Citation Impact
Citing Papers
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
2008
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
2012 StandoutScience
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
2009 Standout
ER Tubules Mark Sites of Mitochondrial Division
2011 StandoutScience
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
2013
ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts
2016
Molecular interaction between parkin and PINK1 in mammalian neuronal cells
2009
The Role of Innate and Adaptive Immunity in Parkinson's Disease
2013
Mutant G-protein-coupled receptors as a cause of human diseases
2004
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
2009
Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation
2015 StandoutNobel
Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission
2009
Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle
2009
Design, Synthesis, Structural and Functional Characterization of Novel Melanocortin Agonists Based on the Cyclotide Kalata B1
2012
Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker
2019
A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment
2013
Loss of iron triggers PINK1/Parkin‐independent mitophagy
2013
The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy
2015 StandoutNobel
The PINK1–Parkin pathway is involved in the regulation of mitochondrial remodeling process
2008
Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases
2009
Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria
2012
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
2010
Autophagosomes form at ER–mitochondria contact sites
2013 StandoutNature
A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids
2011
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
2010 Standout
Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism
2013
Ca2+-dependent regulation of mitochondrial dynamics by the Miro–Milton complex
2009
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
2004 Standout
Role for ELOVL3 and Fatty Acid Chain Length in Development of Hair and Skin Function
2004 StandoutNobel
MC4R Agonists: Structural Overview on Antiobesity Therapeutics
2018 StandoutNobel
Central nervous system control of food intake and body weight
2006 StandoutNature
Melanocortin Signalling Mechanisms
2010
Molecular pathogenesis of Parkinson disease: insights from genetic studies
2009
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
2015 Standout
Parkin and PINK1: much more than mitophagy
2014
Random mutagenesis in the mouse as a tool in drug discovery
2002
Select E2 enzymes differentially regulate parkin activation and mitophagy
2014
The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy
2014
Hallmarks of aging: An expanding universe
2023 Standout
Parkin and mitochondrial quality control: toward assembling the puzzle
2014
Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice
2011
Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
2011
Genetic Animal Models of Parkinson's Disease
2010
Mitochondrial diseases
2012
Mitochondria and autophagy: Critical interplay between the two homeostats
2011
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
1999
Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane
2011
Autophagy: Renovation of Cells and Tissues
2011 Standout
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy
2012
Mitochondria: In Sickness and in Health
2012 Standout
Mitochondrial dynamics in cell death and neurodegeneration
2010
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
2016 Standout
The melanocortin receptors and their accessory proteins
2013
PINK1 cleavage at position A103 by the mitochondrial protease PARL
2010
The Rise and Fall of the Chemoattractant Receptor GPR33
2005 StandoutNobel
PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
2011
Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation
2009
Mitochondrial fragmentation in neurodegeneration
2008
Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering
2014
Parkinson's disease
2015 Standout
Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner
2012
Central nervous system control of food intake
2000 StandoutNature
Melanocortin-5 receptor and sebogenesis
2011
S-Nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration
2010
Structure-based Analyses Reveal Distinct Binding Sites for Atg2 and Phosphoinositides in Atg18
2012 StandoutNobel
The Melanocortin-1 Receptor
2001
The Yeast Complex I Equivalent NADH Dehydrogenase Rescues pink1 Mutants
2012
Structure of the Novel C-terminal Domain of Vacuolar Protein Sorting 30/Autophagy-related Protein 6 and Its Specific Role in Autophagy
2012 StandoutNobel
Autophagy in Human Health and Disease
2013 Standout
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
2013 Nature
Loss-of-Function Analysis Suggests ThatOmi/HtrA2Is Not an Essential Component of thepink1/parkinPathwayIn Vivo
2008
Mechanisms of mitophagy
2010 Standout
Solution structures of cyclic melanocortin agonists and antagonists by NMR
2003
Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism
2012 Nobel
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
1998 Standout
Small Molecule Inhibitors of Mitochondrial Division: Tools that Translate Basic Biological Research into Medicine
2010
Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress
2015
Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-dPhe-Arg-Trp-Lys]-NH2
2003
Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts
2011
Melanocortin control of energy balance: evidence from rodent models
2011
Autophagy and Aging
2011 Standout
Design of new small cyclic melanocortin receptor-binding peptides using molecular modelling: Role of the His residue in the melanocortin peptide core
2001
Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants
2014
Functional interplay between Parkin and Drp1 in mitochondrial fission and clearance
2014
“The role of melanocortins in body weight regulation: opportunities for the treatment of obesity”
2002
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
2009
Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands
2002
Melanocortin-5 Receptor Deficiency in Mice Blocks a Novel Pathway Influencing Pheromone-Induced Aggression
2006
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
2013 Nature
Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
2009
Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons
2012
Obesity and the Regulation of Energy Balance
2001 Standout
Perturbations in Mitochondrial Dynamics Induced by Human Mutant PINK1 Can Be Rescued by the Mitochondrial Division Inhibitor mdivi-1
