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Citing Papers
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
2006 StandoutNobel
Differential Distribution of Angiotensin AT2 Receptors in the Normal and Failing Human Heart
1998
Characterization of biochemical responses of angiotensin II (AT2) binding sites in the rat pheochromocytoma PC12W cells
1992
Angiotensin II AT2 receptor stimulation increases cerebrovascular resistance during hemorrhagic hypotension in rats
1994
G Protein-coupled Receptor Kinase and β-Arrestin-mediated Desensitization of the Angiotensin II Type 1A Receptor Elucidated by Diacylglycerol Dynamics
2006 StandoutNobel
Pharmacology of nootropics and metabolically active compounds in relation to their use in dementia
1990
Abdominal obesity and metabolic syndrome
2006 StandoutNature
Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?
2002
Pharmacological characterization of angiotensin II binding sites in the canine pancreas
1992
Independent β-Arrestin2 and Gq/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor
2009 StandoutNobel
β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation
2002 StandoutNobel
Angiotensin II receptor subtypes play opposite roles in regulating phosphatidylinositol hydrolysis in rat skin slices
1992
Myometrial angiotensin II receptor subtypes change during ovine pregnancy.
1993
Heterogeneous expression of angiotensin II AT1 receptors in neointima of rat carotid artery and aorta after balloon catheter injury
1994
The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure
1996 Standout
Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis
2008 Standout
The Failing Heart — An Engine Out of Fuel
2007 Standout
Assessment of dietary vitamin D requirements during pregnancy and lactation
2004
Angiotensin II Receptor Pharmacology
1994
Prevalence and severity of disordered mineral metabolism in Blacks with chronic kidney disease
2008
Identification and characterization of a new binding site for angiotensin II in mouse neuroblastoma neuro-2A cells
1992
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
1995 StandoutNatureNobel
β-Arrestin 1 and Gαq/11 Coordinately Activate RhoA and Stress Fiber Formation following Receptor Stimulation
2004 StandoutNobel
The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.
1996
Changes in skin angiotensin II receptors in rats during wound healing
1992
The development of positive inotropic agents for chronic heart failure: How have we gone astray?
1993
Radioiodinated CGP 42111A: A novel high affinity and highly selective ligand for the characterization of angiotensin AT2 receptors
1991
Vitamin D Deficiency
2007 Standout
Angiotensin II induces TIMP-1 production in rat heart endothelial cells
1996
Changes in expression of angiotensin receptor subtypes in the rat aorta during development
1991
Brain angiotensin receptor subtypes AT1, AT2, and AT4 and their functions
1995
Subtype 2 of angiotensin II receptors controls pressure-natriuresis in rats.
1995
Phosphodiesterase inhibitory profile of some related xanthine derivatives pharmacologically active on the peripheral microcirculation
1994
Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway
1999 StandoutNobel
Anagrelide: A potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity
1988
Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes.
1997 StandoutNobel
Effect of Oral Milrinone on Mortality in Severe Chronic Heart Failure
1991 Standout
Biochemical Properties of the Ovarian Granulosa Cell Type 2-Angiotensin II Receptor*
1991
VITAMIN D IN HEALTH AND DISEASE: Vitamin D for Health and in Chronic Kidney Disease
2005
Angiotensin-II Receptor Subtypes and Coupling to Signaling Systems in Cultured Fetal Fibroblasts
1991
Expression of angiotensin II AT2 receptors in the rat skin during experimental wound healing
1992
Expression of Angiotensin Type-1 (AT1) and Type-2 (AT2) Receptor mRNAs in the Adult Rat Brain: A Functional Neuroanatomical Review
1997
Animal Models of Heart Failure Recent Developments and Perspectives
1997
Angiotensin II AT2 receptors do not interact with guanine nucleotide binding proteins
1991
Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C
1996 StandoutNobel
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
2005 StandoutNobel
Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains
1996 Standout
Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes.
1997 StandoutNobel
Vasopeptidase Inhibition with Omapatrilat Improves Cardiac Geometry and Survival in Cardiomyopathic Hamsters More Than Does ACE Inhibition with Captopril
1999
Modulation of net outward current in cultured neurons by angiotensin II: involvement of AT1 and AT2 receptors
1992
Nitric oxide in skeletal muscle
1994 Nature
Cloning of the cDNA and the genomic DNA of the mouse angiotensin II type 2 receptor
1994
Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease
2004 Standout
The effect of SK&F 95654, a novel phosphodiesterase inhibitor, on cardiovascular, respiratory and platelet function
1992
Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome
1992 StandoutNobel
Catalyst‐Free N‐Arylation Using Unactivated Fluorobenzenes
2012
Bemoradan—a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue
1991
Effect of phosphodiesterase inhibitors on survival of patients with chronic congestive heart failure
1989
Role of controlled cardiac reoxygenation in reducing nitric oxide production and cardiac oxidant damage in cyanotic infantile hearts.
