Citation Impact
Citing Papers
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans
2012 StandoutNobel
Navigating the protein fitness landscape with Gaussian processes
2012 StandoutNobel
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
Protein stability promotes evolvability
2006 StandoutNobel
The impact of aromatase mechanism on other P450s
1997
Progress towards the easier use of P450 enzymes
2006
SCHEMA Recombination of a Fungal Cellulase Uncovers a Single Mutation That Contributes Markedly to Stability
2009 StandoutNobel
Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450
2006 StandoutNobel
Crystal structure and refinement of cytochrome P450terp at 2·3 Å resolution
1994 Nobel
High throughput assay for cytochrome P450 BM3 for screening libraries of substrates and combinatorial mutants
2002
Protein engineering of oxygenases for biocatalysis
2002 StandoutNobel
Developmental Expression of Genes Involved in Neurosteroidogenesis: 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase in the Rat Brain
2003
Critical Role of the Residue Size at Position 87 in H2O2-Dependent Substrate Hydroxylation Activity and H2O2 Inactivation of Cytochrome P450BM-3
2001
Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo
2013 StandoutNobel
Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation
1999 StandoutNatureNobel
Stopped-flow spectrophotometric analysis of intermediates in the peroxo-dependent inactivation of cytochrome P450 by aldehydes
2000
Evolution of the cytochrome P450 superfamily: sequence alignments and pharmacogenetics
1998
Cost-Effective Whole-Cell Assay for Laboratory Evolution of Hydroxylases in Escherichia coli
2001 StandoutNobel
Preparation of human metabolites of propranolol using laboratory‐evolved bacterial cytochromes P450
2005 StandoutNobel
Estrogen: Consequences and Implications of Human Mutations in Synthesis and Action1
1999
Pro-resolving lipid mediators are leads for resolution physiology
2014 StandoutNature
Laboratory evolution of cytochrome P450 BM‐3 monooxygenase for organic cosolvents
2003 StandoutNobel
Modulation of Human CYP19A1 Activity by Mutant NADPH P450 Oxidoreductase
2007
Directed Evolution of the Fatty-Acid Hydroxylase P450 BM-3 into an Indole-Hydroxylating Catalyst
2000
Does central obesity reflect “Cushing's disease of the omentum”?
1997
Thiazolidinediones but Not Metformin Directly Inhibit the Steroidogenic Enzymes P450c17 and 3β-Hydroxysteroid Dehydrogenase
2001
The Protective Effects of Estrogen on the Cardiovascular System
1999 Standout
A Continuous Spectrophotometric Assay for P450 BM-3, a Fatty Acid Hydroxylating Enzyme, and Its Mutant F87A
1999
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Control of the stereo-selectivity of styrene epoxidation by cytochrome P450 BM3 using structure-based mutagenesis
2011
Are branched chain fatty acids the natural substrates for P450BM3?
2006
Biocatalysts for the formation of three- to six-membered carbo- and heterocycles
2015
A Self‐Sufficient Peroxide‐Driven Hydroxylation Biocatalyst
2003 StandoutNobel
Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells
2003 Standout
Androgen synthesis in adrenarche
2008
The regulation of 17,20 lyase activity
1997
Hydroxylation activity of P450 BM-3 mutant F87V towards aromatic compounds and its application to the synthesis of hydroquinone derivatives from phenolic compounds
2004
Terpene Hydroxylation with Microbial Cytochrome P450 Monooxygenases
2015
Coupling between Cyclooxygenase, Terminal Prostanoid Synthase, and Phospholipase A2
2001
Using proteins in their natural environment: potential and limitations of microbial whole-cell hydroxylations in applied biocatalysis
2001
P450BM3(CYP102A1): connecting the dots
2011
Organocatalytic Asymmetric Hydrolysis of Epoxides
2014 StandoutNobel
Enantioselective Epoxidation of Terminal Alkenes to (R)‐ and (S)‐Epoxides by Engineered Cytochromes P450 BM‐3
2005 StandoutNobel
Structural basis for androgen specificity and oestrogen synthesis in human aromatase
2009 Nature
Protein engineering of Bacillus megaterium CYP102
2001
A key enzyme in the biosynthesis of neurosteroids, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase (3β-HSD), is expressed in rat brain
1995
