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Rat growth hormone gene expression. Both cell-specific and thyroid hormone response elements are required for thyroid hormone regulation.
1988
Expansive discovery of chemically diverse structured macrocyclic oligoamides
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Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements.
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Differential Regulation of Thyroid Hormone Receptor Messenger Ribonucleic Acid Levels by Thyrotropin-Releasing Hormone
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Type 2 iodothyronine deiodinase is highly expressed in human thyroid.
1996
Thyroid Hormone Receptor Mutations that Interfere with Transcriptional Activation also Interfere with Receptor Interaction with a Nuclear Protein
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Type I iodothyronine deiodinase is a selenocysteine-containing enzyme
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1989 Nature
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Thyroid Hormone Receptors: Multiple Forms, Multiple Possibilities*
1993
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
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Effects of Varying the Position of Thyroid Hormone Response Elements within the Rat Growth Hormone Promoter: Implications for Positive and Negative Regulation by 3,5,3′-Triiodothyronine
1991
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1989
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The Role of Selenium in Thyroid Hormone Action*
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Regulation of gene expression by thyroid hormone.
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The Type 2 Deiodinase A/G (Thr92Ala) Polymorphism Is Associated with Decreased Enzyme Velocity and Increased Insulin Resistance in Patients with Type 2 Diabetes Mellitus
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Placental iodothyronine deiodinase III and II ratios, mRNA expression compared to enzyme activity
1998
The α and β thyroid receptors are expressed by cultured ependymal cells. Correlation with the effect of l-3,5,3′-triiodothyronine on glutamine synthetase mRNAs
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Thrombin signalling and protease-activated receptors
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Thyroid hormone resistance syndrome. Inhibition of normal receptor function by mutant thyroid hormone receptors.
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Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
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IκB: a Specific Inhibitor of the NF-κB Transcription Factor
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MINIREVIEW: Interactions Among a Subfamily of Nuclear Hormone Receptors: The Regulatory Zipper Model
1990
Thyroid Hormone Negatively Regulates the Transcriptional Activity of the β-Amyloid Precursor Protein Gene
1998
Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone.
1990
Structure of the mammalian ribosomal pre-termination complex associated with eRF1•eRF3•GDPNP
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Mast cell tryptases and chymases in inflammation and host defense
2007
Investigation of type I and type III iodothyronine deiodinases in rat tissues using N-bromoacetyl-iodothyronine affinity labels
1995
Topological Analysis of the Integral Membrane Protein, Type 1 Iodothyronine Deiodinase (D1)
1995
The development of allergic inflammation
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A transcriptional co-repressor that interacts with nuclear hormone receptors
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Cloning and Expression of a cDNA for a Mammalian Type III Iodothyronine Deiodinase
1995
Ligand-activated thyroid hormone and retinoic acid receptors inhibit growth factor receptor promoter expression
1990
Characterization of the Promoter of the Rat Sarcoplasmic Endoplasmic Reticulum Ca2+-ATPase 1 Gene and Analysis of Thyroid Hormone Responsiveness
1996
Mast Cell Proteases
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Asthma
2001 Standout
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
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PAS is a dimerization domain common to Drosophila Period and several transcription factors
1993 StandoutNatureNobel
An immunocytochemical analysis of the expression of thyroid hormone receptor α and β proteins during natural and thyroid hormone‐induced metamorphosis in Xenopus
1997
Ligand-dependent Heterodimerization of Thyroid Hormone Receptor and Retinoid X Receptor
1997
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
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Isolation and characterization of the 5â²-upstream and untranslated regions of the mouse type II iodothyronine deiodinase gene
2000
Structure of the Human Type I Iodothyronine 5′-Deiodinase Gene and Localization to Chromosome 1p32–p33
1997
Ligand-independent and -dependent Functions of Thyroid Hormone Receptor Isoforms Depend upon Their Distinct Amino Termini
1995
Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors
1991 Standout
Quantitative Measurements for Type 1 Deiodinase Messenger Ribonucleic Acid in Human Peripheral Blood Mononuclear Cells: Mechanism of the Preferential Increase of T3 in Hyperthyroid Graves' Disease
1998
Identification of two novel splicing variants of human type II iodothyronine deiodinase mRNA
2001
A novel mechanism of action for v-ErbA: Abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors
1991
Cloning of a cDNA for the Type II Iodothyronine Deiodinase
1995
Isolation and Characterization of the Mouse Gene for the Type 3 Iodothyronine Deiodinase1
1999
Recognition of UGA as a selenocysteine codon in Type I deiodinase requires sequences in the 3′ untranslated region
1991 Nature
Mast-Cell Infiltration of Airway Smooth Muscle in Asthma
2002
Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency.
