Citation Impact
Citing Papers
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2002
Skeletal and CNS Defects in Presenilin-1-Deficient Mice
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Endoproteolytic Cleavage and Proteasomal Degradation of Presenilin 2 in Transfected Cells
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Notch Receptors, Partners and Regulators: From Conserved Domains to Powerful Functions
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Modeling familial Alzheimer's disease with induced pluripotent stem cells
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Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain
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Novel Class of Polytopic Proteins with Domains Associated with Putative Protease Activity
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Atomic structures of amyloid cross-β spines reveal varied steric zippers
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Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins
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Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical Neurons
2000
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Molecular Dissection of Domains in Mutant Presenilin 2 That Mediate Overproduction of Amyloidogenic Forms of Amyloid β Peptides
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An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos
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Subcellular Localization of Presenilins: Association with a Unique Membrane Pool in Cultured Cells
2000
The Endosomal-Lysosomal System of Neurons in Alzheimer's Disease Pathogenesis: A Review
2000
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics
2001
A New Pathogenic Mutation in the APP Gene (I716V) Increases the Relative Proportion of A 42(43)
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Autophagy and neurodegeneration: when the cleaning crew goes on strike
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γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?
2002
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2009
Observation of metastable Aβ amyloid protofibrils by atomic force microscopy
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Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response
1999
Subcellular Distribution and Turnover of Presenilins in Transfected Cells
1998
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1
2004
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production
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The Cerebral β-Amyloid Angiopathies: Hereditary and Sporadic
2006
Presenilin-1 Regulates Intracellular Trafficking and Cell Surface Delivery of β-Amyloid Precursor Protein
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The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
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A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor
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Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors
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2000
Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice
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Etazolate, a neuroprotective drug linking GABAA receptor pharmacology to amyloid precursor protein processing
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Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons
1998
The role of Aβ42 in Alzheimer's disease
1998
Persistent Amyloidosis following Suppression of Aβ Production in a Transgenic Model of Alzheimer Disease
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Presenilins: Genes for Life and Death
1997
Comparison of Aβ levels in the brain of familial and sporadic Alzheimer's disease
2009
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
2006 Standout
APP Processing and Synaptic Function
2003
Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin
1997
Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein
1998
Intraneuronal Aβ42 Accumulation in Human Brain
2000
Stable Association of Presenilin Derivatives and Absence of Presenilin Interactions with APP
1998
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
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Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation
2012
Increased Aβ42(43) from cell lines expressing presenilin 1 mutations
1998
Distinct cerebrospinal fluid amyloid β peptide signatures in sporadic and PSEN1A431E-associated familial Alzheimer's disease
2010
Retromer disruption promotes amyloidogenic APP processing
2011
The Amyloid State of Proteins in Human Diseases
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Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca2+ stabilization
2001
Familial Danish Dementia
2005
Multiple Effects of Aspartate Mutant Presenilin 1 on the Processing and Trafficking of Amyloid Precursor Protein
2001
Non-fibrillar oligomeric species of the amyloid ABri peptide, implicated in familial British dementia, are more potent at inducing apoptotic cell death than protofibrils or mature fibrils11Edited by J. Karn
2001
Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins
1997
Eph receptors and ephrins in cancer: bidirectional signalling and beyond
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Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
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The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex
1998
Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm
1997 Nature
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
1998
Evidence for a Six-transmembrane Domain Structure of Presenilin 1
