Citation Impact
Citing Papers
Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response
2013 StandoutNobel
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs
2013
Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent
2017 Science
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
2016 Science
Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells
2011
CRISPR/Cas9 in Genome Editing and Beyond
2016
Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection
2012
A genomic region associated with protection against severe COVID-19 is inherited from Neandertals
2021 StandoutNobel
CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1
2011
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
2023 StandoutNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)
2013 StandoutNobel
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor–Transduced Human T cells in Solid Tumors
2014
Regulation of Virus-Specific CD4+ T Cell Function by Multiple Costimulatory Receptors during Chronic HIV Infection
2010
Phenotype, Function, and Gene Expression Profiles of Programmed Death-1hi CD8 T Cells in Healthy Human Adults
2011
Atypical Memory B Cells Are Greatly Expanded in Individuals Living in a Malaria-Endemic Area
2009
CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1–Mediated Inhibition
2010
TGF-β Blockade Does Not Improve Control of an Established Persistent Viral Infection
2012
NFATc1 Regulates PD-1 Expression upon T Cell Activation
2008
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
2015
Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
2013
Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases
2015
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Structure and Engineering of Francisella novicida Cas9
2016
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
2013
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion
2012
Systemic Immunity Is Required for Effective Cancer Immunotherapy
2017
Epigenetic Manipulation Restores Functions of Defective CD8+ T Cells From Chronic Viral Infection
2014
Enhancing SIV-specific immunity in vivo by PD-1 blockade
2008 Nature
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection
2011
Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo
2009
De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation
2017
Tolerance and exhaustion: defining mechanisms of T cell dysfunction
2013
Oncology Meets Immunology: The Cancer-Immunity Cycle
2013 Standout
Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion
2016
Diversity in T Cell Memory: An Embarrassment of Riches
2009
DC-based cancer vaccines
2007
CRISPR RNAs trigger innate immune responses in human cells
2018
Combination cancer immunotherapy and new immunomodulatory targets
2015
T cell exhaustion
2011 Standout
Networking at the Level of Host Immunity: Immune Cell Interactions during Persistent Viral Infections
2013
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
2015
Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family
2016
PDL1 Regulation by p53 via miR-34
2015
Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation
2010
Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells
2008
SUSD2 suppresses CD8+ T cell antitumor immunity by targeting IL-2 receptor signaling
2022
T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection
2014
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
2016 Nature
The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection
2014
T cell exhaustion in protozoan disease
2012
Transcriptional control of effector and memory CD8+ T cell differentiation
2012
PD‐1 signaling in primary T cells
2009
sgRNAcas9: A Software Package for Designing CRISPR sgRNA and Evaluating Potential Off-Target Cleavage Sites
2014
Role of interleukin-12 family cytokines in the cellular response to mycobacterial disease
2009
Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy
2018
T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion
2013
Evolving synergistic combinations of targeted immunotherapies to combat cancer
2015
Distinctive features of CD4+ T cell dysfunction in chronic viral infections
2014
Integrating Genomic Signatures for Immunologic Discovery
2010
Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection
2016
Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties
2009
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA
2014
Redefining Chronic Viral Infection
2009
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
Overcoming T cell exhaustion in infection and cancer
2015
Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells
2013
Immune Memory and Exhaustion: Clinically Relevant Lessons from the LCMV Model
2015
TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer
2021
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
2015 Standout
Programmed Cell Death 1-Directed Immunotherapy for Enhancing T-Cell Function
2013
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
2010
The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8 + T Cell Effector Function
2014
Inhibitory Molecules That Regulate Expansion and Restoration of HCV-Specific CD4+ T Cells in Patients With Chronic Infection
2011
Control of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathways
2008
Memory Inflation during Chronic Viral Infection Is Maintained by Continuous Production of Short-Lived, Functional T Cells
2008
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
2008 Standout
A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection
2009
Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation
2010
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion
2019
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
2014
Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection
2014
The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses
2009
Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory
2012
Eomesodermin is required for antitumor immunity mediated by 4-1BB-agonist immunotherapy
2014
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Cell-Intrinsic IL-27 and gp130 Cytokine Receptor Signaling Regulates Virus-Specific CD4+ T Cell Responses and Viral Control during Chronic Infection
2013
BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination
2010
IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2
2017
Molecular and cellular insights into T cell exhaustion
2015 Standout
In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni
2017
Genotyping with CRISPR-Cas-derived RNA-guided endonucleases
2014
