Standout Papers
Citation Impact
Citing Papers
Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains
1991 StandoutNobel
By-passing immunization
1991 StandoutNobel
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
1988 Standout
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 StandoutNatureNobel
Man-made antibodies
1991 NatureNobel
Foundations for engineering biology
2005 StandoutNature
By-passing immunisation
1992 StandoutNobel
A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast
1989 StandoutNatureNobel
Building Antibodies from their Genes
1992 StandoutNobel
By–Passing Immunization: Building High Affinity Human Antibodies by Chain Shuffling
1992 StandoutNobel
Retroviral vectors displaying functional antibody fragments
1993 StandoutNobel
Phage antibodies: filamentous phage displaying antibody variable domains
1990 StandoutNatureNobel
A comparison of strategies to stabilize immunoglobulin Fv-fragments
1990
Making antibody fragments using phage display libraries
1991 StandoutNatureNobel
mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans
1988 StandoutNobel
Mosaic Organization of Orthologous Sequences in Grass Genomes
2002
[2] New M13 vectors for cloning
1983 Standout
The map-based sequence of the rice genome
2005 StandoutNature
Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product
1987 Standout
Studies on transformation of Escherichia coli with plasmids
1983 Standout
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
1985 StandoutNature
Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis
1983 Standout
The theoretical possibility of reverse translation of proteins into genes
1981
Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin
1982 Nature
A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments
1982 Standout
The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine-specific protein kinases.
1984 StandoutNobel
Rapid synthesis of oligodeoxyribonucleotides VI. Effident, mechanised synthesis of heptadecadeoxyribonucleotides by an improved solid phase phosphotriester route
1981
The nucleotide sequence of the maize controlling element Activator
1984
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene
1983 Nature
Isolation of the human insulin-like growth factor I gene using a single synthetic DNA probe.
1984
Insulin-like growth factor II precursor gene organization in relation to insulin gene family
1984 Nature
Isolation of the yeast nuclear gene encoding the mitochondrial protein, cytochrome c peroxidase.
1982 StandoutNobel
Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors
1985 Standout
Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: A proposal for a synonymous codon choice that is optimal for the E. coli translational system
1981
Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum
1984 StandoutNatureNobel
Green Fluorescent Protein as a Marker for Gene Expression
1994 StandoutScienceNobel
The filamentous phage (Ff) as vectors for recombinant DNA— a review
1982
"Nonrandom" DNA sequence analysis in bacteriophage M13 by the dideoxy chain-termination method.
1982
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA
1983 StandoutNobel
Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison.
1982 StandoutNobel
Design and operation of a completely automated Beckman microsequencer
1984
[7] Synthetic adaptors for cloning DNA
1979
Single-Chain Antigen-Binding Proteins
1988 Science
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
A homeobox-containing marker of posterior neural differentiation shows the importance of predetermination in neural induction
1987 StandoutNobel
Nucleotide sequence of the human N-myc gene.
1986 StandoutNobel
Nucleotide sequence of bacteriophage λ DNA
1982 Nobel
Molecular mechanisms of nucleotide-sequences rearrangement in cDNA clones of human fibroblast interferon mRNA
1981
Nucleotide sequence of the yeast nuclear gene for cytochrome c peroxidase precursor. Functional implications of the pre sequence for protein transport into mitochondria.
1982 StandoutNobel
Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
1982 StandoutNature
Complete sequence of constant and 3′ noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing
1978 StandoutNobel
The structure of the gene encoding the nucleoprotein of human influenza virus A/PR/8/34
1981 StandoutNobel
Nucleotide sequences of influenza virus segments 1 and 3 reveal mosaic structure of a small viral RNA segment
1982 StandoutNobel
GEL, a DNA sequencing project management system
1982
Novel Proteinaceous Infectious Particles Cause Scrapie
1982 StandoutScienceNobel
DNA sequences from the adenovirus 2 genome.
1984 StandoutNobel
The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers
1982 Standout
Efficient isolation of genes by using antibody probes.
1983 Standout
Nucteotide sequence of human influenza A/PR/8/34 segment 2
1982 StandoutNobel
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors
1986 Nature
Human leukocyte interferon: Isolation and characterization of several molecular forms
1981
Efficiency in cloning and sequencing using the single-stranded bacteriophage M13
1984
Sequence of DNA complementry to a small RNA segment of influenza virus A/NT/60/68
1981
"Diabodies": small bivalent and bispecific antibody fragments.
