Standout Papers
- A gelsolin-like Ca2+-dependent actin-binding domain in villin (1985)
- α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies (1998)
- Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. (1988)
- Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease (1989)
Citation Impact
Citing Papers
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2002
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2010 StandoutScienceNobel
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2017
Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins
2017
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment
2016
Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change
2008
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2010
Elucidating Tau function and dysfunction in the era of cryo-EM
2019
Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation
2013
A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity
2014
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2019
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2006
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1991 StandoutNatureNobel
Inducible Expression of Tau Repeat Domain in Cell Models of Tauopathy
2005
Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial
2016
Detection and characterization of a folding intermediate in barnase by NMR
1990 Nature
Familial Parkinson disease mutations influence α-synuclein assembly
2011
Proteasomal Inhibition by α-Synuclein Filaments and Oligomers
2004
Pathological Proteins in Parkinson's Disease: Focus on the Proteasome
2004
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
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Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo
2013
Peripheral Nervous System-specific Genes Identified by Subtractive cDNA Cloning
1995
Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli
1989 StandoutNatureNobel
Conversion of Wild-type α-Synuclein into Mutant-type Fibrils and Its Propagation in the Presence of A30P Mutant
2009
Interaction of Human α-Synuclein and Parkinson's Disease Variants with Phospholipids
2000
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2002
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)
1994 Standout
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
2012 Standout
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2004 StandoutNobel
Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
2013
Classification and basic pathology of Alzheimer disease
2009
The α‐Synucleinopathies: Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy
2000
A century-old debate on protein aggregation and neurodegeneration enters the clinic
2006 Nature
An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin
2001
Tau phosphorylation and aggregation in Alzheimer's disease pathology
2006
Detecting hidden sequence propensity for amyloid fibril formation
2004
Synoretin—A New Protein Belonging to the Synuclein Family
1999
Lipid Rafts Mediate the Synaptic Localization of α-Synuclein
2004
Physiology and Pathophysiology of α‐Synuclein: Cell Culture and Transgenic Animal Models Based on a Parkinson's Disease‐associated Protein
2000
Amino acid determinants of α‐synuclein aggregation: putting together pieces of the puzzle
2002
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
1998 StandoutNatureNobel
Spreading of pathology in neurodegenerative diseases: a focus on human studies
2015
Alpha-synuclein and transgenic mouse models
2004
Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model
2010
Co‐expression of C‐terminal truncated alpha‐synuclein enhances full‐length alpha‐synuclein‐induced pathology
2010
Comparison of Structure and Dynamics of Micelle-bound Human α-Synuclein and Parkinson Disease Variants
2005
Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice
2006
Lipid Droplet Binding and Oligomerization Properties of the Parkinson's Disease Protein α-Synuclein
2002
Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight
2018
A Broken α-Helix in Folded α-Synuclein
2003 StandoutNobel
Structural Principles of Tau and the Paired Helical Filaments of Alzheimer’s Disease
2007
Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease
2002
A Precipitating Role for Truncated α-Synuclein and the Proteasome in α-Synuclein Aggregation
2005
Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation
1990 StandoutNatureNobel
Role of α-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice
2003 StandoutNobel
Association of an Extended Haplotype in the Tau Gene with Progressive Supranuclear Palsy
1999
Development of α-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson’s disease
2007
Constitutive Phosphorylation of the Parkinson's Disease Associated α-Synuclein
2000
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
Cellular Source of Apolipoprotein E4 Determines Neuronal Susceptibility to Excitotoxic Injury in Transgenic Mice
2010
Spin‐Label EPR on α‐Synuclein Reveals Differences in the Membrane Binding Affinity of the Two Antiparallel Helices
2008
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
1995 Standout
Membrane-bound α-Synuclein Has a High Aggregation Propensity and the Ability to Seed the Aggregation of the Cytosolic Form
2002
The E46K Mutation in α-Synuclein Increases Amyloid Fibril Formation
2005
Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice
2004
Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons
1997
Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
1993
Prediction of “Aggregation-prone” and “Aggregation-susceptible” Regions in Proteins Associated with Neurodegenerative Diseases
2005
Distinct Region-Specific α-Synuclein Oligomers in A53T Transgenic Mice: Implications for Neurodegeneration
2010
Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease
1998
Both Familial Parkinson's Disease Mutations Accelerate α-Synuclein Aggregation
1999
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
2000
The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
1998
α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
2005 StandoutNobel
α-Synuclein: Normal Function and Role in Neurodegenerative Diseases
2004
α-Synuclein is phosphorylated in synucleinopathy lesions
2002 Standout
A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly
2001
Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy
2013
Regulation of Tau Pathology by the Microglial Fractalkine Receptor
2010
Tau proteins with FTDP‐17 mutations have a reduced ability to promote microtubule assembly
1998
α-Synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: Lessons from viral transduction of knockout mice
2008
α-Synuclein Populates Both Elongated and Broken Helix States on Small Unilamellar Vesicles
2011
Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
2010
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
2007 StandoutNatureNobel
The cDNA cloning and ontogeny of mouse α-synuclein
1998
Alzheimer's Disease
2010 Standout
Structure and Dynamics of Micelle-bound Human α-Synuclein
2004
Structure of tyrosyl-tRNA synthetase refined at 2.3 Å resolution
1989
Alpha-synuclein and neurodegenerative diseases
2001
Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model
2001
Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes
1998
Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein
2008
α‐Synuclein produces a long‐lasting increase in neurotransmitter release
2004
A Drosophila model of Parkinson's disease
2000 StandoutNature
Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits α-Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions
2010
Phosphorylation of Ser-129 Is the Dominant Pathological Modification of α-Synuclein in Familial and Sporadic Lewy Body Disease
2006
Abnormal Neurites Containing C-Terminally Truncated α-Synuclein Are Present in Alzheimer's Disease without Conventional Lewy Body Pathology
2010
Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
2014
Accelerated Oligomerization by Parkinson's Disease Linked α‐Synuclein Mutants
2000
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER
1993 StandoutNatureNobel
Systematic Mutagenesis of α-Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
2012 StandoutNobel
Conformational properties of α-synuclein in its free and lipid-associated states 1 1Edited by P. E. Wright
2001
Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts
2011
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
α-Synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers
2006
α-Synuclein Is Phosphorylated by Members of the Src Family of Protein-tyrosine Kinases
2001
Linking pathways in the developing and aging brain with neurodegeneration
2014
Glia and alpha-synuclein in neurodegeneration: A complex interaction
2015
A brain-specific activator of cyclin-dependent kinase 5
1994 StandoutNatureNobel
Axonal transport defects: a common theme in neurodegenerative diseases
2005
Transmission and spreading of tauopathy in transgenic mouse brain
2009
Crystallographic study at 2·5 Å resolution of the interaction of methionyl-tRNA synthetase from Escherichia coli with ATP
1990
Tau pathology in Alzheimer disease and other tauopathies
2004
Structural basis of anticodon loop recognition by glutaminyl-tRNA synthetase
1991 StandoutNatureNobel
The role of the C-terminus of human α-synuclein: Intra-disulfide bonds between the C-terminus and other regions stabilize non-fibrillar monomeric isomers
2011
The Formation of Straight and Twisted Filaments from Short Tau Peptides
2004
Ubiquitination of α-Synuclein in Lewy Bodies Is a Pathological Event Not Associated with Impairment of Proteasome Function
2003
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Molecular genetics of Alzheimer’s disease
2000
Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
2000
Cryo-EM structures of tau filaments from Alzheimer’s disease
2017 Nature
Dissection of the structure and activity of the tyrosyl-tRNA synthetase by site-directed mutagenesis
1987
A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides
2008 StandoutNobel
Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract and by Amyloid-β Deposition in APP × Tau Transgenic Mice
2007
Sequence analysis of the complete Caenorhabditis elegans myosin heavy chain gene family
1989
Mutant and Wild Type Human α-Synucleins Assemble into Elongated Filaments with Distinct Morphologies in Vitro
1999
Parkinson's Disease
2003 Standout
The molecular pathology of Alzheimer's disease
1991 Standout
A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer’s Disease
2008
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
2000 StandoutNature
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
2003
The aminoacyl-tRNA synthetase-tRNA complex: Detection by differential labelling of lysine residues involved in complex formation
1978
Construction of heterodimer tyrosyl-tRNA synthetase shows tRNATyr interacts with both subunits.
