Standout Papers
Citation Impact
Citing Papers
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Observation of Covalent Intermediates in an Enzyme Mechanism at Atomic Resolution
2001 Science
An enumerative algorithm for de novo design of proteins with diverse pocket structures
2020 StandoutNobel
Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59
2012 StandoutNobel
Navigating the protein fitness landscape with Gaussian processes
2012 StandoutNobel
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
Principles for designing proteins with cavities formed by curved β sheets
2017 StandoutScienceNobel
Origins of catalysis by computationally designed retroaldolase enzymes
2010 StandoutNobel
Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion
2020 StandoutNobel
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction
2010 StandoutScienceNobel
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
Ultrahigh‐Throughput FACS‐Based Screening for Directed Enzyme Evolution
2009
Evolution of a designed retro-aldolase leads to complete active site remodeling
2013 StandoutNobel
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription
2011
Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly
2006
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Robust design and optimization of retroaldol enzymes
2012 StandoutNobel
Development of protein, peptide, and small molecule catalysts using catalysis‐based selection strategies
2005
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Structural Analyses of Covalent Enzyme–Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme Design
2011 StandoutNobel
Exploration of Alternate Catalytic Mechanisms and Optimization Strategies for Retroaldolase Design
2013 StandoutNobel
Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly
2009
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Comparison of designed and randomly generated catalysts for simple chemical reactions
2012 StandoutNobel
Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells
2017
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
2013 Standout
Enabling functional genomics with genome engineering
2015
Chimeric rabbit/human Fab and IgG specific for members of the Nogo-66 receptor family selected for species cross-reactivity with an improved phage display vector
2006
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
De novo design of luciferases using deep learning
2023 StandoutNatureNobel
Principles for designing ideal protein structures
2012 StandoutNatureNobel
Analysis of the Class I Aldolase Binding Site Architecture Based on the Crystal Structure of 2-Deoxyribose-5-phosphate Aldolase at 0.99 Å Resolution
2004
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
High-throughput screening of enzyme libraries
2000
The coming of age of de novo protein design
2016 StandoutNatureNobel
Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase
2016 StandoutNobel
Kemp elimination catalysts by computational enzyme design
2008 StandoutNatureNobel
CRISPR-Cas systems for editing, regulating and targeting genomes
2014 Standout
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
Design, construction and in vitro testing of zinc finger nucleases
2006
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
A Rationally Designed Aldolase Foldamer
2008
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Recent progress in stereoselective synthesis with aldolases
2010
The Human Condition—A Molecular Approach
2014 StandoutNobel
Genome editing with engineered zinc finger nucleases
2010 Standout
The small peptide-catalyzed direct asymmetric aldol reaction in water
2005
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
2013 StandoutNobel
Genome-editing revolution: My whirlwind year with CRISPR
2015 StandoutNatureNobel
Direct Observation of an Enamine Intermediate in Amine Catalysis
2009
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Labeling Live Cells by Copper-Catalyzed Alkyne−Azide Click Chemistry
2010
Harnessing Protein Symmetry for Enzyme Design
2012
Design of Protein Catalysts
2013
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
TALENs: a widely applicable technology for targeted genome editing
2012
Rational design of a split-Cas9 enzyme complex
2015 StandoutNobel
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
Active Site Plasticity of a Computationally Designed Retro‐Aldolase Enzyme
2014 StandoutNobel
C−C Bond-Forming Lyases in Organic Synthesis
2011
Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts
2014 StandoutNobel
Selective Covalent Protein Immobilization: Strategies and Applications
2009
The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope
2015 StandoutNobel
A Pictet-Spengler ligation for protein chemical modification
2012 StandoutNobel
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
De Novo Computational Design of Retro-Aldol Enzymes
2008 StandoutScienceNobel
Asymmetric Enamine Catalysis
2007 StandoutNobel
Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
2014 StandoutNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
Filamentous Phage Display in the New Millennium
2005
Works of Roberta Fuller being referenced
Development of Zinc Finger Domains for Recognition of the 5′-CNN-3′ Family DNA Sequences and Their Use in the Construction of Artificial Transcription Factors
2005
Methods for the generation of chicken monoclonal antibody fragments by phage display
2000
Chimeric TALE recombinases with programmable DNA sequence specificity
2012
Flow cytometric screening of aldolase catalytic antibodies
2004
Modular system for the construction of zinc-finger libraries and proteins
2010
The Origin of Enantioselectivity in Aldolase Antibodies: Crystal Structure, Site-directed Mutagenesis, and Computational Analysis
2004
Evolution of Aldolase Antibodies in Vitro : Correlation of Catalytic Activity and Reaction-based Selection
2003
Development of Small Designer Aldolase Enzymes: Catalytic Activity, Folding, and Substrate Specificity
2005
Development of a Small Peptide Tag for Covalent Labeling of Proteins
2007
Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task
2000 StandoutNobel