Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Functional Genomic Analysis of RNA Interference in C. elegans
2005 StandoutScienceNobel
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Switchable Cas9
2017 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
HIV-1 rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA
1991 StandoutNobel
The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain
1989
The Role of Human TFIIB in Transcription Start Site Selection in Vitro and in Vivo
1999
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
1996 StandoutNatureNobel
Evidence That Transcription Factor IIB Is Required for a Post-assembly Step in Transcription Initiation
1999
Formation of the ∼350-kDa Apg12-Apg5·Apg16 Multimeric Complex, Mediated by Apg16 Oligomerization, Is Essential for Autophagy in Yeast
2002 StandoutNobel
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
1997 StandoutNatureNobel
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins
1998
A Yeast Transcriptional Stimulatory Protein Similar to Human PC4
1996 StandoutNobel
New perspectives on connecting messenger RNA 3′ end formation to transcription
2004
Building the Connectivity Map of epigenetics: Chromatin profiling by quantitative targeted mass spectrometry
2014
Binding of TFIIB to RNA Polymerase II
2003
Regulating Cell Surface Glycosylation by Small Molecule Control of Enzyme Localization
2003 StandoutNobel
The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA
1997 StandoutNobel
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105
1995 StandoutNobel
Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation
1990 StandoutNatureNobel
Intermediates in formation and activity of the RNA polymerase II preinitiation complex: holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB
1999
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
A regulatory hierarchy for cell specialization in yeast
1989 Nature
Analysis of the Role of TFIIE in Transcriptional Regulation through Structure-Function Studies of the TFIIEβ Subunit
1998
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
Clinical Implications of Novel Mutations in Epigenetic Modifiers in AML
2011
A mediator required for activation of RNA polymerase II transcription in vitro
1991 StandoutNatureNobel
PRC2 mediated H3K27 methylations in cellular identity and cancer
2015
Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures
1992 StandoutNatureNobel
A Bacterial Small-Molecule Three-Hybrid System
2002
Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
2005 Nature
PAS is a dimerization domain common to Drosophila Period and several transcription factors
1993 StandoutNatureNobel
Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities
2003
In vitro genetics
1992 StandoutNobel
The war of the whorls: genetic interactions controlling flower development
1991 StandoutNature
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
A short, disordered protein region mediates interactions between the homeodomain of the yeast α2 protein and the MCM1 protein
1993
A DNA metalloenzyme with DNA ligase activity
1995 StandoutNatureNobel
De novo design of bioactive protein switches
2019 StandoutNatureNobel
C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons
1992 StandoutNatureNobel
Three-part inventions: intracellular signaling and induced proximity
1996
The many roles of histone deacetylases in development and physiology: implications for disease and therapy
2008 Standout
In vitro evolution of new ribozymes with polynucleotide kinase activity
1994 StandoutNatureNobel
Controlling mammalian gene expression with small molecules
1997
Homeodomain-DNA recognition
1994 StandoutNobel
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Plasmid cDNA-directed protein synthesis in a coupled eukaryoticin vitrotranscription-translation system
1992 StandoutNobel
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
What determines the specificity of action of Drosophila homeodomain proteins?
1990
The protein encoded by the Arabidopsis homeotic gene agamous resembles transcription factors
1990 Nature
A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1
1994 StandoutNatureNobel
Synthetic protein–protein interaction domains created by shuffling Cys 2 His 2 zinc‐fingers
2006
Identification, purification, and cloning of a polypeptide (PRTF/GRM) that binds to mating-specific promoter elements in yeast.
1990
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
Deficiens, a homeotic gene involved in the control of flower morphogenesis in Antirrhinum majus: the protein shows homology to transcription factors.
1990
Genetic Control of Flower Development by Homeotic Genes in Antirrhinum majus
1990 Science
A ligand-reversible dimerization system for controlling protein–protein interactions
2000
Heterodimerization between light-regulated and ubiquitously expressed Arabidopsis GBF bZIP proteins.
1992
Transcriptional repression by a novel member of the bZIP family of transcription factors.
