Standout Papers
Citation Impact
Citing Papers
Hydroxyurea therapy lowers transcranial Doppler flow velocities in children with sickle cell anemia
2007
Impact of hydroxyurea on clinical events in the BABY HUG trial
2012
The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS)
2009
Rib infarcts and acute chest syndrome in sickle cell diseases
1991
The Molecular Genetics of Human Hemoglobin
1984
Climate and painful crisis of sickle-cell disease in Jamaica.
1976
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Management of Sickle Cell Disease
2014
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Survival among children and adults with sickle cell disease in Belgium: Benefit from hydroxyurea treatment
2015
Silent Cerebral Infarcts in Sickle Cell Anemia: A Risk Factor Analysis
1999
Hemoglobin disorders and endothelial cell interactions
2009
The painful crisis of homozygous sickle cell disease: clinical features
1994
The cost of health care for children and adults with sickle cell disease
2009
Prophylactic Red-Cell Transfusions in Pregnant Patients with Sickle Cell Disease
1988
Destabilization of the complete protein secondary structure on binding to the chaperone GroEL
1994 StandoutNatureNobel
Erythroid adhesion molecules in sickle cell disease: Effect of hydroxyurea
2008
Pain in Sickle Cell Disease
1991
Pathogenesis and Treatment of Sickle Cell Disease
1997
Acute chest syndrome of sickle cell disease: new light on an old problem
2001
Hemoglobin: Structure, Function and Allostery
2020
SYSTEMIC FAT EMBOLISM AND PULMONARY HYPERTENSION IN SICKLE CELL DISEASE
1996
Management of Patients with Sickle Cell Disease Using Transfusion Therapy
2016
Prediction of Adverse Outcomes in Children with Sickle Cell Disease
2000
New therapies in sickle cell disease
2002
Hydroxyurea for sickle cell disease in children and for prevention of cerebrovascular events: the Belgian experience
2004
Characteristics of pain managed at home in children and adolescents with sickle cell disease by using diary self-reports
2002
Increased adhesive properties of neutrophils in sickle cell disease may be reversed by pharmacological nitric oxide donation
2008
Stroke prevention in sickle cell disease
2000
The generation of diversity and pattern in animal development
1992 StandoutNobel
Cellular effects of hydroxyurea in Hb SC disease
1997
Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males
2008
Hydroxyurea Therapy for Pediatric Patients With Hemoglobin SC Disease
2001
Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease
2016
Resolution of chronic hypoxemia in pediatric sickle cell patients after treatment with hydroxyurea
2008
Haematopoietic cell transplantation in the treatment of sickle cell disease
2003
Pain site frequency and location in sickle cell disease: The PiSCES project
2009
When Checkpoints Fail
1997 StandoutNobel
Current concerns in haematology. 1. Is the painful crisis of sickle cell disease a "steal" syndrome?
