Standout Papers
Citation Impact
Citing Papers
The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.
1994 Standout
iPLA2β: front and center in human monocyte chemotaxis to MCP-1
2008
Alternative Splicing Increases the Diversity of the Human Protein Kinase C Family
1987
Increased group II phospholipase A2 in colonic mucosa of patients with Crohn's disease and ulcerative colitis.
1994
Diabetes-Induced Oxidative Stress Is Mediated by Ca2+-Independent Phospholipase A2 in Neutrophils
2010
Requirement of JNK-Mediated Phosphorylation for Translocation of Group IVA Phospholipase A2 to Phagosomes in Human Macrophages
2009
Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions
2008
Localizing the Membrane Binding Region of Group VIA Ca2+-independent Phospholipase A2 Using Peptide Amide Hydrogen/Deuterium Exchange Mass Spectrometry
2009
Attenuated Free Cholesterol Loading-induced Apoptosis but Preserved Phospholipid Composition of Peritoneal Macrophages from Mice That Do Not Express Group VIA Phospholipase A2
2007
Ceramide 1-Phosphate Is Required for the Translocation of Group IVA Cytosolic Phospholipase A2 and Prostaglandin Synthesis
2009
Group V Secretory Phospholipase A2 Translocates to the Phagosome after Zymosan Stimulation of Mouse Peritoneal Macrophages and Regulates Phagocytosis
2006
Role of Phosphorylation and Basic Residues in the Catalytic Domain of Cytosolic Phospholipase A2α in Regulating Interfacial Kinetics and Binding and Cellular Function
2009
Function, Activity, and Membrane Targeting of Cytosolic Phospholipase A2ζ in Mouse Lung Fibroblasts
2007
Serine 727 Phosphorylation and Activation of Cytosolic Phospholipase A2 by MNK1-related Protein Kinases
2000
Role of Group V Phospholipase A2 in Zymosan-induced Eicosanoid Generation and Vascular Permeability Revealed by Targeted Gene Disruption
2004
The Genomic Organization, Complete mRNA Sequence, Cloning, and Expression of a Novel Human Intracellular Membrane-associated Calcium-independent Phospholipase A2
2000
Synaptic transmission persists in synaptotagmin mutants of Drosophila
1993
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate
1993
Molecular Cloning, Characterization, and Chromosomal Localization of FKBP23, a Novel FK506-Binding Protein with Ca2+-Binding Ability
1998
A Phospholipid Substrate Molecule Residing in the Membrane Surface Mediates Opening of the Lid Region in Group IVA Cytosolic Phospholipase A2
2008
Phospholipase A2 subclasses in acute respiratory distress syndrome
2009
The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release
1998
Human Pancreatic Islets Express mRNA Species Encoding Two Distinct Catalytically Active Isoforms of Group VI Phospholipase A2 (iPLA2) That Arise from an Exon-skipping Mechanism of Alternative Splicing of the Transcript from the iPLA2 Gene on Chromosome 22q13.1
1999
The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains
1988 StandoutScience
Inhibition of calcium-independent phospholipase A2 activity in rat hippocampus impairs acquisition of short- and long-term memory
2005
Plasma Platelet-activating Factor Acetylhydrolase Is a Secreted Phospholipase A2 with a Catalytic Triad
1995
Molecular Cloning of Two New Human Paralogs of 85-kDa Cytosolic Phospholipase A2
1999
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Proteins regulating Ras and its relatives
1993 StandoutNature
Phospholipase A2 activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease
2008
The role of cytosolic phospholipase A2-alfa in regulation of phagocytic functions
2006
Induction of group VIA phospholipase A2activity during in vitro ischemia in C2C12 myotubes is associated with changes in the level of its splice variants
2007
Highly Selective Hydrolysis of Fatty Acyl-CoAs by Calcium-independent Phospholipase A2β
2006
Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin
1993 StandoutNatureNobel
Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2
2001
Phospholipase A2 structure/function, mechanism, and signaling
2008
Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2
2000
Immunochemical identification of protein kinase C isozymes as products of discrete genes
1987
Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts
1997 Standout
Cytosolic Phospholipase A2 and Lysophospholipids in Tumor Angiogenesis
2010
Identification of Essential Residues for the Catalytic Function of 85-kDa Cytosolic Phospholipase A2
1996
Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis
2000 StandoutNature
Biaryl diacid inhibitors of human s-PLA2 with anti-inflammatory activity
2000
Phospholipase A2 expression in tumours: a target for therapeutic intervention?