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Controlled regioselectivity of fatty acid oxidation by whole cells producing cytochrome P450BM-3 monooxygenase under varied dissolved oxygen concentrations
1999
P450 BM3: the very model of a modern flavocytochrome
2002
How do substrates enter and products exit the buried active site of cytochrome P450cam? 2. Steered molecular dynamics and adiabatic mapping of substrate pathways 1 1Edited by J. Thornton
2000
The genetic and functional basis of isolated 17,20–lyase deficiency
1997
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
The hormone resistin links obesity to diabetes
2001 StandoutNature
Fetal Death in Mice Lacking 5α-Reductase Type 1 Caused by Estrogen Excess
1997
A Hormonal Signaling Pathway Influencing C. elegans Metabolism, Reproductive Development, and Life Span
2001
Structure and function of cytochromes P450:a comparative analysis of three crystal structures
1995 Nobel
Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran
2014 StandoutNobel
Fatty acid metabolism, conformational change, and electron transfer in cytochrome P-450BM-3
1999
Mutation of Proline 409 to Arginine in the Meander Region of Cytochrome P450c17 Causes Severe 17α-Hydroxylase Deficiency
2001
Microbial P450 enzymes in biotechnology
2004
Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene ω-hydroxylase CYP4C7
2009
Cytochromes P450 as versatile biocatalysts
2006
Molecular Modeling of Human P450c17 (17α-Hydroxylase/ 17,20-Lyase): Insights into Reaction Mechanisms and Effects of Mutations
1999
Evolved CYP102A1 (P450BM3) variants oxidise a range of non-natural substrates and offer new selectivity options
2008
The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature
1993 Standout
Escherichia coliFlavodoxin Sepharose as an Affinity Resin for Cytochromes P450 and Use to Identify a Putative Cytochrome P450c17/3β-Hydroxysteroid Dehydrogenase Interaction
1997
Adipose tissue as an endocrine and paracrine organ
1998
Rational evolution of a medium chain-specific cytochrome P -450 BM-3 variant
2001
Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties
2007 StandoutNobel
Switching on the Nucleophilic Reactivity of a Ferric Porphyrin Peroxo Complex
1998
Enantioselective α-Hydroxylation of 2-Arylacetic Acid Derivatives and Buspirone Catalyzed by Engineered Cytochrome P450 BM-3
2006 StandoutNobel
Clinical review 78: Aromatase deficiency in women and men: would you have predicted the phenotypes?
1996
Mimicking Cytochrome P-450 2B4 and Aromatase: Aromatization of a Substrate Analogue by a Peroxo Fe(III) Porphyrin Complex
1998
Expression, Purification, and Characterization of Bacillus subtilis Cytochromes P450 CYP102A2 and CYP102A3: Flavocytochrome Homologues of P450 BM3 from Bacillus megaterium
2004
Practical, enantiospecific syntheses of 14,15-EET and leukotoxin B (vernolic acid)
2001
Understanding and exploiting C–H bond activation
2002 StandoutNature
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
2002 StandoutScienceNobel
Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase
2018 StandoutNobel
Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency*
2000
Tuning P450 Enzymes as Oxidation Catalysts
2012
Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens.
1995
Biocatalyst Engineering by Assembly of Fatty Acid Transport and Oxidation Activities for In Vivo Application of Cytochrome P-450 BM-3 Monooxygenase
1998
Directed Evolution of the Fatty-Acid Hydroxylase P450 BM-3 into an Indole-Hydroxylating Catalyst
2000
Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing
2000
Minireview: Regulation of Steroidogenesis by Electron Transfer
2005
Generation and reproductive phenotypes of mice lacking estrogen receptor β
1998 StandoutNobel
Abolition of male sexual behaviors in mice lacking estrogen receptors α and β (αβERKO)
2000 StandoutNobel
A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans
2009 StandoutNobel
Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene
1998
A Transgenic Model of Visceral Obesity and the Metabolic Syndrome
2001 StandoutScience
Steroid Hormone Biosynthesis and Actions in the Materno Fetoplacental Unit
1998
Single-molecule height measurements on microsomal cytochrome P450 in nanometer-scale phospholipid bilayer disks
2002
Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue.
