Citation Impact
Citing Papers
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
2003 Standout
Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
2010 StandoutScience
TOR Signaling in Growth and Metabolism
2006 Standout
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer
2015 Standout
Mutational landscape and significance across 12 major cancer types
2013 StandoutNature
EGFR Antagonists in Cancer Treatment
2008 Standout
Targeting the mTOR signaling network in cancer
2007
Endometrial Carcinomas
2011
DNA methylation in endometrial cancer
2010
Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity
1999
Neonatal estrogenic exposure suppresses PTEN-related endometrial carcinogenesis in recombinant mice
2006 StandoutNobel
Hallmarks of aging: An expanding universe
2023 Standout
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
2014 StandoutNature
HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression
2005 StandoutNobel
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
2002 StandoutNature
Inactivation of the PTEN tumor suppressor gene is associated with increased angiogenesis in clinically localized prostate carcinoma
1999
The Hallmarks of Cancer
2000 Standout
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
1998 StandoutNobel
Phosphoinositide 3-Kinase-mediated Activation of Cofilin Phosphatase Slingshot and Its Role for Insulin-induced Membrane Protrusion
2004 StandoutNobel
PTEN: One Gene, Many Syndromes
2003
Endometrial cancer: experimental models useful for studies on molecular aspects of endometrial cancer and carcinogenesis.
2003
Assessment of the quality and frequency of mutations occurrence in PTEN gene in endometrial carcinomas and hyperplasias
2002
Macrophage Diversity Enhances Tumor Progression and Metastasis
2010 Standout
PTEN loss in the continuum of common cancers, rare syndromes and mouse models
2011
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
2001 StandoutNobel
The role of PTEN signaling perturbations in cancer and in targeted therapy
2008
PTEN expression in non–small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration
2005
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
The effect Akt2 deletion on tumor development in Pten+/− mice
2011
PTEN mutations and evolving concepts in endometrial neoplasia
2002
Integrated genomic characterization of endometrial carcinoma
2013 StandoutNature
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Heritability and molecular genetic studies of endometriosis
2000
Malignant Gliomas in Adults
2008 Standout
β-Arrestin1 Mediates Insulin-like Growth Factor 1 (IGF-1) Activation of Phosphatidylinositol 3-Kinase (PI3K) and Anti-apoptosis
2003 StandoutNobel
Fecal microbiota transplantation from young donor mice improves ovarian function in aged mice
2022
PTEN: Life as a Tumor Suppressor
2001
Trophic macrophages in development and disease
2009
Genetic basis of Cowden syndrome and its implications for clinical practice and risk management
2016
DNA Mismatch Repair Deficiency Accelerates Endometrial Tumorigenesis in Pten Heterozygous Mice
2002
Mutations of the human PTEN gene
2000
PTEN Deletion and Concomitant c-Myc Activation Do Not Lead to Tumor Formation in Pancreatic β Cells
2008 StandoutNobel
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
2005 StandoutNature
The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway
1998 StandoutNobel
MicroRNA signatures in human cancers
2006 Standout
Loss of a small region around the PTEN locus is a major chromosome 10 alteration in prostate cancer xenografts and cell lines
2003
Inactivation of thePTEN/MMAC1/TEP1 gene in human lung cancers
1998
Endometriosis
2004 Standout
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015 StandoutNature
AKT/PKB Signaling: Navigating the Network
2017 Standout
Protein Tyrosine Phosphatases in the Human Genome
2004 Standout
Idiopathic pulmonary fibrosis
2011 Standout
Use of mutation profiles to refine the classification of endometrial carcinomas
2012
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
The PI3K Pathway in Human Disease
2017 Standout
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice
2007 StandoutNobel
Sirolimus for Kaposi's Sarcoma in Renal-Transplant Recipients
2005 Standout
T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
2001 StandoutNobel
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
1999 Standout
Interaction of the Tumor Suppressor PTEN/MMAC with a PDZ Domain of MAGI3, a Novel Membrane-associated Guanylate Kinase
2000 Standout
Protein tyrosine phosphatases
2002
Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer.
1998
Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.
1999
AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation
1999
The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway
2004
Critical Roles of Pten in B Cell Homeostasis and Immunoglobulin Class Switch Recombination
2003 StandoutNobel
Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer
2003 Standout
Integrin Signaling
1999 StandoutScience
Germline PTEN mutations in Cowden syndrome-like families.
1998
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
1998
Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues.
1998
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems
1999
Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary.
2000
Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN
2000
A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.
1998 Standout
PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics.
1998
Genetics of Cowden syndrome: through the looking glass of oncology.
1998
HIF-1 and human disease: one highly involved factor
2000 StandoutNobel
Regulation of G1progression by thePTENtumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
1999
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
1999
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
The Pten/PI3K pathway governs the homeostasis of Vα14iNKT cells
2006 StandoutNobel
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice.
2000 StandoutNobel
Molecular and Pathologic Aspects of Endometrial Carcinogenesis
2006
Works of Rongde Wu being referenced
Macrophage contributions to ovarian function
2004
Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.
1997