Standout Papers
- A cis-acting mutation in the Sindbis virus junction region which affects subgenomic RNA synthesis (1989)
- Production of infectious RNA transcripts from Sindbis virus cDNA clones: mapping of lethal mutations, rescue of a temperature-sensitive marker, and in vitro mutagenesis to generate defined mutants (1987)
- Sindbis Virus: An Efficient, Broad Host Range Vector for Gene Expression in Animal Cells (1989)
Citation Impact
Citing Papers
Infectious Clones of Chikungunya Virus (La Réunion Isolate) for Vector Competence Studies
2006
Infectious enveloped RNA virus antigenic chimeras.
1992 StandoutNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Amplification and cloning of the full-length genome of Japanese encephalitis virus by a novel long RT-PCR protocol in a cosmid vector
2001
A New Generation of Animal Cell Expression Vectors Based on the Semliki Forest Virus Replicon
1991
The full-length nucleotide sequences of the virulent Trinidad donkey strain of Venezuelan equine encephalitis virus and its attenuated vaccine derivative, strain TC-83
1989
Alphaviruses ? vectors for the expression of heterologous genes
1993
Suppressor Mutations That Allow Sindbis Virus RNA Polymerase to Function with Nonaromatic Amino Acids at the N-Terminus: Evidence for Interaction between nsP1 and nsP4 in Minus-Strand RNA Synthesis
2000
In vitro synthesis of infectious venezuelan equine encephalitis virus RNA from a cDNA clone: Analysis of a viable deletion mutant
1989
Coronaviruses and the human airway: a universal system for virus-host interaction studies
2016
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Phosphorylation of sindbis virus nsP3 in vivo and in vitro
1990 StandoutNobel
A Significantly Improved Semliki Forest Virus Expression System Based on Translation Enhancer Segments from the Viral Capsid Gene
1994
mRNA-based therapeutics — developing a new class of drugs
2014 StandoutNobel
Alphavirus expression systems: Applications to mosquito vector studies
1993
Structure of the Ockelbo virus genome and its relationship to other sindbis viruses
1991
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Complete sequence of the genomic RNA of O'Nyong-Nyong virus and its use in the construction of alphavirus phylogenetic trees
1990
Identification of Mutations in a Sindbis Virus Variant Able to Establish Persistent Infection in BHK Cells: The Importance of a Mutation in the nsP2 Gene
1997
Alphavirus Vectors for Gene Therapy Applications
2001
Alphaviruses as expression vectors
1997
Development of a new Sindbis virus transducing system and its characterization in three Culicine mosquitoes and two Lepidopteran species
2004
A CRISPR toolbox to study virus–host interactions
2017
RNA viruses as gene expression vectors
1989 StandoutNobel
An Infectious Clone of the West Nile Flavivirus
2001
A ‘minimal’ approach in design of flavivirus infectious DNA
2001
Identification of the active site residues in the nsP2 proteinase of sindbis virus
1992
Expression of sindbis virus nsP1 and methyltransferase activity inEscherichia coli
1991
Mutations that confer resistance to mycophenolic acid and ribavirin on sindbis virus map to the nonstructural protein nsP1
1991
Antiidiotypic antibodies as probes for the sindbis virus receptor
1991
Prospects for a vaccine against the hepatitis C virus
2005 StandoutNatureNobel
Intracellular immunization of mosquito cells to LaCrosse virus using a recombinant Sindbis virus vector
1994
The expression of chloramphenicol acetyltransferase in Aedes albopictus (C6/36) cells and Aedes triseriatus mosquitoes using a double subgenomic recombinant sindbis virus
1994 StandoutNobel
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Cleavage between nsP1 and nsP2 initiates the processing pathway of Sindbis virus nonstructural polyprotein P123
1990
Tracking and Elucidating Alphavirus-Host Protein Interactions
2006 StandoutNobel
Sequence of the genome RNA of rubella virus: Evidence for genetic rearrangement during togavirus evolution
1990
Novel infectious particles generated by expression of the vesicular stomatitis virus glycoprotein from a self-replicating RNA
1994
Noncytopathic Flavivirus Replicon RNA-Based System for Expression and Delivery of Heterologous Genes
1999
Molecular Biology of Rubella Virus
1994
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Association of the sindbis virus RNA methyltransferase activity with the nonstructural protein nsP1
1989 StandoutNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Regulation of alphavirus 26S mRNA transcription by replicase component nsP2.