1990
Enalapril and hydroxyurea therapy for children with sickle nephropathy
2005
Techniques for blood administration in sickle cell patients
2001
Genetic modifiers of sickle cell disease
2012
Clinical management of adult sickle-cell disease
2012
Gender and haplotype effects upon hematological manifestations of adult sickle cell anemia
1995
Sickle-cell disease
1997
Cardiopulmonary complications leading to premature deaths in adult patients with sickle cell disease
2009
Measuring and increasing protein stability
1990
Hemoglobin SE disease—A concise review
2007
Outcome of Sickle Cell Anemia
2005
Advances in clinical research in sickle cell disease
2008
Prevention of secondary stroke and resolution of transfusional iron overload in children with sickle cell anemia using hydroxyurea and phlebotomy
2004
Hydroxyurea induces the eNOS-cGMP pathway in endothelial cells
2006
Reconstructing sickle cell disease: A data‐based analysis of the “hyperhemolysis paradigm” for pulmonary hypertension from the perspective of evidence‐based medicine
2010
Investigational drugs in sickle cell anemia
2009
A cell stress signaling model of fetal hemoglobin induction: what doesn't kill red blood cells may make them stronger
2008
Sickle Cell Hemoglobin Polymerization
1990
Novel Use of Hydroxyurea in an African Region With Malaria: Protocol for a Randomized Controlled Clinical Trial
2016
Prevention of a First Stroke by Transfusions in Children with Sickle Cell Anemia and Abnormal Results on Transcranial Doppler Ultrasonography
1998 Standout
Levels of Fetal Hemoglobin Necessary for Treatment of Sickle Cell Disease
1988
Sickle cell disease: no longer a single gene disorder
2001
Sickle-cell disease
2010 Standout
Pregnancy in sickle cell disease in the UK: results of a multicentre survey of the effect of prophylactic blood transfusion on maternal and fetal outcome
1995
Sickle cell disease: challenges and progress
2016
Incentive Spirometry to Prevent Acute Pulmonary Complications in Sickle Cell Diseases
1995
Hydroxyurea therapy in children severely affected with sickle cell disease
1996
The risks and benefits of long‐term use of hydroxyurea in sickle cell anemia: A 17.5 year follow‐up
2010
Clinical and hematologic effects of hydroxyurea in children with sickle cell anemia
1996
A two-year pilot trial of hydroxyurea in very young children with sickle-cell anemia
2001
Risk of recurrent stroke in patients with sickle cell disease treated with erythrocyte transfusions
1995
Mortality In Sickle Cell Disease -- Life Expectancy and Risk Factors for Early Death
1994 Standout
Hydroxyurea is associated with lower prevalence of albuminuria in adults with sickle cell disease
2013
Guidelines for the management of the acute painful crisis in sickle cell disease
2003
Therapeutic Strategies for Prevention of Sickle Cell Dehydration
2001
Beneficial Effect of Blood Transfusion in Children With Sickle Cell Chest Syndrome
1988
Effect of transfusion in acute chest syndrome of sickle cell disease
1995
Sickle cell disease in Africa: burden and research priorities
2007
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Pulmonary hypertension in patients with sickle cell disease: a longitudinal study
2006
Long-term hydroxyurea treatment in young sickle cell patients
1999
Effect of Hydroxyurea Therapy on Resting Energy Expenditure in Children With Sickle Cell Disease
2001
A Comparison of Conservative and Aggressive Transfusion Regimens in the Perioperative Management of Sickle Cell Disease
1995
Exposure to Hydroxyurea and Pregnancy Outcomes in Patients With Sickle Cell Anemia
2009
Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb
1989 StandoutNobel
The paradox of hemoglobin SC disease
2003
Bone Marrow Transplantation for Sickle Cell Disease
1996
Similarities of the heme environment in vertebrate and non‐vertebrate oxygen‐binding hemoproteins
1972 StandoutNobel
A pilot study of hydroxyurea to prevent chronic organ damage in young children with sickle cell anemia
2008
Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension
2007
Sickle cell disease in North London
1987
Pharmacologic Modulation of Fetal Hemoglobin
2001
Day‐care management of sickle cell painful crisis in Jamaica: a model applicable elsewhere?
1999
Pathophysiology and treatment of stroke in sickle-cell disease: present and future
2006
Principles and problems of transfusion in sickle cell disease
2001
Sickle cell vaso-occlusion: multistep and multicellular paradigm
2002
Extended Therapy with Intravenous Arginine Butyrate in Patients with β-Hemoglobinopathies
1995
Chronic and acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia
2014
Advances in thalassemia research
1984
Efficacy and safety of deferasirox compared with deferoxamine in sickle cell disease: Two‐year results including pharmacokinetics and concomitant hydroxyurea
2013
Structural patterns in globular proteins
1976 StandoutNatureNobel
2016
Biochemical surrogate markers of hemolysis do not correlate with directly measured erythrocyte survival in sickle cell anemia
2016
Hemoglobin S polymerization: primary determinant of the hemolytic and clinical severity of the sickling syndromes
1985
Fetal Hemoglobin Variants in Mice
1968 StandoutScienceNobel
Effects of 5-aza-2′-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease
2003
Human Haemoglobins
1965
Sickle cell anemia day hospital: an approach for the management of uncomplicated painful crises
2000
Decrease of Very Late Activation Antigen-4 and CD36 on Reticulocytes in Sickle Cell Patients Treated With Hydroxyurea
1997
Predictors of fetal hemoglobin response in children with sickle cell anemia receiving hydroxyurea therapy
2002
Altering Genotype and Phenotype by DNA-Mediated Gene Transfer
1980 StandoutScienceNobel
Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.
