008
CTLA-4 regulates cell cycle progression during a primary immune response
2002
Chronic inflammation in the etiology of disease across the life span
2019 Standout
Secondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cells
1998 StandoutNobel
CD28-mediated co-stimulation: a quantitative support for TCR signalling
2003
Regulatory T Cells
2000 StandoutNobel
CTLA-4: new insights into its biological function and use in tumor immunotherapy
2002 StandoutNobel
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
CTLA-4 Regulates Induction of Anergy In Vivo
2001
B7.1 and B7.2 co-stimulatory molecules regulate crescentic glomerulonephritis
2000
B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4
2001
Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
2014 StandoutNobel
The Interaction Properties of Costimulatory Molecules Revisited
2002
The Role of the Immune System in Metabolic Health and Disease
2017
CD28/CTLA-4 and CD80/CD86 families
1999
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
2021 StandoutNobel
The Emerging Role of CTLA-4 as an Immune Attenuator
1997 StandoutNobel
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Structure and Dimerization of a Soluble Form of B7-1
2000
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
2017
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
2011
Pioneer transcription factors: establishing competence for gene expression
2011
The murine mutation scurfy (sf) results in an antigen-dependent lymphoproliferative disease with altered T cell sensitivity
2001
B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes
2000 Standout
Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme Isomerization
2001
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
T-cell regulation by CD28 and CTLA-4
2001
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
2003 StandoutNobel
Ubiquitous heterogeneity and asymmetry of the chromatin environment at regulatory elements
2012
Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
2013 Standout
Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
2001
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
2006 StandoutNobel
B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse
2004 StandoutNobel
What's the difference between CD80 and CD86?
2003
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Costimulatory regulation of T cell function
1999 StandoutNobel
Variability in the immune system: of vaccine responses and immune states
2013
Systems immunology: just getting started
2017
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
2003 StandoutNobel
Innate immunity: an overview
2003 StandoutNobel
The expanding B7 superfamily: Increasing complexity in costimulatory signals regulating T cell function
2001
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
The B7–CD28 superfamily
2002
Lymphoproliferation in CTLA-4–Deficient Mice Is Mediated by Costimulation-Dependent Activation of CD4 + T Cells
1997 StandoutNobel
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses
2000
High-Resolution Description of Antibody Heavy-Chain Repertoires in Humans
2011
B7 Costimulation in the Development of Lupus: Autoimmunity Arises Either in the Absence of B7.1/B7.2 or in the Presence of Anti-B7.1/B7.2 Blocking Antibodies
1999
Polarization of Naive CD4+ T Cells Toward the Th1 Subset by CTLA-4 Costimulation
2000
B7-1 or B7-2 Is Required to Produce the Lymphoproliferative Phenotype in Mice Lacking Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4)
1999
Cutting Edge: Two Distinct Mechanisms Lead to Impaired T Cell Homeostasis in Janus Kinase 3- and CTLA-4-Deficient Mice
2001
Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4+ T Cells
1998 StandoutNobel
Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2.
1999
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses
2011
Cytomegalovirus infection enhances the immune response to influenza
2015
Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy
2017
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
2013 StandoutScienceNobel
The lymphoproliferative defect in CTLA-4–deficient mice is ameliorated by an inhibitory NK cell receptor
2002 StandoutNobel
A Critical Role for B7/CD28 Costimulation in Experimental Autoimmune Encephalomyelitis: A Comparative Study Using Costimulatory Molecule-Deficient Mice and Monoclonal Antibody Blockade
2000
Cell intrinsic mechanisms of T‐cell inhibition and application to cancer therapy
2008 StandoutNobel
Structural Analysis of CTLA-4 Function In Vivo
2000
Re-establishing Peripheral Tolerance in the Absence of CTLA-4: Complementation by Wild-Type T Cells Points to an Indirect Role for CTLA-4
2002
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
2022 StandoutScienceNobel
CD28 disruption exacerbates inflammation in Tgf-β1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-β1
2004 StandoutNobel
Mechanisms Underlying Ubiquitination
2001 Standout
Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Restricts Clonal Expansion of Helper T Cells
2001
Constitutive Expression of the B7h Ligand for Inducible Costimulator on Naive B Cells Is Extinguished after Activation by Distinct B Cell Receptor and Interleukin 4 Receptor–mediated Pathways and Can Be Rescued by CD40 Signaling
2002
Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation
2000 Standout
The future of immune checkpoint therapy
2015 StandoutScienceNobel
CD86 and CD80 Differentially Modulate the Suppressive Function of Human Regulatory T Cells
2004
Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis
1999
Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation
2001
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
2000 StandoutNobel
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+T cells
2000 StandoutNobel
Blockade of CTLA-4 Enhances Host Resistance to the Intracellular Pathogen,Leishmania donovani
1998
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy
2001 StandoutNobel
B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells
2001
GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large
2006 StandoutNobel
The Role of B7 Costimulation in CD4/CD8 T Cell Homeostasis
2000 StandoutNobel
Friends Not Foes: CTLA-4 Blockade and mTOR Inhibition Cooperate during CD8+ T Cell Priming To Promote Memory Formation and Metabolic Readiness
2015 StandoutNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and Ubiquitination
2001 StandoutNobel
Cutting Edge: Chronic Inflammatory Liver Disease in Mice Expressing a CD28-Specific Ligand
2012 StandoutNobel
Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
2006 StandoutScienceNobel
Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered
2001
Cutting Edge: A Crucial Role for B7-CD28 in Transmitting T Help from APC to CTL
2002 StandoutNobel
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
2002 StandoutNobel
B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions
2004 StandoutNobel
Works of Scott D. Boyd being referenced
Influenza vaccine–induced human bone marrow plasma cells decline within a year after vaccination
2020 Science
Determinants of nucleosome organization in primary human cells
2011 NatureNobel
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53
2000
Predicting Vaccine Responsiveness
2015
Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination
2016
B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation
1997
New tools for classification and monitoring of autoimmune diseases
2012
Effects of Aging, Cytomegalovirus Infection, and EBV Infection on Human B Cell Repertoires
2013 Nobel
Measurement and Clinical Monitoring of Human Lymphocyte Clonality by Massively Parallel V-D-J Pyrosequencing
2009 Nobel
Diversity and clonal selection in the human T-cell repertoire
2014
CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice.
1997
The Role of CTLA-4 in Regulating Th2 Differentiation
1999