1994 StandoutNobel
Sarcoplasmic reticulum-associated cyclic adenosine 5'-monophosphate phosphodiesterase activity in normal and failing human hearts.
1991
Important roles for angiotensin III and IV in the brain renin-angiotensin system
1997
Enoximone
1991
The structure of neuropeptide receptors
1992
Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure
2014 Standout
Caveolar Localization Dictates Physiologic Signaling of β2-Adrenoceptors in Neonatal Cardiac Myocytes
2002 StandoutNobel
The angiotensin hexapeptide 3–8 fragment potently inhibits [125I]angiotensin II binding to non-AT1 or -AT2 recognition sites in bovine adrenal cortex
1992
Losartan-sensitive AII Receptors Linked to Depolarization- dependent Cortisol Secretion through a Novel Signaling Pathway
1995
Angiotensin receptor subtypes in rat, rabbit and monkey tissues: Relative distribution and species dependency
1991
Homeostasis in Mice with Genetically Decreased Angiotensinogen Is Primarily by an Increased Number of Renin-producing Cells
1999 StandoutNobel
Regulated expression of angiotensin II (AT2) binding sites in R3T3 cells
1993
Role of angiotensin II receptor subtypes on the regulation of aldosterone secretion in the adrenal glomerulosa zone in the rat
1992
β1-Adrenergic Receptor Association with PSD-95
2000 StandoutNobel
Subclasses of cyclic AMP phosphodiesterase in cardiac muscle
1987
Inhibition of Spontaneous β2-Adrenergic Activation Rescues β1-Adrenergic Contractile Response in Cardiomyocytes Overexpressing β2-Adrenoceptor
2000 StandoutNobel
Balloon angioplasty enhances the expression of angiotensin II AT1 receptors in neointima of rat aorta.
1992
The Isoenzyme Selectivity of AH 21–132 as an Inhibitor of Cyclic Nucleotide Phosphodiesterase Activity
1991
Brain angiotensin receptor subtypes in the control of physiological and behavioral responses
1994
Cyclic guanosine 3',5'‐monophosphate regulates the calcium current in single cells from frog ventricle.
1987
Linkage of β1-adrenergic stimulation to apoptotic heart cell death through protein kinase A–independent activation of Ca2+/calmodulin kinase II
2003 StandoutNobel
Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory
1998 StandoutNobel
A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.
1994 StandoutNobel
The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP.
1989
Angiotensin II binding sites in the rat fetus: characterization of receptor subtypes and interaction with guanyl nucleotides
1993
Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
1998 StandoutNobel
Compartmentation of cAMP in adult canine ventricular myocytes. Relation to single-cell free Ca2+ transients.
1991
Molecular structure and transcriptional function of the rat vascular AT1a angiotensin receptor gene.
1993
Inotropic responses to isoproterenol and phosphodiesterase inhibitors in intact guinea pig hearts: comparison of cyclic AMP levels and phosphorylation of sarcoplasmic reticulum and myofibrillar proteins.
1989
Human AT1 receptor is a single copy gene: Characterization in a stable cell line
1994
Cotransfection of Second and Third Intracellular Loop Fragments Inhibit Angiotensin AT1a Receptor Activation of Phospholipase C in HEK-293 Cells
1998
Studies of controlled reperfusion after ischemia
1990
Characterization and pharmacological relevance of high affinity binding sites for [3H]LY186126, a cardiotonic phosphodiesterase inhibitor, in canine cardiac membranes.
1989
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
2002 StandoutNobel
Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.
1987
Overexpression of angiotensin AT 1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block
1997 StandoutNobel
An efficient copper-catalyzed coupling of aryl halides with imidazoles
1999
The Effect of Digoxin on Mortality and Morbidity in Patients with Heart Failure
1997 Standout
Angiotensin II receptor subtypes are coupled with distinct signal-transduction mechanisms in neurons and astrocytes from rat brain.
1991
Novel Molecular Mechanism of Increased Myocardial Endothelin-1 Expression in the Failing Heart Involving the Transcriptional Factor Hypoxia-Inducible Factor-1α Induced for Impaired Myocardial Energy Metabolism
2001
Characterization of angiotensin II receptor subtypes in rat heart.
1992
Myocyte Adrenoceptor Signaling Pathways
2003 StandoutScienceNobel
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes
2006 StandoutNobel
Compartmentation of G Protein-Coupled Signaling Pathways in Cardiac Myocytes
2001
International Union of Pharmacology. XXIII. The Angiotensin II Receptors
2000 Standout
Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium.
1991
Regional variation in adipose tissue metabolism of severely obese premenopausal women.
1995
cGMP-Elevating Agents Suppress Proliferation of Vascular Smooth Muscle Cells by Inhibiting the Activation of Epidermal Growth Factor Signaling Pathway
1997
Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms
1995 Standout
Linkage of β1-adrenergic stimulation to apoptotic heart cell death through protein kinase A–independent activation of Ca2+/calmodulin kinase II
2003 StandoutNobel
Angiotensin II AT2Receptor Stimulation Extends the Upper Limit of Cerebral Blood Flow Autoregulation: Agonist Effects of CGP 42112 and PD 123319
1994
Role of angiotensin receptor subtypes in the response of rabbit brain arterioles to angiotensin.