Clinical blockade of PD1 and LAG3 — potential mechanisms of action
2014
IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection
2013
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
2013 StandoutNobel
Diversity in CD8+ T cell differentiation
2009
Targeting T cell metabolism for therapy
2015
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells
2015
Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
2011
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy
2023 StandoutNobel
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection
2014
Liver-Directed Gamma Interferon Gene Delivery in Chronic Hepatitis C
2005 StandoutNobel
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Revealing the role of CD4+ T cells in viral immunity
2012
Roles of regulatory T cells in cancer immunity
2016
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
Selective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockade
2008
T Cell Ig and Mucin Domain–Containing Protein 3 Is Recruited to the Immune Synapse, Disrupts Stable Synapse Formation, and Associates with Receptor Phosphatases
2013
B7x in the Periphery Abrogates Pancreas-Specific Damage Mediated by Self-reactive CD8 T Cells
2012 StandoutNobel
PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV
2009
Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1
2014
Programmed Cell Death 1-Directed Immunotherapy for Enhancing T-Cell Function
2013
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
2013
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients
2011
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
2009
Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution
2009
Inhibitory Receptors on Lymphocytes: Insights from Infections
2012
Sprouty-2 regulates HIV-specific T cell polyfunctionality
2013
Immunotherapeutic effects of IL-7 during a chronic viral infection in mice
2011
Cell intrinsic mechanisms of T‐cell inhibition and application to cancer therapy
2008 StandoutNobel
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
2014 Standout
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
2018 StandoutNobel
The epigenetic landscape of T cell exhaustion
2016 Science
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
2008 StandoutNobel
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Early CD4+ T Cell Help Prevents Partial CD8+ T Cell Exhaustion and Promotes Maintenance of Herpes Simplex Virus 1 Latency
2009
Progenitor and Terminal Subsets of CD8 + T Cells Cooperate to Contain Chronic Viral Infection
2012 Science
Myeloid‐derived suppressor cells: the dark knight or the joker in viral infections?
2013
Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses
2015
Dynamics of the Cytotoxic T Cell Response to a Model of Acute Viral Infection
2015
Unique potential of 4-1BB agonist antibody to promote durable regression of HPV + tumors when combined with an E6/E7 peptide vaccine
2015 StandoutNobel
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Computational design of mechanically coupled axle-rotor protein assemblies
2022 StandoutScienceNobel
Lipopolysaccharide or Whole Bacteria Block the Conversion of Inflammatory Monocytes into Dendritic Cells In Vivo
2003 StandoutNobel
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
Cutting Edge: Prolonged Exposure to HIV Reinforces a Poised Epigenetic Program for PD-1 Expression in Virus-Specific CD8 T Cells
2013
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities
2016 StandoutNobel
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
Tissue-Specific Differences in PD-1 and PD-L1 Expression during Chronic Viral Infection: Implications for CD8 T-Cell Exhaustion
2009
IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
2008
Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans
2013
Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection
2014
Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity
2012
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells
2009
PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
2014
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Therapeutic Blockade of Transforming Growth Factor Beta Fails To Promote Clearance of a Persistent Viral Infection
2012
De novo design of protein logic gates
2020 StandoutScienceNobel
Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
2008
The Yin and Yang of regulatory T cells in infectious diseases and avenues to target them
2017
Works of Sang‐Jun Ha being referenced
Chronic Virus Infection Enforces Demethylation of the Locus that Encodes PD-1 in Antigen-Specific CD8+ T Cells
2011
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
2007 Standout
Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases
2013
PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice
2010
Negative Regulation of Type I IFN Expression by OASL1 Permits Chronic Viral Infection and CD8+ T-Cell Exhaustion
2013
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells
2022
Hepatitis C Virus Core Protein Inhibits Interleukin 12 and Nitric Oxide Production from Activated Macrophages
2001
Tumor-infiltrating regulatory T cells delineated by upregulation of PD-1 and inhibitory receptors
2012
PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells
2013
Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections
2008
Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection
2008
Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection
2011
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
2007
Stimulation History Dictates Memory CD8 T Cell Phenotype: Implications for Prime-Boost Vaccination
2006
IL-23 Induces Stronger Sustained CTL and Th1 Immune Responses Than IL-12 in Hepatitis C Virus Envelope Protein 2 DNA Immunization
2004
4-1BB Signaling Synergizes with Programmed Death Ligand 1 Blockade To Augment CD8 T Cell Responses during Chronic Viral Infection
2011
A Novel Function of IL-12p40 as a Chemotactic Molecule for Macrophages
1999
PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8+ T Cell Immune Response via the Interaction with PD-L1 Expressed on CD8+ T Cells
2015
Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection
2009
Enhanced Immunogenicity and Protective Efficacy with the Use of Interleukin-12-Encapsulated Microspheres plus AS01B in Tuberculosis Subunit Vaccination
2006
Interleukin-21 Is a Critical Cytokine for the Generation of Virus-Specific Long-Lived Plasma Cells
2013
IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection
2008
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
2010