Citation Impact
Citing Papers
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
2005 StandoutScience
Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
2005 StandoutNobel
Selective dysregulation of the FcγIIB receptor on memory B cells in SLE
2006
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
CDw150 Associates with Src-Homology 2-Containing Inositol Phosphatase and Modulates CD95-Mediated Apoptosis
1999
Hallmarks of Cancer: The Next Generation
2011 Standout
The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction
1993 Nature
The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the Dok1 phosphoprotein in Bcr-Abl transformed cells
2000
Structure and function of phosphoinositide 3-kinases
1998
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
1994
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
1998 StandoutNature
Inflammation in autoimmunity: receptors for IgG revisited
2001
Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus
2005
Oncogenic kinase signalling
2001 StandoutNature
The B Cell Inhibitory Fc Receptor Triggers Apoptosis by a Novel c-Abl Family Kinase-dependent Pathway
2005
Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes
2017 StandoutNobel
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
PtdIns-3,4,5-P3
1998
Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter
1993
CD22 Forms a Quaternary Complex with SHIP, Grb2, and Shc
2000
FcγRIIb controls bone marrow plasma cell persistence and apoptosis
2007
FcR γ chain deletion results in pleiotrophic effector cell defects
1994
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
Inhibitory Pathways Triggered by ITIM-Containing Receptors
1999
Genetically determined aberrant down-regulation of FcγRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus
1999
Transcriptional Regulation of the Interferon- γ-inducible Tryptophanyl-tRNA Synthetase Includes Alternative Splicing
1995
A novel IL-4 responsive element of the Eα MHC class II promoter that binds to an inducible factor
1995
Osteoporosis: now and the future
2011 Standout
Fcγ receptors as regulators of immune responses
2007 Standout
Receptor activator of NF-?B ligand, macrophage inflammatory protein-1?, and the proteasome
2003
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins
1993 Nature
The inhibitory Fcγ receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cells
2004
The mast cell IgG receptors and their roles in tissue inflammation
2007
Interaction between PU.1 and Another Ets Family Transcription Factor Promotes Macrophage-specific Basal Transcription Initiation
1998
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
1994 StandoutScience
PU.1 and Interferon Consensus Sequence-binding Protein Regulate the Myeloid Expression of the Human Toll-like Receptor 4 Gene
2000 StandoutNobel
FcγRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling
2005
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
The SH2 Domain-containing Inositol 5′-Phosphatase (SHIP) Recruits the p85 Subunit of Phosphoinositide 3-Kinase during FcγRIIb1-mediated Inhibition of B Cell Receptor Signaling
1999
The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma
2003
Taking dendritic cells into medicine
2007 StandoutNatureNobel
A novel polymorphism in the Fcγ receptor IIB (CD32B) transmembrane region alters receptor signaling
2003
Osteoclast differentiation and activation
2003 StandoutNature
Structural Basis for Discrimination of 3-Phosphoinositides by Pleckstrin Homology Domains
2000
Tumor Cell Responses to IFNγ Affect Tumorigenicity and Response to IL-12 Therapy and Antiangiogenesis
1998
Stat1 Depends on Transcriptional Synergy with Sp1
1995
Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4
1993 Science
Activating and inhibitory FcγRs in autoimmune disorders
2006
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Growth Hormone Induction of Hepatic Serine Protease Inhibitor 2.1 Transcription Is Mediated by a Stat5-related Factor Binding Synergistically to Two γ-Activated Sites
1995
Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate
1999
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway
1993 Nature
Bone metastasis: the importance of the neighbourhood
2016
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Mechanisms of Bone Metastasis
2004 Standout
The RasGAP-Binding Protein p62dok Is a Mediator of Inhibitory FcγRIIB Signals in B Cells
2000
A novel member of the interferon receptor family complements functionality of the murine interferon γ receptor in human cells
1994
Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific Epistasis
2000
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
Roles of Fc receptors in autoimmunity
2002
Augmented humoral and anaphylactic responses in FcγRII-deficient mice
1996 Nature
An immunoreceptor tyrosine‐based inhibitory motif, with serine at site Y‐2, binds SH2‐domain‐containing phosphatases
2000
Neoplastic development in plasma cells
2003
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
Fcγ Receptors: Old Friends and New Family Members
2006
Molecular Basis of Fc Receptor Function
1994
Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma
2012
Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).
1994
A Promoter Haplotype of the Immunoreceptor Tyrosine-Based Inhibitory Motif-Bearing FcγRIIb Alters Receptor Expression and Associates with Autoimmunity. II. Differential Binding of GATA4 and Yin-Yang1 Transcription Factors and Correlated Receptor Expression and Function
2004
TFEC Is a Macrophage-Restricted Member of the Microphthalmia-TFE Subfamily of Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
1999
A Critical Role for Syk Protein Tyrosine Kinase in Fc Receptor-Mediated Antigen Presentation and Induction of Dendritic Cell Maturation
2003
Cutting Edge: Role of the Inositol Phosphatase SHIP in B Cell Receptor-Induced Ca2+ Oscillatory Response
1998
Structure, function, and biology of SHIP proteins
2000
Cooperatively between catalytic sites in the mechanism of action of beef heart mitochondrial adenosine triphosphatase.