1993
Compilation of transcription regulating proteins
1988
Tadpole competence and tissue‐specific temporal regulation of amphibian metamorphosis: Roles of thyroid hormone and its receptors
1996
Deletion of the Thyroid Hormone β1 Receptor Increases Basal and Triiodothyronine-Induced Growth Hormone Messenger Ribonucleic Acid in GH3Cells*
1997
Developmental and Thyroidal Regulation of the Nuclear T3 Receptors/c-erb a Oncogene Products in the Ob 17 Preadipocyte Cell Line
1991
Nuclear thyroid hormone receptors.
1990
Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*
1994
Synthesis and Microcontact Printing of Dual End‐Functionalized Mucin‐like Glycopolymers for Microarray Applications
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Steroid hormone receptors: Many Actors in search of a plot
1995 Standout
Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues.
1996
Thyroid Hormone Receptors Form Distinct Nuclear Protein-Dependent and Independent Complexes with a Thyroid Hormone Response Element
1990
Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors.
1995
A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors
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The PI3K Pathway in Human Disease
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Ligand Modulates the Interaction of Thyroid Hormone Receptor β with the Basal Transcription Machinery
1995
The RXR heterodimers and orphan receptors
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Triiodothyronine Receptor β-2 Messenger Ribonucleic Acid Expression by Somatotropes and Thyrotropes: Effect of Propylthiouracil-Induced Hypothyroidism in Rats*
1991
Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks
2002 StandoutNobel
Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme.
1995
A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds.
1990
Regulation of thyroid hormone metabolism during fetal development
1999
Expression of Chicken Hepatic Type I and Type III Iodothyronine Deiodinases during Embryonic Development1
1997
A Unique Role of the β-2 Thyroid Hormone Receptor Isoform in Negative Regulation by Thyroid Hormone
1997
The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors
1991
Effects of selenium supplementation on thyroid hormone metabolism in phenylketonuria subjects on a phenylalanine restricted diet
1995
Dominant Negative Transcriptional Regulation by a Mutant Thyroid Hormone Receptor-β in a Family with Generalized Resistance to Thyroid Hormone
1990
RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements
1991
Structure-Activity Relationships for Thyroid Hormone Deiodination by Mammalian Type I Iodothyronine Deiodinases1
1997
Phosphorylation of Thyroid Hormone Receptors by Protein Kinase A Regulates DNA Recognition by Specific Inhibition of Receptor Monomer Binding
1998
Gene regulation by steroid hormones
1989 Standout
Basal and Thyroid Hormone Receptor Auxiliary Protein- Enhanced Binding of Thyroid Hormone Receptor Isoforms to Native Thyroid Hormone Response Elements
1991
A potential role of activated NF-κB in the pathogenesis of euthyroid sick syndrome
2000
Thyroid Hormone Regulation of Thyrotropin Gene Expression
1993
High affinity and specificity of dimeric binding of thyroid hormone receptors to DNA and their ligand-dependent dissociation.
1993
Type 2 Iodothyronine Deiodinase Expression is Upregulated by the Protein Kinase A-Dependent Pathway and is Downregulated by the Protein Kinase C-Dependent Pathway in Cultured Human Thyroid Cells
2001
Spatial and temporal expression of alpha- and beta-thyroid hormone receptor mRNAs, including the beta 2-subtype, in the developing mammalian nervous system
1992
Ligand-dependent synergy of thyroid hormone and retinoid X receptors.
1992
Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency.
1995
Identification of critical amino acids for 3,5,3'-triiodothyronine deiodination by human type 1 deiodinase based on comparative functional-structural analyses of the human, dog, and rat enzymes.
1994
Ligand-dependent, Pit-1/growth hormone factor-1 (GHF-1)-independent transcriptional stimulation of rat growth hormone gene expression by thyroid hormone receptors in vitro.
1993
Delineation of three different thyroid hormone-response elements in promoter of rat sarcoplasmic reticulum Ca2+ATPase gene. Demonstration that retinoid X receptor binds 5' to thyroid hormone receptor in response element 1.
