Standout Papers
Citation Impact
Citing Papers
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
2006
Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
2015 StandoutNobel
Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage
2004
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
2015 StandoutScienceNobel
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling
2018
Regulation of Insulin Secretion by SIRT4, a Mitochondrial ADP-ribosyltransferase
2007
Inhibition of PPARγ2 Gene Expression by the HIF-1-Regulated Gene DEC1/Stra13
2002
Liver X receptors are regulators of adipocyte gene expression but not differentiation
2004
Sirtuins as regulators of metabolism and healthspan
2012 Standout
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells
2004
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Induction of human neuronal cells by defined transcription factors
2011 StandoutNatureNobel
Promotion of embryonic cortico-cerebral neuronogenesis by miR-124
2009
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Activation of Double-stranded RNA-activated Protein Kinase (PKR) by Interferon-stimulated Gene 15 (ISG15) Modification Down-regulates Protein Translation
2012
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
EPAS1 Promotes Adipose Differentiation in 3T3-L1 Cells
2004
Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
2010
The Plasticity of Aging: Insights from Long-Lived Mutants
2005
Nuclear Trapping of the Forkhead Transcription Factor FoxO1 via Sirt-dependent Deacetylation Promotes Expression of Glucogenetic Genes
2005
Central and peripheral factors contributing to obstructive sleep apneas
2013
Caenorhabditis elegans HCF-1 Functions in Longevity Maintenance as a DAF-16 Regulator
2008
Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors
1998
Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses
2018 StandoutNobel
SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
2007
Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis
2010
Mechanism of Human SIRT1 Activation by Resveratrol
2005
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
The interaction between FOXO and SIRT1: tipping the balance towards survival
2004
Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
2005
A conformational switch controls hepatitis delta virus ribozyme catalysis
2004 StandoutNatureNobel
The retinoblastoma gene family in differentiation and development
1999
E2Fs Regulate Adipocyte Differentiation
2002
Requirement of fibroblast growth factor 10 in development of white adipose tissue
2002
A systematic RNAi screen for longevity genes in C. elegans
2005 StandoutNobel
Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
2010
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
The Sir2 family of protein deacetylases
2005
Insulin-induced Adipocyte Differentiation
2001
Cooperation between C/EBPα TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation
2001
PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
2004
Hedgehog signaling plays a conserved role in inhibiting fat formation
2006
The Krüppel-like Factor KLF2 Inhibits Peroxisome Proliferator-activated Receptor-γ Expression and Adipogenesis
2003
Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor–1 (Pref-1)
2003
SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α
2005
DBC1 is a negative regulator of SIRT1
2008 Nature
Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice
2002
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
2020 StandoutNatureNobel
Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin
2001
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons
2008
A Role for C/EBPβ in Regulating Peroxisome Proliferator-activated Receptor γ Activity during Adipogenesis in 3T3-L1 Preadipocytes
2001
Sirtuins, Aging, and Medicine
2011
Stimulation of 3T3-L1 Adipogenesis by Signal Transducer and Activator of Transcription 5
2002
Wnt signaling in osteoblasts and bone diseases
2004
Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification
2008
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
2007
Direct lineage conversions: unnatural but useful?
