Citation Impact
Citing Papers
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
Selective Activation of MEK1 but Not MEK2 by A-Raf from Epidermal Growth Factor-stimulated Hela Cells
1996
Activation of Store-Operated Ca2+ Current in Xenopus Oocytes Requires SNAP-25 but Not a Diffusible Messenger
1999 StandoutNobel
From molecular to modular cell biology
1999 StandoutNatureNobel
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Proteins regulating Ras and its relatives
1993 StandoutNature
Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein
1997
Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95
1995 StandoutScience
A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements
1997
FAR1 links the signal transduction pathway to the cell cycle machinery in yeast
1993
Characterization of Pak2p, a Pleckstrin Homology Domain-containing, p21-activated Protein Kinase from Fission Yeast
1998
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Sex, stress and integrity: the importance of MAP kinases in yeast
1994
The complexity of Raf-1 regulation
1997
A Role for Shc, Grb2, and Raf-1 in FcγRI Signal Relay
1996
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
1995 Standout
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
1994
Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery
1999
Intrinsic disorder in scaffold proteins: Getting more from less
2008
Post-translational Modification of H-Ras Is Required for Activation of, but Not for Association with, B-Raf
1996
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
1996 StandoutNatureNobel
Endomembrane Trafficking of Ras
1999
Heterochronic Genes Control Cell Cycle Progress and Developmental Competence of C. elegans Vulva Precursor Cells
1996 StandoutNobel
Molecular Characterization of Ste20p, a Potential Mitogen-activated Protein or Extracellular Signal-regulated Kinase Kinase (MEK) Kinase Kinase from Saccharomyces cerevisiae
1995
Conservation and reiteration of a kinase cascade
1993
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
1994 Nature
Interactions between Ras proteins and their effectors
1996
Purification of a Ras-dependent Mitogen-activated Protein Kinase Kinase Kinase from Bovine Brain Cytosol and Its Identification as a Complex of B-Raf and 14-3-3 Proteins
1995
The Hallmarks of Cancer
2000 Standout
Ras-dependent growth factor regulation of MEK kinase in PC12 cells
1994 Science
Courtship in S. cerevisiae: Both cell types choose mating partners by responding to the strongest pheromone signal
1990 StandoutNobel
Mating in Saccharomyces cerevisiae: The Role of the Pheromone Signal Transduction Pathway in the Chemotropic Response to Pheromone
1997 StandoutNobel
Two Distinct Raf Domains Mediate Interaction with Ras
1995
Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity
1995
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine
1995 Standout
How MAP Kinases Are Regulated
1995 Standout
A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade
1997 Nature
Phosphatidylinositol-3-OH kinase direct target of Ras
1994 StandoutNature
NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain
1997
Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization
1996
Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells
1999
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Spm1, a stress-activated MAP kinase that regulates morphogenesis in S.pombe
1997
Rho GTPases and signaling networks
1997 Standout
Regulation of Phosphorylation Pathways by p21 GTPases
1996
Direct Interaction between Ras and the Kinase Domain of Mitogen-activated Protein Kinase Kinase Kinase (MEKK1)
1995
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Regulation of LNS Domain Function by Alternative Splicing: The Structure of the Ligand-Binding Domain of Neurexin Iβ
1999 StandoutNobel
Activation of Raf-1 by 14-3-3 proteins
1994 Nature
The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue
1995 Nature
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
1998
A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases
1995
Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo
1996
The MEK Kinase Activity of the Catalytic Domain of RAF-1 Is Regulated Independently of Ras Binding in T Cells
1995
EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor
1994
The Rac and Rho pathways as a source of drug targets for Ras-mediated malignancies
1995
A conserved kinase cascade for MAP kinase activation in yeast
1993
Cooperative interaction of S. pombe proteins required for mating and morphogenesis
1994
PROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONS
1992
MAP kinase pathways in yeast: For mating and more
1995
Rhotekin, a New Putative Target for Rho Bearing Homology to a Serine/Threonine Kinase, PKN, and Rhophilin in the Rho-binding Domain
1996
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
1997
The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
1998 StandoutNatureNobel
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
A Tripartite Protein Complex with the Potential to Couple Synaptic Vesicle Exocytosis to Cell Adhesion in Brain
1998 StandoutNobel
Signal transduction by MAP kinase cascades in budding yeast
1998
Mis-specification of cortical identity in a fission yeast PAK mutant
1999 StandoutNobel
MAP Kinases with Distinct Inhibitory Functions Impart Signaling Specificity during Yeast Differentiation
1997
An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites
1995 StandoutNobel
Cohesin Rec8 is required for reductional chromosome segregation at meiosis
1999 StandoutNatureNobel
The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously
1995 StandoutNobel
Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes
1998
Ras Interaction with Two Distinct Binding Domains in Raf-1 5 Be Required for Ras Transformation
1996
CNK, a RAF-Binding Multidomain Protein Required for RAS Signaling
1998
Isolation of MEK5 and Differential Expression of Alternatively Spliced Forms
1995
CLIP170-like tip1p Spatially Organizes Microtubular Dynamics in Fission Yeast
2000 StandoutNobel
Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3
1996
Multiple ras functions can contribute to mammalian cell transformation
1995
Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade
1996
Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ
1996 StandoutNobel
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
1994 Nature
The MAP Kinase Cascade
1995 Nobel
Binding of 14-3-3 Proteins to the Protein Kinase Raf and Effects on Its Activation
1994 Science
Signaling in the Yeast Pheromone Response Pathway: Specific and High-Affinity Interaction of the Mitogen-Activated Protein (MAP) Kinases Kss1 and Fus3 with the Upstream MAP Kinase Kinase Ste7
1996
Reconstitution of a yeast protein kinase cascade in vitro: activation of the yeast MEK homologue STE7 by STE11.
