Citation Impact
Citing Papers
Accelerated telomere shortening in response to life stress
2004 StandoutNobel
Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor
2000 StandoutScience
Knockdown of Oncogenic KRAS in Non–Small Cell Lung Cancers Suppresses Tumor Growth and Sensitizes Tumor Cells to Targeted Therapy
2011
Human Ageing and Telomeres
2007
Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
2006
Hallmarks of Cancer: The Next Generation
2011 Standout
Reversal of Senescence in Mouse Fibroblasts through Lentiviral Suppression of p53
2003
The DNA-damage response in human biology and disease
2009 StandoutNature
Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation
2004
PIK3CA Mutations and Copy Number Gains in Human Lung Cancers
2008
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
2002 Nature
Patterns of Proliferation and Apoptosis during Murine Hair Follicle Morphogenesis
2001
Telomeres, the nucleolus and aging
1998
The RB and p53 pathways in cancer
2002 Standout
Replicative senescence: a critical review
2004
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
2013 StandoutNature
Mechanisms of cellular senescence in human and mouse cells
2004
Cellular senescence: when bad things happen to good cells
2007 Standout
Cell-cycle checkpoints and cancer
2004 StandoutNature
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
2008
Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis
2010
Developmental differences in the immortalization of lung fibroblasts by telomerase
2003
Reversal of human cellular senescence: roles of the p53 and p16 pathways
2003
The biology and management of non-small cell lung cancer
2018 StandoutNature
1 The regulatory biology of the human pilosebaceous unit
1997
Confronting Complexity: the Interlink of Phototransduction and Retinoid Metabolism in the Vertebrate Retina
2001
Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human Cells
2007
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
2013 StandoutNature
Wound repair and regeneration
2008 StandoutNature
Functional requirement of p23 and Hsp90 in telomerase complexes
1999
BRAFE600-associated senescence-like cell cycle arrest of human naevi
2005 StandoutNature
Lung Cancer
2008 Standout
Smurf2 up-regulation activates telomere-dependent senescence
2004
Different telomere damage signaling pathways in human and mouse cells
2002
Cellular Senescence in Cancer and Aging
2007 Standout
p16INK4a inactivation is not required to immortalize human mammary epithelial cells
2002
Living on a break: cellular senescence as a DNA-damage response
2008
Telomere states and cell fates
2000 StandoutNatureNobel
Putting the stress on senescence
2001
Telomeres and telomerase in cancer
2009
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
Involvement of the INK4a/Arf gene locus in senescence
2003
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
1997 StandoutNobel
The Hallmarks of Cancer
2000 Standout
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
2005 Standout
Conditional telomerase induction causes proliferation of hair follicle stem cells
2005 Nature
A DNA damage checkpoint response in telomere-initiated senescence
2003 StandoutNature
Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells
2002
Understanding the progression of melanocytic neoplasia using genomic analysis: from fields to cancer
2003
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
2005 StandoutNobel
Hallmarks of senescence in carcinogenesis and cancer therapy
2004
When cells get stressed: an integrative view of cellular senescence
2004
Proliferation-Associated Regulation of Telomerase Activity in Human Endometrium and Its Potential Implication in Early Cancer Diagnosis
1997
Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions
2004
In Situ Hybridization Analysis of the Expression of Human Telomerase RNA in Normal and Pathologic Conditions of the Skin
1998
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
2007 StandoutNature
Telomerase in human development and cancer
1997
Tumor suppression by Ink4a–Arf: progress and puzzles
2003
Contribution of p16INK4a to replicative senescence of human fibroblasts
2004
Telomerase is Not an Epidermal Stem Cell Marker and is Downregulated by Calcium
1998
A Translational View of the Molecular Pathogenesis of Lung Cancer
2007
Immunity, Inflammation, and Cancer
2010 Standout
The essence of senescence: Figure 1.