1986 StandoutNobel
Cloning and Amplified Expression of the Tyrosyl-tRNA Synthetase Genes of Bacillus stearothermophilus and Escherichia coli
1982
The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.
1992
Purification and properties of alanine tRNA synthetase from Escherichia coli A tetramer of identical subunits.
1981
β-Synuclein Inhibits α-Synuclein Aggregation
2001
Osp/Claudin-11 Forms a Complex with a Novel Member of the Tetraspanin Super Family and β1 Integrin and Regulates Proliferation and Migration of Oligodendrocytes
2001
Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin
1998 Standout
APOLIPOPROTEIN E ALLELES AS RISK FACTORS IN ALZHEIMER'S DISEASE
1996
Neutron scattering studies of Escherichia coli tyrosyl-tRNA synthetase and of its interaction with tRNATyr
1982
γ‐Synuclein and the progression of cancer
2007
Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.
1992
Neurodegenerative Tauopathies
2001 Standout
Determination and analysis of the primary structure of the nerve terminal specific phosphoprotein, synapsin I.
1986
The Amino Acid Sequence of the Tyrosy1-tRNA Synthetase from Bacillus stearothermophilus
1983 StandoutNobel
Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia
2009
The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
1995
β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
2001
Neurons Expressing the Highest Levels of γ-Synuclein Are Unaffected by Targeted Inactivation of the Gene
2003
Hyperphosphorylation and insolubility of α‐synuclein in transgenic mouse oligodendrocytes
2002
β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2
2000
Demonstration of two active sites on a monomeric aminoacyl-tRNA synthetase. Possible roles of negative cooperativity and half-of-the-sites reactivity in oligomeric enzymes
1975
Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.
2000
Electrostatic and hydrophobic interactions of synapsin I and synapsin I fragments with phospholipid bilayers.
1989
Specificity and Regulation of Casein Kinase-Mediated Phosphorylation of α-Synuclein
2008
A Century of Alzheimer's Disease
2006 StandoutScience
Expression of Human Apolipoprotein E3 or E4 in the Brains ofApoe−/−Mice: Isoform-Specific Effects on Neurodegeneration
1999
Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders
2000 Science
Anti‐tau antibody reduces insoluble tau and decreases brain atrophy
2015
Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding
1982 StandoutNatureNobel
Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation
1997 Standout
Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.
1996
Sequence similarities among the family of aminoacyl-tRNA synthetases
1986
Assembly of τ protein into Alzheimer paired helical filaments depends on a local sequence motif ( 306 VQIVYK 311 ) forming β structure
2000
Sequence analysis of phosphoserine‐containing peptides
1986
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels
1991 StandoutScienceNobel
Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure.
1994
Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.
1995
A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau
1991 Science
Experimental evidence for kinetic proofreading in the aminoacylation of tRNA by synthetase.
1977 StandoutNobel
Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro.
1992
Deletion mutagenesis using an ‘M13 splint’: the N-terminal structural domain of tyrosyl-tRNA synthetase (B. stearothermophilus) catalyses the formation of tyrosyl adenylate.
1983 StandoutNobel
A Topological Model of the Interaction between α-Synuclein and Sodium Dodecyl Sulfate Micelles
2004
Characterization of Hydrophobic Residue Requirements for α-Synuclein Fibrillization
2009
Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements
1999
Interactions of synapsin I with small synaptic vesicles: distinct sites in synapsin I bind to vesicle phospholipids and vesicle proteins.
1989
Double-knockout mice for α- and β-synucleins: Effect on synaptic functions
2004 StandoutNobel
Glycobiology: Toward Understanding the Function of Sugars
1996 Standout
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
1998 Nobel
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP
2001 Science
Binding of Neuroligins to PSD-95
1997 StandoutScienceNobel
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
2013
Conserved cysteine and histidine residues in the structures of the tyrosyl and methionyl‐tRNA synthetases
1982 StandoutNobel
Alpha-synuclein: between synaptic function and dysfunction.
