Standout Papers
Citation Impact
Citing Papers
The Molecular Genetics of Human Hemoglobin
1984
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
X-Ray Crystal Structure of Proto-Oncogene Product c-Rel Bound to the CD28 Response Element of IL-2
2001
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation
1990
Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli
1989 StandoutNatureNobel
The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
1990 Standout
Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure
2001
Expression of a single transfected cDNA converts fibroblasts to myoblasts
1987 Standout
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation
1990 StandoutNatureNobel
NF-κB: Ten Years After
1996 StandoutNobel
Missing Pieces in the NF-κB Puzzle
2002 Standout
The Phosphorylation Status of Nuclear NF-ΚB Determines Its Association with CBP/p300 or HDAC-1
2002
Unresponsiveness of MyD88-Deficient Mice to Endotoxin
1999 Standout
SNAP receptors implicated in vesicle targeting and fusion
1993 StandoutNatureNobel
PAS is a dimerization domain common to Drosophila Period and several transcription factors
1993 StandoutNatureNobel
Failure of Lymphopoiesis after Adoptive Transfer of NF-κB–Deficient Fetal Liver Cells
1997 Nobel
Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.
1995 Standout
The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene
1989
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
2001 StandoutNatureNobel
COPII–cargo interactions direct protein sorting into ER-derived transport vesicles
1998 StandoutNatureNobel
A light-entrainment mechanism for the Drosophila circadian clock
1996 StandoutNatureNobel
High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro
1993
SPXX, a frequent sequence motif in gene regulatory proteins
1989
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
DNA sequences at immunoglobulin switch region recombination sites
1993
The binding site for C1q on IgG
1988 StandoutNatureNobel
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb
1989 StandoutNobel
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
1988 StandoutNatureNobel
Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice
1999
The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression
2000
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50
1991
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Differential expression of two Xenopus c-myc proto-oncogenes during development.
1989
Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture
1998
Costimulation via Glucocorticoid-Induced TNF Receptor in Both Conventional and CD25+ Regulatory CD4+ T Cells
2004 StandoutNobel
Characterization of immunoglobulin enhancer deletions in murine plasmacytomas.
1985
Translocations Among Antibody Genes in Human Cancer
1983 Science
Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks
1986 Nature
The long and the short of long–term memory—a molecular framework
1986 StandoutNatureNobel
Distinct activities of p52/NF-kappa B required for proper secondary lymphoid organ microarchitecture: functions enhanced by Bcl-3.
1999
Regulation of the human c-myc gene: 5' noncoding sequences do not affect translation.
1985
Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation.
1984
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
1998 StandoutScienceNobel
Mechanisms of nonhomologous recombination in mammalian cells.
1985
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
RAV-1 insertional mutagenesis: disruption of the c-myb locus and development of avian B-cell lymphomas
1989
Altering the Genome by Homologous Recombination
1989 StandoutScienceNobel
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.
1985 StandoutNobel
Transcriptionally active c- myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia
1983
Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals
1984
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
1985 Nature
Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes
1985 Nature
THE MOLECULAR GENETICS OF CELLULAR ONCOGENES
1984
Rapid induction of B-cell lymphomas: insertional activation of c-myb by avian leukosis virus
1988
Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase Complex
2000
Recombinant antibodies possessing novel effector functions
1984 Nature
Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.
1986
Generation of long mRNA for membrane immunoglobulin γ2a chains by differential splicing
1981 Nature
CREB-binding protein/p300 are transcriptional coactivators of p65
1997
Activation of the c-myc gene by translocation: a model for translational control.
1983 StandoutNobel
Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster.
1989
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification
1983 StandoutNatureNobel
Organization and evolution of immunoglobulin VH gene subgroups.
1982
Diversity of murine gamma genes and expression in fetal and adult T lymphocytes
1986 StandoutNatureNobel
Structural and functional domains of the myb oncogene: requirements for nuclear transport, myeloid transformation, and colony formation
1988
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch.
1989
Activation of transcription by v-myb: evidence for two different mechanisms.
1989
Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains.
1982 StandoutNobel
Mouse c-myc Oncogene Is Located on Chromosome 15 and Translocated to Chromosome 12 in Plasmacytomas
1982 Science
Aberrant c-myc RNAs of Burkitt's lymphoma cells have longer half-lives.
1985
Conservation of the c-myc coding sequence in transduced feline v-myc genes
1986
A ChineseGγ+(Aγδβ)0thalassemia deletion: comparison to other deletions in the human β-globin gene cluster and sequence analysis of the breakpoints
1985 StandoutNobel
A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells
1983 StandoutNatureNobel
Structure, organization, and somatic rearrangement of T cell gamma genes
1985
Molecular Mechanisms Underlying Differential Contribution of CD28 Versus Non-CD28 Costimulatory Molecules to IL-2 Promoter Activation
2002
Evolution of tumours and the impact of molecular oncology
1985 Nature
Mutations, Duplication, and Deletion of Recombined Switch Regions Suggest a Role for DNA Replication in the Immunoglobulin Heavy-Chain Switch
1989
Frequency of expressed immunoglobulin light chain genes in lipopolysaccharide-stimulated BALB/c spleen cells.