1978
Duplication within the haptoglobin Hp2 gene
1984 StandoutNatureNobel
Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy
2008
Acute Chest Syndrome in Sickle Cell Disease: Clinical Presentation and Course
1997
Organization of human δ- and β-globin genes in cellular DNA and the presence of intragenic inserts
1978
Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes
1981 StandoutNobel
A gene deletion ending within a complex array of repeated sequences 3' to the human beta-globin gene cluster.
1986 StandoutNobel
Maintenance of elevated fetal hemoglobin levels by decitabine during dose interval treatment of sickle cell anemia
2002
A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy
1996
Genetic disruption of the KLF1 gene to overexpress the γ‐globin gene using the CRISPR/Cas9 system
2016
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
1988 StandoutScienceNobel
Cerebrovascular accidents in sickle cell disease: rates and risk factors.
1998 Standout
Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice
2012
Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S.
1979
Hydroxyurea for Sickle Cell Disease: A Systematic Review for Efficacy and Toxicity in Children
2008
Foetal Haemoglobin, Erythrocytes Containing Foetal Haemoglobin, and Hematological Features in Congolese Patients with Sickle Cell Anaemia
2012
Nitric oxide therapy in sickle cell disease
2001
The effect of temperature-sensitive RNA mutants on the transcription products from cloned ribosomal protein genes of yeast
1981 StandoutNobel
Gene amplification and gene correction in somatic cells
1982 StandoutNobel
Sickle Cell Disease: A Question of Equity and Quality
2006
Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease
2016
The natural history of stroke in sickle cell disease
1978
The Absence of "Heme-Heme" Interactions in Hemoglobin
1969 StandoutScienceNobel
Pulmonary hypertension and nitric oxide depletion in sickle cell disease
2010
Phospholipase A2 levels in acute chest syndrome of sickle cell disease
1996
Photoregulation of RNA Digestion by RNase H with Azobenzene-Tethered DNA
2004
A mouse α-globin-related pseudogene lacking intervening sequences
1980 StandoutNatureNobel
Hydroxyurea Generates Nitric Oxide in Human Erythroid Cells: Mechanisms for γ-Globin Gene Activation
2009
Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain
1985 StandoutNobel
Polycythemia: Mechanisms and Management
1981
A gene deletion ending at the midpoint of a repetitive DNA sequence in one form of hereditary persistence of fetal haemoglobin
1982 Nature
Novel bacteriophage lambda cloning vector.
1980 StandoutNobel
Natural History of Sickle Cell Anemia in Saudi Arabs
1978
THE MUTATION AND POLYMORPHISM OF THE HUMAN β-GLOBIN GENE AND ITS SURROUNDING DNA
1984
Fetal hemoglobin in sickle cell anemia: relationship to erythrocyte adhesion markers and adhesion
2001
Effect of active prenatal management on pregnancy outcome in sickle cell disease in an African setting
2000
Aqp1 expression in erythroleukemia cells: genetic regulation of glucocorticoid and chemical induction
1997 StandoutNobel
Survival of children with sickle cell disease
2004
Surgery and anesthesia in sickle cell disease. Cooperative Study of Sickle Cell Diseases
1995
THE PRESENT STATUS OF THE HETEROGENEITY OF FETAL HEMOGLOBIN IN β‐THALASSEMIA: AN ATTEMPT TO UNIFY SOME OBSERVATIONS IN THALASSEMIA AND RELATED CONDITIONS*
1974
Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia
1985 StandoutScienceNobel
Acute chest syndrome in sickle cell disease: Etiology and clinical correlates
1985
Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.
