Standout Papers
- Pten Deficiency in Melanocytes Results in Resistance to Hair Graying and Susceptibility to Carcinogen-Induced Melanomagenesis (2008)
- Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. (2003)
- Induction of gene encoding FABP4 in Pten‐null keratinocytes (2009)
Citation Impact
Citing Papers
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Probing mucin-type O-linked glycosylation in living animals
2006 StandoutNobel
A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation
2003 StandoutNobel
Selective delivery of β cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8 + T cells in NOD mice
2008 StandoutNobel
Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
2010 Science
Hyperplasia and Carcinomas in Pten-Deficient Mice and Reduced PTEN Protein in Human Bladder Cancer Patients
2006 StandoutNobel
Challenges in the Treatment of Chronic Wounds
2015 Standout
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation
2006
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
2013
Distinct Roles of the IκB Kinase α and β Subunits in Liberating Nuclear Factor κB (NF-κB) from IκB and in Phosphorylating the p65 Subunit of NF-κB
2002
IKKi/IKKϵ Plays a Key Role in Integrating Signals Induced by Pro-inflammatory Stimuli
2003
The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche
2011
Langerhans Cells Activate Naive Self-Antigen-Specific CD8 T Cells in the Steady State
2004
A Novel Ubiquitin-like Domain in IκB Kinase β Is Required for Functional Activity of the Kinase
2004
Chemical Technologies for Probing Glycans
2006 StandoutNobel
The I B Kinase: A Master Regulator of NF- B, Innate Immunity, and Epidermal Differentiation
1999
Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties
2017
Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation
2006
Characterization of the IκB-kinase NEMO Binding Domain
2002
Pathogenesis and clinical features of psoriasis
2007 Standout
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
2004 Standout
Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche
2013
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Death by TNF: a road to inflammation
2022
Carbachol Activates IκB Kinase in Isolated Canine Gastric Parietal Cells
1999
Keratins and the Keratinocyte Activation Cycle
2001
Race Does Not Predict Melanocyte Heterogeneous Responses to Dermal Fibroblast-Derived Mediators
2015
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Toll signaling pathways in the innate immune response
2000
The IκB Kinase (IKK) Complex Is Tripartite and Contains IKKγ but Not IKAP as a Regular Component
2000
NF-κB, the first quarter-century: remarkable progress and outstanding questions
2012 Standout
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription
2000
Organoids: Modeling Development and the Stem Cell Niche in a Dish
2016
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Hairy tale of signaling in hair follicle development and cycling
2012
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
1999
Links between innate and adaptive immunity via type I interferon
2002
Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression
2003 Nature
NF-κB and the innate immune response
2000
IKKα controls formation of the epidermis independently of NF-κB
2001 Nature
The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways
2002
A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre‐mediated recombination
2000
What does Stat3 do?
2002 Standout
NF-κB signaling pathways in mammalian and insect innate immunity
2001
To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis
2003
JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection
1999
A Method for the Acute and Rapid Degradation of Endogenous Proteins
2017
Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins
2005 Nature
IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain
1999
Gene Switching and the Stability of Odorant Receptor Gene Choice
2004 StandoutNobel
Missing Pieces in the NF-κB Puzzle
2002 Standout
Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling
2006
Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis
2002
TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway
2003
Interleukin-1 and Cutaneous Inflammation: A Crucial Link Between Innate and Acquired Immunity
2000
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
2004
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
2004
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes
2008
Choreographing Immunity in the Skin Epithelial Barrier
2019
Differential Phosphorylation of the Signal-responsive Domain of IκBα and IκBβ by IκB Kinases
2003
Transient activation of NF-κB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation
2003
Getting under the skin of epidermal morphogenesis
2002
IκB kinase-α acts in the epidermis to control skeletal and craniofacial morphogenesis
2004 Nature
Female Mice Heterozygous for IKKγ/NEMO Deficiencies Develop a Dermatopathy Similar to the Human X-Linked Disorder Incontinentia Pigmenti
2000
The RIP kinases: crucial integrators of cellular stress
2005
Characterization of the Recombinant IKK1/IKK2 Heterodimer
2000
Receptor-interacting protein (RIP) kinase family
2010
Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway
2001
Role of NF-κB in the skeleton
2010
Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium
2013
Finding One's Niche in the Skin
2009
NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti
2000
Complete Reconstitution of Human IκB Kinase (IKK) Complex in Yeast
2001
The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey
2008 StandoutNobel
Portrait of PTEN: Messages from mutant mice
2008 StandoutNobel
STATs in cancer inflammation and immunity: a leading role for STAT3
2009 Standout
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
1999 Standout
Protein Phosphatase 2Cβ Association with the IκB Kinase Complex Is Involved in Regulating NF-κB Activity
2004
Tumor necrosis factor signaling
2003 Standout
The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling
2000
Direct Phosphorylation of NF-κB1 p105 by the IκB Kinase Complex on Serine 927 Is Essential for Signal-induced p105 Proteolysis
2001
A Fresh Look at iPS Cells
2009 StandoutNobel
Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration
2011
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Inflammation and Cancer: Is the Link as Simple as We Think?
