Standout Papers
Citation Impact
Citing Papers
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
2020 StandoutScienceNobel
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
2020 StandoutScience
Medicinal strategies in the treatment of obesity
2000 Nature
A stomatin-like protein necessary for mechanosensation in C. elegans
1995 StandoutNatureNobel
The emerging role of ACE2 in physiology and disease
2007
Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin
1993 StandoutNatureNobel
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
1996 StandoutNatureNobel
Angiotensin-converting enzyme 2 is an essential regulator of heart function
2002 Nature
Two catalytic subunits of cAMP-dependent protein kinase generated by alternative RNA splicing are expressed in Aplysia neurons
1988
Absence of Soluble Leptin Receptor in Plasma fromdbPas/dbPas and Otherdb/db Mice
1998
Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles
1997
A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA
1993
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
2003 StandoutNature
Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice
1996
Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
1996
The Leptin Receptor
1997
IRS-2 pathways integrate female reproduction and energy homeostasis
2000 Nature
ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis
2004
Collectrin, a Collecting Duct-specific Transmembrane Glycoprotein, Is a Novel Homolog of ACE2 and Is Developmentally Regulated in Embryonic Kidneys
2001
Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice
1997 Standout
Angiotensin-Converting Enzyme 2 — A New Cardiac Regulator
2002
Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme
2002
Novel Peptide Inhibitors of Angiotensin-converting Enzyme 2
2003
Leptin Receptor (OB-R) Signaling
1997
A human leptin mutant induces weight gain in normal mice
1997
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel
2002 StandoutNatureNobel
Pathophysiological Significance of theObeseGene Product, Leptin, in Ventromedial Hypothalamus (VMH)-Lesioned Rats: Evidence for Loss of Its Satiety Effect in VMH-Lesioned Rats1
1997
Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis
2004 Standout
Molecular Cloning, mRNA Expression and Chromosomal Localization of Mouse Angiotensin-converting Enzyme-related Carboxypeptidase (mACE2)
2002
Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine
1995 StandoutNatureNobel
Feeding and body-weight regulation by hypothalamic neuropeptides—mediation of the actions of leptin
1999
The C. elegans genome sequencing project: a beginning
1992 StandoutNatureNobel
Interaction of ACE2 and integrin β1 in failing human heart
2004
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3
1995 StandoutNatureNobel
Angiotensin-converting enzyme 2 protects from severe acute lung failure
2005 StandoutNature
Cerebrospinal Fluid Leptin in Anorexia Nervosa: Correlation with Nutritional Status and Potential Role in Resistance to Weight Gain1
1997
Multiple products of the drosophila Shaker gene may contribute to potassium channel diversity
1988
Adipogenesis and Obesity: Rounding Out the Big Picture
1996
Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase
2002
Life without white fat: a transgenic mouse
1998
A light-entrainment mechanism for the Drosophila circadian clock
1996 StandoutNatureNobel
Inflammation in atherosclerosis
2002 StandoutNature
The MyoD family of transcription factors and skeletal myogenesis
1995
Molecular analysis of no-on-transient A, a gene required for normal vision in drosophila
1990
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
2000
The biology of leptin: a review.
1998
Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding
1997
From Lesions to Leptin
1999
Obesity and the Regulation of Energy Balance
2001 Standout
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
1997 Nature
Structure of human phenylethanolamine n-methyltransferase gene: existence of two types of mRNA with different transcription initiation sites
1989
Determination of the subunit stoichiometry of a voltage-activated potassium channel
1991 StandoutNatureNobel
Leptin and the regulation of body weight in mammals
1998 StandoutNature
Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen
1989 StandoutNatureNobel
Essential functions of synapsins I and II in synaptic vesicle regulation
1995 StandoutNatureNobel
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance
1996
ACE2: A New Target for Cardiovascular Disease Therapeutics
2007
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
Leptin Inhibits Bone Formation through a Hypothalamic Relay
2000 Standout
Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice
2000
Genetics of body-weight regulation
2000 Nature
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
1998 StandoutNatureNobel
A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1
1994 StandoutNatureNobel
Helix-loop-helix proteins as regulators of muscle-specific transcription.
