Standout Papers
Citation Impact
Citing Papers
Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
2015 StandoutNobel
Comprehensive single-cell transcriptional profiling of a multicellular organism
2017 Science
Spatially resolved, highly multiplexed RNA profiling in single cells
2015 StandoutScience
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
2015 StandoutScience
Nucleic acid detection with CRISPR-Cas13a/C2c2
2017 StandoutScience
Programmable RNA recognition using a CRISPR-associated Argonaute
2018 StandoutNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
Pathophysiology of Migraine: A Disorder of Sensory Processing
2017 Standout
Sleep Drives Metabolite Clearance from the Adult Brain
2013 StandoutScience
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
2005 StandoutScience
Single-Cell RNA-Seq Reveals Dynamic, Random Monoallelic Gene Expression in Mammalian Cells
2014 Science
Identification of neuropeptide-like protein gene families in Caenorhabditis elegans and other species
2001
Quartz-Seq: a highly reproducible and sensitive single-cell RNA sequencing method, reveals non-genetic gene-expression heterogeneity
2013
RNA-seq Profiling of Small Numbers of Drosophila Neurons
2014 StandoutNobel
Narcolepsy
1999
Metabolic cycles as an underlying basis of biological oscillations
2006
Validation of noise models for single-cell transcriptomics
2014
Scaling single-cell genomics from phenomenology to mechanism
2017 Nature
Molecular Architecture of the Mouse Nervous System
2018 Standout
Single-cell sequencing-based technologies will revolutionize whole-organism science
2013
RNA-seq analysis of Drosophila clock and non-clock neurons reveals neuron-specific cycling and novel candidate neuropeptides
2017 StandoutNobel
Stress and Arousal: The Corticotrophin-Releasing Factor/Hypocretin Circuitry
2005
Hypothalamic regulation of sleep and circadian rhythms
2005 StandoutNature
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Sleep State Switching
2010
Smart-seq2 for sensitive full-length transcriptome profiling in single cells
2013 Standout
Deconstructing transcriptional heterogeneity in pluripotent stem cells
2014 Nature
Rest in Drosophila Is a Sleep-like State
2000
Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex
2005
The hypocretins: Setting the arousal threshold
2002
Unified rational protein engineering with sequence-based deep representation learning
2019
Reduced Number of Hypocretin Neurons in Human Narcolepsy
2000 Standout
The changing landscape of atherosclerosis
2021 StandoutNature
Effects of lateral hypothalamic lesion with the neurotoxin hypocretin-2–saporin on sleep in Long–Evans rats
2003
The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
2014 Standout
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Hypocretin/Orexin Overexpression Induces An Insomnia-Like Phenotype in Zebrafish
2006
Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle
2005
Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons
2005
Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning
2015 Standout
Input organization and plasticity of hypocretin neurons
2005
Image-based transcriptomics in thousands of single human cells at single-molecule resolution
2013
Differential Distribution and Regulation of OX1 and OX2 Orexin/Hypocretin Receptor Messenger RNA in the Brain upon Fasting
2000
Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice
2003
The single-cell transcriptional landscape of mammalian organogenesis
2019 StandoutNature
Accounting for technical noise in single-cell RNA-seq experiments
2013
Central administration of neuropeptide Y induces wakefulness in rats
2006
The Human Prepro-orexin Gene Regulatory Region That Activates Gene Expression in the Lateral Region and Represses It in the Medial Regions of the Hypothalamus
2002
Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq
2014 Nature
Bayesian approach to single-cell differential expression analysis
2014
Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice
2005
Genome-wide RNA Tomography in the Zebrafish Embryo
2014
Reducing ligation bias of small RNAs in libraries for next generation sequencing
2012
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
2013 Nature
Interaction between the Corticotropin-Releasing Factor System and Hypocretins (Orexins): A Novel Circuit Mediating Stress Response
2004
Central nervous system control of food intake
2000 StandoutNature
Quantitative single-cell RNA-seq with unique molecular identifiers
2013
Differential expression of orexin receptors 1 and 2 in the rat brain
2001
An efficient and sensitive method for preparing cDNA libraries from scarce biological samples
2014 StandoutNobel
Neocortical excitation/inhibition balance in information processing and social dysfunction
2011 StandoutNature
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
2007
Narcolepsy in orexin Knockout Mice
1999 Standout
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Deep learning and process understanding for data-driven Earth system science
2019 StandoutNature