1998
Antigenic and genetic characterization of sindbis virus monoclonal antibody escape mutants which define a pathogenesis domain on glycoprotein E2
1990
A Plasmid-Based Self-Amplifying Sindbis Virus Vector
1995
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
A chimeric alphavirus RNA replicon gene-based vaccine for human parainfluenza virus type 3 induces protective immunity against intranasal virus challenge
2006
Molecular Pathogenesis of Sindbis Virus Encephalitis in Experimental Animals
1989
Alphavirus expression vectors and their use as recombinant vaccines: a minireview
1997
Evidence that sindbis virus NSP2 is an autoprotease which processes the virus nonstructural polyprotein
1989
Infectious RNA transcripts from ross river virus cDNA clones and the construction and characterization of defined chimeras with sindbis virus
1991
Temperature sensitive shut-off of alphavirus minus strand RNA synthesis maps to a nonstructural protein, nsP4
1990 StandoutNobel
Construction and Characterization of Subgenomic Replicons of New York Strain of West Nile Virus
2002
TNFα, Interferon, and Stress Response Induction as a Function of Age-Related Susceptibility to Fatal Sindbis Virus Infection of Mice
1999
Conserved elements in the 3′ untranslated region of flavivirus RNAs and potential cyclization sequences
1987 StandoutNobel
Attenuating mutations in the E2 glycoprotein gene of Venezuelan equine encephalitis virus: Construction of single and multiple mutants in a full-length cDNA clone
1991
Cis-acting RNA elements at the 5′ end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis
2001 StandoutNobel
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Chapter 3 Recombinant Sindbis Virus as an Expression System for Cell Biology
1994
Nucleotide sequence of classical swine fever virus strain Alfort/187 and transcription of infectious RNA from stably cloned full-length cDNA
1996
Evolution of the Sindbis virus subgenomic mRNA promoter in cultured cells
1995
Sindbis virus expression vectors: packaging of RNA replicons by using defective helper RNAs
1993 StandoutNobel
In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3
1990
Sequence Requirements for Sindbis Virus Subgenomic mRNA Promoter Function in Cultured Cells
2001
Defined mutations in the 5' nontranslated sequence of Sindbis virus RNA
1990
Attenuation of Sindbis virus neurovirulence by using defined mutations in nontranslated regions of the genome RNA
1992
Roles of Nonstructural Protein nsP2 and Alpha/Beta Interferons in Determining the Outcome of Sindbis Virus Infection
2002 StandoutNobel
NS2B-3 proteinase-mediated processing in the yellow fever virus structural region: in vitro and in vivo studies
1994 StandoutNobel
Functional Analysis of nsP3 Phosphoprotein Mutants ofSindbisVirus
2003
The alphaviruses: gene expression, replication, and evolution
1994 Standout
Attenuation of Venezuelan equine encephalitis virus strain TC-83 is encoded by the 5'-noncoding region and the E2 envelope glycoprotein
1993
Alphavirus RNA Genome Repair and Evolution: Molecular Characterization of Infectious Sindbis Virus Isolates Lacking a Known Conserved Motif at the 3′ End of the Genome
2000
Sindbis Virus Nonstructural Protein nsP2 Is Cytotoxic and Inhibits Cellular Transcription
2006
Sindbis virus RNA-negative mutants that fail to convert from minus-strand to plus-strand synthesis: role of the nsP2 protein
1996
Selection of RNA Replicons Capable of Persistent Noncytopathic Replication in Mammalian Cells
1999 StandoutNobel
The Zinc Finger Antiviral Protein Directly Binds to Specific Viral mRNAs through the CCCH Zinc Finger Motifs
2004
Evidence for specificity in the encapsidation of Sindbis virus RNAs
1989
Sindbis virus nsP1 functions in negative-strand RNA synthesis
1991
Molecularly engineered resistance to California serogroup virus replication in mosquito cells and mosquitoes.