1993
BROWN ADIPOSE TISSUE, β3-ADRENERGIC RECEPTORS, AND OBESITY
1997
Mutations Affecting Internal TEA Blockade Identify the Probable Pore-Forming Region of a K + Channel
1991 StandoutScienceNobel
Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
1998
Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor
1997
The Role of SOCS-3 in Leptin Signaling and Leptin Resistance
1999
Genome organization and transactivation of the human immunodeficiency virus type 2
1987 StandoutNatureNobel
Mutant Potassium Channels with Altered Binding of Charybdotoxin, a Pore-Blocking Peptide Inhibitor
1989 StandoutScienceNobel
Block of Ca 2+ Wave and Ca 2+ Oscillation by Antibody to the Inositol 1,4,5-Trisphosphate Receptor in Fertilized Hamster Eggs
1992 StandoutScienceNobel
Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor
1989 StandoutNatureNobel
Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.
1988
Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic Receptor
1994 StandoutScienceNobel
Defective STAT signaling by the leptin receptor in diabetic mice.
1996
Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance
1997
Identification of a Peptide Specific for Aplysia Sensory Neurons by PCR-based Differential Screening
1991 StandoutScienceNobel
Diversity of murine gamma genes and expression in fetal and adult T lymphocytes
1986 StandoutNatureNobel
A generic intron increases gene expression in transgenic mice.
1991
A Novel, Tissue-Restricted Zinc Finger Protein (HF-1b) Binds to the Cardiac Regulatory Element (HF-1b/MEF-2) in the Rat Myosin Light-Chain 2 Gene
1993
The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.
1996
Muscle and nerve-specific regulation of a novel NK-2 class homeodomain factor in Caenorhabditis elegans
1998 StandoutNobel
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor
1998
The regulation of myogenin gene expression during the embryonic development of the mouse.
1993
Control of Memory Formation Through Regulated Expression of a CaMKII Transgene
1996 StandoutScienceNobel
HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA
1986
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
1993 StandoutNatureNobel
Alternative 5′ exons in c-abl mRNA
1986 Nobel
Tissue specificity of Drosophila P element transposition is regulated at the level of mRNA splicing
1986
Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y
1996 Science
Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface
1992 StandoutScienceNobel
The memory gene dunce+ encodes a remarkable set of RNAs with internal heterogeneity.
1986
Molecular Advances in Cardiovascular Biology
1993 Science
Introns increase transcriptional efficiency in transgenic mice.
1988
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Structure and expression of the rat inositol 1,4,5-trisphosphate receptor.
1990 StandoutNobel
Regulation of the Twist target gene tinman by modular cis-regulatory elements during early mesoderm development
1997
Fine Structure of the Murine Leptin Receptor Gene: Splice Site Suppression Is Required to Form Two Alternatively Spliced Transcripts
1997
Substrate-Based Design of the First Class of Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Inhibitors
2002
The Mating of a Fly
1994 StandoutScienceNobel
The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle
1994 StandoutNobel
Increased Angiotensin-(1-7)–Forming Activity in Failing Human Heart Ventricles
2003
Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm
1989 StandoutNobel
Neurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin
1992 StandoutScienceNobel
Synapsins: Mosaics of Shared and Individual Domains in a Family of Synaptic Vesicle Phosphoproteins
1989 StandoutScienceNobel
A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene
1987 StandoutNatureNobel
Mutations Affecting Tea Blockade and Ion Permeation in Voltage-activated K + Channels
1990 StandoutScienceNobel
Combinatorial structure of a body muscle-specific transcriptional enhancer in Caenorhabditis elegans.
1994 StandoutNobel
Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus
1998
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
1997
Spontaneous Neurodegeneration in Transgenic Mice with Mutant Prion Protein
1990 StandoutScienceNobel
Positional Cloning and Sequence Analysis of the Drosophila Clock Gene, timeless
1995 Science
Works of Roger E. Breitbart being referenced
Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice
2006
Alternative splicing is an efficient mechanism for the generation of protein diversity: Contractile protein genes as a model system
1991
A Newtinman-Related Gene,nkx2.7,Anticipates the Expression ofnkx2.5andnkx2.3in Zebrafish Heart and Pharyngeal Endoderm
1996
Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice
1996 Standout
A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9
2000 Standout
MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex.
1993
Expression of Neutrophil Collagenase (Matrix Metalloproteinase-8) in Human Atheroma
2001
Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.
1992
A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage
1993
ALTERNATIVE SPLICING: A UBIQUITOUS MECHANISM FOR THE GENERATION OF MULTIPLE PROTEIN ISOFORMS FROM SINGLE GENES
1987
Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene
1985