Standout Papers
Citation Impact
Citing Papers
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility
2021 StandoutNobel
A small-molecule switch for Golgi sulfotransferases
2004 StandoutNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Creating new fluorescent probes for cell biology
2002 StandoutNobel
Ubiquitin-independent Mechanisms of Mouse Ornithine Decarboxylase Degradation Are Conserved between Mammalian and Fungal Cells
2003
Exploring New Chemical Space by Stereocontrolled Diversity-Oriented Synthesis
2005
Matrix metalloproteinases and the regulation of tissue remodelling
2007 Standout
Inflammation and cancer
2002 StandoutNature
A comparison of epithelial-to-mesenchymal transition and re-epithelialization
2012
Synthesis of Natural Product Inspired Compound Collections
2009
Separation of cathepsin A-like enzyme and the proteasome: evidence that lactacystin/β-lactone is not a specific inhibitor of the proteasome
2000 StandoutNobel
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
2015 StandoutNature
Chemical genetics: tailoring tools for cell biology
2003
Proteasome inhibitors: from research tools to drug candidates
2001
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration
2003
Catalytic Three‐Component Ugi Reaction
2008 StandoutNobel
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
2008 NatureNobel
Wound repair and regeneration
2008 StandoutNature
Imaging in the era of molecular oncology
2008 StandoutNature
Proteasome-Mediated Processing of Nrf1 Is Essential for Coordinate Induction of All Proteasome Subunits and p97
2014
HIF2α cooperates with RAS to promote lung tumorigenesis in mice
2009 StandoutNobel
Proteasome Inhibitors: Complex Tools for a Complex Enzyme
2002
Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells
2000
Lack of Proteasome Active Site Allostery as Revealed by Subunit-Specific Inhibitors
2001
A Strategy for Functional Proteomic Analysis of Glycosidase Activity from Cell Lysates
2004 StandoutNobel
Strategies for MMP inhibition in cancer: innovations for the post-trial era
2002
Ubiquitination of soluble and membrane‐bound tyrosine hydroxylase and degradation of the soluble form
2002
Cell Death
2004 Standout
Regulation of apoptosis by the ubiquitin and proteasome pathway
2002
Probing Structural Determinants Distal to the Site of Hydrolysis that Control Substrate Specificity of the 20S Proteasome
2002 Nobel
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
2006 StandoutNature
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
2002
Ectopic Expression of Nonliganded Retinoic Acid Receptor β Abrogates AP-1 Activity by Selective Degradation of c-Jun in Cervical Carcinoma Cells
2004 StandoutNobel
Protein‐Reactive Natural Products
2005
New Approaches and Therapeutics Targeting Apoptosis in Disease
2005
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
2003
Matrix Metalloproteinase 9 Promoter Activity Is Induced Coincident with Invasion during Tumor Progression
2000
Protein degradation and protection against misfolded or damaged proteins
2003 StandoutNature
A transgenic mouse model of the ubiquitin/proteasome system
2003
Integrated genomic characterization of endometrial carcinoma
2013 StandoutNature
Evidence for partial epithelial‐to‐mesenchymal transition (pEMT) and recruitment of motile blastoderm edge cells during avian epiboly
2011
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
2010 Standout
Autophagy in Human Health and Disease
2013 Standout
The proteasome: structure, function, and role in the cell
2003
Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes
2007
EMT: 2016
2016 Standout
A Simple Enantioconvergent and Chemoenzymatic Synthesis of Optically Active α‐Substituted Amides
2011 StandoutNobel
Targeted Deletion of Metalloproteinase 9 Attenuates Experimental Colitis in Mice: Central Role of Epithelial-Derived MMP
2005
Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools
2000
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14
2001
Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling
2002
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic β-subunits
2001
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Proteasome Inhibitors: An Expanding Army Attacking a Unique Target
2012
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
2009 Standout
Structural analysis and promoter characterization of the human membrane-type matrix metalloproteinase-1 (MT1-MMP) gene
2000
Extracellular matrix remodelling and cellular differentiation
1999
Chapter 11 Proteinase families and their inhibitors
2001
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Proteasome inhibitors: fromin vitro uses to clinical trials
2000
Tumorigenesis and the angiogenic switch
2003 Standout
De Novo-Designed Enzymes as Small-Molecule-Regulated Fluorescence Imaging Tags and Fluorescent Reporters
2014 StandoutNobel
Conversion of PrP to a Self-Perpetuating PrP Sc -like Conformation in the Cytosol
2002 Science
Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival
2001
Increased Antigen Presentation Efficiency by Coupling Antigens to MHC Class I Trafficking Signals
2008
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Mass spectrometry-based proteomics
2003 StandoutNature
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1
2016 StandoutNobel
Sox17 and Sox4 Differentially Regulate β-Catenin/T-Cell Factor Activity and Proliferation of Colon Carcinoma Cells
2007
The Ubiquitin-Proteasome System Plays an Important Role during Various Stages of the Coronavirus Infection Cycle
2010
Ribosomal Synthesis of Dehydroalanine-Containing Peptides
2006 StandoutNobel
Effects of Matrix Metalloproteinase-9 Gene Knock-Out on Morphological and Motor Outcomes after Traumatic Brain Injury
2000
Proteasome Inhibition Alleviates SNARE-Dependent Neurodegeneration
2012 StandoutNobel
Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification
2018 StandoutNobel
Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling
2002
Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors
2001
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
Proteasome selectivity towards Michael acceptor containing oligopeptide-based inhibitors
2010
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
2004 StandoutScience
Emerging Targets in Photopharmacology
2016 StandoutNobel
How Matrix Metalloproteinases Regulate Cell Behavior
2001 Standout
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Wound-Healing Studies in Transgenic and Knockout Mice
2004
Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation
2001 Standout
Angiogenesis in Endocrine Tumors
2003
Increased inflammation delays wound healing in mice deficient in collagenase‐2 (MMP‐8)
2007
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditions
2003
Unexpected Transcriptional Induction of Monocyte Chemoattractant Protein 1 by Proteasome Inhibition: Involvement of the c-Jun N-Terminal Kinase-Activator Protein 1 Pathway
2001
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity
2000
Crystal Structure of Epoxomicin:20S Proteasome Reveals a Molecular Basis for Selectivity of α‘,β‘-Epoxyketone Proteasome Inhibitors
2000 Nobel
Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues
2011 StandoutNobel
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Royce Mohan being referenced
LMP2-Specific Inhibitors: Chemical Genetic Tools for Proteasome Biology
2007
Small-molecule inhibitors of the cell cycle
2000
The Tumor Inhibitor and Antiangiogenic Agent Withaferin A Targets the Intermediate Filament Protein Vimentin
2007
Gelatinase B/lacZ Transgenic Mice, a Model for Mapping Gelatinase B Expression during Developmental and Injury-related Tissue Remodeling
1998
Matrix Metalloproteinase Gelatinase B (MMP-9) Coordinates and Effects Epithelial Regeneration
2002
Curcuminoids Inhibit the Angiogenic Response Stimulated by Fibroblast Growth Factor-2, Including Expression of Matrix Metalloproteinase Gelatinase B
2000
Towards subunit-specific proteasome inhibitors: synthesis and evaluation of peptide α', β'-epoxyketones
1999
The antiangiogenic agent TNP-470 requires p53 and p21 CIP/WAF for endothelial cell growth arrest
2000
Epoxomicin, a potent and selective proteasome inhibitor, exhibitsin vivoantiinflammatory activity
1999