Citation Impact
Citing Papers
Recruitment of Mec1 and Ddc1 Checkpoint Proteins to Double-Strand Breaks Through Distinct Mechanisms
2001 Science
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
2003 StandoutNobel
Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint
2003
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
2005 StandoutScienceNobel
Human Mismatch Repair
2005 StandoutNobel
Mechanisms in Eukaryotic Mismatch Repair
2006 StandoutNobel
Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases
1994 StandoutNobel
A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage
1995 StandoutNobel
DNA Ligase IV from HeLa Cell Nuclei
1996 StandoutNobel
Differential Requirement for Proliferating Cell Nuclear Antigen in 5′ and 3′ Nick-directed Excision in Human Mismatch Repair
2004
Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
1995
Claspin, a Chk1-Regulatory Protein, Monitors DNA Replication on Chromatin Independently of RPA, ATR, and Rad17
2003
Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancers
2002
Specific Function of DNA Ligase I in Simian Virus 40 DNA Replication by Human Cell-free Extracts Is Mediated by the Amino-terminal Non-catalytic Domain
1997 StandoutNobel
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
1996 StandoutNatureNobel
Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9‐1‐1 and Rad17‐RFC
2002
The genetic regulation of apoptosis
1995
Strand-specific Mismatch Repair in Mammalian Cells
1997 StandoutNobel
Mechanism Whereby Proliferating Cell Nuclear Antigen Stimulates Flap Endonuclease 1
2000
Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69
1997 StandoutNobel
Replication Fork Bypass of a Pyrimidine Dimer Blocking Leading Strand DNA Synthesis
1997
PCNA binding proteins
1999
DNA polymerase switching: II. Replication factor C abrogates primer synthesis by DNA polymerase α at a critical length
2000
Identification of RFC(Ctf18p, Ctf8p, Dcc1p)
2001
Yeast DNA polymerases and their role at the replication fork
1995
Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1
1997
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase
2003 StandoutNobel
Expression of the HPV E7 Oncoprotein Mimics but Does Not Evoke a p53-Dependent Cellular DNA Damage Response Pathway
1999
Production of active mouse DNA polymerase β in bacteria
1995
Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision—repair
1994
Regulatory Roles of p21 and Apurinic/Apyrimidinic Endonuclease 1 in Base Excision Repair
2001
Cdk inhibitors: on the threshold of checkpoints and development
1994
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.
1995
Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen
1998
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Assembly of Functional Replication Factor C Expressed Using Recombinant Baculoviruses
1997
DNA polymerase ϵ links the DNA replication machinery to the S phase checkpoint
1995
A Novel Mutation Avoidance Mechanism Dependent on S. cerevisiae RAD27 Is Distinct from DNA Mismatch Repair
1997
Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA
1996
The roles of the eukaryotic DNA polymerases in DNA repair synthesis
1997
Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway
1999
Telomerase-Mediated Telomere Addition In Vivo Requires DNA Primase and DNA Polymerases α and δ
1999
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
1995 Nature
Smart machines at the DNA replication fork
1994
Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit
2013 StandoutNatureNobel
Biochemical Characterization of DNA Damage Checkpoint Complexes: Clamp Loader and Clamp Complexes with Specificity for 5′ Recessed DNA
2003
Requirement for PCNA in DNA Mismatch Repair at a Step Preceding DNA Resynthesis
1996
G2 / M checkpoint genes of Saccharomyces cerevisiae : further evidence for roles in DNA replication and / or repair
1997
Radiation-induced cell cycle arrest compromised by p21 deficiency
1995 Nature
Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue
2000 StandoutNobel
Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen
1994 Science
Lagging Strand DNA Synthesis at the Eukaryotic Replication Fork Involves Binding and Stimulation of FEN-1 by Proliferating Cell Nuclear Antigen
1995
The RAD2 Domain of Human Exonuclease 1 Exhibits 5′ to 3′ Exonuclease and Flap Structure-specific Endonuclease Activities
1999
Functional Interactions among the Subunits of Replication Factor C Potentiate and Modulate Its ATPase Activity
1998
Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1
1998
Papillomaviruses and cancer: from basic studies to clinical application
2002 StandoutNobel
Cleavage Specificity of Saccharomyces cerevisiae Flap Endonuclease 1 Suggests a Double-Flap Structure as the Cellular Substrate
2002
Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1
1995 Nature
DNA Polymerase δ Is Required for Human Mismatch Repair in Vitro
1997 StandoutNobel
A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen
1995
Identification and Cloning of Two Histone Fold Motif-containing Subunits of HeLa DNA Polymerase ε
2000
Stimulation of human DNA polymerase epsilon by MDM2
2003
UV Irradiation Triggers Ubiquitin-Dependent Degradation of p21WAF1 to Promote DNA Repair
2003
Biochemical properties and biological effects of p53
1995
Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1)
1997
DNA Polymerase ε Catalytic Domains Are Dispensable for DNA Replication, DNA Repair, and Cell Viability
1999
Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA
1994
Reconstitution of Recombinant Human Replication Factor C (RFC) and Identification of an RFC Subcomplex Possessing DNA-dependent ATPase Activity
1998
Cleavage of Substrates with Mismatched Nucleotides by Flap Endonuclease-1
1999
G1 phase progression: Cycling on cue
1994 Standout
The Cdk and PCNA domains on p21Cip1both function to inhibit G1/S progression during hyperoxia
2004
Reconstitution and Molecular Analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA Damage Responsive Checkpoint Complex
2001
ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
1998
Multiple competition reactions for RPA order the assembly of the DNA polymerase delta holoenzyme
1999
Human cells deficient in p53 regulated p21waf1/cip1 expression exhibit normal nucleotide excision repair of UV-induced DNA damage
2002
Regulatory Functions of the Vascular Endothelium
1990 StandoutNobel
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Switching and Signaling at the Telomere
2001 StandoutNobel
Identification of a Fourth Subunit of Mammalian DNA Polymerase δ
2000
Mechanism of Stimulation of Human DNA Ligase I by the Rad9-Rad1-Hus1 Checkpoint Complex
2006 StandoutNobel
Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21CIP-dependent pathways
2000
Structure of the DNA Repair and Replication Endonuclease and Exonuclease FEN-1
1998
A 39 Amino Acid Fragment of the Cell Cycle Regulator p21 Is Sufficient to Bind PCNA and Partially Inhibit DNA Replication in vivo
1996
p21waf1/cip1-null human fibroblasts are deficient in nucleotide excision repair downstream the recruitment of PCNA to DNA repair sites
2001
A newly identified DNA ligase of Saccharomyces cerevisiaeinvolved in RAD52-independent repair of DNA double-strand breaks
1997 StandoutNobel
Mechanism of Inhibition of Proliferating Cell Nuclear Antigen-Dependent DNA Synthesis by the Cyclin-Dependent Kinase Inhibitor p21
1995
A Conserved Region in the Amino Terminus of DNA Polymerase δ Is Involved in Proliferating Cell Nuclear Antigen Binding
1995
Analysis of the Essential Functions of the C-terminal Protein/Protein Interaction Domain of Saccharomyces cerevisiae pol ε and Its Unexpected Ability to Support Growth in the Absence of the DNA Polymerase Domain
1999
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
The p53-regulated Cyclin-dependent Kinase Inhibitor, p21 (cip1, waf1, sdi1), Is Not Required for Global Genomic and Transcription-coupled Nucleotide Excision Repair of UV-induced DNA Photoproducts
2001
Inhibitors of mammalian G1 cyclin-dependent kinases.
1995 Standout
DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability
1996
Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway
1999
Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
2000
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
1994 Standout
Nucleotide Excision Repair DNA Synthesis by DNA Polymerase .epsilon. in the Presence of PCNA, RFC, and RPA
1995
A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein
1999
Cdk inhibitors in development and cancer
1996
DNA Ligase I and Proliferating Cell Nuclear Antigen Form a Functional Complex
2001
A Defined Human System That Supports Bidirectional Mismatch-Provoked Excision
2004 StandoutNobel
Mammalian DNA nucleotide excision repair reconstituted with purified protein components
1995
Inhibition of Nucleotide Excision Repair by the Cyclin-dependent Kinase Inhibitor p21
1995 StandoutNobel
Local Supercoil-Stabilized DNA Structure
1991
Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity
1999
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
1995 Standout
Excision Repair in Mammalian Cells
1995 StandoutNobel
Molecular mechanism of nucleotide excision repair
1999
Inhibition of Papillomavirus Protein Function in Cervical Cancer Cells by Intrabody Targeting
2005 StandoutNobel
Mechanisms of Human Papillomavirus-Induced Oncogenesis
2004
Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius
1999 Nobel
A Mutational Analysis of the Yeast Proliferating Cell Nuclear Antigen Indicates Distinct Roles in DNA Replication and DNA Repair
1995
Enzymatic completion of mammalian lagging-strand DNA replication.
1994
Saccharomyces cerevisiaeCTF18 and CTF4 Are Required for Sister Chromatid Cohesion
2001
Phosphorylated and unphosphorylated forms of human single-stranded DNA-binding protein are equally active in simian virus 40 DNA replication and in nucleotide excision repair.