2003
Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway
2003
Structure-activity relationships of methionyl-tRNA synthetase: graphics modelling and genetic engineering
1987
Structural homology in the amino-terminal domains of two aminoacyl-tRNA synthetases
1983
Primary Structure of a Large Aminoacyl-tRNA Synthetase
1981 Science
A nucleated assembly mechanism of Alzheimer paired helical filaments
1998
A suppressor mutation in the nematode acting on specific alleles of many genes
1978 StandoutNatureNobel
Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease
2006
Zeroing in on the Pathogenic Form of α-Synuclein and Its Mechanism of Neurotoxicity in Parkinson's Disease
2003
Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro
1994 Science
Rapid Assembly of Alzheimer-like Paired Helical Filaments from Microtubule-Associated Protein Tau Monitored by Fluorescence in Solution
1998
Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS
1990 StandoutScienceNobel
The crystal structure of tyrosyl-transfer RNA synthetase at 2.7 Å resolution
1976
Cysteinyl-tRNA synthetase from Escherichia coli does not need an editing mechanism to reject serine and alanine. High binding energy of small groups in specific molecular interactions
1979
Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein
1994
The 3D profile method for identifying fibril-forming segments of proteins
2006 StandoutNobel
Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.
1993
Persyn, a Member of the Synuclein Family, Has a Distinct Pattern of Expression in the Developing Nervous System
1998
Effects of apolipoprotein E (apoE) isoforms, β-amyloid (Aβ) and apoE/Aβ complexes on Protein Kinase C-α (PKC-α) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts
2001
α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
2002
Crystal structure of Escherichia coli methionyl-tRNA synthetase at 2.5 Å resolution
1982
Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders.
1998
Replacing the complementarity-determining regions in a human antibody with those from a mouse
1986 StandoutNatureNobel
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease
2003
Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant α-Synuclein in Human and Transgenic Mouse Brain
2000
Characterization of synapsin I fragments produced by cysteine-specific cleavage: a study of their interactions with F-actin.
1989
Synapsins: Mosaics of Shared and Individual Domains in a Family of Synaptic Vesicle Phosphoproteins
1989 StandoutScienceNobel
Acanthamoeba profilin interacts with G-actin to increase the rate of exchange of actin-bound adenosine 5'-triphosphate
1980
Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein
2002
Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA Gln and ATP at 2.8 Å Resolution
1989 StandoutScienceNobel
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
1998
Evidence for Dispensable Sequences Inserted into a Nucleotide Fold
1987 Science
The Impact of the E46K Mutation on the Properties of α-Synuclein in Its Monomeric and Oligomeric States
2007
A large increase in enzyme–substrate affinity by protein engineering
1984 StandoutNatureNobel
Hydrogen bonding and biological specificity analysed by protein engineering
1985 StandoutNatureNobel
Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons
2000
Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering.
1985 StandoutNobel
Prediction of Nucleating Sequences from Amyloidogenic Propensities of Tau-Related Peptides
2006
Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.
1999
Site-directed mutagenesis as a probe of enzyme structure and catalysis: tyrosyl-tRNA synthetase cysteine-35 to glycine-35 mutation
1983 StandoutNobel
O-GlcNAc Modification Protects against Protein Misfolding and Aggregation in Neurodegenerative Disease
2019
α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins
1999
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.