1993
Engineering Cytochrome P450 BM-3 for Oxidation of Polycyclic Aromatic Hydrocarbons
2001
Core glycosylation of cytochrome P-450(arom). Evidence for localization of N terminus of microsomal cytochrome P-450 in the lumen.
1993
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
2011 Standout
Tissue-specific expression of human P-450AROM. The promoter responsible for expression in adipose tissue is different from that utilized in placenta
1991
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Role of Prostacyclin in the Cardiovascular Response to Thromboxane A 2
2002 StandoutScience
Clinical review 78: Aromatase deficiency in women and men: would you have predicted the phenotypes?
1996
A family of thermostable fungal cellulases created by structure-guided recombination
2009 StandoutNobel
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes
2016 StandoutNobel
Engineering Cytochrome P450 BM3 for Terminal Alkane Hydroxylation
2006 StandoutNobel
Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlI, a Cytochrome P450 of Streptomyces avermitilis
2006 StandoutNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Reduction of Dioxygen Catalyzed by Pyrene-Wired Heme Domain Cytochrome P450 BM3 Electrodes
2004 StandoutNobel
A Single Mutation in Cytochrome P450 BM3 Changes Substrate Orientation in a Catalytic Intermediate and the Regiospecificity of Hydroxylation
1997
Roles of key active-site residues in flavocytochrome P450 BM3
1999
Residue size at position 87 of cytochrome P450 BM‐3 determines its stereoselectivity in propylbenzene and 3‐chlorostyrene oxidation
2001
Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3
2003 StandoutNobel
Fatty acid‐specific, regiospecific, and stereospecific hydroxylation by cytochrome P450 (CYP152B1) from Sphingomonas paucimobilis: Substrate structure required for α‐hydroxylation
2000
Flavocytochrome P450 BM3: an update on structure and mechanism of a biotechnologically important enzyme
2005
Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions
2018 StandoutNobel
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
Metalloporphyrin Peroxo Complexes of Iron(III), Manganese(III), and Titanium(IV). Comparative Studies Demonstrating That the Iron(III) Complex Is Extremely Nucleophilic
1997
Identification of a New Class of Cytochrome P450 from a Rhodococcus sp
2002
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
2023 StandoutNobel
Aromatase—A Brief Overview
2002
Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
2005
Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine
2002
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
Functional Interactions in Cytochrome P450BM3: Flavin Semiquinone Intermediates, Role of NADP(H), and Mechanism of Electron Transfer by the Flavoprotein Domain
1997
Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins
2017 StandoutNobel
Pivotal Role of Water in the Mechanism of P450BM-3
2001
Estrogen inhibits the vascular injury response in estrogen receptor β-deficient female mice
1999 StandoutNobel
Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries.
1993
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
2017 StandoutNobel
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of Sandra E. Graham-Lorence being referenced
[35] Structural alignments of P450s and extrapolations to the unknown
1996
The Highly Stereoselective Oxidation of Polyunsaturated Fatty Acids by Cytochrome P450BM-3
1996
Regulation of Estrogen Biosynthesis by Human Adipose Cells*
1989
3β-Hydroxysteroid dehydrogenase/Δ5→4-isomerase expression in rat and characterization of the testis isoform
1991
A three‐dimensional model of aromatase cytochrome P450
1995
P450BM-3: A tale of two domains—or is it three?
1997
Nucleotide sequence of a cDNA encoding porcine testis 17α-hydroxylase cytochrome P-450
1992
Aromatase Cytochrome P450, The Enzyme Responsible for Estrogen Biosynthesis*
1994 Standout
Functional domains of human aromatase cytochrome P450 characterized by linear alignment and site-directed mutagenesis.
1993
Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells.
1988
Structure-function relationships of human aromatase cytochrome P-450 using molecular modeling and site-directed mutagenesis
1991
Cytochrome P-450terp. Isolation and purification of the protein and cloning and sequencing of its operon.
1992
An Active Site Substitution, F87V, Converts Cytochrome P450 BM-3 into a Regio- and Stereoselective (14S,15R)-Arachidonic Acid Epoxygenase
1997
P450s: Structural similarities and functional differences
1996
Aromatase expression in health and disease.
1997