1996
Modification of the 5′ Terminus of Sindbis Virus Genomic RNA Allows nsP4 RNA Polymerases with Nonaromatic Amino Acids at the N Terminus To Function in RNA Replication
2003
Utilization of heterologous alphavirus junction sequences as promoters by Sindbis virus
1992
A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro
1995 StandoutNobel
Inhibition of Transcription and Translation in Sindbis Virus-Infected Cells
2005
Nucleocapsid-glycoprotein interactions required for assembly of alphaviruses
1994
The hepatitis C virus NS3 serine proteinase and NS4A cofactor: establishment of a cell-free trans-processing assay.
1995 StandoutNobel
Mechanism of altered Sindbis virus neurovirulence associated with a single-amino-acid change in the E2 Glycoprotein
1991
Rescue of Sindbis virus-specific RNA replication and transcription by using a vaccinia virus recombinant
1991 StandoutNobel
Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini
1994 StandoutNobel
Development of Sindbis Viruses Encoding nsP2/GFP Chimeric Proteins and Their Application for Studying nsP2 Functioning
2007
Biogenesis of type I cytopathic vacuoles in Semliki Forest virus-infected BHK cells
1991
Conformational alteration of Sindbis virion glycoproteins induced by heat, reducing agents, or low pH
1992
Catalytic Core of Alphavirus Nonstructural Protein nsP4 Possesses Terminal Adenylyltransferase Activity
2006
Intracellular interference of tick-borne flavivirus infection by using a single-chain antibody fragment delivered by recombinant Sindbis virus
1995
Deletion Analysis of a Defective Interfering Semliki Forest Virus RNA Genome Defines a Region in the nsP2 Sequence That Is Required for Efficient Packaging of the Genome into Virus Particles
1998
Solubilization and immunoprecipitation of alphavirus replication complexes
1991
Mapping of RNA- temperature-sensitive mutants of Sindbis virus: complementation group F mutants have lesions in nsP4
1989 StandoutNobel
Host Factors Associated with the Sindbis Virus RNA-Dependent RNA Polymerase: Role for G3BP1 and G3BP2 in Virus Replication
2010 StandoutNobel
Infection initiated by the RNA pregenome of a DNA virus
1991
An infectious arterivirus cDNA clone: Identification of a replicase point mutation that abolishes discontinuous mRNA transcription
1997
Genetic analysis of the nsP3 region of Sindbis virus: evidence for roles in minus-strand and subgenomic RNA synthesis
1994 StandoutNobel
A stable full-length yellow fever virus cDNA clone and the role of conserved RNA elements in flavivirus replication
2003 StandoutNobel
Class I MHC Molecule-Mediated Inhibition of Sindbis Virus Replication
1999 StandoutNobel
In vitro mutagenesis of a full-length cDNA clone of Semliki Forest virus: the small 6,000-molecular-weight membrane protein modulates virus release
1991
Replicon Vectors Derived from Sindbis Virus and Semliki Forest Virus That Establish Persistent Replication in Host Cells
2000
The signal for translational readthrough of a UGA codon in Sindbis virus RNA involves a single cytidine residue immediately downstream of the termination codon
1993 StandoutNobel
Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes
1993
Nonstructural proteins nsP3 and nsP4 of Ross River and O'Nyong-nyong viruses: Sequence and comparison with those of other alphaviruses
1988 StandoutNobel
The efficient intracellular sequestration of the insulin-regulatable glucose transporter (GLUT-4) is conferred by the NH2 terminus
1992
Nuclear localization of Semliki Forest virus-specific nonstructural protein nsP2
1990
A development that may evolve into a revolution in medicine: mRNA as the basis for novel, nucleotide-based vaccines and drugs
2013
Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics
1994 StandoutNobel
Rubella virus-specific cytotoxic T-lymphocyte responses: identification of the capsid as a target of major histocompatibility complex class I-restricted lysis and definition of two epitopes
1993 StandoutNobel
Mutagenesis of the in-frame opal termination codon preceding nsP4 of Sindbis virus: studies of translational readthrough and its effect on virus replication
1989 StandoutNobel
Mutagenesis of the conserved 51-nucleotide region of Sindbis virus
1990
Translation of Sindbis virus mRNA: effects of sequences downstream of the initiating codon
1994
Alphavirus-based expression vectors: strategies and applications.
