Citation Impact
Citing Papers
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Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation.
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2003
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1996
Mechanism Targeted Discovery of Antitumor Marine Natural Products
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1994
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1998
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Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
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1996
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Widely Applicable Pd‐Catalyzed trans‐Selective Monoalkylation of Unactivated 1,1‐Dichloro‐1‐alkenes and Pd‐Catalyzed Second Substitution for the Selective Synthesis of E or Z Trisubstituted Alkenes
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Protein folding in the cell
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From the Sea to Anticancer Therapy
2011
The Catalytic Asymmetric Abramov Reaction
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Cell Wall Active Antifungal Compounds Produced by the Marine Fungus Hypoxylon oceanicum LL-15G256. II. Isolation and Structure Determination.
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Characterization of the Interaction of TZT‐1027, a Potent Antitumor Agent, with Tubulin
2000
High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis
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2011
Stereoselective Synthesis of the Side Chains of Mycolactones A and B Featuring Stepwise Double Substitutions of 1,1‐Dibromo‐1‐alkenes
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Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
1992 StandoutNature
The Biosynthetic Gene Cluster for the Antitumor Rebeccamycin
2002
Catalytic Asymmetric Hydroperoxidation of α,β‐Unsaturated Ketones: An Approach to Enantiopure Peroxyhemiketals, Epoxides, and Aldols
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Microtubules as a target for anticancer drugs
2004 Standout
Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides
2003
Synthesis of Heterocyclic Terpenoids by Promiscuous Squalene–Hopene Cyclases
2013
Towards High‐Performance Lewis Acid Organocatalysis
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A mammalian protein targeted by G1-arresting rapamycin–receptor complex
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Biogenetic Diversity of Cyanobacterial Metabolites
2007
Natural‐Product Diversity of the New Caledonian Marine Ecosystem Compared to Other Ecosystems: A Pharmacologically Oriented View
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A 20-year retrospective review of global aquaculture
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Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives
2006
Sterols from the Caribbean sponge Neofibularia nolitangere. Isolation of two novel polyhydroxysteroids
1995
Structure and Biosynthesis of the Jamaicamides, New Mixed Polyketide-Peptide Neurotoxins from the Marine Cyanobacterium Lyngbya majuscula
2004
Marine natural product drug discovery: Leads for treatment of inflammation, cancer, infections, and neurological disorders
2010
Cytotoxic and antioxidant marine prenylated quinones and hydroquinones
2012
Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones
2000
Can a Ketone Be More Reactive than an Aldehyde? Catalytic Asymmetric Synthesis of Substituted Tetrahydrofurans
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Taveuniamides: new chlorinated toxins from a mixed assemblage of marine cyanobacteria
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Clavatadines C−E, Guanidine Alkaloids from the Australian Sponge Suberea clavata
2009
Lasonolide A: Structural Revision and Synthesis of the Unnatural (−)-Enantiomer
2001
New Structures and Bioactivity Properties of Jasplakinolide (Jaspamide) Analogues from Marine Sponges
2010
Structurally diverse new alkaloids from Palauan collections of the apratoxin-producing marine cyanobacterium Lyngbya sp.
2002
First Enantiospecific Synthesis of the Antitumor Marine Sponge Metabolite (−)-15-Oxopuupehenol from (−)-Sclareol
2005
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2012
Bioactive steroidal glycosides from the marine sponge Erylus lendenfeldi
2005
A chirally catalysed ene reaction in a novel formal total synthesis of the antitumor agent laulimalide
2002
Three new glycolipids from a Red Sea sponge of the genus Erylus
1996
Total Synthesis of the Potent Microtubule-Stabilizing Agent (+)-Discodermolide
2003
Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
2004
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
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2011
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Structural Insights into Microtubule Function
2000
Structural Insights into Microtubule Function
2001
Isolation and Structure Determination of Obyanamide, a Novel Cytotoxic Cyclic Depsipeptide from the Marine Cyanobacterium Lyngbya confervoides
2001
Three New Peroxides from the Sponge Plakinastrella Species
2001
Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines.
2000
Bioactive compounds in seaweed: functional food applications and legislation
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Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs.
