Rowan Stringer

TRP Channels as Potential Drug Targets

2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines

Activation of Lung p53 by Nutlin-3a Prevents and Reverses Experimental Pulmonary Hypertension

Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α

Mast cell progenitors: Origin, development and migration to tissues

PI3K signalling in inflammation

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

Irritant-evoked activation and calcium modulation of the TRPA1 receptor

Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac

β-Arrestins modulate Adenovirus-vector-induced innate immune responses: Differential regulation by β-arrestin-1 and β-arrestin-2

Therapeutic potential of β-arrestin- and G protein-biased agonists

Inflammation and tumor progression: signaling pathways and targeted intervention

A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain

Microfluidic organs-on-chips

A simple practice guide for dose conversion between animals and human

Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation

Revolutionizing healthcare: the role of artificial intelligence in clinical practice

The role of drug metabolizing enzymes in clearance

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens

The PI3K Pathway in Human Disease

TRPA1 as a drug target—promise and challenges

Cardiovascular Safety of Tyrosine Kinase Inhibitors: With a Special Focus on Cardiac Repolarisation (QT Interval)

Cellular senescence: from physiology to pathology

Continuous-Flow Synthesis of Deuterium-Labeled Antidiabetic Chalcones: Studies towards the Selective Deuteration of the Alkynone Core

The Hitchhiker’s Guide to Flow Chemistry

Applications of Deuterium in Medicinal Chemistry

The Catalytic Asymmetric Intermolecular Prins Reaction

Endothelial Hypoxia-Inducible Factor-2α Is Required for the Maintenance of Airway Microvasculature

Artificial Intelligence in Drug Metabolism and Excretion Prediction: Recent Advances, Challenges, and Future Perspectives

Thymol inhibits oral squamous cell carcinoma growth via mitochondria‐mediated apoptosis

Wild-type adenoviruses from groups A–F evoke unique innate immune responses, of which HAd3 and SAd23 are partially complement dependent

Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes

Reliability of human cryopreserved hepatocytes and liver microsomes asin vitrosystems to predict metabolic clearance

Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy

Application of a Deuterium Replacement Strategy to Modulate the Pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a Novel CRF1 Antagonist

Evaluation of Recombinant Cytochrome P450 Enzymes as an in Vitro System for Metabolic Clearance Predictions

A Novel Murine Model of Severe Pulmonary Arterial Hypertension

Discovery, Optimization, and Biological Evaluation of 5-(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists

Clearance Mechanism Assignment and Total Clearance Prediction in Human Based upon in Silico Models