2005
Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo
2004
Crosstalk in NF-κB signaling pathways
2011 Standout
Signaling to NF-κB
2004 Standout
The NF-κB Activation Pathway:A Paradigm in Information Transfer from Membrane to Nucleus
1999
Specific Ablation of Stat3β Distorts the Pattern of Stat3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock
2002 Nobel
Cytokine Signaling in 2002
2002 Standout
IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development
2001
Cancer-related inflammation
2008 StandoutNature
Antimicrobial peptides of multicellular organisms
2002 StandoutNature
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Analysis of Domains in the IKKα and IKKβ Proteins That Regulate Their Kinase Activity
2000
Human T-cell Lymphotropic Virus Type 1 Tax Induction of Biologically Active NF-κB Requires IκB Kinase-1-mediated Phosphorylation of RelA/p65
2004
Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells
2011
Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models
2006
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
NAK is an IκB kinase-activating kinase
2000 Nature
Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
2009
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
2006 StandoutNature
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
2002 StandoutNobel
Muscle-Specific Pten Deletion Protects against Insulin Resistance and Diabetes
2005 StandoutNobel
A Genetic Approach to Mammalian Glycan Function
2003
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
2004 StandoutNobel
A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα
2010 StandoutNobel
Activation of the δ‐opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration
2014
Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons
2010
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.
2000
The role of protein kinase C δ activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation
2006
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
Primary Human CD4+ T Cells Contain Heterogeneous IκB Kinase Complexes: Role in Activation of the IL-2 Promoter
1999
Two distinctive pathways for recruitment of naïve and primed IgM+B cells to the gut lamina propria
2005 StandoutNobel
PKR Stimulates NF-κB Irrespective of Its Kinase Function by Interacting with the IκB Kinase Complex
2000
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
2004
Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3
2007
Functional Isoforms of IκB Kinase α (IKKα) Lacking Leucine Zipper and Helix-Loop-Helix Domains Reveal that IKKα and IKKβ Have Different Activation Requirements
2000
Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis
2007
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
The extracellular matrix geneFrem1is essential for the normal adhesion of the embryonic epidermis
2004 StandoutNobel
Complete lack of NF-κB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation
2000
Links between α-catenin, NF-κB, and squamous cell carcinoma in skin
2006
Severe liver degeneration and lack of NF-κB activation in NEMO/IKKγ-deficient mice
2000
Requirement of NF-κB/Rel for the development of hair follicles and other epidermal appendices
2001
Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin
2011
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
2004
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Essential Role of Nuclear Factor (NF)-κB–Inducing Kinase and Inhibitor of κb (Iκb) Kinase α in Nf-κb Activation through Lymphotoxin β Receptor, but Not through Tumor Necrosis Factor Receptor I
2001
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
2001 Science
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
Wound Healing: A Cellular Perspective
2018 Standout
A chemical approach to unraveling the biological function of the glycosylphosphatidylinositol anchor
2007 StandoutNobel
The Carboxyl-Terminal Region of IκB Kinase γ (IKKγ) Is Required for Full IKK Activation
2002
CIKS, a connection to IκB kinase and stress-activated protein kinase
2000
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
Annexins: From Structure to Function
2002 Standout
TAPping into mRNA Export
2001 StandoutScienceNobel
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants ofDrosophila
2000 StandoutNobel
IKKβ Plays an Essential Role in the Phosphorylation of RelA/p65 on Serine 536 Induced by Lipopolysaccharide
2003
Regulation and Function of IKK and IKK-Related Kinases
2006
The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research
1999
Human skin pigmentation: melanocytes modulate skin color in response to stress
2007 Standout
Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity
2000 Standout
Primary human CD4+ T cells contain heterogeneous I kappa B kinase complexes: role in activation of the IL-2 promoter.
1999
Iκb Kinase α Is Essential for Mature B Cell Development and Function
2001
Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex
2000 Science
IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes
2005
Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon cre-mediated excision
2000
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Works of Satoshi Itami being referenced
Pten Deficiency in Melanocytes Results in Resistance to Hair Graying and Susceptibility to Carcinogen-Induced Melanomagenesis
2008 StandoutNobel
Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis
2009
Two distinct signaling pathways in hair cycle induction: Stat3-dependent and -independent pathways
2000
The Inhibitory Effect of Androgen and Sex‐Hormone‐Binding Globulin on the Intracellular cAMP Level and Tyrosinase Activity of Normal Human Melanocytes
2003
Human Genital Melanocytes as Androgen Target Cells
1997
Induction of T‐cell‐mediated skin disease specific for antigen transgenically expressed in keratinocytes
2003
Annexin VII as a Novel Marker for Invasive Phenotype of Malignant Melanoma
2000
Involvement of insulin-like growth factor-I in psoriasis as a paracrine growth factor: dermal fibroblasts play a regulatory role in developing psoriatic lesions
2000
Successful Transplantation of Cultured Human Outer Root Sheath Cells as Epithelium
1994
Stat3 in Thymic Epithelial Cells Is Essential for Postnatal Maintenance of Thymic Architecture and Thymocyte Survival
2001
Rapid healing of intractable diabetic foot ulcers with exposed bones following a novel therapy of exposing bone marrow cells and then grafting epidermal sheets
2004
STAT3 Deficiency in Keratinocytes Leads to Compromised Cell Migration through Hyperphosphorylation of p130
2002
Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function
2003
Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
2004
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling
2012
Signal Transducer and Activator of Transcription 3 Is a Key Regulator of Keratinocyte Survival and Proliferation following UV Irradiation
2005
Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD)
1997
Mesenchymal–epithelial interactions in the skin
2004
Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation.
2003 StandoutNobel
In vivo cooperation between Bcl‐x L and the phosphoinositide 3‐kinase‐Akt signaling pathway for the protection of epidermal keratinocytes from apoptosis
2003
Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development
1997
Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function
2003
A New IFN-Like Cytokine, Limitin Modulates the Immune Response Without Influencing Thymocyte Development
2001
Limb and Skin Abnormalities in Mice Lacking IKKα
1999 Science