2002
Metabolites from the Marine-Derived Fungus Chromocleista sp. Isolated from a Deep-Water Sediment Sample Collected in the Gulf of Mexico
2006
Two New C22 1,2-Dioxane Polyketides from the Marine Sponge Acarnus cf. bergquistae
1998
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
2000
Grenadadiene and Grenadamide, Cyclopropyl-Containing Fatty Acid Metabolites from the Marine Cyanobacterium Lyngbya majuscula
1998
Evolution of a Gram-Scale Synthesis of (+)-Discodermolide
2000
BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy.
2001
Neopeltolide, a Macrolide from a Lithistid Sponge of the Family Neopeltidae
2007
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2010
Widely Applicable Pd‐Catalyzed trans‐Selective Monoalkylation of Unactivated 1,1‐Dichloro‐1‐alkenes and Pd‐Catalyzed Second Substitution for the Selective Synthesis of E or Z Trisubstituted Alkenes
2005 StandoutNobel
Stereoselective Synthesis of the C1−C13 Fragment of (+)-Discodermolide Using Asymmetric Allyltitanations
2003
A Selective Account of Effective Paradigms and Significant Outcomes in the Discovery of Inspirational Marine Natural Products
2009
Extremely Active Organocatalysts Enable a Highly Enantioselective Addition of Allyltrimethylsilane to Aldehydes
2016 StandoutNobel
Mechanisms of Action of and Resistance to Antitubulin Agents: Microtubule Dynamics, Drug Transport, and Cell Death
1999
Molluscicidal Metabolites from an Assemblage of Palmyra Atoll Cyanobacteria
2011
Highly Stereo- and Regioselective Synthesis of (Z)-Trisubstituted Alkenes via 1-Bromo-1-alkyne Hydroboration−Migratory Insertion−Zn-Promoted Iodinolysis and Pd-Catalyzed Organozinc Cross-Coupling
2007 StandoutNobel
Crotylsilane Reagents in the Synthesis of Complex Polyketide Natural Products: Total Synthesis of (+)-Discodermolide
2005
Utilizing the Power of Microbial Genetics to Bridge the Gap Between the Promise and the Application of Marine Natural Products
2005
Total Synthesis of (+)-Discodermolide: An Improved Endgame Exploiting a Still−Gennari-Type Olefination with a C1−C8 β-Ketophosphonate Fragment
2004
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2010 StandoutNobel
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2012 Standout
Development and Applications of Disulfonimides in Enantioselective Organocatalysis
2015 StandoutNobel
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2008
Enantioselective Synthesis of the R-Enantiomer of the Feeding Deterrent (S)-Ypaoamide
2009
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
1991 StandoutScience
Total Synthesis of (−)-Discodermolide: An Application of a Chelation-Controlled Alkylation Reaction
1997
A Practical Improvement, Enhancing the Large-Scale Synthesis of (+)-Discodermolide: A Third-Generation Approach
2003
Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei
2012
Gram-Scale Synthesis of (+)-Discodermolide
1999
Late activation of apoptotic pathways plays a negligible role in mediating the cytotoxic effects of discodermolide and epothilone B in non-small cell lung cancer cells.