1981
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
2009
Anti-inflammatory Activity of IVIG Mediated Through the Inhibitory Fc Receptor
2001 Science
Tertiary lymphoid structures, drivers of the anti‐tumor responses in human cancers
2016
Hypothalamic Regulatory Hormones
1973 StandoutScienceNobel
The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide ofStreptococcus pneumoniaein the marginal zone of mouse spleen
2003 StandoutNobel
STATs and Gene Regulation
1997 StandoutScience
Signal-dependent membrane targeting by pleckstrin homology (PH) domains
2000
Role of the inositol phosphatase SHIP in B cell receptor-induced Ca2+ oscillatory response.
1998
Targeting the bone marrow microenvironment in multiple myeloma
2014
Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation
1993 Science
Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds.
1993
AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation
1999
A Nuclear Tyrosine Phosphatase Downregulates Interferon-Induced Gene Expression
1993
Restriction of interferon gamma responsiveness and basal expression of the myeloid human Fc gamma R1b gene is mediated by a functional PU.1 site and a transcription initiator consensus.
1994
Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fc gamma receptor.
1994
A Promoter Haplotype of the Immunoreceptor Tyrosine-Based Inhibitory Motif-Bearing FcγRIIb Alters Receptor Expression and Associates with Autoimmunity. I. Regulatory FCGR2B Polymorphisms and Their Association with Systemic Lupus Erythematosus
2004
A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ
1993 Science
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
1982 StandoutNobel
Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1
1995
Characterization of a Pathway for Ciliary Neurotrophic Factor Signaling to the Nucleus
1993 Science
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.
1995
Translocation events in the evolution of aminoacyl-tRNA synthetases.
1996 StandoutNobel
IgG Fc Receptors
2001
Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6
1994 StandoutScience
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
1995 StandoutNobel
Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.
1996
Dual effects of macrophage inflammatory protein-1α on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease
2003
Fcγ Receptor Iib–Deficient Mice Develop Goodpasture's Syndrome upon Immunization with Type IV Collagen
2000
Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.
1993 Standout
T-Independent Immune Response: New Aspects of B Cell Biology
2000 StandoutScienceNobel
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice
2002 StandoutNobel
The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds.
1993
Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300
1997
Cancer Genome Landscapes
2013 StandoutScience
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
2001 StandoutNobel
Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α
1999 Science
Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice
2015
Tyrosine Phosphorylation of DNA Binding Proteins by Multiple Cytokines
1993 Science
A nuclear tyrosine phosphatase downregulates interferon-induced gene expression.
1993
Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO
2003
A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.
1996
Inducing Tumor Immunity through the Selective Engagement of Activating Fcγ Receptors on Dendritic Cells
2002
Reconstitution of human Fc gamma RIII cell type specificity in transgenic mice.
1996
Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.
1994
In vitro activation of a transcription factor by gamma interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate.
1993
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Stat3 and Stat4: members of the family of signal transducers and activators of transcription.
1994
Macrophages Control the Retention and Trafficking of B Lymphocytes in the Splenic Marginal Zone
2003
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.
1996 StandoutNobel
Luteinizing Hormone-Releasing Activity in Hypophysial Stalk Blood and Elevation by Dopamine
1969 Science
Immune Inhibitory Receptors
2000 Science
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.
1993
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
1999 StandoutNobel
THE HIGH-AFFINITY Ig E RECEPTOR (FcεRI): From Physiology to Pathology
1999
Works of Roger Pearse being referenced
SHIP Recruitment Attenuates FcγRIIB-Induced B Cell Apoptosis
1999
SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk
1998
RANK-Fc: A therapeutic antagonist for RANK-L in myeloma
2003
Clarithromycin (Biaxin)‐lenalidomide‐low‐dose dexamethasone (BiRd) versus lenalidomide‐low‐dose dexamethasone (Rd) for newly diagnosed myeloma
2010
Myeloma interacts with the bone marrow microenvironment
to induce osteoclastogenesis and is dependent on osteoclast activity
2002
Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
2001
Organization of the Human and Mouse Low-affinity FcγR Genes: Duplication and Recombination
1990 Science
PU.1 and an HLH family member contribute to the myeloid-specific transcription of the Fc gamma RIIIA promoter.
1994
Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3.
1993
Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements.
1991
Monoamine Oxidase Activity in Various Parts of the Rat Brain during the Estrous Cycle
1966 Science