1994
Increased Accumulation of Tissue ACE in Human Atherosclerotic Coronary Artery Disease
1996
Effects of LHRH and ANG II on prolactin stimulation are mediated by hypophysial AT1 receptor subtype
1994
Pyridazine derivatives. Part 33: Sonogashira approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones
2003
Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification
2018 StandoutNobel
Beta 2-adrenergic receptor-stimulated increase in cAMP in rat heart cells is not coupled to changes in Ca2+ dynamics, contractility, or phospholamban phosphorylation.
1994
Phosphodiesterase 4D is required for β 2 adrenoceptor subtype-specific signaling in cardiac myocytes
2005 StandoutNobel
Catalytic Asymmetric Conjugate Addition and Allylic Alkylation with Grignard Reagents
2008 StandoutNobel
Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling
2005 StandoutNobel
G PROTEIN–COUPLED RECEPTOR KINASES
1998 StandoutNobel
Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.
1993
Catalyst‐Free N‐Arylation Using Unactivated Fluorobenzenes
2012
Molecular cloning of a cDNA encoding the “61-kDa” calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms.
1993
Nomenclature for angiotensin receptors. A report of the Nomenclature Committee of the Council for High Blood Pressure Research.
1991
Tyr292 in the seventh transmembrane domain of the AT1A angiotensin II receptor is essential for its coupling to phospholipase C.
1994
Unsaturated Nitriles: Conjugate Additions of Carbon Nucleophiles to a Recalcitrant Class of Acceptors
2003
Short-term desensitization of the angiotensin II receptor of bovine adrenal glomerulosa cells corresponds to a shift from a high to a low affinity state.
1994
Section Review: Cardiovascular & Renal: Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiovascular diseases
1995
Catecholamines, Cardiac β-Adrenergic Receptors, and Heart Failure
2000 StandoutNobel
The AT2 Receptor Selectively Associates with Giα2 and Giα3 in the Rat Fetus
1996
What Are the Molecular Mechanisms for the Antiproliferative Effects of Nitric Oxide and cGMP in Vascular Smooth Muscle?
1997 StandoutNobel
Aryl−Aryl Bond Formation One Century after the Discovery of the Ullmann Reaction
2002 Standout
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
2005 StandoutNobel
Reduced growth, abnormal kidney structure, and type 2 (AT 2 ) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT 1A and AT 1B receptors for angiotensin II
1998 StandoutNobel
Enalapril Treatment Increases Cardiac Performance and Energy Reserve Via the Creatine Kinase Reaction in Myocardium of Syrian Myopathic Hamsters With Advanced Heart Failure
1995
Works of Ronald E. Weishaar being referenced
Evidence for a functional tissue renin-angiotensin system in the rat mesenteric vasculature and its involvement in regulating blood pressure.
1990
Involvement of 1,25-dihydroxyvitamin D3 in regulating myocardial calcium metabolism: Physiological and pathological actions
1988
The Involvement of the Endocrine System in Regulating Cardiovascular Function: Emphasis on Vitamin D3*
1989
Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correlation with in vivo positive inotropic activity
1987
Effect of diltiazem, a calcium antagonist, on myocardial ischemia
1979
The Relationship of Regional Coronary Blood Flow to Mitoehondrial Function during Reperfusion of the Ischemic Myocardium
1979
Subclasses of angiotensin II binding sites and their functional significance.
1990
A New Generation of Phosphodiesterase Inhibitors: Multiple Molecular Forms of Phosphodiesterase and the Potential for Drug Selectivity
1985
Strategy for the discovery and development of a positive inotropic agent
1982
Cardiotonic agents. 3. Synthesis and biological activity of novel 6-(substituted 1H-imidazol-4(5)-yl)-3(2H)-pyridazinones
1986
Regulation of myosin isozyme expression by vitamin D3 deficiency and 1,25-dihydroxyvitamin D3 in the rat heart.
1994
Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets
1986
Vitamin D3 and cardiovascular function in rats.
1987
Subclasses of cyclic GMP-specific phosphodiesterase and their role in regulating the effects of atrial natriuretic factor.
1990
Involvement of vitamin D3 with cardiovascular function. II. Direct and indirect effects
1987
Involvement of vitamin D3 with cardiovascular function. III. Effects on physical and morphological properties
1990
Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure
1984
Studies aimed at elucidating the mechanism of action of CI-914, a new cardiotonic agent
1985
Subclasses of cyclic AMP-specific phosphodiesterase in left ventricular muscle and their involvement in regulating myocardial contractility.
1987
Effects of quinapril, a new angiotensin converting enzyme inhibitor, on left ventricular failure and survival in the cardiomyopathic hamster. Hemodynamic, morphological, and biochemical correlates.
1991