2002
Isolation and structure of the cancer cell growth inhibitor dictyostatin 1
1994
Biologically active Phytophthora mating hormone prepared by catalytic asymmetric total synthesis
2008 StandoutNobel
Enzyme Inhibitors from Marine Invertebrates
2007
Isolation and Structures of Erylosides from the Carribean Sponge Erylus goffrilleri
2007
Total Synthesis of (+)-Lasonolide A
2006
Micromide and Guamamide: Cytotoxic Alkaloids from a Species of the Marine CyanobacteriumSymploca
2003
Total Synthesis and Antiproliferative Activity Screening of (±)-Aplicyanins A, B and E and Related Analogues
2009
The role of 1,3-dithianes in natural product synthesis
2003
Chemoenzymatic Synthesis of the C10−C23 Segment of Dictyostatin
2006
Antineoplastic Agents. 542. Isolation and Structure of Sesterstatin 6 from the Indian Ocean Sponge Hyrtios erecta
2005
Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones
2000
Asymmetric Synthesis of 1,2-Dioxolane-3-acetic Acids: Synthesis and Configurational Assignment of Plakinic Acid A
2006
Diastereoselective Allylation of Carbonyl Compounds and Imines: Application to the Synthesis of Natural Products
2013 Standout
Stereoselective preparation of trisubstituted (Z)-alkenes; synthesis of the C17–C27 fragment of (−)-laulimalide
2005
Total Synthesis of Immunosuppressants: Unified Strategies Exploiting Dithiane Couplings and σ-Bond Olefin Constructions
1998
Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands
1991 Science
Bioactive Sesterterpenes and Triterpenes from Marine Sponges: Occurrence and Pharmacological Significance
2010
Three new oxylipins related to 3,6-dioxo-4-docosenoic acid from Okinawan marine sponges, Plakortis spp
1995
First total synthesis of theopederin B
2009
The Cinchona Primary Amine-Catalyzed Asymmetric Epoxidation and Hydroperoxidation of α,β-Unsaturated Carbonyl Compounds with Hydrogen Peroxide
2013 StandoutNobel
Total synthesis of the marine natural product (+)-discodermolide in multigram quantities
2007
Confined Acid-Catalyzed Asymmetric Carbonyl–Ene Cyclization
2015 StandoutNobel
A Second-Generation Total Synthesis of (+)-Discodermolide: The Development of a Practical Route Using Solely Substrate-Based Stereocontrol
2004
Didemnimides A−D: Novel, Predator-Deterrent Alkaloids from the Caribbean Mangrove Ascidian Didemnum conchyliatum
1997
Disulfonimide-Catalyzed Asymmetric Synthesis of β3-Amino Esters Directly from N-Boc-Amino Sulfones
2013 StandoutNobel
Chiral Allenes via Alkynylogous Mukaiyama Aldol Reaction
2016 StandoutNobel
Alkaloids from Marine Ascidians
2011
Cytotoxic Pyrroloiminoquinones from Four New Species of South African Latrunculid Sponges
2004
Copper-Catalyzed Enantioselective Synthesis of trans-1-Alkyl-2-substituted Cyclopropanes via Tandem Conjugate Addition−Intramolecular Enolate Trapping
2010 StandoutNobel
Staurosporine Derivatives from the Ascidian Eudistoma toealensis and Its Predatory Flatworm Pseudoceros sp.
1999
Isolation and structure of halistatin 3 from the Western Pacific (Chuuk) marine sponge Phakellia sp
1995
A short synthesis of staurosporinone (K-252c)
2003
Microtubule-Stabilizing Activity of Zampanolide, a Potent Macrolide Isolated from the Tongan Marine Sponge Cacospongia mycofijiensis
2009
Systems biology of cyanobacterial secondary metabolite production and its role in drug discovery
2008
Three New Cyclic Peroxides from the Marine Sponge Plakortis aff simplex
2003
Deracemizing α‐Branched Carboxylic Acids by Catalytic Asymmetric Protonation of Bis‐Silyl Ketene Acetals with Water or Methanol
2019 StandoutNobel
PRIM: Proximity imaging of green fluorescent protein-tagged polypeptides
1998 StandoutNobel
Further New Staurosporine Derivatives from the Ascidian Eudistoma toealensis and Its Predatory Flatworm Pseudoceros sp.
2002
Photoinduced Electron Transfer in a Triad That Can Be Assembled/Disassembled by Two Different External Inputs. Toward Molecular-Level Electrical Extension Cables
2002 StandoutNobel
Carmabins A and B, New Lipopeptides from the Caribbean Cyanobacterium Lyngbya majuscula
1998
Nitrated Confined Imidodiphosphates Enable a Catalytic Asymmetric Oxa-Pictet–Spengler Reaction
2016 StandoutNobel
Microsclerodermins C - E, antifungal cyclic peptides from the lithistid marine sponges Theonella sp. and Microscleroderma sp.
