Citation Impact
Citing Papers
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
Nucleic acid detection with CRISPR-Cas13a/C2c2
2017 StandoutScience
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
2009 Standout
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B.
2003
Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines.
2003
Detection of Clonal and Subclonal Copy-Number Variants in Cell-Free DNA from Patients with Breast Cancer Using a Massively Multiplexed PCR Methodology
2015
Head and neck squamous cell carcinoma
2020 Standout
Role of Caspases, Bid, and p53 in the Apoptotic Response Triggered by Histone Deacetylase Inhibitors Trichostatin-A (TSA) and Suberoylanilide Hydroxamic Acid (SAHA)
2003
Cancer statistics, 2018
2018 Standout
Acetylation of Stat1 modulates NF-κB activity
2006
pVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of the NF-κB Agonist Card9 by CK2
2007 StandoutNobel
A view on drug resistance in cancer
2019 StandoutNature
Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions
2013 StandoutNature
Nuclear factor-κB inhibitors as sensitizers to anticancer drugs
2005
Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes
2002
Cell-cycle checkpoints and cancer
2004 StandoutNature
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
2006 StandoutNature
Issues and progress with protein kinase inhibitors for cancer treatment
2003
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
2014 StandoutNature
The biology and management of non-small cell lung cancer
2018 StandoutNature
Physiology of Cell Volume Regulation in Vertebrates
2009
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
2013 StandoutNature
Integrating liquid biopsies into the management of cancer
2017
Deoxycholic Acid Activates the c-Jun N-terminal Kinase Pathway via FAS Receptor Activation in Primary Hepatocytes
2004
Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA)
2002
AI in health and medicine
2022 Standout
Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia
2001
Apicidin potentiates the imatinib‐induced apoptosis of Bcr–Abl‐positive human leukaemia cells by enhancing the activation of mitochondria‐dependent caspase cascades
2003
Principles of bioactive lipid signalling: lessons from sphingolipids
2008 Standout
HSP90 and the chaperoning of cancer
2005 Standout
The effect of the USPSTF PSA screening recommendation on prostate cancer incidence patterns in the USA
2016
The Epigenomics of Cancer
2007 Standout
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
2007 Standout
Epigenetics in Cancer
2008 Standout
Anticancer activities of histone deacetylase inhibitors
2006 Standout
Lung cancer: current therapies and new targeted treatments
2016 Standout
Histone-deacetylase inhibitors: novel drugs for the treatment of cancer
2002
Evidence of a Functional Role for p21/ Down-Regulation in Synergistic Antileukemic Interactions between the Histone Deacetylase Inhibitor Sodium Butyrate and Flavopiridol
2004
Histone deacetylase inhibitors: from target to clinical trials
2002
Multi‐marker analysis of circulating cell‐free DNA toward personalized medicine for colorectal cancer
2014
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
p21 in cancer: intricate networks and multiple activities
2009 Standout
Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1
2005
Chk1 is haploinsufficient for multiple functions critical to tumor suppression
2004
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
Histone deacetylases and cancer: causes and therapies
2001 Standout
Bile salt biotransformations by human intestinal bacteria
2005 Standout
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
2010 Standout
Liquid biopsies come of age: towards implementation of circulating tumour DNA
2017 Standout
Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria
2003
Gene Silencing in Cancer in Association with Promoter Hypermethylation
2003 Standout
Ursodeoxycholic Acid (UDCA) Can Inhibit Deoxycholic Acid (DCA)-induced Apoptosis via Modulation of EGFR/Raf-1/ERK Signaling in Human Colon Cancer Cells
2004
Diet rapidly and reproducibly alters the human gut microbiome
2013 StandoutNature
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
2016 Standout
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
limma powers differential expression analyses for RNA-sequencing and microarray studies
2015 Standout
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
2014 Standout
Down-regulation of Histone Deacetylases Stimulates Adipocyte Differentiation
2006
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
Molecular mechanisms of necroptosis: an ordered cellular explosion
2010 Standout
Histone deacetylase inhibitors: Signalling towards p21cip1/waf1
2007
Bile acids as regulatory molecules
2009
A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase
2018 StandoutNobel
Adipocyte differentiation from the inside out
2006 Standout
Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans
2015 StandoutNobel
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
2004 Standout
Bile salt—induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation
2003
Destructive cycles: the role of genomic instability and adaptation in carcinogenesis
2004
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
2009 Standout
Elimination of unaltered DNA in mixed clinical samples via nuclease-assisted minor-allele enrichment
2016
Transcription therapy for cancer
2001
Artificial intelligence in radiation oncology
2020
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
Comparison of particle beam therapy and stereotactic body radiotherapy for early stage non-small cell lung cancer: A systematic review and hypothesis-generating meta-analysis
2017
Tumorigenesis and the angiogenic switch
2003 Standout
Integrating cell-signalling pathways with NF-κB and IKK function
2006 Standout
Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways†
2004
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21CIP1/WAF1 induction rather than AKT inhibition
2003
Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
2010 Standout
Deoxycholic Acid Activates β-Catenin Signaling Pathway and Increases Colon Cell Cancer Growth and Invasiveness
2004
Histone Deacetylase Inhibitors as Anticancer Drugs
2017
Development of anin SilicoProfiler for Mitochondrial Toxicity
2015
Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells
2004
Abrogation of p21 Expression by Flavopiridol Enhances Depsipeptide-Mediated Apoptosis in Malignant Pleural Mesothelioma Cells
2004
Epigenetic and Chromatin Modifiers As Targeted Therapy of Hematologic Malignancies
2005
Head and Neck Cancer
2020 Standout
Synergistic Induction of Oxidative Injury and Apoptosis in Human Multiple Myeloma Cells by the Proteasome Inhibitor Bortezomib and Histone Deacetylase Inhibitors
2004
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.