2003
Group VIA Phospholipase A2 Forms a Signaling Complex with the Calcium/Calmodulin-dependent Protein Kinase IIβ Expressed in Pancreatic Islet β-Cells
2004
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
1988 StandoutNature
Interfacial activation, lysophospholipase and transacylase activity of Group VI Ca2+-independent phospholipase A2
1998
The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
1990 Standout
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
A Novel Intracellular Membrane-Bound Calcium-Independent Phospholipase A2
2000
Characterization of the human patatin-like phospholipase family
2006
Role of Group VIA Calcium-independent Phospholipase A2 in Arachidonic Acid Release, Phospholipid Fatty Acid Incorporation, and Apoptosis in U937 Cells Responding to Hydrogen Peroxide
2004
Desnutrin, an Adipocyte Gene Encoding a Novel Patatin Domain-containing Protein, Is Induced by Fasting and Glucocorticoids
2004
Cloning of cDNAs coding for the heavy chain region and connecting region of human factor V, a blood coagulation factor with four types of internal repeats
1987
The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors
1991
Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism
1988
A pyrrolidine-based specific inhibitor of cytosolic phospholipase A2α blocks arachidonic acid release in a variety of mammalian cells
2001
decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo
1992
Sequence similarity of phospholipase C with the non-catalytic region of src
1988 Nature
Ceramide 1-Phosphate Is a Direct Activator of Cytosolic Phospholipase A2
2004
Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts
1988
Ceramide 1-Phosphate Acts as a Positive Allosteric Activator of Group IVA Cytosolic Phospholipase A2α and Enhances the Interaction of the Enzyme with Phosphatidylcholine
2005
The ABC's of Group IV cytosolic phospholipase A2
2004
Mechanism of Regulation of Group IVA Phospholipase A2 Activity by Ser727 Phosphorylation
2007
Group V Phospholipase A2 Induces Leukotriene Biosynthesis in Human Neutrophils through the Activation of Group IVA Phospholipase A2
2002
The molecular basis of blood coagulation
1988 Standout
Identification of the Phosphorylation Sites of Cytosolic Phospholipase A2 in Agonist-stimulated Human Platelets and HeLa Cells
1998
Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2.
1997
Identification of Novel Cytosolic Phospholipase A2s, Murine cPLA2δ, ϵ, and ζ, Which Form a Gene Cluster with cPLA2β
2005
Inhibition of Ca2+‐independent phospholipase A2 by bromoenol lactone attenuates prostaglandin generation induced by interleukin‐1β and dibutyryl cAMP in rat mesangial cells
1998
Expression of human group II PLA2 in transgenic mice results in epidermal hyperplasia in the absence of inflammatory infiltrate.