2010 Standout
Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype
2011
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
Telomerase in the human organism
2002
Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence
2004
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging
2004
Historical claims and current interpretations of replicative aging
2002
Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals
1998
A survey of telomerase activity in human cancer
1997 Standout
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Telomere shortening in peripheral blood cells was related with aging but not with white blood cell count
1996
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
2007
Oxidative stress shortens telomeres
2002 Standout
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
2005 StandoutNature
Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging
2007
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Quantitative in situ evaluation of telomeres in fluorescence in situ hybridization-processed sections of cutaneous melanocytic lesions and correlation with telomerase activity
2002
Pancreatic cancer biology and genetics
2002
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
2015 StandoutNature
Senescence and immortalization: role of telomeres and telomerase
2004
Molecular Regulation of Melanocyte Senescence
2002
Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
1997
The role of senescent cells in ageing
2014 StandoutNature
The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia
2010
p16INK4A is a robust in vivo biomarker of cellular aging in human skin
2006
Clonal evolution in cancer
2012 StandoutNature
Genetic Control of Telomerase and Replicative Senescence in Human and Rodent Cells
2007
The Hallmarks of Aging
2013 Standout
Three-dimensional culture models of normal and malignant breast epithelial cells
2007
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Telomerase: A target for cancer therapeutics
2002
Creation of human tumour cells with defined genetic elements
1999 StandoutNature
Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock
2004
Lung cancer in never smokers — a different disease
2007
Genetics and biology of pancreatic ductal adenocarcinoma
2006
The cancer genome
2009 StandoutNature
Cell senescence and cancer
2001
Tetrahymena proteins p80 and p95 are not core telomerase components
2001 StandoutNobel
Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1
2002
Telomerase core components protect Candida telomeres from aberrant overhang accumulation
2007 StandoutNobel
Does a Sentinel or a Subset of Short Telomeres Determine Replicative Senescence?
2004
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
1999 StandoutNobel
Regulation of Telomerase by Telomeric Proteins
2004
Oncogenic transformation and experimental models of human cancer
2007
Telomerase activity, cell proliferation, and cancer
1998 StandoutNobel
The rate of telomere sequence loss in human leukocytes varies with age
1998 StandoutNobel
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
Telomeres: Cancer to Human Aging
2006
Organogenesis in a dish: Modeling development and disease using organoid technologies
2014 StandoutScience
Keratinocyte Stem Cells: a Commentary1
2002
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
1997 StandoutScienceNobel
Molecular Predictors of Response to Epidermal Growth Factor Receptor Antagonists in Non–Small-Cell Lung Cancer
2007
Four faces of cellular senescence
2011 Standout
p16INK4a Modulates p53 in Primary Human Mammary Epithelial Cells
2006
Normal Human Fibroblasts Are Resistant to RAS-Induced Senescence
2004
Controls of Hair Follicle Cycling
2001 Standout
Telomerase in kinetoplastid parasitic protozoa
1999 StandoutNobel
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
2010 StandoutNobel
When cells get stressed: an integrative view of cellular senescence
2004
Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci
2003
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
A Two-Stage, p16INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status
2002
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Loss of linker histone H1 in cellular senescence
2006
Real-time in vivo imaging of p16Ink4a reveals cross talk with p53
2009
Human melanocyte senescence and melanoma susceptibility genes
2003
Works of Ruben D. Ramirez being referenced
Detection of Telomerase Activity in Malignant and Nonmalignant Skin Conditions
1996
Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells
2003
Acid Has Antiproliferative Effects in Nonneoplastic Barrett's Epithelial Cells
2007
EGFR Signaling Is Required for TGF-β1–Mediated COX-2 Induction in Human Bronchial Epithelial Cells
2007
Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
2001
A three-dimensional model of differentiation of immortalized human bronchial epithelial cells
2006
Progressive Increase in Telomerase Activity From Benign Melanocytic Conditions to Malignant Melanoma
1999
Expression of Nicotinic Acetylcholine Receptor Subunit Genes in Non–Small-Cell Lung Cancer Reveals Differences between Smokers and Nonsmokers
2007
Retinyl ester hydrolase and the visual cycle in the chicken eye
1995
Different Roles for Caveolin-1 in the Development of Non-Small Cell Lung Cancer versus Small Cell Lung Cancer
2004
Telomerase Activity Concentrates in the Mitotically Active Segments of Human Hair Follicles
1997
Multiple Oncogenic Changes (K-RASV12, p53 Knockdown,Mutant EGFRs, p16Bypass, Telomerase) Are Not Sufficient to Confer a Full Malignant Phenotype on Human Bronchial Epithelial Cells
2006