1993 StandoutNobel
The structure of two subgenomic RNAs from human infhienza virus A/PR/8/34
1981 StandoutNobel
Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene
1985 StandoutScience
The making of strand-specific M13 probes
1982
Two new restriction endonucleases from Proteus vulgaris
1981 StandoutNobel
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
1984 StandoutNature
Invertase signal and mature sequence substitutions that delay intercompartmental transport of active enzyme.
1985 StandoutNobel
The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways
1985 StandoutNobel
Structure of the neuraminidase gene in human influenza virus A/PR/8/34
1981 StandoutNatureNobel
The sequence of the nucleoprotein gene of human influenza A virus, strain A/NT/60/68
1982
[29] Synthesis and sequence-specific proteolysis of hybrid proteins produced in Escherichia coli
1987
Assembly of combinatorial antibody libraries on phage surfaces: the gene III site.
1991
Construction and characterization of new cloning vehicles III. Derivatives of plasmid pBR322 carrying unique Eco RI sites for selection of Eco RI generated recombinant DNA molecules
1978
Plasmid vectors containing the tryptophan operon promoter suitable for efficient regulated expression of foreign genes
1980
Synthesis of hepatitis B surface and core antigens in E. coli
1981 Nature
Sequences of the Escherichia coli photolyase gene and protein.
1984 StandoutNobel
Human transforming growth factor-α: Precursor structure and expression in E. coli
1984
Synthetic oligonucleotide probes deduced from amino acid sequence data
1985
Nucleotide-sequence heterogeneity and sequence rearrangements in influenza virus cDNA
1981 StandoutNobel
Expression of human immunoglobulin E ε chain cDNA inE.coli
1983 StandoutNobel
Site-specific mutagenesis of avian erythroblastosis virus: erb-B is required for oncogenicity
1983 StandoutNobel
Heterogeneity at the 5' termini of mouse dihydrofolate reductase mRNAs. Evidence for multiple promoter regions.
1985
Nucleotide sequence to the v-myc oncogene of avian retrovirus MC29.
1983 StandoutNobel
Sequence analysis of zein cDNAs obtained by an efficient mRNA cloning method
1983
Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells
1985 StandoutNature
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
1984 Nature
Transcription of muscle-specific actin genes in early xenopus development: Nuclear transplantation and cell dissociation
1984 StandoutNobel
The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains
1984 StandoutNatureNobel
The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes.
1982
Nucleotide sequence of cloned cDNA of human c-myc oncogene
1983 Nature
Human anti-self antibodies with high specificity from phage display libraries.
1993
Molecular evolution of proteins on filamentous phage. Mimicking the strategy of the immune system.
1992 StandoutNobel
Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29
1983 Nature
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
1984 Standout
A comprehensive set of sequence analysis programs for the VAX
1984 StandoutNobel
Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome
1989 StandoutScienceNobel
Nucleotide sequence of the haemagglutinin gene of a human influenza virus H1 subtype
1981 StandoutNatureNobel
Computer programs for nucleic acid sequence manipulation
1982 StandoutNobel
Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas
1983 Nature
Isolation of a mouse cDNA coding for a developmentally regulated, testis-specific transcript containing homeo box homology.
1986
Nucleotide sequences from the adenovirus-2 genome.
1982 StandoutNobel
Prediction of protein antigenic determinants from amino acid sequences.
1981 Standout
Direct immunoassay for detecting Escherichia coli colonies that contain polypeptides encoded by cloned DNA segments.
1981
Works of Roberto Crea being referenced
Human leukocyte interferon produced by E. coli is biologically active
1980 Nature
Production of biologically active N.alpha.-deacetylthymosin .alpha.1 in Escherichia coli through expression of a chemically synthesized gene
1980
Expression in Escherichia coli of chemically synthesized genes for human insulin.
1979
Synthesis of oligonucleotides on cellulose by a phosphotriester method
1980
Rapid synthesis of oligodeoxyribonucleotides
1979
Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.
1988
Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone
1979 Nature
Synthesis of oligonucleotides on cellulose. Part II: Design and synthetic strategy to the synthesis of 22 oligodeoxynucleotides coding for gastric inhibitory polypeptide (GIP).
1980
Synthesis of human fibroblast interferon by E. coli
1980
A system for shotgun DNA sequencing
1981 Standout
Expression in Escherichia coli of a Chemically Synthesized Gene for the Hormone Somatostatin
1977 Science
Rapid synthesis of trideoxyribonucleotide blocks
1978
Chemical synthesis of genes for human insulin.
1978