1994
Identification of fuz7, a Ustilago maydis MEK/MAPKK homolog required for a-locus-dependent and -independent steps in the fungal life cycle.
1994
MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase.
1995
AKR1Encodes a Candidate Effector of the Gβγ Complex in theSaccharomyces cerevisiaePheromone Response Pathway and Contributes to Control of both Cell Shape and Signal Transduction
1996 StandoutNobel
Pheromone Response in Yeast: Association of Bem1p with Proteins of the MAP Kinase Cascade and Actin
1995 Science
Small GTP-Binding Proteins
2001 Standout
Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast.
1996
The Fission Yeast pmk1+ Gene Encodes a Novel Mitogen-Activated Protein Kinase Homolog Which Regulates Cell Integrity and Functions Coordinately with the Protein Kinase C Pathway
1996
The Ras GTPase-Activating-Protein-Related Human Protein IQGAP2 Harbors a Potential Actin Binding Domain and Interacts with Calmodulin and Rho Family GTPases
1996
14-3-3: Modulators of Signaling Proteins?
1994 Science
Cooperating oncogenes converge to regulate cyclin/cdk complexes.
1997
The role of p21ras in receptor tyrosine kinase signaling
1995
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
Osmotic Activation of the HOG MAPK Pathway via Ste11p MAPKKK: Scaffold Role of Pbs2p MAPKK
1997 Science
Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2
1995 Science
NPK1, a tobacco gene that encodes a protein with a domain homologous to yeast BCK1, STE11, and Byr2 protein kinases.
1993
The posttranslational processing of ras p21 is critical for its stimulation of yeast adenylate cyclase.
1992
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
FAR1 is required for oriented polarization of yeast cells in response to mating pheromones.
1995
Ras2 signals via the Cdc42/Ste20/mitogen-activated protein kinase module to induce filamentous growth in Saccharomyces cerevisiae.
1996
Mesoderm induction by activin requires FGF-mediated intracellular signals
1994
lin-25, a gene required for vulval induction in Caenorhabditis elegans.
1995
Functional Characterization of theMKC1Gene ofCandida albicans, Which Encodes a Mitogen-Activated Protein Kinase Homolog Related to Cell Integrity
1995
Stimulatory Effects of Yeast and Mammalian 14-3-3 Proteins on the Raf Protein Kinase
1994 Science
Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth.
1994
RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.
1994
HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.
1996
Signaling Through Scaffold, Anchoring, and Adaptor Proteins
1997 StandoutScience
RAC Regulation of Actin Polymerization and Proliferation by a Pathway Distinct from Jun Kinase
1996 Science
cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.
1994
Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.
1994
Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways Is Sufficient To Cause Tumorigenic Transformation
1996
Tea2p Is a Kinesin-like Protein Required to Generate Polarized Growth in Fission Yeast
2000 StandoutNobel
Identification and Functional Analysis of a Developmentally Regulated Extracellular Signal-Regulated Kinase Gene in Dictyostelium discoideum
1994
Identification of a Protein with Homology to hsp90 That Binds the Type 1 Tumor Necrosis Factor Receptor
1995
FAR1 links the signal transduction pathway to the cell cycle machinery in yeast
1993
Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating.