1980 StandoutNobel
Fine Structure Genetic Analysis of a β-Globin Promoter
1986 Science
Sickle cell disease and stroke
2009
The internally located telomeric sequences in the germ-line chromosomes of tetrahymena are at the ends of transposon-like elements
1985 StandoutNobel
Hydroxyurea as an Alternative to Blood Transfusions for the Prevention of Recurrent Stroke in Children With Sickle Cell Disease
1999
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.
1999
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
1996 StandoutNobel
Comparing the Means of Several Groups
1985
A modified transfusion program for prevention of stroke in sickle cell disease
1992
Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells
2007
Characterisation of deletions which affect the expression of fetal globin genes in man
1979 Nature
Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes
1982 StandoutNobel
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
1995 Standout
The thalassemia syndromes
1978
Six Months of Hydroxyurea Reduces Albuminuria in Patients with Sickle Cell Disease
2015
High-Dose Intravenous Methylprednisolone Therapy for Pain in Children and Adolescents with Sickle Cell Disease
1994
Organization of the constant-region gene family of the mouse immunoglobulin heavy chain
1982 StandoutNobel
Transgenic sickle mice have vascular inflammation
2003
Prenatal Diagnosis of α-Thalassemia
1976
beta 0 thalassemia, a nonsense mutation in man.
1979
Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.
1984
Hematologically and Genetically Distinct Forms of Sickle Cell Anemia in Africa
1985
Customizing the genome as therapy for the β-hemoglobinopathies
2016
Heterogeneity in the molecular basis of three types of hereditary persistence of fetal hemoglobin and the relative synthesis of the G? and A? types of ? chain
1984
Five years of experience with hydroxyurea in children and young adults with sickle cell disease
2001
Hydroxyurea for treatment of severe sickle cell anemia: a pediatric clinical trial
1996
Primary role for adherent leukocytes in sickle cell vascular occlusion: A new paradigm
2002
Alpha 4 beta 1-integrin expression on sickle reticulocytes: vascular cell adhesion molecule-1-dependent binding to endothelium
1993
Induction of human γ globin gene expression by histone deacetylase inhibitors
2003
CpG-rich islands and the function of DNA methylation
1986 StandoutNature
Structure and function of haemoglobin
1976
Transfusion and alloimmunization in sickle cell disease. The Cooperative Study of Sickle Cell Disease
1990
Hydroxyurea corrects the dysregulated L-selectin expression and increased H2O2 production of polymorphonuclear neutrophils from patients with sickle cell anemia
2002
Transfusion management of sickle cell disease
1993
Mutation in LDL Receptor: Alu-Alu Recombination Deletes Exons Encoding Transmembrane and Cytoplasmic Domains
1985 StandoutScienceNobel
Cloning Human Fetal γ Globin and Mouse α-Type Globin DNA: Characterization and Partial Sequencing
1978 StandoutScienceNobel
Ameliorating effects of fluorocarbon emulsion on sickle red blood cell–induced obstruction in an ex vivo vasculature
2001
Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas
1982 StandoutNatureNobel
A mouse model for beta 0-thalassemia.
1995 StandoutNobel
THE MOLECULAR GENETICS OF HUMAN HEMOGLOBINS
1980
Pulmonary fat embolism: a distinct cause of severe acute chest syndrome in sickle cell anemia
1994
beta zero thalassemia in Sardinia is caused by a nonsense mutation.