1996
Identification of three additional members of rat protein kinase C family: gd‐, ϵ‐ and ξ‐subspecies
1987
ESDN, a Novel Neuropilin-like Membrane Protein Cloned from Vascular Cells with the Longest Secretory Signal Sequence among Eukaryotes, Is Up-regulated after Vascular Injury
2001 StandoutNobel
Functional Interaction of Calcium-/Calmodulin-dependent Protein Kinase II and Cytosolic Phospholipase A2
2001
The emerging role of group VI calcium-independent phospholipase A2 in releasing docosahexaenoic acid from brain phospholipids
2008
Roles for cytosolic phospholipase A2α as revealed by gene-targeted mice
2002
Crystal Structure of Human Cytosolic Phospholipase A2 Reveals a Novel Topology and Catalytic Mechanism
1999
Eicosanoid generation from antigen‐primed mast cells by extracellular mammalian 14‐kDa group II phospholipase A2
1991
Similarity between phospholipase C and the regulatory domain of protein kinase C
1989
Transgenic Expression of Group V, but Not Group X, Secreted Phospholipase A2 in Mice Leads to Neonatal Lethality because of Lung Dysfunction
2006
Synaptotagmin and neurotransmitter release
1993
Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
1993 StandoutNatureNobel
The effect on synaptic physiology of synaptotagmin mutations in drosophila
1994
Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis
1993 Nature
DANCE, a Novel Secreted RGD Protein Expressed in Developing, Atherosclerotic, and Balloon-injured Arteries
1999 StandoutNobel
Identification of Calcium-independent Phospholipase A2 (iPLA2) β, and Not iPLA2γ, as the Mediator of Arginine Vasopressin-induced Arachidonic Acid Release in A-10 Smooth Muscle Cells
2002
Calcium-Independent Activation of Hypothalamic Type I Protein Kinase C by Unsaturated Fatty Acids
1988
Synaptotagmin–Syntaxin Interaction: The C2 Domain as a Ca2+-Dependent Electrostatic Switch
1997 StandoutNobel
Characterization of an ATP-stimulatable calcium2+ independent phospholipase A2 from clonal insulin-secreting HIT cells and rat pancreatic islets: a possible molecular component of the .beta.-cell fuel sensor
1994
Cytosolic Phospholipase A2α Is Targeted to the p47 -PX Domain of the Assembled NADPH Oxidase via a Novel Binding Site in Its C2 Domain
2008
Phospholipase A2 Biochemistry
2008
The human calcium‐independent phospholipase A2 gene
1999
SNAP receptors implicated in vesicle targeting and fusion
1993 StandoutNatureNobel
Calcium‐independent phospholipase A2 mediates proliferation of human promonocytic U937 cells
2008
A monoclonal antibody recognising the site of limited proteolysis of protein kinase C
1988
Evolution of the transforming growth factor-beta superfamily
1994
The discoidin domain family revisited: New members from prokaryotes and a homology‐based fold prediction
1998
Biochemical properties and pathophysiological roles of cytosolic phospholipase A2s
2006
Inherited human cPLA2α deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction
2008
Storage and release of neurotransmitters
1993
Mutation in blood coagulation factor V associated with resistance to activated protein C
1994 StandoutNature
Essential Requirement of Cytosolic Phospholipase A2for Activation of the Phagocyte NADPH Oxidase
1998
Synaptotagmin I functions as a calcium regulator of release probability
2001 StandoutNatureNobel
Collectins: pattern recognition molecules involved in first line host defense
1993
Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling
2002
Modified hippocampal long-term potentiation in PKCγ-mutant mice
1993 Nobel
Differential expression of multiple protein kinase C subspecies in rat central nervous tissue
1987
Identity between the Ca2+-independent Phospholipase A2 Enzymes from P388D1 Macrophages and Chinese Hamster Ovary Cells
1997
Metal ion and salt effects on the phospholipase A2, lysophospholipase, and transacylase activities of human cytosolic phospholipase A2
1993
C2-domains, Structure and Function of a Universal Ca2+-binding Domain
1998 StandoutNobel
Expression ofmyc-family,myc-interacting, andmyc-target genes during preimplantation mouse development
1997
Multiple Splice Variants of the Human Calcium-independent Phospholipase A2 and Their Effect on Enzyme Activity
1998
The phospholipase A2 superfamily and its group numbering system
2006 Standout
Essential Ca2+-independent Role of the Group IVA Cytosolic Phospholipase A2 C2 Domain for Interfacial Activity
2003
Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins
1995 StandoutNatureNobel
Group VIA Ca2+-independent phospholipase A2 (iPLA2β) and its role in β-cell programmed cell death
2010
Identification of the Calmodulin-binding Domain of Recombinant Calcium-independent Phospholipase A2β