2003
Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl–positive human acute leukemia cells
2003
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species
2001
Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells.
2003
The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571
2003
Up-Regulation of p21WAF1/CIP1 by Histone Deacetylase Inhibitors Reduces Their Cytotoxicity
2001
Treatment deintensification in human papillomavirus‐positive oropharynx cancer: Outcomes from the National Cancer Data Base
2017
Guide to detecting epidermal growth factor receptor (EGFR) mutations in ctDNA of patients with advanced non-small-cell lung cancer
2016
Suberoylanilide Hydroxamic Acid as a Potential Therapeutic Agent for Human Breast Cancer Treatment
2000
Multimodality Therapy for Limited-Stage Small-Cell Lung Cancer
2016
Adjuvant Systemic Therapy and Adjuvant Radiation Therapy for Stage I to IIIA Completely Resected Non–Small-Cell Lung Cancers: American Society of Clinical Oncology/Cancer Care Ontario Clinical Practice Guideline Update
2017
Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells.
2003
Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes
2003
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells.
2003
Molecular sequelae of histone deacetylase inhibition in human malignant B cells
2003
Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors
2005
Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells.
2003
Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia
2001
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
2006 StandoutScience
Histone deacetylase inhibitor selectively induces p21 WAF1 expression and gene-associated histone acetylation
2000
Works of Roy H. Decker being referenced
Ultrasensitive Measurement of Hotspot Mutations in Tumor DNA in Blood Using Error-Suppressed Multiplexed Deep Sequencing
2012
Pretreatment Identification of Head and Neck Cancer Nodal Metastasis and Extranodal Extension Using Deep Learning Neural Networks
2018
Upfront surgery versus definitive chemoradiotherapy in patients with human Papillomavirus-associated oropharyngeal squamous cell cancer
2018
Surveillance Epidemiology and End Results Evaluation of the Role of Surgery for Stage I Small Cell Lung Cancer
2010
Re-evaluation of the Role of Postoperative Radiotherapy and the Impact of Radiation Dose for Non–Small-Cell Lung Cancer Using the National Cancer Database
2014
Hypofractionated Radiotherapy for Patients with Early-Stage Glottic Cancer: Patterns of Care and Survival
2017
Inhibitors of MEK1/2 Interact with UCN-01 to Induce Apoptosis and Reduce Colony Formation in Mammary and Prostate Carcinoma Cells
2002
Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53
1999
Central versus Peripheral Tumor Location: Influence on Survival, Local Control, and Toxicity Following Stereotactic Body Radiotherapy for Primary Non–Small-Cell Lung Cancer
2015
Comparison of survival outcomes among standard radiotherapy regimens in limited-stage small cell lung cancer patients receiving concurrent chemoradiation
2015
The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway
2001
Changes in prostate cancer presentation for radiation oncology care after USPSTF recommendations, 2007-2013.
2015
The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells.
2001
Deoxycholic Acid (DCA) Causes Ligand-independent Activation of Epidermal Growth Factor Receptor (EGFR) and FAS Receptor in Primary Hepatocytes: Inhibition of EGFR/Mitogen-activated Protein Kinase-Signaling Module Enhances DCA-induced Apoptosis
2001
A Comparison of Prognostic Ability of Staging Systems for Human Papillomavirus–Related Oropharyngeal Squamous Cell Carcinoma
2016
Detection of sensitizing and resistance EGFR mutations from circulating tumor DNA (ctDNA) in blood using multiplexed next-generation sequencing in patients with advanced EGFR-mutant lung adenocarcinoma.
2014