1981
Molecular analysis of spontaneous somatic mutants
1977 StandoutNatureNobel
Hydroxyurea Therapy for Children With Sickle Cell Anemia in Sub‐Saharan Africa: Rationale and Design of the REACH Trial
2015
Structural investigations of modified haemoglobins by nuclear magnetic resonance spectroscopy
1972 StandoutNobel
Changes in restricted human cellular DNA fragments containing globin gene sequences in thalassemias and related disorders
1978
The Heterogeneity of Normal Hb A2‐β Thalassaemia in Greece
1979
Sparing effect of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S at physiologic ligand saturations.
1993
The silent carrier allele: β thalassemia without a mutation in the β-globin gene or its immediate flanking regions
1984 StandoutNobel
Different 3' end points of deletions causing delta beta-thalassemia and hereditary persistence of fetal hemoglobin: implications for the control of gamma-globin gene expression in man.
1983
Physical mapping of the globin gene deletion in hereditary persistence of foetal haemoglobin (HPFH)
1980
Systematic Review: Hydroxyurea for the Treatment of Adults with Sickle Cell Disease
2008
Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group.
1999
Phosphatidylserine externalization in sickle red blood cells: associations with cell age, density, and hemoglobin F
2003
Nuclear magnetic resonance studies of hemoglobins
1969
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
Sustained long-term hematologic efficacy of hydroxyurea at maximum tolerated dose in children with sickle cell disease
2003
The acute chest syndrome in sickle cell disease: incidence and risk factors. The Cooperative Study of Sickle Cell Disease
1994
Mechanism of action of hydroxyurea.
1992
Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion
2003
Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes
1986 StandoutNatureNobel
Hemoglobin casper: β 106 (G8) Leu→Pro
1973
An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing
1980 StandoutNatureNobel
Unexpected relationships between four large deletions in the human β-globin gene cluster
1983 StandoutNobel
The Interaction of Alpha-Thalassemia and Homozygous Sickle-Cell Disease
1982
Physical mapping of the globin gene deletion in (δβ)° - thalassaemia
1979
Prevention of conversion to abnormal transcranial D oppler with hydroxyurea in sickle cell anemia: A P hase III international randomized clinical trial
2015
Factors affecting prepubertal growth in homozygous sickle cell disease.
1996
A Second Type of Hereditary Persistence of Foetal Haemoglobin in India
1973
Conservation of sequence and structure flanking the mouse and human β-globin loci: The β-globin genes are embedded within an array of odorant receptor genes
1999 StandoutNobel
Cloning Human Fetal γ Globin and Mouse α-Type Globin DNA: Preparation and Screening of Shotgun Collections
1978 StandoutScienceNobel
Recombination and balanced chromosome polymorphism suggested by DNA sequences 5' to the human delta-globin gene.
1983 StandoutNobel
Two routes to functional adaptation: Tibetan and Andean high-altitude natives
2007
Differences in human α- and β-globin gene expression in mouse erythroleukemia cells: The role of intragenic sequences
1984 StandoutNobel
Targeted Therapeutic Strategies for Fetal Hemoglobin Induction
2011
Works of Samuel Charache being referenced
Fetal Hemoglobin, Sickling, and Sickle Cell Disease
1990
'Acute Chest Syndrome' in Adults With Sickle Cell Anemia
1979
Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia
1995 Standout
Cost-effectiveness of hydroxyurea in sickle cell anemia
2000
Fetal Hemoglobin in Sickle Cell Anemia: Determinants of Response to Hydroxyurea
1997
Effect of hydroxyurea on the rheological properties of sickle erythrocytes in vivo
1989
Design of the multicenter study of hydroxyurea in sickle cell anemia
1995
Treatment of Sickle Cell Anemia with Hydroxyurea and Erythropoietin
1990
Hydroxyurea and Sickle Cell Anemia Clinical Utility of a Myelosuppressive “Switching” Agent
1996
Pathogenesis of Hemolytic Anemia in Homozygous Hemoglobin C Disease*
1967
Hemoglobin Richmond. Subunit dissociation and oxygen equilibrium properties.