2001
[27] The signal sequence trap method
1999 StandoutNobel
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C
1990 Nature
Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms
2007
Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2
1998
Ceramide-1-phosphate Binds Group IVA Cytosolic Phospholipase a2 via a Novel Site in the C2 Domain
2007
Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors––reducing the lipophilicity of the arachidonyl chain isostere
2004
Localization of the gene encoding human Factor V to chromosome 1q21–25
1988
Properties of the Group IV phospholipase A2 family
2006
Fibulin-5/DANCE is essential for elastogenesis in vivo
2002 StandoutNatureNobel
Structure of the gene for human coagulation factor V
1992
Stem Cell-derived Neural Stem/Progenitor Cell Supporting Factor Is an Autocrine/Paracrine Survival Factor for Adult Neural Stem/Progenitor Cells
2003 StandoutNobel
Calcium Binding Rigidifies the C2 Domain and the Intradomain Interaction of GIVA Phospholipase A2 as Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry
2008
Calcium-independent phospholipase A2: structure and function
2000
Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2
1993
Expression, Purification, and Kinetic Characterization of a Recombinant 80-kDa Intracellular Calcium-independent Phospholipase A2
1996
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold
1995 StandoutNobel
Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides
1991
Activation of human factor V by factor Xa and thrombin
1990
SPXX, a frequent sequence motif in gene regulatory proteins
1989
Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2
1997 Nature
Purified Group X Secretory Phospholipase A2 Induced Prominent Release of Arachidonic Acid from Human Myeloid Leukemia Cells
1999
Cloning of a Gene for a Novel Epithelium-specific Cytosolic Phospholipase A2, cPLA2δ, Induced in Psoriatic Skin
2004
Modulation of phospholipase A2 activity in primary cultures of rat cortical neurons
2005
The Highly Selective Production of 2-Arachidonoyl Lysophosphatidylcholine Catalyzed by Purified Calcium-independent Phospholipase A2γ
2005
Distinct Roles of Two Intracellular Phospholipase A2s in Fatty Acid Release in the Cell Death Pathway
2000
Human Neuropathy Target Esterase Catalyzes Hydrolysis of Membrane Lipids
2002
Fas-induced Arachidonic Acid Release Is Mediated by Ca2+-independent Phospholipase A2 but Not Cytosolic Phospholipase A2, Which Undergoes Proteolytic Inactivation
1998
Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate
1996
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
1993 StandoutNatureNobel
Group IV Cytosolic Phospholipase A2 Binds with High Affinity and Specificity to Phosphatidylinositol 4,5-Bisphosphate Resulting in Dramatic Increases in Activity
1998
Groups IV, V, and X Phospholipases A2s in Human Neutrophils
2002
A Novel Function for the Second C2 Domain of Synaptotagmin
1996
Regulation of Lysophospholipase Activity of the 85-kDa Phospholipase A2 and Activation in Mouse Peritoneal Macrophages
1995
A pivotal role of cytosolic phospholipase A2 in bleomycin-induced pulmonary fibrosis
2002
Male Mice That Do Not Express Group VIA Phospholipase A2 Produce Spermatozoa with Impaired Motility and Have Greatly Reduced Fertility
2004
Roles of Catalytic Domain Residues in Interfacial Binding and Activation of Group IV Cytosolic Phospholipase A2
2002
The expanding superfamily of phospholipase A2 enzymes: classification and characterization
2000 Standout
Insulin Secretory Responses and Phospholipid Composition of Pancreatic Islets from Mice That Do Not Express Group VIA Phospholipase A2 and Effects of Metabolic Stress on Glucose Homeostasis
2006
Identification of the Expressed Form of Human Cytosolic Phospholipase A2β (cPLA2β)
2006
Human Calcium-independent Phospholipase A2 Mediates Lymphocyte Proliferation
2000
Skepinone-L, a Novel Potent and Highly Selective Inhibitor of p38 MAP Kinase, Effectively Impairs Platelet Activation and Thrombus Formation
2013 Standout
Phospholipase A2inhibitors as potential therapeutic agents for the treatment of inflammatory diseases
2009
Suppression of inflammatory responses to 12‐O‐tetradecanoylphorbol‐13‐acetate and carrageenin by YM‐26734, a selective inhibitor of extracellular group II phospholipase A2
1993
Function and Inhibition of Intracellular Calcium-independent Phospholipase A2
1997
Nucleotide sequences of cDNAs for α and γ subspecies of rat brain protein kinase C
1988
Identification, Cloning, Expression, and Purification of Three Novel Human Calcium-independent Phospholipase A2 Family Members Possessing Triacylglycerol Lipase and Acylglycerol Transacylase Activities
