Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling
2009
TKTL1 Is Activated by Promoter Hypomethylation and Contributes to Head and Neck Squamous Cell Carcinoma Carcinogenesis through Increased Aerobic Glycolysis and HIF1α Stabilization
2010
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation
2010
SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions
2012 Science
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases
2011 StandoutNobel
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer
2010
Hallmarks of Cancer: The Next Generation
2011 Standout
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Cancer Cell Metabolism
2011
CTLA4Ig: Bridging the Basic Immunology with Clinical Application
2006
Gene Sets Identified with Oncogene Cooperativity Analysis Regulate In Vivo Growth and Survival of Leukemia Stem Cells
2012
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
2020 Standout
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
Brick by brick: metabolism and tumor cell growth
2008
p53 and metabolism
2009
Modular click chemistry libraries for functional screens using a diazotizing reagent
2019 StandoutNatureNobel
Targeting microRNAs in cancer: rationale, strategies and challenges
2010
T cell co-stimulation and in vivo tolerance
1993
Building the Connectivity Map of epigenetics: Chromatin profiling by quantitative targeted mass spectrometry
2014
Regulatory T Cells
2000 StandoutNobel
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
B70 antigen is a second ligand for CTLA-4 and CD28
1993 Nature
Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity
2009
Cancer Cell Metabolism: Warburg and Beyond
2008 Standout
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Otto Warburg's contributions to current concepts of cancer metabolism
2011 Standout
Opportunities and challenges in phenotypic drug discovery: an industry perspective
2017
Treatment of Obesity with Celastrol
2015 Standout
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
2009 Nature
Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation.
1995
CD28-B7 interactions in T-cell activation
1994 StandoutNobel
Causes and Consequences of Increased Glucose Metabolism of Cancers
2008
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
2014 StandoutNature
Targeting metabolic transformation for cancer therapy
2010
Tumor Cell Metabolism: Cancer's Achilles' Heel
2008 Standout
The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury.
1997
Developmental regulation of MHC class II transport in mouse dendritic cells
1997 StandoutNatureNobel
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
2006
Absence of B7-dependent responses in CD28-deficient mice
1994
The ER UDPase ENTPD5 Promotes Protein N-Glycosylation, the Warburg Effect, and Proliferation in the PTEN Pathway
2010
Enhanced expression of B7-1, B7-2, and intercellular adhesion molecule 1 in sinusoidal endothelial cells by warm ischemia/reperfusion injury in rat liver
2001 StandoutNobel
Insulin and insulin-like growth factor signalling in neoplasia
2008 Standout
Blinded by the Light: The Growing Complexity of p53
2009 Standout
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Epigenetic Modulation of miR-122 Facilitates Human Embryonic Stem Cell Self-Renewal and Hepatocellular Carcinoma Proliferation
2011
Regulation of cancer cell metabolism
2011 Standout
Tumor suppressors and cell metabolism: a recipe for cancer growth
2009
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
2012 Nature
Metabolomics: the apogee of the omics trilogy
2012 Standout
CTLA-4 can function as a negative regulator of T cell activation
1994 Standout
Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells
2009
Extracellular Matrix Regulation of Metabolism and Implications for Tumorigenesis
2011
Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons
2011
Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins
2012
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
1995 Standout
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth
2011
Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance
1994
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
2011 Nature
Treatment of Murine Lupus with CTLA4Ig
1994 Science
Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis
2009
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
1994
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Pyruvate kinase M2 is a phosphotyrosine-binding protein
2008 Nature
The Complexities of T‐Cell Co‐stimulation: CD28 and Beyond
1996
Metabolite profiles and the risk of developing diabetes
2011 Standout
The role of p53 in glucose metabolism
2010
lincRNAs act in the circuitry controlling pluripotency and differentiation
2011 StandoutNature
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Metabolic Profiling of the Response to an Oral Glucose Tolerance Test Detects Subtle Metabolic Changes
2009
Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer
2012
The B7 and CD28 receptor families
1994
New perspectives of C1328-137-mediated T cell costimulation
1995
Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase
2012
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis.
1996
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Clues from cell metabolism
2010 StandoutNatureNobel
Antigen Concentration and Precursor Frequency Determine the Rate of CD8+ T Cell Tolerance to Peripherally Expressed Antigens
1999
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
2011 Standout
Expression and functional significance of an additional ligand for CTLA-4.
1993
Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.
1996
HOW DO MONOCLONAL ANTIBODIES INDUCE TOLERANCE? A Role for Infectious Tolerance?
1998
CD28/B7 SYSTEM OF T CELL COSTIMULATION
1996 Standout
A Critical Role for B7/CD28 Costimulation in Experimental Autoimmune Encephalomyelitis: A Comparative Study Using Costimulatory Molecule-Deficient Mice and Monoclonal Antibody Blockade
2000
CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.
1995
Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection.
1996
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
2003 StandoutNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
PKM2 Tyrosine Phosphorylation and Glutamine Metabolism Signal a Different View of the Warburg Effect
2009
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
2009
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
2012
Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice
1993 Science
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Network Medicine Framework for Identifying Drug Repurposing Opportunities for COVID-19
2020
Causal analysis approaches in Ingenuity Pathway Analysis
2013 Standout
Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation
2001
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism
2010
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
2009
Enhancement of Antitumor Immunity by CTLA-4 Blockade
1996 StandoutScienceNobel
B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.
1994
Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
2011 Science
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
2002 StandoutNobel
Activation of fibroblasts in cancer stroma
2010
Differential T Cell Costimulatory Requirements in CD28-Deficient Mice
1993 Science
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
2010
Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation
1993 Science
Works of Ru Wei being referenced
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
2008
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
2008 StandoutNature
T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.
1992
Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.
1993
Preventing allograft rejection with CTLA4IG: effect of donor-specific transfusion route or timing.
1996
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
2006 StandoutScience