Citation Impact
Citing Papers
Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
2004 StandoutScience
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae
2000 StandoutScience
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
2004 StandoutScience
Regulation of Corepressor Function by Nuclear NADH
2002 Science
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines.
2003
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs
2007
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1
2002
The Sirtuins Hst3 and Hst4p Preserve Genome Integrity by Controlling Histone H3 Lysine 56 Deacetylation
2006
Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State
2003
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Chromatin Modifications and Their Function
2007 Standout
The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells
2001
The Sir2 family of protein deacetylases
2005
The genetics of ageing
2010 StandoutNature
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis
2006
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes
2017
HDAC6 is a microtubule-associated deacetylase
2002 StandoutNature
BRAFE600-associated senescence-like cell cycle arrest of human naevi
2005 StandoutNature
Genome-wide patterns of histone modifications in yeast
2006
Calorie restriction effects on silencing and recombination at the yeast rDNA
2009
Phylogenetic Classification of Prokaryotic and Eukaryotic Sir2-like Proteins
2000
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Conserved Metabolic Regulatory Functions of Sirtuins
2008
Regulation of bacterial priming and daughter strand synthesis through helicase-primase interactions
2006
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
2002 StandoutNature
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
2002 StandoutNature
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
2017 StandoutNature
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
2002
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
2003 Nature
Mitochondrial longevity pathways
2010
dSIR2 and dHDAC6: Two Novel, Inhibitor-Resistant Deacetylases in Drosophila melanogaster
2001
Nampt/PBEF/Visfatin: A regulator of mammalian health and longevity?
2006
TRP channels as cellular sensors
2003 StandoutNature
Autophagy in the Pathogenesis of Disease
2008 Standout
Histone deacetylases and cancer: causes and therapies
2001 Standout
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
2001 StandoutNature
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
SirT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
2007
A Role for SIR-2.1 Regulation of ER Stress Response Genes in Determining C. elegans Life Span
2005
25 years after the nucleosome model: chromatin modifications
2000
Identification of Selective Inhibitors of NAD+-dependent Deacetylases Using Phenotypic Screens in Yeast
2003
Sir2 and calorie restriction in yeast: A skeptical perspective
2007
Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
2007
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
2004 StandoutNature
Genetic pathways that regulate ageing in model organisms
2000 Nature
Analysis of O-Acetyl-ADP-ribose as a Target for Nudix ADP-ribose Hydrolases
2002
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Telomeric chromatin: replicating and wrapping up chromosome ends
2001
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
2005 StandoutNature
Calorie restriction extends yeast life span by lowering the level of NADH
2004
The Hallmarks of Aging
2013 Standout
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
2005 StandoutNature
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
2002 Nature
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
2004 StandoutNature
Topological domains in mammalian genomes identified by analysis of chromatin interactions
2012 StandoutNature
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
2003 StandoutNature
Coordination of circadian timing in mammals
2002 StandoutNature
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
2003 StandoutNature
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
2001 Standout
SIRT1 Regulates HIV Transcription via Tat Deacetylation
2005
SIR2 and aging – the exception that proves the rule
2001
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
2001 Standout
In vivo base editing of post-mitotic sensory cells
2018
RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae
2001
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
Mammalian SIRT1 Represses Forkhead Transcription Factors
2004
RecBCD Enzyme and the Repair of Double-Stranded DNA Breaks
2008
High Osmolarity Extends Life Span in Saccharomyces cerevisiae by a Mechanism Related to Calorie Restriction
2002
Mechanisms for Initiating Cellular DNA Replication
2013
The Biochemistry of Sirtuins
2006
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
2012
Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease
2003
Deracemization of α-Aryl Hydrocoumarins via Catalytic Asymmetric Protonation of Ketene Dithioacetals
2012 StandoutNobel
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
2002 StandoutNobel
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems
2016 StandoutScience
Eukaryotic DNA Replication Fork
2017
The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis
2002
Broken Limits to Life Expectancy
2002 StandoutScience
Circadian Control of the NAD + Salvage Pathway by CLOCK-SIRT1
2009 Science
Genetics and the Specificity of the Aging Process
2003 Science
Identification of a small molecule inhibitor of Sir2p
2001
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Structure of Hexameric DnaB Helicase and Its Complex with a Domain of DnaG Primase
2007 StandoutScienceNobel
Ubp10/Dot4p Regulates the Persistence of Ubiquitinated Histone H2B: Distinct Roles in Telomeric Silencing and General Chromatin
2005
Extending Healthy Life Span—From Yeast to Humans
2010 StandoutScience
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Structural analysis of the RSC chromatin-remodeling complex
2002 StandoutNobel
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
2006 StandoutScience
Works of Ryan C. Heller being referenced
Mec1 Is One of Multiple Kinases that Prime the Mcm2-7 Helicase for Phosphorylation by Cdc7
2010
Replication fork reactivation downstream of a blocked nascent leading strand
2006 Nature
Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases
2011
Replisome assembly and the direct restart of stalled replication forks
2006
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
2000
A Novel Form of Transcriptional Silencing by Sum1-1 Requires Hst1 and the Origin Recognition Complex
2001