Citation Impact
Citing Papers
Akt1 and Akt2 promote peripheral B-cell maturation and survival
2009
Akt1 Ablation Inhibits, whereas Akt2 Ablation Accelerates, the Development of Mammary Adenocarcinomas in Mouse Mammary Tumor Virus (MMTV)-ErbB2/Neu and MMTV-Polyoma Middle T Transgenic Mice
2007
Role of target geometry in phagocytosis
2006 Standout
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis
2010 StandoutNobel
β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
2009 StandoutNobel
The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity
1997 Standout
Loss of Akt1 Leads to Severe Atherosclerosis and Occlusive Coronary Artery Disease
2007
Epithelial-mesenchymal transition and its implications for fibrosis
2003 Standout
mTOR Signaling in Growth Control and Disease
2012 Standout
Functions of the adapter protein Cas: signal convergence and the determination of cellular responses
2001
Fyn, Yes, and Syk Phosphorylation Sites in c-Cbl Map to the Same Tyrosine Residues That Become Phosphorylated in Activated T Cells
1998
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Hematologic and Cytogenetic Responses to Imatinib Mesylate in Chronic Myelogenous Leukemia
2002 Standout
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
2009 Standout
Evidence That DOCK180 Up-regulates Signals from the CrkII-p130Cas Complex
1998
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Structure of HDAC3 bound to co-repressor and inositol tetraphosphate
2012 Nature
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
2012
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
2010 Standout
Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia
2001 Standout
Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates
2013
Bcr–Abl variants: biological and clinical aspects
2002
Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes
2011
Focal adhesions: Structure and dynamics
2000
BCR/ABL induces multiple abnormalities of cytoskeletal function.
1997
Dasatinib in Imatinib-Resistant Philadelphia Chromosome–Positive Leukemias
2006 Standout
A journey into space
2001 StandoutNobel
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
2000 StandoutNobel
Autophagy: Renovation of Cells and Tissues
2011 Standout
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
2005 Standout
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Conservation, Variability and the Modeling of Active Protein Kinases
2007 StandoutNobel
Akt1/protein kinase B is critical for ischemic and VEGF-mediated angiogenesis
2005
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Phosphorylation of c-Crk II on the Negative Regulatory Tyr222 Mediates Nerve Growth Factor-induced Cell Spreading and Morphogenesis
2000
mTOR: from growth signal integration to cancer, diabetes and ageing
2010 Standout
Phagocytosis and innate immunity
2002
The GLUT4 Glucose Transporter
2007
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
Serine Phosphorylation of Cbl Induced by Phorbol Ester Enhances Its Association with 14-3-3 Proteins in T Cells via a Novel Serine-rich 14-3-3-binding Motif
1997
The Two TORCs and Akt
2007
Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome
2001 Standout
The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo
2015
Structure-based optimization of click-based histone deacetylase inhibitors
2011
Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance
2009
PKB and the mitochondria: AKTing on apoptosis
2007
PI3K/Akt: getting it right matters
2008
An expanding role for mTOR in cancer
2005
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Akt3 Deficiency in Macrophages Promotes Foam Cell Formation and Atherosclerosis in Mice
2012
Crk family adaptors–signalling complex formation and biological roles
2001
AKT/PKB Signaling: Navigating the Network
2017 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
The PI3K Pathway in Human Disease
2017 Standout
Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability
2006
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
2011 StandoutNobel
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1
1999 StandoutNobel
Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase
2003 Standout
A General and Selective Iron‐Catalyzed Aminocarbonylation of Alkynes: Synthesis of Acryl‐ and Cinnamides
2010
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
2009 StandoutNobel
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
2006
Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations
2012
Chronic Myeloid Leukemia
1999
A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation
2015
Integrins Regulate the Association and Phosphorylation of Paxillin by c-Abl
1998
Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice
2014
Mutant Mice Lacking Crk-II Caused by the Gene Trap Insertional Mutagenesis: Crk-II Is Not Essential for Embryonic Development
1999
Growth Factor-Dependent Trafficking of Cerebellar NMDA Receptors via Protein Kinase B/Akt Phosphorylation of NR2C
2009
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Iron Catalysis in Organic Synthesis
2015 Standout
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
2008
Cu and Cu-Based Nanoparticles: Synthesis and Applications in Catalysis
2016 Standout
Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases.