1995
Dynamic Localization of Fus3 Mitogen-Activated Protein Kinase Is Necessary To Evoke Appropriate Responses and Avoid Cytotoxic Effects
2010
Arabidopsis Ethylene-Response Gene ETR1 : Similarity of Product to Two-Component Regulators
1993 StandoutScience
AGα1 Is the Structural Gene for the Saccharomyces cerevisiae α-Agglutinin, a Cell Surface Glycoprotein Involved in Cell-Cell Interactions during Mating
1989
14-3-3 proteins associate with cdc25 phosphatases.
1995
Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation.
1993
Targeting the Receptor-G q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy
1998 StandoutScienceNobel
Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients.
1995 StandoutNobel
Association of the Yeast Pheromone Response G Protein βγ Subunits with the Map Kinase Scaffold Ste5p
1995 Science
Binding of Neuroligins to PSD-95
1997 StandoutScienceNobel
Elements of the Yeast Pheromone Response Pathway Required for Filamentous Growth of Diploids
1993 Science
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Partial purification of a mitogen-activated protein kinase kinase activator from bovine brain. Identification as B-Raf or a B-Raf-associated activity.
1994
A Human Protein Selected for Interference with Ras Function Interacts Directly with Ras and Competes with Raf1
1995
The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog
1996
Rewiring MAP Kinase Pathways Using Alternative Scaffold Assembly Mechanisms
2003 Science
Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes
1997
A human oncogene of the RAS superfamily unmasked by expression cDNA cloning.
1994
The proliferation of MAP kinase signaling pathways in yeast
1995
ralGDS family members interact with the effector loop of ras p21.
1994
Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts
1993
Ste5 RING-H2 Domain: Role in Ste4-Promoted Oligomerization for Yeast Pheromone Signaling
1997 Science
Uncoupling of Membrane Ruffling and Pinocytosis during Ras Signal Transduction
1997
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
1999 Standout
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
2001 StandoutNobel
Inhibition by cAMP of Ras-Dependent Activation of Raf
1993 Science
A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function.
1994
Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes.
1994
Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.
1994
Fission yeast orb 6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle
1998 StandoutNobel
Enzymatic characteristics of the c-Raf-1 proteinkinase.
1994
A Drosophila Homolog of the Rac- and Cdc42-Activated Serine/Threonine Kinase PAK Is a Potential Focal Adhesion and Focal Complex Protein That Colocalizes with Dynamic Actin Structures
1996
The pathway to signal achievement
1993 Nature
14-3-3 Is Not Essential for Raf-1 Function: Identification of Raf-1 Proteins That Are Biologically Activated in a 14-3-3- and Ras-Independent Manner
1995
Mitogen-Activated and Cyclin-Dependent Protein Kinases Selectively and Differentially Modulate Transcriptional Enhancement by the Glucocorticoid Receptor
1997
Activation of Raf as a Result of Recruitment to the Plasma Membrane
1994 Science
The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5.
1994
Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1.
1993
Pheromone Signalling in Saccharomyces cerevisiae Requires the Small GTP-Binding Protein Cdc42p and Its Activator CDC24
1995
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.
1996
Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain.
1996
Rho 1 GTPase activates the (1-3)beta-D-glucan synthase and is involved in Schizosaccharomyces pombe morphogenesis.
1996
Identification of a novel Rac1-interacting protein involved in membrane ruffling.
1996
Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction
1996
Actions of Rho Family Small G Proteins and p21-Activated Protein Kinases on Mitogen-Activated Protein Kinase Family Members
1996
Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.
1994
A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.
1994 StandoutNobel
The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras.
1994
Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae.
1995
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
1994
Rho3 ofSaccharomyces cerevisiae, Which Regulates the Actin Cytoskeleton and Exocytosis, Is a GTPase Which Interacts with Myo2 and Exo70
1999
Regulation of Cell Polarity by Microtubules in Fission Yeast
1998 StandoutNobel
Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins
1998
TC21 Causes Transformation by Raf-Independent Signaling Pathways
1996
Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.
1994
Insulin Stimulation of a MEK-Dependent but ERK-Independent SOS Protein Kinase
1996
De novo design of protein logic gates
2020 StandoutScienceNobel
Works of S Marcus being referenced
Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe.
1994
Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module.
1994
Significance of C-terminal cysteine modifications to the biological activity of the Saccharomyces cerevisiae a-factor mating pheromone.
1991
Towards determination of the structure of the Saccharomyces cerevisiae a-factor: an acylated pentadecapeptide blocks a-factor activity.
1987
Complex formation between RAS and RAF and other protein kinases.
1993
Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms.
1993
Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe.
1995