2004
Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11
1995 StandoutNatureNobel
Benzhydrylquinazolinediones: Novel cytosolic phospholipase A2α inhibitors with improved physicochemical properties
2009
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis
1989 StandoutNatureNobel
iPLA2 inhibitor blocks negative inotropic effect of HIV gp120 on cardiac myocytes
2005
Localization and function of cytosolic phospholipase A2α at the Golgi
2010
JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2β
2001
Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA
1988
Mechanism of Group IVA Cytosolic Phospholipase A2 Activation by Phosphorylation
2003
Calcium-independent phospholipase A2 and apoptosis
2006
Primary structures of human protein kinase C βI and βII differ only in their C‐terminal sequences
1987
Phospholipase A2 enzymes
2002
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
The heterogeneity of protein kinase C in various rat tissues
1988
Synaptic Vesicles and Exocytosis
1994
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Cytosolic phospholipase A2 gene in human and rat: chromosomal localization and polymorphic markers
1995
Role of cytosolic phospholipase A2 in allergic response and parturition
1997 Nature
The common structure and activities of four subspecies of rat brain protein kinase C family
1987
cPLA2 is phosphorylated and activated by MAP kinase
1993 Standout
Ceramide-1-phosphate: The "missing" link in eicosanoid biosynthesis and inflammation
2005
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
Inhibition of Cytosolic Phospholipase A2 by Annexin V in Differentiated Permeabilized HL-60 Cells
1997
Calcium-independent phospholipase A2modulates cytosolic oxidant activity and contractile function in murine skeletal muscle cells
2005
Identification of Phosphorylation Sites of Human 85-kDa Cytosolic Phospholipase A2 Expressed in Insect Cells and Present in Human Monocytes
1996
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis
2006 StandoutNatureNobel
Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A 2 1 1Edited by J. Karn
1998
The patatin-like lipase family in Gallus gallus
2008
Patterning in the vertebrate limb
1991
Phospholipase A 2 in Eicosanoid Generation
2000
Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain
1987 Science
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
1991 StandoutScience
High Cooperativity, Specificity, and Multiplicity in the Protein Kinase C-Lipid Interaction
1989
Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain.
1987
Cytosolic Phospholipase A2α–deficient Mice Are Resistant to Collagen-induced Arthritis
2003
The complete cDNA sequence of bovine coagulation factor V.
1992
Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders
1988
Location of the Membrane-Docking Face on the Ca2+-Activated C2 Domain of Cytosolic Phospholipase A2
1998
Purification and characterization of three types of protein kinase C from rabbit brain cytosol.
1987
Immunochemical evidence that three protein kinase C isozymes increase in abundance during HL-60 differentiation induced by dimethyl sulfoxide and retinoic acid.
1988
Three distinct forms of rat brain protein kinase C: Differential response to unsaturated fatty acids
1987
Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure.
1991
Cytosolic Phospholipase A2-α Mediates Endothelial Cell Proliferation and Is Inactivated by Association with the Golgi Apparatus
2005
Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.
1989
Structural determinants of the action against Escherichia coli of a human inflammatory fluid phospholipase A2 in concert with polymorphonuclear leukocytes
1994
Macrophage colony stimulating factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase A2.
1992
A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice
2003
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Expression and properties of two distinct classes of the phorbol ester receptor family, four conventional protein kinase C types, and a novel protein kinase C.
1990
Activated Ketones as Inhibitors of Intracellular Ca2+-Dependent and Ca2+-Independent Phospholipase A2
1996
Molecular Genetic Analysis of the Regulatory and Catalytic Domains of Protein Kinase C
1989
Recombinant human bone morphogenetic protein induces bone formation.
1990 Standout
A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family
1988
Cytoplasmic Phospholipase A2 Deletion Enhances Colon Tumorigenesis
2005
Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family.
1987
Identification of a novel transforming growth factor-beta (TGF-beta 5) mRNA in Xenopus laevis.