1992
Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing
1996 StandoutScienceNobel
Conditional Glycosylation in Eukaryotic Cells Using a Biocompatible Chemical Inducer of Dimerization
2008 StandoutNobel
Xenopus Y-box transcription factors: molecular cloning, functional analysis and developmental regulation.
1990
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-II
1990 StandoutNatureNobel
DNA-Binding Specificity of the PAR Basic Leucine Zipper Protein VBP Partially Overlaps Those of the C/EBP and CREB/ATF Families and Is Influenced by Domains That Flank the Core Basic Region
1995
A genetic and molecular model for flower development in Arabidopsis thaliana
1991
AGL1-AGL6, an Arabidopsis gene family with similarity to floral homeotic and transcription factor genes.
1991
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes.
1989
A general approach for chemical labeling and rapid, spatially controlled protein inactivation
2004
A Bifunctional Molecule That Displays Context-Dependent Cellular Activity
2003
The regulation of myogenin gene expression during the embryonic development of the mouse.
1993
The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product
1990
Control of Memory Formation Through Regulated Expression of a CaMKII Transgene
1996 StandoutScienceNobel
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
1989 StandoutScience
MLL leukemia induction by genome editing of human CD34+ hematopoietic cells
2015
The N-terminal Region of Yeast TFIIB Contains Two Adjacent Functional Domains Involved in Stable RNA Polymerase II Binding and Transcription Start Site Selection
1998
RBP-L, a Transcription Factor Related to RBP-Jκ
1997 StandoutNobel
Characterization of the sequence-specific interaction of mouse c-myb protein with DNA.
1990
genetic analysis: Selection and amplification of rare functional nucleic acids
1991 StandoutNobel
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity
1998
Nucleation of COPII Vesicular Coat Complex by Endoplasmic Reticulum to Golgi Vesicle SNAREs
1998 StandoutScienceNobel
Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor
1992 Science
Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms
2004 StandoutScienceNobel
A T7 expression vector for producing N- and C-terminal fusion proteins with glutathione S-transferase
1994
Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen
1997
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development.
1993
Specific Covalent Labeling of Recombinant Protein Molecules Inside Live Cells
1998 StandoutScienceNobel
DIMERIZATION AS A REGULATORY MECHANISM IN SIGNAL TRANSDUCTION
1998
Selection of a Ribozyme That Functions as a Superior Template in a Self-Copying Reaction
1992 StandoutScienceNobel
The zinc ribbon domains of the general transcription factors TFIIB and Brf: conserved functional surfaces but different roles in transcription initiation
2000
COMBINES-CID: An Efficient Method for De Novo Engineering of Highly Specific Chemically Induced Protein Dimerization Systems
2019
Works of Roy M. Pollock being referenced
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
2010
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
2013
Dimerizer-regulated gene expression
2002
DOT1L Inhibitor EPZ-5676 Displays Synergistic Antiproliferative Activity in Combination with Standard of Care Drugs and Hypomethylating Agents in MLL-Rearranged Leukemia Cells
2014
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
2011
MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L
2011
[15] Regulation of gene expression with synthetic dimerizers
1999
A humanized system for pharmacologic control of gene expression
1996
A sensitive method for the determination of protein-DNA binding specificities
1990
Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element
1988
Regulation of endogenous gene expression with a small-molecule dimerizer
2002
Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4.
1996
A versatile synthetic dimerizer for the regulation of protein–protein interactions
1997
Delivery of a stringent dimerizer-regulated gene expression system in a single retroviral vector
2000
Human SRF-related proteins: DNA-binding properties and potential regulatory targets.
1991
Quantitative Analysis of Histone Deacetylase-1 Selective Histone Modifications by Differential Mass Spectrometry
2008
Identification and purification of EBP1: a HeLa cell protein that binds to a region overlapping the 'core' of the SV40 enhancer.
1988
Nonclinical pharmacokinetics and metabolism of EPZ‐5676, a novel DOT1L histone methyltransferase inhibitor
2014
Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML
2004