Citation Impact
Citing Papers
Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination
2006
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
2013 StandoutScience
High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability
2011
PIK3CA Mutation H1047R Is Associated with Response to PI3K/AKT/mTOR Signaling Pathway Inhibitors in Early-Phase Clinical Trials
2012
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
2016 StandoutScience
Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling
2011
A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition
2013
mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling
2011
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
The Allelic Context of the C797S Mutation Acquired upon Treatment with Third-Generation EGFR Inhibitors Impacts Sensitivity to Subsequent Treatment Strategies
2015
Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents
2012
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis
2023
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
2011
Hallmarks of Cancer: The Next Generation
2011 Standout
Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors
2011
MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens
2014 Standout
Shifting paradigms in Hedgehog signaling
2007
mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging
2009
Hedgehog: functions and mechanisms
2008 Standout
The mechanisms of Hedgehog signalling and its roles in development and disease
2013 Standout
mTOR Signaling in Growth Control and Disease
2012 Standout
A view on drug resistance in cancer
2019 StandoutNature
Structural basis of the Axin–adenomatous polyposis coli interaction
2000
Analysis of the genome to personalize therapy for melanoma
2010
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Tumor adaptation and resistance to RAF inhibitors
2013
Genetically engineered mouse models of pancreatic adenocarcinoma
2013
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Boc and Gas1 Each Form Distinct Shh Receptor Complexes with Ptch1 and Are Required for Shh-Mediated Cell Proliferation
2011
The biology and management of non-small cell lung cancer
2018 StandoutNature
Oxysterols are allosteric activators of the oncoprotein Smoothened
2012
Therapeutic Strategies for Targeting Ras Proteins
2011
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
2015 StandoutNature
BRAF Mutations in Colorectal Cancer: Clinical Relevance and Role in Targeted Therapy
2012
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened
2011
Wnt proteins are lipid-modified and can act as stem cell growth factors
2003 StandoutNature
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling
2010
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
2012 Nature
The single-cell transcriptional landscape of mammalian organogenesis
2019 StandoutNature
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Integrated genomic characterization of endometrial carcinoma
2013 StandoutNature
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
2012
Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells
2012
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
2013 Standout
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
C. elegans patched-3 is an essential gene implicated in osmoregulation and requiring an intact permease transporter domain
2011
Emerging Role of mTOR in the Response to Cancer Therapeutics
2016
Gli and hedgehog in cancer: tumours, embryos and stem cells
2002
Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study
2017 Standout
Antipsychotic Drugs Regulate Hedgehog Signaling by Modulation of 7-Dehydrocholesterol Reductase Levels
2010
PI3K and MEK inhibitor combinations: examining the evidence in selected tumor types
2013
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations
2010
A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia
2012
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Hedgehog beyond medulloblastoma and basal cell carcinoma
2010
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
2010
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Overexpression of Orphan G–Protein-Coupled Receptor, Gpr49 , in Human Hepatocellular Carcinomas With β–Catenin Mutations
2003
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
2015 StandoutNature
Oxysterols Are Novel Activators of the Hedgehog Signaling Pathway in Pluripotent Mesenchymal Cells
2007
Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells
2013
Clonal evolution in cancer
2012 StandoutNature
Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas
2012
The Hallmarks of Aging
2013 Standout
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
2008
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
2012 Nature
Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium
2009
Use of mutation profiles to refine the classification of endometrial carcinomas
2012
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
2014 Standout
The PI3K Pathway in Human Disease
2017 Standout
Metastatic colonization by circulating tumour cells
2016 StandoutNature
BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition
2015
SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer
2014
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Hedgehog Signaling in Development and Cancer
2008 Standout
Identification of stem cells in small intestine and colon by marker gene Lgr5
2007 StandoutNature
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Feedback and redundancy in receptor tyrosine kinase signaling: relevance to cancer therapies
2014
Heterogeneous expression of Wnt/β‐catenin target genes within colorectal cancer
2007
Secretion and Signaling Activities of Lipoprotein-Associated Hedgehog and Non-Sterol-Modified Hedgehog in Flies and Mammals
2013
Cancer genomics: from discovery science to personalized medicine
2011
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
2004 StandoutScience
Quantifying Transient 3D Dynamical Phenomena of Single mRNA Particles in Live Yeast Cell Measurements
2013 StandoutNobel
Inhibition of class IA PI3K enzymes in non-small cell lung cancer cells uncovers functional compensation among isoforms
2015
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Kinetics of Hedgehog-Dependent Full-Length Gli3 Accumulation in Primary Cilia and Subsequent Degradation
2010
Patched regulates Smoothened trafficking using lipoprotein-derived lipids
2009
Improving Prospects for Targeting RAS
2015
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
2009
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes
2010
Patched1 Regulates Hedgehog Signaling at the Primary Cilium
2007 StandoutScience
PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context
2014
Wnt signaling and cancer
2000 Standout
Organogenesis in a dish: Modeling development and disease using organoid technologies
2014 StandoutScience
Pushing the Envelope in the mTOR Pathway: The Second Generation of Inhibitors
2011
Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors
2011
Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
2009
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
2009
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Metabolic reprogramming and cancer progression
2020 StandoutScience
Hedgehog-Stimulated Chemotaxis Is Mediated by Smoothened Located Outside the Primary Cilium
2012
Hedgehog signaling
2006
Cancer Genome Landscapes
2013 StandoutScience
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network
2008
Engineering of temperature- and light-switchable Cas9 variants
2013 StandoutNobel
Neurogenesis at the Brain–Cerebrospinal Fluid Interface
2011
Genetics and biology of pancreatic ductal adenocarcinoma
2016
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer
2018
Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling
2007
Paracrine Hedgehog Signaling in Cancer
2009
Circumventing Cancer Drug Resistance in the Era of Personalized Medicine
2012
Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406)
2020
Works of Ryan B. Corcoran being referenced
EGFR-Mediated Reactivation of MAPK Signaling Contributes to Insensitivity of BRAF -Mutant Colorectal Cancers to RAF Inhibition with Vemurafenib
2012
Combined MEK and PI3K Inhibition in a Mouse Model of Pancreatic Cancer
2014
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
2006
STAT3 Plays a Critical Role in KRAS -Induced Pancreatic Tumorigenesis
2011
TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF- Mutant Melanoma
2013
Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers
2011
A Mouse Model for Medulloblastoma and Basal Cell Nevus Syndrome
2001
Pharmacodynamic and efficacy analysis of the BRAF inhibitor dabrafenib (GSK436) in combination with the MEK inhibitor trametinib (GSK212) in patients with BRAFV600 mutant colorectal cancer (CRC).
2013
Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600–Mutant Colorectal Cancer
2015
WISP-1 is a Wnt-1- and β-catenin-responsive oncogene
2000
Effective MAPK Inhibition is critical for therapeutic responses in colorectal cancer with BRAF mutations
2015
BRAF Gene Amplification Can Promote Acquired Resistance to MEK Inhibitors in Cancer Cells Harboring the BRAF V600E Mutation
2010
WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene.
2000
Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process
2009
Insulin-like Growth Factor 2 Is Required for Progression to Advanced Medulloblastoma in patched1 Heterozygous Mice
2008
Efficacy and circulating tumor DNA (ctDNA) analysis of the BRAF inhibitor dabrafenib (D), MEK inhibitor trametinib (T), and anti-EGFR antibody panitumumab (P) in patients (pts) with BRAF V600E–mutated (BRAFm) metastatic colorectal cancer (mCRC)
2016
The PI3K Pathway As Drug Target in Human Cancer
2010
Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers
2011