1990
Characterization of protein kinase C from normal and transformed cultured murine fibroblasts
1987
Down-regulation of protein kinase C is due to an increased rate of degradation
1987
Calcium-independent Phospholipases in the Heart: Mediators of Cellular Signaling, Bioenergetics, and Ischemia-induced Electrophysiologic Dysfunction
2009
An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo
1993
Cloning and expression of rat lung acidic Ca2+-independent PLA2and its organ distribution
1998
Rhodopsin/transducin interactions. II. Influence of the transducin-beta gamma subunit complex on the coupling of the transducin-alpha subunit to rhodopsin.
1992
Two functionally different domains of rabphilin-3A, Rab3A p25/smg p25A-binding and phospholipid- and Ca(2+)-binding domains.
1993
Dynamin I is a Ca(2+)-sensitive phospholipid-binding protein with very high affinity for protein kinase C.
1994 StandoutNobel
A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin.
1990
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
A Bromoenol Lactone Suicide Substrate Inactivates Group VIA Phospholipase A2 by Generating a Diffiusible Bromomethyl Keto Acid That Alkylates Cysteine Thiols
2005
Characterization of a novel inhibitor of cytosolic phospholipase A2α, pyrrophenone
2002
Effects of Biological Oxidants on the Catalytic Activity and Structure of Group VIA Phospholipase A2
2006
Dicarboxylic acid inhibitors of phospholipase A2
1997
Postnatal development of a brain-specific subspecies of protein kinase C in rat
1988
Phosphorylation of the EGF receptor from A431 epidermoid carcinoma cells by three distinct types of protein kinase C
1987
Protein kinase C group B members PKC-δ, -ɛ, -ζ and PKC-L(η). Comparison of properties of recombinant proteins in vitro and in vivo
1992
Monoclonal antibodies against rat brain protein kinase C and their application to immunocytochemistry in nervous tissues
1987
Cell type-specific expression of protein kinase C isozymes in the rabbit cerebellum.
1988
Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2.
1994
Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cells.
1991
Expression, purification, and characterization of protein kinase C-epsilon.
1990
Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones
1992 Science
Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.
1990
Bipartite Ca 2+ -Binding Motif in C 2 Domains of Synaptotagmin and Protein Kinase C
1996 StandoutScienceNobel
Mutations in a Protein Kinase C Homolog Confer Phorbol Ester Resistance on Caenorhabditis elegans
1989 Science
The Crystal Structure, Mutagenesis, and Activity Studies Reveal that Patatin Is a Lipid Acyl Hydrolase with a Ser-Asp Catalytic Dyad
2003
Calcium-independent phospholipases in the heart: mediators of cellular signaling, bioenergetics, and ischemia-induced electrophysiologic dysfunction.
2009
Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family.
1987
Location of Inhibitors Bound to Group IVA Phospholipase A2 Determined by Molecular Dynamics and Deuterium Exchange Mass Spectrometry
2009
GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines.
1993
A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.
1991 StandoutNobel
Unique targeting of cytosolic phospholipase A2 to plasma membranes mediated by the NADPH oxidase in phagocytes
2003
A novel laminin‐induced lysophosphatidic acid autocrine loop in the migration of ovarian cancer cells
2003
Differential Inhibition of Group IVA and Group VIA Phospholipases A2by 2-Oxoamides
2006
Bone morphogenetic protein expression in human atherosclerotic lesions.
1993
Golgi-associated cPLA2α Regulates Endothelial Cell–Cell Junction Integrity by Controlling the Trafficking of Transmembrane Junction Proteins
2009
Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart.
1991
Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.
1989
A third synaptotagmin gene, Syt3, in the mouse.
1994
Potent and Selective Fluoroketone Inhibitors of Group VIA Calcium-Independent Phospholipase A2
2010
MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily
1997 Standout
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling
2005
The structure, expression, and properties of additional members of the protein kinase C family.
1988
Interleukin-1 alpha induces the accumulation of cytosolic phospholipase A2 and the release of prostaglandin E2 in human fibroblasts.
1992
Inhibition of calcium-independent phospholipase A2 suppresses proliferation and tumorigenicity of ovarian carcinoma cells
2007
Diversity of group types, regulation, and function of phospholipase A2.
1994 Standout
Skeletal Muscle Group VIA Phospholipase A2 (iPLA2β): Expression and Role in Fatty Acid Oxidation
2008
Protein kinase C activity appears to be required for the synthesis of platelet-activating factor and leukotriene B4 by human neutrophils.