1997
Mutant Human Presenilin 1 Protects presenilin 1 Null Mouse against Embryonic Lethality and Elevates Aβ1–42/43 Expression
1998
Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis
2006
Amyloid, the presenilins and Alzheimer's disease
1997
Cell Cycle Activation Linked to Neuronal Cell Death Initiated by DNA Damage
2004
Single-cell transcriptomic analysis of Alzheimer’s disease
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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
1999 StandoutNature
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Molecular Mechanisms of Amyloidosis
2003 Standout
Protein Topology of Presenilin 1
1996
Expression of Alzheimer’s Disease-associated Presenilin-1 Is Controlled by Proteolytic Degradation and Complex Formation
1998
Aβ40 Inhibits Amyloid DepositionIn Vivo
2007
The molecular pathology of Alzheimer's disease
1991 Standout
Increased App Expression in a Mouse Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron Degeneration
2006 Standout
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
1999 StandoutNature
The role of presenilin cofactors in the γ-secretase complex
2003 Nature
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
2001
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Loss‐of‐function presenilin mutations in Alzheimer disease
2007
When loss is gain: reduced presenilin proteolytic function leads to increased Aβ42/Aβ40
2007
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
Age-Related Impairment of Synaptic Transmission But Normal Long-Term Potentiation in Transgenic Mice that Overexpress the Human APP695SWE Mutant Form of Amyloid Precursor Protein
2001
Light and Electron Microscopic Localization of Presenilin-1 in Primate Brain
1997
Intramembrane proteolysis by presenilin and presenilin-like proteases
2003
Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model
2008 StandoutNobel
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Alzheimer's disease: a re-examination of the amyloid hypothesis
1998
The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism
2006
MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS
1998
A Century of Alzheimer's Disease
2006 StandoutScience
An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease
1997 Nature
Accelerated A Deposition in APPswe/PS1 E9 Mice with Hemizygous Deletions of TTR (Transthyretin)
2007
Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees
2000 Science
Structure-Based Design of Functional Amyloid Materials
2014 StandoutNobel
Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel- 12 and hop- 1 in Notch-pathway signaling
1999
Exploring the Etiology of Alzheimer Disease Using Molecular Genetics
1997
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
1997
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Evidence That Synaptically Released β-Amyloid Accumulates as Extracellular Deposits in the Hippocampus of Transgenic Mice
2002
Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease
2005 Science
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo
2001
Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP
2001 Science
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease
2010
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
Small Molecule Microarrays Enable the Discovery of Compounds That Bind the Alzheimer’s Aβ Peptide and Reduce its Cytotoxicity
2010
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate
2013 StandoutNobel
Genetics and pathology of alpha-secretase site AβPP mutations in the understanding of Alzheimer's disease
2006
Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes
2003 StandoutScience
Designed amyloid fibers as materials for selective carbon dioxide capture
2013 StandoutNobel
Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons
1999
A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle
2010 StandoutNobel
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Disruption of Corticocortical Connections Ameliorates Amyloid Burden in Terminal Fields in a Transgenic Model of Aβ Amyloidosis
2002
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
2010
ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models
1998
Notch Signaling: Cell Fate Control and Signal Integration in Development
1999 StandoutScience
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease
1997
Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans
1998
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
2003 StandoutScience
Characterization of New Polyclonal Antibodies Specific for 40 and 42 Amino Acid-Long Amyloid β Peptides: Their Use to Examine the Cell Biology of Presenilins and the Immunohistochemistry of Sporadic Alzheimer’s Disease and Cerebral Amyloid Angiopathy Cases
1997
The Alzheimer family of diseases: Many etiologies, one pathogenesis?
1997
Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
1999
Works of Rong Wang being referenced
Ligand Binding and Calcium Influx Induce Distinct Ectodomain/γ-Secretase-processing Pathways of EphB2 Receptor
2007
Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40
2006
Dense-Core Senile Plaques in the Flemish Variant of Alzheimer's Disease Are Vasocentric
2002
Familial Alzheimer Disease-linked Presenilin 1 Variants Enhance Production of Both Aβ1–40 and Aβ1–42 Peptides That Are Only Partially Sensitive to a Potent Aspartyl Protease Transition State Inhibitor of “γ-Secretase”
2003
Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia
1999
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
1996
Quantification of Alzheimer Amyloid β Peptides Ending at Residues 40 and 42 by Novel ELISA Systems
2000
Caloric restriction attenuates β‐amyloid neuropathology in a mouse model of Alzheimer's disease
2005