Neural substrates of awakening probed with optogenetic control of hypocretin neurons
2007 Nature
An ~140-kb deletion associated with feline spinal muscular atrophy implies an essentialLIX1function for motor neuron survival
2006
Orexin receptors as therapeutic drug targets
2012
Spatial reconstruction of single-cell gene expression data
2015 Standout
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Full-length RNA-seq from single cells using Smart-seq2
2014 Standout
A neural circuit for circadian regulation of arousal
2001
Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue
2014
CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq
2016
Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity
2015
Microarray Analysis and Organization of Circadian Gene Expression in Drosophila
2001 StandoutNobel
Exponential scaling of single-cell RNA-seq in the past decade
2018
Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming
2013
Circadian-dependent and circadian-independent behavioral actions of hypocretin/orexin
2002
Cataplexy-Active Neurons in the Hypothalamus
2004
The Drosophila takeout Gene Is a Novel Molecular Link between Circadian Rhythms and Feeding Behavior
2000 StandoutNobel
Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose‐responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus
2004
The neurobiology, diagnosis, and treatment of narcolepsy
2003
The hypocretin/orexin ligand–receptor system: implications for sleep and sleep disorders
2000
The sleep switch: hypothalamic control of sleep and wakefulness
2001
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
Arousal systems
2003
Integrative single-cell analysis
2019
Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells
2013
Comprehensive Integration of Single-Cell Data
2019 Standout
RNA Bind-n-Seq: Quantitative Assessment of the Sequence and Structural Binding Specificity of RNA Binding Proteins
2014 Nobel
The molecular neurobiology of depression
2008 StandoutNature
Decreased plasma orexin-A levels in obese individuals
2002
Evaluation of methods for modeling transcription factor sequence specificity
2013
Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes
2014
A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep
2003
Body weight is regulated by the brain: a link between feeding and emotion
2005
Tet1 controls meiosis by regulating meiotic gene expression
2012 Nature
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
The evolution of gene expression levels in mammalian organs
2011 StandoutNatureNobel
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
2016
Fasting Activates the Nonhuman Primate Hypocretin (Orexin) System and Its Postsynaptic Targets
2003
Single Cell RNA Sequencing in Atherosclerosis Research
2020
Hypoglycemia Activates Orexin Neurons and Selectively Increases Hypothalamic Orexin-B Levels
2001
Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs.
2000
Fos Expression in Orexin Neurons Varies with Behavioral State
2001
Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types
2014 Science
The Human Cell Atlas
2017
Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments
2012
Obesity, migraine, and chronic migraine
2007
Evolutionary-scale prediction of atomic-level protein structure with a language model
2023 StandoutScience
Genetic contributions to generalized arousal of brain and behavior
2003 StandoutNobel
Dopaminergic Role in Stimulant-Induced Wakefulness
2001
Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain
2008 StandoutNobel
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Comprehensive comparative analysis of RNA sequencing methods for degraded or low input samples
2013
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
CSF hypocretin/orexin levels in narcolepsy and other neurological conditions
2001
Trigeminohypothalamic and Reticulohypothalamic Tract Neurons in the Upper Cervical Spinal Cord and Caudal Medulla of the Rat
2000
The Role of Hypocretins (Orexins) in Sleep Regulation and Narcolepsy
2002
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
Release of Hypocretin (Orexin) during Waking and Sleep States
2002
To Eat or to Sleep? Orexin in the Regulation of Feeding and Wakefulness
2001
The CircadianClockMutation Alters Sleep Homeostasis in the Mouse
2000
Critical Role of Dorsomedial Hypothalamic Nucleus in a Wide Range of Behavioral Circadian Rhythms
2003
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Hypocretin-1 Modulates Rapid Eye Movement Sleep through Activation of Locus Coeruleus Neurons
2000
Circadian neuron feedback controls the Drosophila sleep–activity profile
2016 StandoutNatureNobel
Protein–DNA binding: complexities and multi-protein codes
2013
Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system
1999
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
2020 StandoutNobel
Works of Robin Li being referenced
Direct measurement of DNA affinity landscapes on a high-throughput sequencing instrument
2011
Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells
2012
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
1999 Standout