1987
Identification of the structures of multiple subspecies of protein kinase C expressed in rat brain
1987
Differential distribution of protein kinase C isozymes in the various regions of brain.
1987
Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain.
1994
Protein Sorting by Transport Vesicles
1996 StandoutScienceNobel
Characterization of an interaction between protein C and ceruloplasmin.
1990
A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.
1993 StandoutNobel
Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets.
1994
Identification of the binding site for activated protein C on the light chain of factors V and VIII.
1990
Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface
1992 StandoutScienceNobel
Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid.
1992
Netrin-G1: a Novel Glycosyl Phosphatidylinositol-Linked Mammalian Netrin That Is Functionally Divergent from Classical Netrins
2000 StandoutNobel
Association of cPLA2-α and COX-1 with the Golgi apparatus of A549 human lung epithelial cells
2003
Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.
1987
Distinct patterns of expression of different protein kinase C mRNAs in rat tissues
1987
Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases.
1987
Distribution of protein kinase C-like immunoreactive neurons in rat brain
1988
Role of Phosphorylation Sites and the C2 Domain in Regulation of Cytosolic Phospholipase A2
1999
The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-rafcarrying retrovirus
1987
Renal concentrating defect in mice lacking group IV cytosolic phospholipase A2
2001
Lipid activation of protein kinase C.
1991
Inhibition of Cytosolic Phospholipase A2α: Hit to Lead Optimization
2005
A thousand and one protein kinases
1987
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Calcium-dependent activation of protein kinase C. The role of the C2 domain in divalent cation selectivity.
1993
Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene.
1987
Interfacial Catalysis by Human 85 kDa Cytosolic Phospholipase A2 on Anionic Vesicles in the Scooting Mode
1997
Isolation and sequencing of cDNA clones encoding alpha and beta subunits of Drosophila melanogaster casein kinase II.
1987
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
2011 Standout
Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.
1993
A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.
1992
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.
1992
Determination of Cell Adhesion Sites of Neuropilin-1
2000
Identification and distribution of endoplasmic reticulum iPLA2
2004
Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase
1991
Structure−Activity Relationship of 2-Oxoamide Inhibition of Group IVA Cytosolic Phospholipase A2and Group V Secreted Phospholipase A2
2007
REGULATION AND INHIBITION OF PHOSPHOLIPASE A2
1999
Expression and Properties of Two Types of Protein Kinase C: Alternative Splicing from a Single Gene
1987 Science
Deduced primary structure of the beta subunit of brain type II Ca2+/calmodulin-dependent protein kinase determined by molecular cloning.
1987
Group II PLA(2) content of tears in normal subjects.
2001
Morphogen gradient interpretation
2001 StandoutNatureNobel
A single form of protein kinase C is expressed in bovine adrenocortical tissue, as compared to four chromatographically resolved isozymes in rat brain
1987
Role of cytosolic phospholipase A2 in the production of lipid mediators and histamine release in mouse bone-marrow-derived mast cells
2000
Works of Ronald Kriz being referenced
A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP
1991 Standout
A genetic selection for isolating cDNAs encoding secreted proteins
1997
Phospholipase C Isozymes: Structural and Functional Similarities
2007
A Novel Cytosolic Calcium-independent Phospholipase A2 Contains Eight Ankyrin Motifs
1997
A Novel Calcium-independent Phospholipase A2, cPLA2-γ, That Is Prenylated and Contains Homology to cPLA2
1998
[26] A genetic selection for isolating cDNA clones that encode signal peptides
1999
Molecular Characterization of Cytosolic Phospholipase A2-β
1999
Isolation of a cDNA clone encoding a high molecular weight precursor to a 6-kDa pulmonary surfactant-associated protein.
1987
Complete cDNA and derived amino acid sequence of human factor V.
1987
Novel Regulators of Bone Formation: Molecular Clones and Activities
1988 StandoutScience
Cloning and expression of multiple protein kinase C cDNAs
1986
Structure and expression of the murine L-myc gene.
1987
Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein.
1986
Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones.
1986
Myc family of cellular oncogenes
1987
Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain.
1994