1994
Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation.
1992
Negative thyroid hormone control of human growth hormone gene expression is mediated by 3‘-untranslated/3‘-flanking DNA.
1992
Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription
2000 StandoutNobel
Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected β type thyroid hormone receptor
1989
Ligand-Dependent and -Independent Transactivation by Thyroid Hormone Receptor β2 Is Determined by the Structure of the Hormone Response Element
1995
Biochemistry, Cellular and Molecular Biology, and Physiological Roles of the Iodothyronine Selenodeiodinases
2002 Standout
Gene expression from the c-erbA alpha/Rev-ErbA alpha genomic locus. Potential regulation of alternative splicing by opposite strand transcription.
1990
Activation of protein kinase C or cAMP-dependent protein kinase increases phosphorylation of the c-erbA-encoded thyroid hormone receptor and of the v-erbA-encoded protein.
1988
The thyroid hormone receptor binds to multiple domains of the rat growth hormone 5′-flanking sequence.
1988
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid X receptor-related factor.
1994
Transcriptional Silencing by Unliganded Thyroid Hormone Receptor β Requires a Soluble Corepressor That Interacts with the Ligand-Binding Domain of the Receptor
1996
The effects of selenium depletion and repletion on the metabolism of thyroid hormones in the rat
1990
Maternal and Fetal Thyroid Function
1994
Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression.
1993
Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors.
1993
The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein.
1996 StandoutNobel
Translational termination efficiency in mammals is influenced by the base following the stop codon.
1995
Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA
1992
Identification of multiple thyroid hormone response elements located far upstream from the rat S14 promoter.
1990
Characterization of myelin basic protein thyroid hormone response element and its function in the context of native and heterologous promoter.
1992
Specificity and mechanism of thyroid hormone induction from an octamer response element.
1994
Functional characterization and receptor binding studies of the malic enzyme thyroid hormone response element.
1991
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit gene.
1991
The Conserved Ninth C-Terminal Heptad in Thyroid Hormone and Retinoic Acid Receptors Mediates Diverse Responses by Affecting Heterodimer but Not Homodimer Formation
1993
Physiological and Molecular Basis of Thyroid Hormone Action
2001 Standout
Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.
1995 StandoutNobel
Human carboxyl-terminal variant of alpha-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone.
1989
Hormone-dependent and -independent transcriptional activation by thyroid hormone receptors are mediated by different mechanisms.
1996
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
1992 StandoutNobel
Regulation of myosin heavy chain genes in the heart.
1993
Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase
1991
Novel Pathway for Thyroid Hormone Receptor Action through Interaction with jun and fos Oncogene Activities
1991
Update 1 of: Proteases Universally Recognize Beta Strands In Their Active Sites
2010
Thyroid Hormone Inhibition of Human Thyrotropin β-Subunit Gene Expression is Mediated by a Cis-acting Element Located in the First Exon
1989
Thyroid hormone receptor modulates the expression of the rabbit cardiac sarco (endo) plasmic reticulum Ca(2+)-ATPase gene.
1994
Identification of a tHyroid Hormone Receptor That Is Pituitary-Specific
1989 Science
Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons.
1993
Thyroid hormone receptor isoforms are sequentially expressed in oligodendrocyte lineage cells during rat cerebral development
1998
Phosphorylation stimulates the transcriptional activity of the human beta 1 thyroid hormone nuclear receptor.
1992
A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit.
1989
Characterization of thyroid hormone (T3) receptors in three osteosarcoma cell lines of distinct osteoblast phenotype: interactions among T3, vitamin D3, and retinoid signaling.
1994
Half-site arrangement of hybrid glucocorticoid and thyroid hormone response elements specifies thyroid hormone receptor complex binding to DNA and transcriptional activity.
1994
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
1999 StandoutScience
Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression.
1993
Trans-activation by thyroid hormone receptors: functional parallels with steroid hormone receptors.
1989
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
2014 StandoutNobel
The Role of the Active Site Cysteine in Catalysis by Type 1 Iodothyronine Deiodinase*
1997
Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries.
1992
Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients
1990 StandoutScience
Sodium butyrate selectively alters thyroid hormone receptor gene expression in GH3 cells.
1990
Estradiol modulates thyroid hormone regulation of the human glycoprotein hormone alpha subunit gene.