1995
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
XRCC1 Protein Interacts with One of Two Distinct Forms of DNA Ligase III
1997 StandoutNobel
Identification of rad27 Mutations That Confer Differential Defects in Mutation Avoidance, Repeat Tract Instability, and Flap Cleavage
2001
CELLULAR DNA REPLICASES: Components and Dynamics at the Replication Fork
2005
Quality Control by DNA Repair
1999 StandoutScienceNobel
Requirement of the Yeast RTH1 5′ to 3′ Exonuclease for the Stability of Simple Repetitive DNA
1995 Science
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
Replication protein A-mediated recruitment and activation of Rad17 complexes
2003
Ataxia-telangiectasia and cellular responses to DNA damage.
1995
Molecular Cloning and Expression of Human cDNAs Encoding a Novel DNA Ligase IV and DNA Ligase III, an Enzyme Active in DNA Repair and Recombination
1995 StandoutNobel
The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27.
1996 StandoutNobel
The Organization of Replication and Transcription
1999 Science
Effect of Flap Modifications on Human FEN1 Cleavage
1999
Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1.
1995
Purification of nuclear proteins that bind to cisplatin-damaged DNA. Identity with high mobility group proteins 1 and 2.
1992
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Eukaryotic DNA Replication Fork
2017
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.
1995
Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen
1999
Destabilization of Yeast Micro- and Minisatellite DNA Sequences by Mutations Affecting a Nuclease Involved in Okazaki Fragment Processing (rad27) and DNA Polymerase δ (pol3-t)
1998
A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells.
1996
Eukaryotic DNA Polymerases
2002
The C-terminal Domain of p21 Inhibits Nucleotide Excision Repair In Vitro and In Vivo
1999
DNA polymerase epsilon may be dispensable for SV40- but not cellular-DNA replication.
1996
DNA Polymerases Required for Repair of UV-Induced Damage in Saccharomyces cerevisiae
1995
Growth factor modulation of p53-mediated growth arrest versus apoptosis.
1995
Mutations in RAD27 Define a Potential Link between G1 Cyclins and DNA Replication
1995
The N-terminal domain of human DNA ligase I contains the nuclear localization signal and directs the enzyme to sites of DNA replication.
1995
Schizosaccharomyces pombe cdc 20 + encodes DNA polymerase ɛ and is required for chromosomal replication but not for the S phase checkpoint
1997 StandoutNobel
Inhibition of cyclin-dependent kinases by p21.
1995
Interaction of the β sliding clamp with MutS, ligase, and DNA polymerase I
2001
Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin.
1992
Hepatitis C Virus IRES RNA-Induced Changes in the Conformation of the 40 S Ribosomal Subunit
2001 StandoutScienceNobel
Saccharomyces cerevisiae pol30 (Proliferating Cell Nuclear Antigen) Mutations Impair Replication Fidelity and Mismatch Repair
1999
Growth suppression by p16ink4 requires functional retinoblastoma protein.
1995
Flap Endonuclease 1: A Central Component of DNA Metabolism
2004
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
1995
Molecular interactions of human Exo1 with DNA
2002
p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex.
1996
Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I.
1994 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
2004 StandoutNobel
DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast
1995 StandoutNobel
Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16ink4
1995
Mammalian DNA Ligase III: Molecular Cloning, Chromosomal Localization, and Expression in Spermatocytes Undergoing Meiotic Recombination
1995
DNA Ligase I Mediates Essential Functions in Mammalian Cells
1995
Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene
1995
Biochemistry and genetics of eukaryotic mismatch repair.
1996
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4
1998 StandoutNobel
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Reconstitution of Human DNA Polymerase δ Using Recombinant Baculoviruses
2002
Works of S Waga being referenced
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
1994 Nature
Primary structure of non-histone protein HMG1 revealed by the nucleotide sequence
1988
Nonhistone proteins HMG1 and HMG2 suppress the nucleosome assembly at physiological ionic strength
1989
Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro
1994 Nature
Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein
1997
Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
1994 Nature
Distinct roles of DNA polymerases delta and epsilon at the replication fork inXenopusegg extracts
2004
Nonhistone protein HMG1 removes the transcriptional block caused by left-handed Z-form segment in a supercoiled DNA
1988
DNA polymerase ɛ is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts
2001
THE DNA REPLICATION FORK IN EUKARYOTIC CELLS
1998
Endothelium-dependent relaxation of canine basilar arteries. Part 2: Inhibition by hemoglobin and cerebrospinal fluid from patients with aneurysmal subarachnoid hemorrhage.
1987
Reconstitution of complete SV40 DNA replication with purified replication factors.
1994
Chromosomal protein HMG1 removes the transcriptional block caused by the cruciform in supercoiled DNA.
1990
Cyclin-Dependent Kinase Inhibitor p21 Modulates the DNA Primer-Template Recognition Complex
1998