1987 Standout
Amino acid activation in crystalline tyrosyl-tRNA synthetase from Bacillus stearothermophilus
1981
Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice
2016
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
1992
Binding of tyrosine, adenosine triphosphate and analogues to crystalline tyrosyl transfer RNA synthetase
1978
Fibrils Formed in Vitro from α-Synuclein and Two Mutant Forms Linked to Parkinson's Disease are Typical Amyloid
2000
Works of Ross Jakes being referenced
The amino acid sequence of profilin from calf spleen
1979
α-Synuclein Binds to Tau and Stimulates the Protein Kinase A-catalyzed Tau Phosphorylation of Serine Residues 262 and 356
1999
Biophysical Properties of the Synucleins and Their Propensities to Fibrillate
2002
Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease
1994
Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205
1995
Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau
1995
Hypothesis: Microtubule Instability and Paired Helical Filament Formation in the Alzheimer Disease Brain Are Related to Apolipoprotein E Genotype
1994
TauGene Mutation K257T Causes a Tauopathy Similar to Pick's Disease
2000
Epitope mapping of LB509, a monoclonal antibody directed against human α-synuclein
1999
Characterization of mAb AP422, a novel phosphorylation‐dependent monoclonal antibody against tau protein
1996
A panel of epitope-specific antibodies detects protein domains distributed throughout human ?-synuclein in lewy bodies of Parkinson's disease
2000
Molecular dissection of the paired helical filament
1995
Identification of two distinct synucleins from human brain
1994
Early‐onset Dementia with Lewy Bodies
2004
Cingulin, a new peripheral component of tight junctions
1988 Nature
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease
1989 Standout
Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding
1993
Assembly of Alzheimer‐like filaments from full‐length tau protein
1994
Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of α‐synuclein protein implicated in Parkinson's disease
1998
Localization of the Alz-50 epitope in recombinant human microtubule-associated protein tau
1991
Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein
2000
Protein Phosphatase 2A Is the Major Enzyme in Brain that Dephosphorylates τ Protein Phosphorylated by Proline‐Directed Protein Kinases or Cyclic AMP‐Dependent Protein Kinase
1995
Phosphorylation of microtubule‐associated protein tau by stress‐activated protein kinases
1997
Synthetic filaments assembled from C‐terminally truncated α‐synuclein
1998
Binding of α-Synuclein to Brain Vesicles Is Abolished by Familial Parkinson's Disease Mutation
1998
Aggregates from mutant and wild‐type α‐synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β‐sheet and amyloid‐like filaments
1998
Alzheimer-like Changes in Microtubule-associated Protein Tau Induced by Sulfated Glycosaminoglycans
1997
p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A1 Implications for Alzheimer's disease
1992
Staging of Cytoskeletal and β-Amyloid Changes in Human Isocortex Reveals Biphasic Synaptic Protein Response during Progression of Alzheimer’s Disease
2000
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
1996 Nature
The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease
1992
Mutation E46K increases phospholipid binding and assembly into filaments of human α‐synuclein
2004
Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
1998
Intraneuronal filamentous tau protein and α-synuclein deposits in neurodegenerative diseases
1998
Sequence Determinants for Amyloid Fibrillogenesis of Human α-Synuclein
2007
Reduced Binding of Protein Phosphatase 2A to Tau Protein with Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 Mutations
2000
Demonstration of two reaction pathways for the aminoacylation of tRNA. Application of the pulsed quenched flow technique
1975
Tyrosyl-tRNA synthetase from Escherichia coli. Stoichiometry of ligand binding and half-of-the-sites reactivity in aminoacylation
1975
Localisation of light chain and actin binding sites on myosin
1986
Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein
2002
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.
1988 StandoutNobel
Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease.
1991
Phosphorylation site sequence of smooth muscle myosin light chain (Mr = 20 000)
1984
α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies
1998 Standout
Binding of Aβ to α- and β-synucleins: identification of segments in α-synuclein/NAC precursor that bind Aβ and NAC
1997
AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease
1996
Mutations causing neurodegenerative tauopathies
2004
Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform.
1995
Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation
2000
Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease.
1990
Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51.
1991 Nobel
Active site titration and aminoacyl adenylate binding stoichiometry of aminoacyl-tRNA synthetases
1975
Mapping the cysteine residues and actin-binding regions of villin by using antisera to the amino and carboxyl termini of the molecule.
1985
From genetics to pathology: tau and a–synuclein assemblies in neurodegenerative diseases
2001
PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhabditis elegans
1996
Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356
1996
Gram‐Scale Purification of Methionyl‐tRNA and Tyrosyl‐tRNA Synthetases from Escherichia coli
1975
The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.
1993
The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bɛ at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase
2001
Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization.
1990
Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.
1994
Methionyl-tRNA synthetase from Escherichia coli. Primary structure of the active crystallised tryptic fragment.
1982
Effects of frontotemporal dementia FTDP‐17 mutations on heparin‐induced assembly of tau filaments
1999
Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease.
1990
Repeated sequences in methionyl‐tRNA synthetase from E. coli
1974
Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein
1994
Methionyl‐tRNA Synthetase from Escherichia coli
1982
A gelsolin-like Ca2+-dependent actin-binding domain in villin
1985 StandoutNatureNobel