Citation Impact
Citing Papers
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
Fusion of Cells by Flipped SNAREs
2003 StandoutScienceNobel
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
2003 StandoutNobel
Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse
1994 StandoutNobel
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate
1993
Isolation of a putative phospholipase c gene of drosophila, norpA, and its role in phototransduction
1988
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Cloning and sequence of multiple forms of phospholipase C
1988
The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain
1989
Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction
1989
Phosphoinositide metabolism and the control of cell proliferation
1989
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Cloning of bovine GAP and its interaction with oncogenic ras p21
1988 Nature
A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP
1991 Standout
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 StandoutNatureNobel
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
1992 Standout
The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein
1992
A Novel Nociceptor Signaling Pathway Revealed in Protein Kinase C ε Mutant Mice
1999
The Coiled-coil Region of the G Protein β Subunit
1997
Involvement of Gs and Gi Proteins in Dual Coupling of the Luteinizing Hormone Receptor to Adenylyl Cyclase and Phospholipase C
1996
Specific Involvement of PKC-ε in Sensitization of the Neuronal Response to Painful Heat
1999
Crystal structure of a Src-homology 3 (SH3) domain
1992 Nature
A capsaicin-receptor homologue with a high threshold for noxious heat
1999 StandoutNatureNobel
Mechanism of Activation of Cholera Toxin by ADP-Ribosylation Factor (ARF): Both Low- and High-Affinity Interactions of ARF with Guanine Nucleotides Promote Toxin Activation
1990
Primary structure of the brain alpha-spectrin [published erratum appears in J Cell Biol 1989 Mar;108(3):following 1175]
1989
Phospholipase C Isozymes: Structural and Functional Similarities
2007
Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C
1992 Nature
Studies of Inositol Phospholipid-Specific Phospholipase C
1989 Science
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
1997 StandoutNobel
SNAREpins: Minimal Machinery for Membrane Fusion
1998 StandoutNobel
Molecular Events Mediating T Cell Activation
1990
C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains
1992 Nature
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits
1992 Nature
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase
1991
Similarity between phospholipase C and the regulatory domain of protein kinase C
1989
The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization
1989 Nobel
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
The C. elegans genome sequencing project: a beginning
1992 StandoutNatureNobel
Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I
1990 Nature
Synaptotagmin I functions as a calcium regulator of release probability
2001 StandoutNatureNobel
The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions
1991
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling
1989
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins
1995 StandoutNatureNobel
Oncogenes and signal transduction
1991 Standout
Male–female differences in fertility and blood pressure in ACE-deficient mice
1995 StandoutNatureNobel
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
1995 StandoutNature
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
1994 Standout
[19] Purification of 110 kDa phosphoinositide phospholipase C activated by G-protein βλ subunits
1994
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold
1995 StandoutNobel
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
A Novel Function for the Second C2 Domain of Synaptotagmin
1996
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
1991 Science
SH3 — an abundant protein domain in search of a function
1992
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
1991
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
1990 Nature
Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro
1989
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator
1992
Synaptic Vesicles and Exocytosis
1994
A novel viral oncogene with structural similarity to phospholipase C
1988 Nature
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis
2006 StandoutNatureNobel
Determination of the primary structure of PLC-154 demonstrates diversity of phosphoinositide-specific phospholipase C activities
1988
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
1998 StandoutNatureNobel
CRYSTAL STRUCTURE OF THE SH3 DOMAIN IN HUMAN FYN; COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF SH3 DOMAINS IN TYROSINE KINASES AND SPECTRIN
1993
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
1991 StandoutScience
Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain.
1990
Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation
1990
Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.
1989
Presence of an SH2 Domain in the Actin-Binding Protein Tensin
1991 Science
Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage.
1989
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.
1989 Nobel
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.
1990
Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.
1989
The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.
1991 Nobel
Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor.
1992
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.
1992
Members of the Gq alpha subunit gene family activate phospholipase C beta isozymes.
1992
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits.
1993 StandoutNobel
Removal of the carboxyl-terminal region of phospholipase C-beta 1 by calpain abolishes activation by G alpha q.
1993
A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release
1995 StandoutScienceNobel
Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.
1990
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.
1992
Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors
1992
S-phase induction and transformation of quiescent NIH 3T3 cells by microinjection of phospholipase C.
1989
cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.
1994
Characterization of the 47-Kilodalton Autosomal Chronic Granulomatous Disease Protein: Tissue-Specific Expression and Transcriptional Control by Retinoic Acid
1990
Purification, molecular cloning, and sequencing of phospholipase C-beta 4.
1993
Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors
1990 Science
The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function.
1989
Proteins with SH2 domains: transducers in the tyrosine kinase signaling pathway.
1992
Requirement for a GTPase-Activating Protein in Vesicle Budding from the Endoplasmic Reticulum
1993 StandoutScienceNobel
Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.
1990
Bipartite Ca 2+ -Binding Motif in C 2 Domains of Synaptotagmin and Protein Kinase C
1996 StandoutScienceNobel
Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.
1991
A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.
1991 StandoutNobel
Deletions in the SH2 domain of p60v-src prevent association with the detergent-insoluble cellular matrix.
1991
Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.
1990
Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells.
1990
Binding of Neuroligins to PSD-95
1997 StandoutScienceNobel
Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.
1989
Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3.
1993
Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids
1994
Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain.
1994
Activation of phospholipase C-beta 2 mutants by G protein alpha q and beta gamma subunits.
1993 StandoutNobel
Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability
1989
Activation of phospholipase C isozymes by G protein beta gamma subunits.
1993
A Second Type of Rat Phosphoinositide-specific Phospholipase C Containing a src-related Sequence Not Essential for Phosphoinositide-hydrolyzing Activity
1989
Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface
1992 StandoutScienceNobel
Identification of critical regions on phospholipase C-beta 1 required for activation by G-proteins.
1993
Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif.
1991
A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region
1991 Science
Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.
1990
Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
1990
Generation of Calcium Oscillations in Fibroblasts by Positive Feedback Between Calcium and IP 3
1991 StandoutScienceNobel
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins.
1989
Calcium-dependent activation of protein kinase C. The role of the C2 domain in divalent cation selectivity.
1993
Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein.
1989
Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits
1993
The Mating of a Fly
1994 StandoutScienceNobel
Identification and characterization of p59fyn (a src-like protein tyrosine kinase) in normal and polyoma virus transformed cells.
1988
Inhibition of Adenylyl Cyclase by G iα
1993 StandoutScienceNobel
A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner
1989
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Src homology region 2 domains direct protein-protein interactions in signal transduction.
1990
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Transformation of Chicken Embryo Fibroblast Cells by Avian Retroviruses Containing the Human Fyn Gene and Its Mutated Genes
1990
Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutants
1989
Stable Association of Activated pp60src with Two Tyrosine-Phosphorylated Cellular Proteins
1989
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995 StandoutScienceNobel
Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins
1990 Science
Polyphosphoinositides Produced by Phosphatidylinositol 3-Kinase Are Poor Substrates for Phospholipases C from Rat Liver and Bovine Brain
1989
Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain.
1994
Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 c-src
1990 Science
Works of Ron Kriz being referenced
Sequence similarity of phospholipase C with the non-catalytic region of src
1988 Nature
Identification, purification and characterization of a novel phosphatidylinositol‐specific phospholipase C, a third member of the β subfamily
1992
Unique substrate specificity and regulatory properties of PKC‐ε: a rationale for diversity
1989
Phospholipase C-148: Chromosomal Location and Deletion Mapping of Functional Domains
1988
Molecular cloning of murine FLT and FLT4.
1993
Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.
1992