Citation Impact
Citing Papers
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles
2009 StandoutNobel
Genetic Dissection of the Amyloid Precursor Protein in Developmental Function and Amyloid Pathogenesis
2010 StandoutNobel
Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor
2001 StandoutNobel
Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I] Transgenic Mice
2002
Mature Glycosylation and Trafficking of Nicastrin Modulate Its Binding to Presenilins
2002
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Apoptosis in the nervous system
2000 StandoutNature
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
The Value of Transgenic Models for the Study of Neurodegenerative Diseases
2000
Mechanisms and Functional Implications of Adult Neurogenesis
2008 Standout
Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration
2004 Nobel
Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport
2004 StandoutNobel
Conditional Inactivation of Presenilin 1 Prevents Amyloid Accumulation and Temporarily Rescues Contextual and Spatial Working Memory Impairments in Amyloid Precursor Protein Transgenic Mice
2005
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase
2003
Loss of γ-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis
2008
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
2003 Nature
Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils
2003
Uncoupled Packaging of Amyloid Precursor Protein and Presenilin 1 into Coat Protein Complex II Vesicles
2004 StandoutNobel
Presenilin 1 Regulates Epidermal Growth Factor Receptor Turnover and Signaling in the Endosomal-Lysosomal Pathway
2007
The Notch Ligands, Delta1 and Jagged2, Are Substrates for Presenilin-dependent “γ-Secretase” Cleavage
2003
Maturation and Endosomal Targeting of β-Site Amyloid Precursor Protein-cleaving Enzyme
2000
Dendritic cells: versatile controllers of the immune system
2007 StandoutNobel
The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture
2001
Subcellular Localization of Presenilins: Association with a Unique Membrane Pool in Cultured Cells
2000
Cell Surface Presenilin-1 Participates in the γ-Secretase-like Proteolysis of Notch
1999
Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration
2009 StandoutNobel
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Autophagy: Renovation of Cells and Tissues
2011 Standout
Presenilin-1 Regulates Intracellular Trafficking and Cell Surface Delivery of β-Amyloid Precursor Protein
2003
Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression
2000
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease
2002
A common enzyme connects Notch signaling and Alzheimer's disease
2000
Gerstmann‐Sträussler‐Scheinker Disease and the Indiana Kindred
1995
Presenilin-1 Forms Complexes with the Cadherin/Catenin Cell–Cell Adhesion System and Is Recruited to Intercellular and Synaptic Contacts
1999
Presenilin-1 and Presenilin-2 Exhibit Distinct yet Overlapping γ-Secretase Activities
2003
The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
1998
Endogenous Presenilin-1 Targets to Endocytic Rather Than Biosynthetic Compartments
2000
Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
1999 Nature
Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation
2004 StandoutNobel
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Identification of a novel family of presenilin homologues
2002
Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch
2000
Endogenous β-amyloid production in presenilin-deficient embryonic mouse fibroblasts
2001
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects
1999
Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways
1999
New protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage
2001
Aspartate Mutations in Presenilin and γ‐Secretase Inhibitors Both Impair Notch1 Proteolysis and Nuclear Translocation with Relative Preservation of Notch1 Signaling
2000
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
2002
Alzheimer's Disease
2010 Standout
Loss of autophagy in the central nervous system causes neurodegeneration in mice
2006 StandoutNature
Implication of APP Secretases in Notch Signaling
2001
Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
2010
Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase
2009 StandoutNobel
Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice
1999
Multiple Effects of Aspartate Mutant Presenilin 1 on the Processing and Trafficking of Amyloid Precursor Protein
2001
Localization of presenilin–nicastrin complexes and γ‐secretase activity to the trans‐Golgi network
2003
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
A Loss of Function Mutation of Presenilin-2 Interferes with Amyloid β-Peptide Production and Notch Signaling
1999
A Loss of Function Mutant of the Presenilin Homologue SEL-12 Undergoes Aberrant Endoproteolysis in Caenorhabditis elegans and Increases Aβ42 Generation in Human Cells
2000
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking
2006 StandoutNobel
Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis
2006
Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce Aβ42 in response to tunicamycin
2004
Molecular genetics of Alzheimer’s disease
2000
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
SEC23-SEC31 the Interface Plays Critical Role for Export of Procollagen from the Endoplasmic Reticulum
2012 StandoutNobel
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain
2003
Notch and Presenilin: a proteolytic mechanism emerges
2001
Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch
2001
Deficient Neurogenesis in Forebrain-Specific Presenilin-1 Knockout Mice Is Associated with Reduced Clearance of Hippocampal Memory Traces
2001
Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms
2006
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
1999 StandoutNature
Molecular pathways to neurodegeneration
2004
Presenilin diversifies its portfolio
2007
Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1
2000
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
2001
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
2004 StandoutScience
γ-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation
2003
Intramembrane proteolysis by presenilin and presenilin-like proteases
2003
Processing of Notch and amyloid precursor protein by γ-secretase is spatially distinct
2004
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation
1997 StandoutNobel
The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism
2006
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
1999
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation
2000
Inhibition of Adipogenesis by Wnt Signaling
2000 StandoutScience
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
2003 StandoutScience
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Alzheimer’s Disease: The Challenge of the Second Century
2011
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
γ-Secretase Cleavage and Binding to FE65 Regulate the Nuclear Translocation of the Intracellular C-Terminal Domain (ICD) of the APP Family of Proteins
2003
Molecular Targets of Lithium Action
2001
Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons
1999
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
2004 StandoutScience
Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path
1998
ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models
1998
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Tolerogenic Dendritic Cells
2003 StandoutNobel
The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein
2001
APL-1, a Caenorhabditis elegans protein related to the human β-amyloid precursor protein, is essential for viability
2007
Degradative organelles containing mislocalized α- and β-synuclein proliferate in presenilin-1 null neurons
2004
Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ
2001
The Presenilins in Alzheimer's Disease--Proteolysis Holds the Key
1999 Science
Evidence for a physical interaction between presenilin and Notch
1999
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
2004 StandoutNobel
Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
1999
Works of Satoshi Naruse being referenced
An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos
1998
Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons
1998
Presenilin 1 Facilitates the Constitutive Turnover of β-Catenin: Differential Activity of Alzheimer’s Disease–Linked PS1 Mutants in the β-Catenin–Signaling Pathway
1999
A missense mutation at codon 105 with codon 129 polymorphism of the prison protein gene in a new variant of Gerstmann‐Strassler‐Scheinker disease
1993
Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.
1999