Citation Impact
Citing Papers
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein
2002 StandoutScience
Chromosome 21: a small land of fascinating disorders with unknown pathophysiology
2002
Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination and White Matter Angiogenesis
2014
Identification of a Novel Basic Helix-Loop-Helix–PAS Factor, NXF, Reveals a Sim2 Competitive, Positive Regulatory Role in Dendritic-Cytoskeleton Modulator Drebrin Gene Expression
2003
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
1998 StandoutScience
Gene ontology analysis for RNA-seq: accounting for selection bias
2010 Standout
A scaling normalization method for differential expression analysis of RNA-seq data
2010 Standout
Schwann cell interactions with axons and microvessels in diabetic neuropathy
2017
Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
2016 Standout
Structures, sequence characteristics, and synteny relationships of the transcription factor E4TF1, the splicing factor U2AF35 and the cystathionine beta synthetase genes from Fugu rubripes
1999
High cholesterol level is essential for myelin membrane growth
2005
Disease-Specific Induced Pluripotent Stem Cells
2008 Standout
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
2006 StandoutNature
Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease
2005
Transcript Level Alterations Reflect Gene Dosage Effects Across Multiple Tissues in a Mouse Model of Down Syndrome
2004
Measuring normal and pathological anxiety-like behaviour in mice: a review
2001
Back to Central Tolerance
2004 Standout
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Protein–protein interactions: General trends in the relationship between binding affinity and interfacial buried surface area
2013
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
2019 Standout
Astrocytes and Microglia as Major Players of Myelin Production in Normal and Pathological Conditions
2020
Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice
2007
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
2017 Standout
Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency
2000
EHSH1/Intersectin, a Protein That Contains EH and SH3 Domains and Binds to Dynamin and SNAP-25
1999 StandoutNobel
Identification of a Novel Neural Cell Adhesion Molecule-related Gene with a Potential Role in Selective Axonal Projection
1997
Mitochondria and endoplasmic reticulum crosstalk in amyotrophic lateral sclerosis
2015
Myelin basic protein‐dependent plasma membrane reorganization in the formation of myelin
2006 StandoutNobel
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
2007 Standout
Cloning of a Human RNA Editing Deaminase (ADARB1) of Glutamate Receptors That Maps to Chromosome 21q22.3
1997
Regulation of Cardiovascular Development and Physiology by Hypoxia‐Inducible Factor 1a
1999 StandoutNobel
Mitochondrial fusion and fission in cell life and death
2010 Standout
Commitment to the Regulatory T Cell Lineage Requires CARMA1 in the Thymus but Not in the Periphery
2009 StandoutNobel
Effect of insulin and an erythropoietin-derived peptide (ARA290) on established neuritic dystrophy and neuronopathy in Akita (Ins2Akita) diabetic mouse sympathetic ganglia
2011
Tau in physiology and pathology
2015 Standout
Alu-splice cloning of human Intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome
1999
Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome
2001
Structural Basis for Recognizing Phosphoarginine and Evolving Residue-Specific Protein Phosphatases in Gram-Positive Bacteria
2013 StandoutNobel
Two Isoforms of a Human Intersectin (ITSN) Protein Are Produced by Brain-Specific Alternative Splicing in a Stop Codon
1998
Mitotoxicity in distal symmetrical sensory peripheral neuropathies
2014
Gene Expression From the Aneuploid Chromosome in a Trisomy Mouse Model of Down Syndrome
2004
Mitochondrial dynamics and apoptosis
2008
The Energetics of CNS White Matter
2012
Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
2009
DNA Methylation and Its Basic Function
2012 Standout
Stress and the brain: from adaptation to disease
2005 Standout
Nanoparticle-assisted optical tethering of endosomes reveals the cooperative function of dyneins in retrograde axonal transport
2015 StandoutNobel
Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice
1997
Chromosome 21 and Down syndrome: from genomics to pathophysiology
2004 Standout
Global up-regulation of chromosome 21 gene expression in the developing down syndrome brain
2003
Positional cloning of the APECED gene
1997
HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology
2016
A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function
2008 Standout
New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain
2017
Cellular Fatty Acid Metabolism and Cancer
2013 Standout
Serial analysis of gene expression predicts structural differences in hippocampus of long attack latency and short attack latency mice
2003
Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping
2006
Blood-Brain Barrier Breakdown in the Aging Human Hippocampus
2015 Standout
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
2011 Standout
Nineteen Additional Unpredicted Transcripts from Human Chromosome 21
2002
p63 is a p53 homologue required for limb and epidermal morphogenesis
1999 StandoutNature