2010
Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1
2011
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Structure-Activity Relationships (SAR) of Melanocortin and Agouti-Related (AGRP) Peptides
2010
Cardiovascular effects of melanocortins
2011
VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations
2013
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Structure–activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 at the mouse melanocortin receptors
2003
The PI3K Pathway in Human Disease
2017 Standout
Leptin and the regulation of body weight in mammals
1998 StandoutNature
PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila
2014
The role of parkin in familial and sporadic Parkinson's disease
2010
Recent advances into the understanding of mitochondrial fission
2012
Autophagy-related Protein 32 Acts as Autophagic Degron and Directly Initiates Mitophagy
2012 StandoutNobel
Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy
2013
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
2015 StandoutNature
Yeast and mammalian autophagosomes exhibit distinct phosphatidylinositol 3-phosphate asymmetries
2014 StandoutNobel
Regulation of mitochondrial permeability transition pore by PINK1
2012
Analogs of MTII, Lactam Derivatives of α-Melanotropin, Modified at the N-Terminus, and Their Selectivity at Human Melanocortin Receptors 3, 4, and 5
1999
Structure of the human Parkin ligase domain in an autoinhibited state
2013
Atg9 Vesicles Recruit Vesicle-tethering Proteins Trs85 and Ypt1 to the Autophagosome Formation Site
2012 StandoutNobel
Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control
2011
Mitochondrial Dysfunction in Genetic Animal Models of Parkinson's Disease
2011
The Interplay Between Mitochondrial Dynamics and Mitophagy
2010
Mitochondrial Quality Control and Dynamics in Parkinson's Disease
2011
ULK1, Mammalian Target of Rapamycin, and Mitochondria: Linking Nutrient Availability and Autophagy
2011
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling
2011 Standout
Exosomes
2019 Standout
Recent Advances in the Genetics of Parkinson's Disease
2011
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
2010
The 1,4-Benzodiazepine-2,5-dione Small Molecule Template Results in Melanocortin Receptor Agonists with Nanomolar Potencies
2008
DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function
2010
Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli
2010
Analysis of neural subtypes reveals selective mitochondrial dysfunction in dopaminergic neurons from parkin mutants
2012
Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin
2014
Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors
2015
Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
2008
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
Mitochondria—Striking a balance between host and endosymbiont
2019 Science
What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease
2011
Mitochondrial Fission, Fusion, and Stress
2012 StandoutScience
60 YEARS OF POMC: Melanocortin receptors: evolution of ligand selectivity for melanocortin peptides
2016
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission
2011
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice
2009
Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson’s disease factors Pink1 and Parkin
2008
Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
2014
MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin
2014
Spermidine in health and disease
2018 StandoutScience
Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands
2002
Polydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields
2014 Standout
A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands
2017
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
2013
Phosphorylated ubiquitin chain is the genuine Parkin receptor
2015
Design of cyclized selective melanotropins
2016
Mitochondrial Contribution to Parkinson's Disease Pathogenesis
2011
Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists
2017 StandoutNobel
Scraggly, a new hair loss mutation on mouse Chromosome 19
1999
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
2008
Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers
2013
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
2008
The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology
2010
Melanocortin receptors: their functions and regulation by physiological agonists and antagonists
2001
Autophagy and Metabolism
2010 StandoutScience
Structure–Activity Relationships of Peptides Incorporating a Bioactive Reverse-Turn Heterocycle at the Melanocortin Receptors: Identification of a 5800-fold Mouse Melanocortin-3 Receptor (mMC3R) Selective Antagonist/Partial Agonist versus the Mouse Melanocortin-4 Receptor (mMC4R)
2013
Synthesis and Pharmacology of α/β3-Peptides Based on the Melanocortin Agonist Ac-His-d Phe-Arg-Trp-NH2 Sequence
2015
Synthesis, Biophysical, and Pharmacological Evaluation of the Melanocortin Agonist AST3-88: Modifications of Peptide Backbone at Trp 7 Position Lead to a Potent, Selective, and Stable Ligand of the Melanocortin 4 Receptor (MC4R)
2014
Design, Synthesis, and Evaluation of Proline and Pyrrolidine Based Melanocortin Receptor Agonists. A Conformationally Restricted Dipeptide Mimic Approach
2006
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control
2014
Mutations in Fis1 disrupt orderly disposal of defective mitochondria
2013
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
2010
Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions☆
2000
Genes associated with Parkinson's disease: regulation of autophagy and beyond
2015
PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function
2011
The Role of Atg Proteins in Autophagosome Formation
2011 StandoutNobel
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
2008 Standout
Works of Ruth E. Thomas being referenced
The PINK1/Parkin pathway regulates mitochondrial morphology
2008
Melanocortin-5 receptor deficiency promotes defensive behavior in male mice
2003
PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix
2014
The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway
2010
Exocrine Gland Dysfunction in MC5-R-Deficient Mice: Evidence for Coordinated Regulation of Exocrine Gland Function by Melanocortin Peptides
1997
Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles
2018
Autophagy accounts for approximately one-third of mitochondrial protein turnover and is protein selective
2019
The PINK1–Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo
2013