2011
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1
2007
Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses
2005
Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
2008
Transcriptional targets of sirtuins in the coordination of mammalian physiology
2008
Cellular and molecular control of neurogenesis in the mammalian telencephalon
2005
p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans
2006
Wnt5b partially inhibits canonical Wnt/β-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes
2005
Activation of CCAAT/Enhancer-binding Protein (C/EBP) α Expression by C/EBPβ during Adipogenesis Requires a Peroxisome Proliferator-activated Receptor-γ-associated Repression of HDAC1 at the C/ebpα Gene Promoter
2006
Adipose Development: From Stem Cell to Adipocyte
2005
PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
2011
Mitochondria, Oxidants, and Aging
2005 Standout
FOXOs: signalling integrators for homeostasis maintenance
2013
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
2005
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
2009
Reconstitution of Insulin-sensitive Glucose Transport in Fibroblasts Requires Expression of Both PPARγ and C/EBPα
1999
Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells
2004
Molecular basis of transdifferentiation of pancreas to liver
2000
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
2007 Standout
LXRβ Is Required for Adipocyte Growth, Glucose Homeostasis, and β Cell Function
2005
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells
2004
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Wnt10b Inhibits Development of White and Brown Adipose Tissues
2004
Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase
2005
SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity
2006
Activation of β-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation
2003
Building strong bones: molecular regulation of the osteoblast lineage
2011
Recent progress in the biology and physiology of sirtuins
2009 Nature
daf-16 Protects the Nematode Caenorhabditis elegans During Food Deprivation
2006
Role of MAPK Phosphatase-1 (MKP-1) in Adipocyte Differentiation
2004
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
2005
Toward a unified theory of caloric restriction and longevity regulation
2005
Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
2009
AMP-activated protein kinase and its downstream transcriptional pathways
2010
Reciprocal Roles of Msx2 in Regulation of Osteoblast and Adipocyte Differentiation
2004
Rosiglitazone Causes Bone Loss in Mice by Suppressing Osteoblast Differentiation and Bone Formation
2005
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
2005
HTR7 Mediates Serotonergic Acute and Chronic Itch
2015
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation
2005
Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin
2005
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
2004 StandoutNature
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade
2015
Constitutively Active Mitogen-activated Protein Kinase Kinase 6 (MKK6) or Salicylate Induces Spontaneous 3T3-L1 Adipogenesis
1999
Mitochondrial sirtuins
2010
Negative regulation of the deacetylase SIRT1 by DBC1
2008 Nature
PIEZO2 in sensory neurons and urothelial cells coordinates urination
2020 StandoutNatureNobel
DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
2010
Adipocyte differentiation from the inside out
2006 Standout
Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?
2011
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
2006 Standout
SMK-1, an Essential Regulator of DAF-16-Mediated Longevity
2006
The chemical repertoire of natural ribozymes
2002 StandoutNatureNobel
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
2005 StandoutNature
SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells
2006
Active Regulator of SIRT1 Cooperates with SIRT1 and Facilitates Suppression of p53 Activity
2007
The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch
2013
Gene array analysis of Wnt-regulated genes in C3H10T1/2 cells
2005
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
2009
Adipogenesis: forces that tip the scales
2002
Inhibition of Histone Deacetylase Activity by Valproic Acid Blocks Adipogenesis
2004
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
Conditional deletion of β-catenin in the mesenchyme of the developing mouse uterus results in a switch to adipogenesis in the myometrium
2005
PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
2009
Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics
2016
The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation
2003
The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor
2007
SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
2010
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
FOXO1 is an essential regulator of pluripotency in human embryonic stem cells
2011
CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
2011
Inhibition of p38MAPK Increases Adipogenesis From Embryonic to Adult Stages
2006
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