1993
The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling
2011
Functional Regulation of Thyroid Hormone Receptor Variant TRα2 by Phosphorylation
1995
v-erbA overexpression is required to extinguish c-erbA function in erythroid cell differentiation and regulation of the erbA target gene CAII.
1991
3,5,3'-L-triiodothyronine (thyroid hormone)-induced protein-DNA interactions in the thyroid hormone response elements and cell type-specific elements of the rat growth hormone gene revealed by in vivo dimethyl sulfate footprinting
1994
Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway
1998
The Ligand-Binding Domains of the Thyroid Hormone/Retinoid Receptor Gene Subfamily Function in Vivo To Mediate Heterodimerization, Gene Silencing, and Transactivation
1995
Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene.
1995
Thyroid Hormone Regulation of the Rat Glycoprotein Hormone α-Subunit Gene Promoter Activity
1989
In contrast to the glucocorticoid receptor, the thyroid hormone receptor is translated in the DNA binding state and is not associated with hsp90.
1990
Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors.
1992
Notch Signaling: Cell Fate Control and Signal Integration in Development
1999 StandoutScience
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
1995 StandoutScience
Polyvalente Wechselwirkungen in biologischen Systemen: Auswirkungen auf das Design und die Verwendung multivalenter Liganden und Inhibitoren
1998
A nuclear factor that enhances binding of thyroid hormone receptors to thyroid hormone response elements.
1990
Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta.
1989
Time course of the in vivo effects of thyroid hormone on cardiac gene expression.
1992
Vitamin D Interferes with Transactivation of the Growth Hormone Gene by Thyroid Hormone and Retinoic Acid
1996
Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor.
1991
Thyroid hormone receptor-induced bending of specific DNA sequences is modified by an accessory factor.
1993
A major thyroid hormone response element in the third intron of the rat growth hormone gene.
1990
A Novel Retinoid X Receptor-Independent Thyroid Hormone Response Element Is Present in the Human Type 1 Deiodinase Gene
1995
Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites
1997 StandoutScience
The structure of the coding and 5'-flanking region of the type 1 iodothyronine deiodinase (dio1) gene is normal in a patient with suspected congenital dio1 deficiency.
1996
Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor-auxiliary protein heterodimers.
1992
DNA sequences in the rat osteocalcin gene that bind the 1,25-dihydroxyvitamin D3 receptor and confer responsiveness to 1,25-dihydroxyvitamin D3.
1990
Characterization of a Propylthiouracil-Insensitive Type I Iodothyronine Deiodinase*
1997
Characterization of Mammalian Selenoproteomes
2003 StandoutScience
Thyroid hormone concentrations in selenium deficient and selenium sufficient cattle
1988
Cloning and Expression of a 5′-Iodothyronine Deiodinase from the Liver ofFundulus heteroclitus1
1997
Identification of a Nuclear Receptor for Bile Acids
1999 StandoutScience
Alpha and beta thyroid hormone receptors bind immediately adjacent to the rat growth hormone gene TATA box in a negatively hormone-responsive promoter region.
1990
Recombinant thyroid hormone receptor and retinoid Xreceptor stimulate ligand-dependent transcription in vitro.
1994
Relationship of c-erbA mRNA content to tissue triiodothyronine nuclear binding capacity and function in developing and adult rats.
1990
In Vivo Genomic Footprinting of Thyroid Hormone-Responsive Genes in Pituitary Tumor Cell Lines
1996
Identification of a thyroid hormone response element in the malic enzyme gene.
1990
Works of Robert Warne being referenced
Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep.
1995
Mutations of the Rat Growth Hormone Promoter which Increase and Decrease Response to Thyroid Hormone Define a Consensus Thyroid Hormone Response Element
1989
Mast Cell Tryptase: A New Target for Therapeutic Intervention in Asthma
1995
Design and synthesis of benzoazepin-2-one analogs as allosteric binders targeting the PIF pocket of PDK1
2010
Dibasic inhibitors of human mast cell tryptase. Part 1: Synthesis and optimization of a novel class of inhibitors
2000
Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone.
1987
A Novel Approach to Serine Protease Inhibition: Kinetic Characterization of Inhibitors Whose Potencies and Selectivities Are Dramatically Enhanced by Zinc(II)
2000
Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase.
1992
Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor.
1988