Standout Papers
Citation Impact
Citing Papers
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
2007 StandoutScienceNobel
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Hypoxia — a key regulatory factor in tumour growth
2002 Standout
Early Expression of Angiogenesis Factors in Acute Myocardial Ischemia and Infarction
2000
Arginine, arginine analogs and nitric oxide production in chronic kidney disease
2006
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1
2000 StandoutNobel
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Hypoxia-inducible factor 1, a master transcription factor of cellular hypoxic gene expression
2002
The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway
2004 StandoutNobel
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3.
1998
ENDOTHELIAL CELL RESPONSES TO HYPOXIC STRESS
1999
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
2019 Nature
Hypoxia-Inducible Factor 1-Alpha Reduces Infarction and Attenuates Progression of Cardiac Dysfunction After Myocardial Infarction in the Mouse
2005
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases
2005 StandoutNobel
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
Relationship Among the Severity of Sleep Apnea Syndrome, Cardiac Arrhythmias, and Autonomic Imbalance
2003
New insights into nNOS regulation of vascular homeostasis
2005 StandoutNobel
Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells
2010
An independent association between obstructive sleep apnoea and coronary artery disease
1999
HIF-1 and mechanisms of hypoxia sensing
2001 StandoutNobel
HIF-1, O2, and the 3 PHDs
2001 StandoutNobel
Hypoxia Upregulates Inducible (Type II) Nitric Oxide Synthase in an HIF-1 Dependent Manner in Rat Pulmonary Microvascular But Not Aortic Smooth Muscle Cells
1998
Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension
2000 Standout
Structural Basis of Inward Rectification
2002 StandoutNobel
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
The Human Hypoxia-Inducible Factor 1α Gene:HIF1AStructure and Evolutionary Conservation
1998 StandoutNobel
Neuron–glia crosstalk gets serious: role in pain hypersensitivity
2008
Constitutively active and G-protein coupled inward rectifier K+ channels: Kir2.0 and Kir3.0
2007
Characterization of Endothelium- Dependent Relaxation in Guinea Pig Basilar Artery – Effect of Hypoxia and Role of Cytochrome P<sub>450</sub> Mono-Oxygenase
1998
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Regulation of HIF-1α Stability through S-Nitrosylation
2007
Role of controlled cardiac reoxygenation in reducing nitric oxide production and cardiac oxidant damage in cyanotic infantile hearts.
1994 StandoutNobel
Hypoxia: A key regulator of angiogenesis in cancer
2007
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
1999 StandoutNobel
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
Receptors and G proteins as primary components of transmembrane signal transduction
1995
Continuous Positive Airway Pressure Treatment of Mild to Moderate Obstructive Sleep Apnea Reduces Cardiovascular Risk
2007
Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission
1992 StandoutNobel
Long-term Effects of Nasal Continuous Positive Airway Pressure Therapy on Cardiovascular Outcomes in Sleep Apnea Syndrome
2005
Warm Temperature-sensitive Transient Receptor Potential Vanilloid 4 (TRPV4) Plays an Essential Role in Thermal Hyperalgesia
2004
Neuronal Nitric Oxide Synthase Self-inactivates by Forming a Ferrous-Nitrosyl Complex during Aerobic Catalysis
1995 StandoutNobel
Long-Term Potentiation Is Reduced in Mice That Are Doubly Mutant in Endothelial and Neuronal Nitric Oxide Synthase
1996 StandoutNobel
NO and CO as second messengers in oxygen sensing in the carotid body
1999
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Perspectives on Oxygen Sensing
1999 StandoutNobel
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
2006 StandoutNobel
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
S-Nitrosothiols signal the ventilatory response to hypoxia
2001 Nature
Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial
2002
Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity
2009 Standout
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Obstructive sleep apnoea and its cardiovascular consequences
2008 Standout
Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation
2009
Augmentation of hypoxia-induced nitric oxide generation in the rat carotid body adapted to chronic hypoxia: an involvement of constitutive and inducible nitric oxide synthases
2002
Host protective roles of type 2 immunity: Parasite killing and tissue repair, flip sides of the same coin
2014
Protein S-nitrosylation: purview and parameters
2005 Standout
Randomized Placebo-controlled Trial of Continuous Positive Airway Pressure on Blood Pressure in the Sleep Apnea–Hypopnea Syndrome
2001
Enhanced Release of Superoxide from Polymorphonuclear Neutrophils in Obstructive Sleep Apnea
2000
Sleep-disordered Breathing and Coronary Artery Disease
2001
Obstructive Sleep Apnea–Hypopnea and Related Clinical Features in a Population-based Sample of Subjects Aged 30 to 70 Yr
2001 Standout
S-Nitrosothiol Signaling in Respiratory Biology
2006
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
2000 StandoutNobel
Differential signaling pathways ofHO-1gene expression in pulmonary and systemic vascular cells
1999
Life with Oxygen
2007 StandoutScienceNobel
Mammalian Oxygen Sensing, Signalling and Gene Regulation
2000
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
PROLINE HYDROXYLATION AND GENE EXPRESSION
2005 StandoutNobel
Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.