2005 Standout
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
ETO/MTG8 Is an Inhibitor of C/EBPβ Activity and a Regulator of Early Adipogenesis
2004
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
2004
Regulatory circuits controlling white versus brown adipocyte differentiation
2006
The Biochemistry of Sirtuins
2006
The application of targeted mass spectrometry‐based strategies to the detection and localization of post‐translational modifications
2014
Transcriptional regulation of adipogenesis
2000 Standout
On Acetyl-CoA as a Gauge of Cellular Metabolic State
2011
Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1
2009 Science
Foxo3a is essential for maintenance of the hematopoietic stem cell pool
2009
Differential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation
2004
Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations
2006
Pain regulation by non-neuronal cells and inflammation
2016 StandoutScience
Testosterone Inhibits Adipogenic Differentiation in 3T3-L1 Cells: Nuclear Translocation of Androgen Receptor Complex with β-Catenin and T-Cell Factor 4 May Bypass Canonical Wnt Signaling to Down-Regulate Adipogenic Transcription Factors
2005
C/EBPα is required for differentiation of white, but not brown, adipose tissue
2001
Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1
2011
Regulation of osteoblastogenesis and bone mass by Wnt10b
2005
A Calcium-Regulated MEF2 Sumoylation Switch Controls Postsynaptic Differentiation
2006 Science
Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway
2004 Science
Mammalian Sirtuins: Biological Insights and Disease Relevance
2010 Standout
The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice
2018 StandoutNobel
Peroxisome-proliferator-activated receptor γ suppresses Wnt/β-catenin signalling during adipogenesis
2003
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells
2006 StandoutNobel
Regulation of Peroxisome Proliferator–Activated Receptor-γ Activity by Mammalian Target of Rapamycin and Amino Acids in Adipogenesis
2004
Early B-Cell Factor (O/E-1) Is a Promoter of Adipogenesis and Involved in Control of Genes Important for Terminal Adipocyte Differentiation
2002
Direct pKa Measurement of the Active-Site Cytosine in a Genomic Hepatitis Delta Virus Ribozyme
2001 StandoutNobel
Activated Liver X Receptors Stimulate Adipocyte Differentiation through Induction of Peroxisome Proliferator-Activated Receptor γ Expression
2004
PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
2004
The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease
2017
Molecular Targets of Lithium Action
2001
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice
2011 StandoutNobel
Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal
2012 StandoutNobel
PIEZO2 mediates injury-induced tactile pain in mice and humans
2018
Molecular Regulation of Adipogenesis
2000
Activation of an adipogenic program in adult myoblasts with age
2002
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Sirtuins — novel therapeutic targets to treat age-associated diseases
2008
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Wnt10b Deficiency Promotes Coexpression of Myogenic and Adipogenic Programs in Myoblasts
2005
The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways
2010
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
2006 Standout
Works of Sarah E. Ross being referenced
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
2004 StandoutScience
Identification of molecular markers of bipolar cells in the murine retina
2008
Bhlhb5 and Prdm8 Form a Repressor Complex Involved in Neuronal Circuit Assembly
2012
Growth Hormone Regulates Phosphorylation and Function of CCAAT/Enhancer-binding Protein β by Modulating Akt and Glycogen Synthase Kinase-3
2001
Wnt Signaling Protects 3T3-L1 Preadipocytes from Apoptosis through Induction of Insulin-like Growth Factors
2002
Identification of Spinal Circuits Transmitting and Gating Mechanical Pain
2014
Regulation of Wnt Signaling during Adipogenesis
2002
Basic Helix-Loop-Helix Factors in Cortical Development
2003
Developmental Origin of PreBötzinger Complex Respiratory Neurons
2010
Pain and itch: insights into the neural circuits of aversive somatosensation in health and disease
2011
Signaling Pathways through Which Insulin Regulates CCAAT/Enhancer Binding Protein α (C/EBPα) Phosphorylation and Gene Expression in 3T3-L1 Adipocytes
1997
The Role of C/EBP Genes in Adipocyte Differentiation
1998
SUMO-1 Modification Represses Sp3 Transcriptional Activation and Modulates Its Subnuclear Localization
2002
p300 Coactivates the Adipogenic Transcription Factor CCAAT/Enhancer-binding Protein α
2001
Keratinocytes can modulate and directly initiate nociceptive responses
2015
Inhibition of Adipogenesis by Wnt Signaling
2000 StandoutScience
Glycogen Synthase Kinase 3 Is an Insulin-Regulated C/EBPα Kinase
1999
Phosphorylation of C/EBPα Inhibits Granulopoiesis
2003
Microarray Analyses during Adipogenesis: Understanding the Effects of Wnt Signaling on Adipogenesis and the Roles of Liver X Receptor α in Adipocyte Metabolism
2002