Isolation and Initial Characterization of a Novel Zinc Finger Gene, DNMT3L, on 21q22.3, Related to the Cytosine-5- Methyltransferase 3 Gene Family
2000
Down's syndrome
2003 Standout
The immunopathology of sepsis and potential therapeutic targets
2017 Standout
Widespread transcription at neuronal activity-regulated enhancers
2010 StandoutNature
Hippocampal Long-Term Potentiation Suppressed by Increased Inhibition in the Ts65Dn Mouse, a Genetic Model of Down Syndrome
2004
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
1998 StandoutNobel
Identification of a Novel Oligodendrocyte Cell Adhesion Protein Using Gene Expression Profiling
2006
The Pathobiology of Vascular Dementia
2013 Standout
Diabetic neuropathy
2019
Global disruption of the cerebellar transcriptome in a Down syndrome mouse model
2003
A High-Resolution Physical Map of Human Chromosome 21p Using Yeast Artificial Chromosomes
1999
10 Years ofGenomics,Chromosome 21, and Down Syndrome
1998
Transcriptome-Wide Identification of Novel Imprinted Genes in Neonatal Mouse Brain
2008
Negative regulation of myelination: Relevance for development, injury, and demyelinating disease
2008
The Molecular Architecture of Odor and Pheromone Sensing in Mammals
2000 StandoutNobel
Transcriptome analysis of human autosomal trisomy
2002
Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene ( PDE9A ) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence
1998
Increased App Expression in a Mouse Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron Degeneration
2006 Standout
Axonal transport deficits and neurodegenerative diseases
2013
TORC2 Regulates Hepatic Insulin Signaling via a Mammalian Phosphatidic Acid Phosphatase, LIPIN1
2009
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
2009 StandoutNobel
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Late changes in spliceosomal introns define clades in vertebrate evolution
1999 StandoutNobel
Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor
2010
EUKARYOTIC CYTOSINE METHYLTRANSFERASES
2005 Standout
Mitochondrial Fission, Fusion, and Stress
2012 StandoutScience
Antiviral Actions of Interferons
2001 Standout
The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications
2009
Neuropathic Pain: From Mechanisms to Treatment
2020 Standout
Antigenic Targeting of the Human Mannose Receptor Induces Tumor Immunity
2007
Myelination of the Nervous System: Mechanisms and Functions
2014
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum
2012
Mechanisms of Diabetic Complications
2013 Standout
A multidrug resistance transporter from human MCF-7 breast cancer cells
1998 Standout
The Murine Sim-2 Gene Product Inhibits Transcription by Active Repression and Functional Interference
1997
Diabetic Neuropathy: A Position Statement by the American Diabetes Association
2016 Standout
Hypoxia-inducible factor 1: master regulator of O2 homeostasis
1998 StandoutNobel
Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3.
1996
The Molecular Biology of Axon Guidance
1996 StandoutScience
Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody
2020 StandoutNobel
Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling
2007 Standout
An Aneuploid Mouse Strain Carrying Human Chromosome 21 with Down Syndrome Phenotypes
2005 Science
Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?
2015
Works of Roman Chrast being referenced
Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome
2000
Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models
2010
Oligodendroglial myelination requires astrocyte-derived lipids
2017
Differential gene expression studies to explore the molecular pathophysiology of Down syndrome
2001
Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration
2015
The Mouse Brain Transcriptome by SAGE: Differences in Gene Expression between P30 Brains of the Partial Trisomy 16 Mouse Model of Down Syndrome (Ts65Dn) and Normals
2000
SH3TC2, a protein mutant in Charcot–Marie–Tooth neuropathy, links peripheral nerve myelination to endosomal recycling
2010
Linearization and purification of BAC DNA for the development of transgenic mice
1999
Refined localization of dominant intermediate Charcot-Marie-Tooth neuropathy and exclusion of seven known candidate genes in the region
2003
Global Transcriptional Programs in Peripheral Nerve Endoneurium and DRG Are Resistant to the Onset of Type 1 Diabetic Neuropathy in Ins2Akita/+ Mice
2010
Mapping of the Human Transcription Factor GABPA (E4TF1-60) Gene to Chromosome 21
1995
Expression of mitofusin 2R94Q in a transgenic mouse leads to Charcot–Marie–Tooth neuropathy type 2A
2010
Distribution of Monocarboxylate Transporters in the Peripheral Nervous System Suggests Putative Roles in Lactate Shuttling and Myelination
2015
Local regulation of fat metabolism in peripheral nerves
2003
Localization of 102 exons to a 2.5 Mb region involved in Down syndrome
1995
Phosphatidic acid mediates demyelination in Lpin1 mutant mice
2008
Altered Distribution of Juxtaparanodal Kv1.2 Subunits Mediates Peripheral Nerve Hyperexcitability in Type 2 Diabetes Mellitus
2012
Novel pathogenic pathways in diabetic neuropathy
2013
Generation and phenotypic analysis of protein S–deficient mice
2009
Cloning of 559 potential exons of genes of human chromosome 21 by exon trapping.
1996
Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice
2013