1996 StandoutNobel
Requirements at the 3′ End of the Sindbis Virus Genome for Efficient Synthesis of Minus-Strand RNA
2005 StandoutNobel
Identification of a putative alphavirus receptor on mouse neural cells
1991
Functions of alphavirus nonstructural proteins in RNA replication
2002
Alphavirus nsP3 functions to form replication complexes transcribing negative-strand RNA
1994
Virus Maturation by Budding
1998
Cleavage-site preferences of Sindbis virus polyproteins containing the non-structural proteinase. Evidence for temporal regulation of polyprotein processing in vivo.
1990
DNA Immunization against Herpes Simplex Virus: Enhanced Efficacy Using a Sindbis Virus-Based Vector
1998
Identification of a Dominant Negative Inhibitor of Human Zinc Finger Antiviral Protein Reveals a Functional Endogenous Pool and Critical Homotypic Interactions
2010 StandoutNobel
A viral vaccine vector that expresses foreign genes in lymph nodes and protects against mucosal challenge
1996
Multiple binding sites for cellular proteins in the 3' end of Sindbis alphavirus minus-sense RNA
1993
Comparison of the effects of Sindbis virus and Sindbis virus replicons on host cell protein synthesis and cytopathogenicity in BHK cells
1994
Deduced consensus sequence of Sindbis virus strain AR339: mutations contained in laboratory strains which affect cell culture and in vivo phenotypes
1996
Genesis of Sindbis virus by in vivo recombination of nonreplicative RNA precursors
1995
A second nonstructural protein functions in the regulation of alphavirus negative-strand RNA synthesis
1993
Construction of rubella virus genome-length cDNA clones and synthesis of infectious RNA transcripts
1994
RNA-RNA recombination in Sindbis virus: roles of the 3' conserved motif, poly(A) tail, and nonviral sequences of template RNAs in polymerase recognition and template switching
1997
Molecular analysis of Sindbis virus pathogenesis in neonatal mice by using virus recombinants constructed in vitro
1988 StandoutNobel
Inhibition of Filovirus Replication by the Zinc Finger Antiviral Protein
2006
Noncytopathic Replication of Venezuelan Equine Encephalitis Virus and Eastern Equine Encephalitis Virus Replicons in Mammalian Cells
2005
Alphaviruses in Gene Therapy
2009
Neurovirulent strains of Alphavirus induce apoptosis in bcl-2-expressing cells: role of a single amino acid change in the E2 glycoprotein.
1994
Mutations which alter the level or structure of nsP4 can affect the efficiency of Sindbis virus replication in a host-dependent manner
1990 StandoutNobel
In Vivo Addition of Poly(A) Tail and AU-Rich Sequences to the 3′ Terminus of the Sindbis Virus RNA Genome: a Novel 3′-End Repair Pathway
1999
Sindbis virus RNA polymerase is degraded by the N-end rule pathway.
1991
Viral determinants of age-dependent virulence of Sindbis virus for mice
1993
Negative-strand RNA viruses: genetic engineering and applications.
1996
Infectious Japanese encephalitis virus RNA can be synthesized from in vitro-ligated cDNA templates
1992
Reverse Genetics System for the Avian Coronavirus Infectious Bronchitis Virus
2001
A Novel Coronavirus from Patients with Pneumonia in China, 2019
2020 Standout
Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation.
1992 StandoutNobel
Roles of nonstructural polyproteins and cleavage products in regulating Sindbis virus RNA replication and transcription
1993 StandoutNobel
PKR-Dependent and -Independent Mechanisms Are Involved in Translational Shutoff during Sindbis Virus Infection
2004 StandoutNobel
Selection of Functional 5′ cis -Acting Elements Promoting Efficient Sindbis Virus Genome Replication
2003 StandoutNobel
Formation of nsP3-Specific Protein Complexes during Sindbis Virus Replication
2006
Pathogen-derived resistance to dengue type 2 virus in mosquito cells by expression of the premembrane coding region of the viral genome
1996
CD8+ T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope.