1989 StandoutNobel
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Cellular adaptation to hypoxia: O 2 ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O 2 ‐regulated gene expression
2002
Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter
2005
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
2005 StandoutScienceNobel
Partial HIF-1α deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia
2001 StandoutNobel
Isoforms of nitric oxide synthase
1995
Inhibitory Substrate Binding Site of Human Indoleamine 2,3-Dioxygenase
2009
Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases
2003
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
Treatment with Continuous Positive Airway Pressure Is Not Effective in Patients with Sleep Apnea but No Daytime Sleepiness
2001
Alterations in a redox oxygen sensing mechanism in chronic hypoxia
2001
Daytime blood pressure elevation after nocturnal hypoxia
1999
Effect of Nasal Continuous Positive Airway Pressure Treatment on Blood Pressure in Patients With Obstructive Sleep Apnea
2003
Hypoxia-Induced Pulmonary Vascular Remodeling
2006
Inflammatory mediators and modulators of pain
2006
Regulation of Mammalian O2Homeostasis by Hypoxia-Inducible Factor 1
1999 StandoutNobel
Role of nitric oxide in the regulation of HIF-1α expression during hypoxia
2002
Hypoxia. 2. Hypoxia regulates cellular metabolism
2010
Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.
1994 StandoutNobel
Hypoxia-inducible factor 1: master regulator of O2 homeostasis
1998 StandoutNobel
THE REGULATION AND PHARMACOLOGY OF ENDOTHELIAL NITRIC OXIDE SYNTHASE
2005
Mechanisms of cigarette smoke-induced COPD: insights from animal models
2008
HIF-1 and human disease: one highly involved factor
2000 StandoutNobel
Dysfunctional Endothelial Nitric Oxide Biosynthesis in Healthy Smokers With Impaired Endothelium-Dependent Vasodilatation
2001
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Effect of Hyperbaric Oxygen Treatment on Nitric Oxide and Oxygen Free Radicals in Rat Brain
2000
Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung
1998 StandoutNobel
Works of Roger A. Johns being referenced
Cell-permeable Peptide Tat-PSD-95 PDZ2 Inhibits Chronic Inflammatory Pain Behaviors in Mice
2008
Regulation of nitric oxide synthase by nitric oxide.
1993
Normoxic Stabilization of Hypoxia-Inducible Factor-1 Expression and Activity: Redox-Dependent Effect of Nitrogen Oxides
2000
Effect of knock down of spinal cord PSD-93/chapsin-110 on persistent pain induced by complete Freund's adjuvant and peripheral nerve injury
2003
Activation and up-regulation of spinal cord nitric oxide receptor, soluble guanylate cyclase, after formalin injection into the rat hind paw
2002
Post-synaptic density-93 mediates tyrosine-phosphorylation of the N-methyl-d-aspartate receptors
2008
Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord
2005
Activation of cGMP-dependent protein kinase Iα is required for N-methyl-d-aspartate- or nitric oxide-produced spinal thermal hyperalgesia
2000
Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain
2005
Regression of chronic hypoxic pulmonary hypertension by simvastatin
2007
New role for spinal Stargazin in α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor‐mediated pain sensitization after inflammation
2006
Differential roles of neuronal and endothelial nitric oxide synthases during carrageenan-induced inflammatory hyperalgesia
2004
Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase
2003
Knockdown of PSD-95/SAP90 delays the development of neuropathic pain in rats
2001
Expression and action of cyclic GMP-dependent protein kinase Iα in inflammatory hyperalgesia in rat spinal cord
1999
Expression of PSD-95/SAP90 is critical for N-methyl-d-aspartate receptor-mediated thermal hyperalgesia in the spinal cord
2000
Attenuation of chronic hypoxic pulmonary hypertension by simvastatin
2003
Health effects of obstructive sleep apnoea and the effectiveness of continuous positive airways pressure: a systematic review of the research evidence
1997
Determination of Km for oxygen of nitric oxide synthase isoforms.
1996
Para-bromophenacyl bromide inhibits endothelium-dependent arterial relaxation and cyclic GMP accumulation by effects produced exclusively in the smooth muscle.
1988
Regulation of Ciliary Beat Frequency by the Nitric Oxide–Cyclic Guanosine Monophosphate Signaling Pathway in Rat Airway Epithelial Cells
2000
Hypoxic Regulation of Inducible Nitric Oxide Synthase via Hypoxia Inducible Factor-1 in Cardiac Myocytes
2000
Decreased Exhaled Nitric Oxide in Pulmonary Arterial Hypertension
2005
Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung
1996
Impaired NMDA Receptor-Mediated Postsynaptic Function and Blunted NMDA Receptor-Dependent Persistent Pain in Mice Lacking Postsynaptic Density-93 Protein
2003
eNOS-deficient mice show reduced pulmonary vascular proliferation and remodeling to chronic hypoxia
2000
Upregulation of Nitric Oxide Synthase Correlates Temporally With Onset of Pulmonary Vascular Remodeling in the Hypoxic Rat
1996
Chronic inhaled nitric oxide: effects on pulmonary vascular endothelial function and pathology in rats
1996
Receptors and channels
2004
Endothelium-dependent relaxation and cyclic GMP accumulation in rabbit pulmonary artery are selectively impaired by moderate hypoxia.
1989
Direct and reversible inhibition of endothelial nitric oxide synthase by nitric oxide
1995
FIZZ1/RELMα, a Novel Hypoxia-Induced Mitogenic Factor in Lung With Vasoconstrictive and Angiogenic Properties
2003
Evidence for Dysregulation of Dimethylarginine Dimethylaminohydrolase I in Chronic Hypoxia–Induced Pulmonary Hypertension
2003
Distribution of NOS in normoxic vs. hypoxic rat lung: upregulation of NOS by chronic hypoxia
1994
Characterization of endothelium-derived relaxing factor/nitric oxide synthase from bovine cerebellum and mechanism of modulation by high and low oxygen tensions.
1991
Immunochemical detection of inducible NO synthase in human lung
1994
Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1
1998 StandoutNobel