2002
A facile procedure for synthesis of 3-[2-(N,N-dialkylamino)ethyl]-3-fluorooxindoles by direct fluorination of N,N-dialkyltryptamines
2011
Direct Binding of CRKL to BCR-ABL Is Not Required for BCR-ABL Transformation
1997
Crk Adapter Proteins Promote an Epithelial–Mesenchymal-like Transition and Are Required for HGF-mediated Cell Spreading and Breakdown of Epithelial Adherens Junctions
2002
Structural Requirements for Function of the Crkl Adapter Protein in Fibroblasts and Hematopoietic Cells
1998
A growing family of guanine nucleotide exchange factors is responsible for activation of ras-family GTPases
2002
Phagocytosis and the actin cytoskeleton
2001
Physiological roles of PKB/Akt isoforms in development and disease
2007
Differential regulation of the p70 S6 kinase pathway by interferon α (IFNα) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells
2005
Differential Effects of Protein Kinase B/Akt Isoforms on Glucose Homeostasis and Islet Mass
2009
A circadian gene expression atlas in mammals: Implications for biology and medicine
2014 Standout
Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology
2013
Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation
2017 StandoutNobel
Integrated Cross-Coupling Strategy for an α-Carboline-Based Aurora B Kinase Inhibitor
2015
Translocation of CrkL to Focal Adhesions Mediates Integrin-Induced Migration Downstream of Src Family Kinases
2003
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
2017 Standout
Conditional Deletion of Focal Adhesion Kinase Leads to Defects in Ventricular Septation and Outflow Tract Alignment
2007 StandoutNobel
The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response
2019
Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase
2000 StandoutScience
Akt isoforms differentially regulate neutrophil functions
2010
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Handicapping the Race to Develop Inhibitors of the Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin Pathway
2006
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
2021 StandoutNobel
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells
2001 StandoutNobel
Epithelial-mesenchymal transition and its implications for fibrosis
2003 Standout
Interactions of Drosophila Cbl with Epidermal Growth Factor Receptors and Role of Cbl in R7 Photoreceptor Cell Development
1997
Paired Electrolysis in the Simultaneous Production of Synthetic Intermediates and Substrates
2016
Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies
2006
New Approach to 1,4‐Benzoxazin‐3‐ones by Electrochemical C−H Amination
2017
Simple, Efficient, and Applicable Route for Synthesis of 2-Aryl(Heteroaryl)-Benzimidazoles at Room Temperature Using Copper Nanoparticles on Activated Carbon as a Reusable Heterogeneous Catalyst
2011
Akt1 and Akt2 are required for αβ thymocyte survival and differentiation
2007
Works of Ron de Jong being referenced
Biological Characterization of TAK-901, an Investigational, Novel, Multitargeted Aurora B Kinase Inhibitor
2013
Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice.
2001
C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells
1998
Crkl Is Complexed with Tyrosine-phosphorylated Cbl in Ph-positive Leukemia
1995
Discovery and SAR of oxindole–pyridine-based protein kinase B/Akt inhibitors for treating cancers
2006
CRKL Links p210BCR/ABL with Paxillin in Chronic Myelogenous Leukemia Cells
1995
BCR/ABL-induced Leukemogenesis Causes Phosphorylation of Hef1 and Its Association with Crkl
1997
Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors
2013
Quantitative Analysis of Anti-apoptotic Function of Akt in Akt1 and Akt2 Double Knock-out Mouse Embryonic Fibroblast Cells under Normal and Stressed Conditions
2006
Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides
2010
Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity
2010
Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site
1997
Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI).
1998
Rapamycin inhibits Akt-mediated oncogenic transformation and tumor growth.
2004
Differential Interaction of Crkl with Cbl or C3G, Hef-1, and γ Subunit Immunoreceptor Tyrosine-Based Activation Motif in Signaling of Myeloid High Affinity Fc Receptor for IgG (FcγRI)
1998
Quantitative Analysis of Anti-apoptotic Function of Akt in Akt1 and Akt2 Double Knock-out Mouse Embryonic Fibroblast Cells under Normal and Stressed Conditions
2006
Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size
2005