1992 StandoutNobel
Development and Application of a Reverse Genetics System for Japanese Encephalitis Virus
2003 StandoutNobel
Template-Dependent Initiation of Sindbis Virus RNA Replication In Vitro
1998 StandoutNobel
Importance of eIF2α Phosphorylation and Stress Granule Assembly in Alphavirus Translation Regulation
2005
Sindbis virus replicons and Sindbis virus: assembly of chimeras and of particles deficient in virus RNA
1997
Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome
2000
Sindbis virus DNA-based expression vectors: utility for in vitro and in vivo gene transfer
1996
Complementation between Sindbis viral RNAs produces infectious particles with a bipartite genome.
1991
Mapping of RNA- temperature-sensitive mutants of Sindbis virus: assignment of complementation groups A, B, and G to nonstructural proteins
1989
Analysis of Sindbis virus promoter recognition in vivo, using novel vectors with two subgenomic mRNA promoters
1991
Expression of the Zinc-Finger Antiviral Protein Inhibits Alphavirus Replication
2003 StandoutNobel
Sindbis virus ts103 has a mutation in glycoprotein E2 that leads to defective assembly of virions
1989 StandoutNobel
Molecular basis of Sindbis virus neurovirulence in mice
1988
An Alphavirus Replicon Particle Chimera Derived from Venezuelan Equine Encephalitis and Sindbis Viruses Is a Potent Gene-Based Vaccine Delivery Vector
2003
Translation of Sindbis virus mRNA: analysis of sequences downstream of the initiating AUG codon that enhance translation
1996
Processing the nonstructural polyproteins of sindbis virus: nonstructural proteinase is in the C-terminal half of nsP2 and functions both in cis and in trans
1989
Noncytopathic Sindbis virus RNA vectors for heterologous gene expression
1998 StandoutNobel
Recombination between Sindbis virus RNAs
1991
Packaging signals in alphaviruses
1997
Sindbis virus attachment: isolation and characterization of mutants with impaired binding to vertebrate cells
1993 StandoutNobel
Regulation of Sindbis virus RNA replication: uncleaved P123 and nsP4 function in minus-strand RNA synthesis, whereas cleaved products from P123 are required for efficient plus-strand RNA synthesis
1994
Cellular proteins bind to the 3' end of Sindbis virus minus-strand RNA
1992
Genetically Engineered Resistance to Dengue-2 Virus Transmission in Mosquitoes
1996 Science
Infection of Human Dendritic Cells by a Sindbis Virus Replicon Vector Is Determined by a Single Amino Acid Substitution in the E2 Glycoprotein
2000
A sindbis virus mRNA polynucleotide vector achieves prolonged and high level heterologous gene expressionin vivo
1995
Infectious Bovine Viral Diarrhea Virus (Strain NADL) RNA from Stable cDNA Clones: a Cellular Insert Determines NS3 Production and Viral Cytopathogenicity
1998 StandoutNobel
Assembly of functional Sindbis virus RNA replication complexes: requirement for coexpression of P123 and P34
1993 StandoutNobel
Mutagenesis of the 3' nontranslated region of Sindbis virus RNA
1990
Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication
1997 StandoutNobel
Genetic determinants of Sindbis virus neuroinvasiveness
1997 StandoutNobel
Subgenomic replicons of the flavivirus Kunjin: construction and applications
1997
Works of Robin Levis being referenced
Cells of human aminopeptidase N (CD13) transgenic mice are infected by human coronavirus-229E in vitro, but not in vivo
2005
Engineered defective interfering RNAs of Sindbis virus express bacterial chloramphenicol acetyltransferase in avian cells.
1987
Production of infectious RNA transcripts from Sindbis virus cDNA clones: mapping of lethal mutations, rescue of a temperature-sensitive marker, and in vitro mutagenesis to generate defined mutants
1987 StandoutNobel
Promoter for Sindbis virus RNA-dependent subgenomic RNA transcription
1990
Infectious RNA transcripts from full-length dengue virus type 2 cDNA clones made in yeast
1997
A cis-acting mutation in the Sindbis virus junction region which affects subgenomic RNA synthesis
1989 StandoutNobel
Sindbis Virus: An Efficient, Broad Host Range Vector for Gene Expression in Animal Cells
1989 StandoutScienceNobel
Deletion mapping of sindbis virus DI RNAs derived from cDNAs defines the sequences essential for replication and packaging
1986