1998
Cytotoxic β-Carbolines and Cyclic Peroxides from the Palauan Sponge Plakortis nigra
2002
Catalytic Asymmetric Protonation of Silyl Ketene Imines
2013 StandoutNobel
Total Synthesis of (+)-Discodermolide
1998
Aromatic Cyclic Peroxides and Related Keto-Compounds from the Plakortis sp. Component of a Sponge Consortium
2009
Kinase Inhibitors from Marine Sponges
2011
Asymmetric Enamine Catalysis
2007 StandoutNobel
Antimalarial Linear Lipopeptides from a Panamanian Strain of the Marine Cyanobacterium Lyngbya majuscula
2007
Novel pyrroloquinoline ribosides from the South African latrunculid sponge Strongylodesma aliwaliensis
2004
Receptor-Induced Conformation Change of the Immunosuppressant Cyclosporin A
1991 StandoutScienceNobel
Aciculitins A−C: Cytotoxic and Antifungal Cyclic Peptides from the Lithistid Sponge Aciculites orientalis
1996
Structure elucidation of 21,22-dihydroxyonnamides A1–A4 from the marine sponge Theonella swinhoei: an empirical rule to assign the relative stereochemistry of linear 1,5-diols
2008
Works of Ross E. Longley being referenced
Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin
2003
Immunosuppressive Compounds from a Deep Water Marine Sponge, Agelas flabelliformis
1989
New Cytotoxic Peroxylactones from the Marine Sponge, Plakinastrella onkodes
1994
Microcolins A and B, New Immunosuppressive Peptides from the Blue-Green Alga Lyngbya majuscula
1992
Antiproliferative and immunosuppressive properties of microcolin A, a marine-derived lipopeptide
1997
Evaluation of Marine Sponge Metabolites for Cytotoxicity and Signal Transduction Activity
1993
A rapid colorimetric microassay to detect agonists/antagonists of protein kinase C based on adherence of EL-4.IL-2 cells.
1991
Isometachromin, a new cytotoxic sesquiterpenoid from a deep water sponge of the family Spongiidae
1992
DISCODERMOLIDE—A NEW, MARINE-DERIVED IMMUNOSUPPRESSIVE COMPOUND
1991
DISCODERMOLIDE—A NEW, MARINE-DERIVED IMMUNOSUPPRESSIVE COMPOUND
1991
Sesquiterpene-Derived Metabolites from the Deep Water Marine Sponge Poecillastra sollasi
1993
Analogs of the Marine Immunosuppressant Microcolin A: Preparation and Biological Activity
1994
Induction of apoptosis in mouse thymocytes by microcolin A and its synthetic analog
1999
Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian,Eudistoma sp
1994
The Microtubule-Stabilizing Agent Discodermolide Competitively Inhibits the Binding of Paclitaxel (Taxol) to Tubulin Polymers, Enhances Tubulin Nucleation Reactions More Potently than Paclitaxel, and Inhibits the Growth of Paclitaxel-Resistant Cells
1997
Immunosuppression by Discodermolide
1993
Tubercidin, A Cytotoxic Agent from the Marine Sponge Caulospongia biflabellata
2002
Lasonolide A, A New Cytotoxic Macrolide from the Marine Sponge Forcepia sp.
1994
Secobatzellines A and B, Two New Enzyme Inhibitors from a Deep-Water Caribbean Sponge of the Genus Batzella
1999
Lasonolides C−G, Five New Lasonolide Compounds from the Sponge Forcepia sp.
2004
Five New Discodermolide Analogues from the Marine SpongeDiscodermiaSpecies
2002
Agglutinins from marine macroalgae of the southeastern United States
1993
Eryloside E from an atlantic sponge Erylus goffrilleri
1994
A New Cytotoxic Sterol Methoxymethyl Ether from a Deep Water Marine Sponge Scleritoderma sp. cf. paccardi
1996
Two New Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea
2005
Semisynthetic Analogues of the Microtubule-Stabilizing Agent Discodermolide: Preparation and Biological Activity
2002
Theopederins K and L. Highly Potent Cytotoxic Metabolites from a Marine Sponge Discodermia Species
2001
Plakolide A, a New γ-Lactone from the Marine Sponge Plakortis sp.
2003
Acetylated Analogues of the Microtubule-Stabilizing Agent Discodermolide: Preparation and Biological Activity
2001
Discorhabdin P, a New Enzyme Inhibitor from a Deep-Water Caribbean Sponge of the Genus Batzella
1998
Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta
1990
Discodermolide, A Cytotoxic Marine Agent That Stabilizes Microtubules More Potently Than Taxol,
1996
Discorhabdins S, T, and U, New Cytotoxic Pyrroloiminoquinones from a Deep-Water Caribbean Sponge of the Genus Batzella
2003
6-Hydroxydiscodermindole, A New Discodermindole from the Marine SpongeDiscodermia polydiscus
2004