1984 StandoutNobel
Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase
1999 Science
On immunoglobulin heavy chain gene switching: two γ2b genes are rearranged via switch sequences in MPC-11 cells but only one is expressed
1982
c-myc gene is transcribed at high rate in G0-arrested fibroblasts and is post-transcriptionally regulated in response to growth factors
1985 Nature
Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors
1985
Structure and expression of the murine N-myc gene.
1986
mdm2 expression is induced by wild type p53 activity.
1993
Functional Redundancy of the Nuclear Factor κB Inhibitors IκBα and IκBβ
1998
Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter
1986 StandoutNatureNobel
Distinct Activities of p52/NF-κB Required for Proper Secondary Lymphoid Organ Microarchitecture: Functions Enhanced by Bcl-3
1999
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
1998 Standout
Activation and somatic mutation of the translocated c-myc gene in Burkitt lymphoma cells
1984
Activation of a translocated c-myc gene: role of structural alterations in the upstream region.
1984 StandoutNobel
A second c-myb protein is translated from an alternatively spliced mRNA expressed from normal and 5'-disrupted myb loci.
1989
Viruses in Human Cancers
1991 StandoutScienceNobel
Human N-myc is closely related in organization and nucleotide sequence to c-myc
1986 Nature
Isolation and characterization of s-myc, a member of the rat myc gene family.
1989
Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment
2001 Nobel
Increased expression of myc-related oncogene mRNA characterizes most BALB/c plasmacytomas induced by pristane or Abelson murine leukemia virus.
1983
Truncation of exon 1 from the c-myc gene results in prolonged c-myc mRNa stability.
1985
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Drosophila and vertebrate myb proteins share two conserved regions, one of which functions as a DNA-binding domain.
1987
Structure and expression of the murine L-myc gene.
1987
Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development
1986
Gastric Hyperplasia and Increased Proliferative Responses of Lymphocytes in Mice Lacking the COOH-terminal Ankyrin Domain of NF-κB2
1997
Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes
1984
B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo
1985 StandoutScienceNobel
Translocation joins c-myc and immunoglobulin γ1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogene
1983 Nature
The nucleotide sequence of the mouse immunoglobulin epsilon gene: comparison with the human epsilon gene sequence.
1982 StandoutNobel
Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene.
1989
Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response
1997
Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas.
1983
Mr 26,000 antigen of Schistosoma japonicum recognized by resistant WEHI 129/J mice is a parasite glutathione S-transferase.
1986
Translocation and Rearrangements of the c- myc Oncogene Locus in Human Undifferentiated B-Cell Lymphomas
1983 Science
Replacing the complementarity-determining regions in a human antibody with those from a mouse
1986 StandoutNatureNobel
Generation of altered transcripts by retroviral insertion within the c-myb gene in two murine monocytic leukemias
1987
Cell-type-specific contacts to immunoglobulin enhancers in nuclei
1985 StandoutNatureNobel
Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product
1985 StandoutNobel
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
1996 Standout
A conserved sequence at c-myc oncogene chromosomal translocation breakpoints in plasmacytomas
1984 Nature
The human myc gene family: structure and activity of L-myc and an L-myc pseudogene.
1987
Iκb Kinase α Is Essential for Mature B Cell Development and Function
2001
Suppression of the malignant phenotype in somatic cell hybrids between Burkitt's lymphoma cells and Epstein-Barr virus-immortalized lymphoblastoid cells despite deregulated c-myc expression.
1990
Characterization of rat c-mycand adjacent regions
1987
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes
1983
Molecular cloning of cDNA encoding human interleukin-2 receptor
1984 StandoutNatureNobel
The protein encoded by the human proto-oncogene c-myc.
1984 StandoutNobel
Activation of the c-myc oncogene by the immunoglobulin heavy-chain gene enhancer after multiple switch region-mediated chromosome rearrangements in a murine plasmacytoma.
1985
Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas
1983 Nature
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture
1985 StandoutNatureNobel
The complete murine immunoglobulin class switch region of the alpha heavy chain gene-hierarchic repetitive structure and recombination breakpoints.
1993 StandoutNobel
Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses
1998
Works of S Gerondakis being referenced
Regulation of an essential innate immune response by the p50 subunit of NF-kappaB.
1998
Structure of the protein encoded by the chicken proto-oncogene c-myb.
1986 StandoutNobel
Organization and Expression of Murine Immunoglobulin Genes
1981
Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activities.
1994
The murine c-rel proto-oncogene encodes two mRNAs the expression of which is modulated by lymphoid stimuli.
1990
Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.
1983
Translocation of the myc cellular oncogene to the immunoglobulin heavy chain locus in murine plasmacytomas is an imprecise reciprocal exchange
1984
Interchromosomal recombination of the cellular oncogene c-myc with the immunoglobulin heavy chain locus in murine plasmacytomas is a reciprocal exchange.
1983
Activation of immunoglobulin mu gene expression involves stepwise demethylation.
1984
Structure of a mammalian c-rel protein deduced from the nucleotide sequence of murine cDNA clones.
1989
Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors.
1982
Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.
1996
Cloned embryonic DNA sequences flanking the mouse immunoglobulin Cγ3and Cγ1genes
1980
mRNA for surface immunoglobulin gamma chains encodes a highly conserved transmembrane sequence and a 28-residue intracellular domain.
1982
Structure of the Protein Encoded by the Chicken Proto-Oncogene c-myb
1986 StandoutNobel
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.
1995