1975
Hydroxyurea induction of hemoglobin F production in sickle cell disease: relationship between cytotoxicity and F cell production
1986
Infarction of Bone Marrow in the Sickle Cell Disorders
1967
THALASSEMIA IN BLACK AMERICANS*
1974
Hemoglobin Hasharon (α247 his(CD5)β2): a hemoglobin found in low concentration
1969
5-Azacytidine increases HbF production and reduces anemia in sickle cell disease: dose-response analysis of subcutaneous and oral dosage regimens
1985
Nuclear magnetic resonance studies of hemoglobin. IV. The structure-function relationship of human adult hemoglobins a and Chesapeake and its implication to the nature of oxygenation of hemoglobin
1970
Variability of oxygen affinity of blood: human subjects native to high altitude
1981
Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate
1994
Differences in the infrared stretching frequency of carbon monoxide bound to abnormal hemoglobins
1969
The Negro Variety of Hereditary Persistence of Fetal Haemoglobin is a Mild Form of Thalassaemia
1976
Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia [see comments]
1992
Relation between Structure and Function in Hemoglobin Chesapeake*
1967
Rate of Sickling of Red Cells during Deoxygenation of Blood from Persons with Various Sickling Disorders
1964
Hereditary Persistence of Fetal Hemoglobin
1971
Life Span of Carbamylated Red Cells in Sickle Cell Anemia
1973
beta-Thalassemia in American Blacks: novel mutations in the "TATA" box and an acceptor splice site.
1984
Pregnancy in Sickle Cell Disease
1985
Polycythemia associated with a hemoglobinopathy.
1966
EYE DISEASE IN SICKLING DISORDERS
1996
δβ-Thalassemia is due to a gene deletion
1976
Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate
1994
Electron paramagnetic resonance studies of spin-labeled hemoglobins. II. Roles of subunit interactions and of intermediate structures in the cooperative oxygenation of hemoglobin and the results on hemoglobin Yakima, hemoglobin J Capetown, and carboxypeptidases A and B treated hemoglobin A
1970
Hereditary Persistence of Fetal Hemoglobin: A Study of 79 Affected Persons in 15 Negro Families in Baltimore
1963
Nuclear magnetic resonance studies of hemoglobins. VII. Tertiary structure around ligand binding site in carbonmonoxyhemoglobin
1972
Increased blood viscosity in a patient with sickle cell anemia.
1982
Hydroxyurea induction of fetal hemoglobin synthesis in sickle-cell disease.
1992
HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN1
1969
Deletion of the β-globin structure gene in hereditary persistence of foetal haemoglobin
1975 Nature
Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex.
1983
Differences in the reaction sequences associated with drug-induced oxidation of hemoglobins E, S, A, and F.
1983
Individual Variation in the Production and Survival of F Cells in Sickle-Cell Disease
1978
Hydroxyurea-induced augmentation of fetal hemoglobin production in patients with sickle cell anemia
1987
Nuclear magnetic resonance studies of hemoglobins
1971
Nuclear magnetic resonance studies of hemoglobins. V. The heme proton spectra of human deoxyhemoglobins A, F, Zürich, and Chesapeake
1970
Effects of blood transfusion on exercise capacity in patients with sickle-cell anemia
1983
Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia [see comments]
1992
5-Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin.
1985
Social disability and psychiatric morbidity in sickle cell anemia and diabetes patients
1982
Delayed intracranial hemorrhage following cerebral infarction in sickle cell anemia.
1990
Sickle-Cell Anemia: The Known and the Unknown
1972
Who should get HU? … And how?
2002
Experimental therapy of sickle cell disease. Use of hydroxyurea.
1994
Clinical Studies and Physiological Properties of Hopkins-2 Haemoglobin
1971
Clinical Studies and Physiological Properties of Hopkins-2 Haemoglobin
1972
Hydroxyurea as Treatment for Sickle Cell Anemia
1991
Mechanism of action of hydroxyurea in the management of sickle cell anemia in adults.
1997
Management of sickle cell disease in pregnant patients.
1980
The Treatment of Sickle Cell Anemia
1974