Citation Impact
Citing Papers
Notch Inhibits Expression of the Kruppel-Like Factor 4 Tumor Suppressor in the Intestinal Epithelium
2008
High burden and pervasive positive selection of somatic mutations in normal human skin
2015 StandoutScience
Notch Signaling in the Regulation of Stem Cell Self-Renewal and Differentiation
2010
Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate
2010
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
2009 Nobel
Genetic Evidence That Intestinal Notch Functions Vary Regionally and Operate through a Common Mechanism of Math1 Repression
2011
Notch Signaling Promotes the Generation of EphrinB1-Positive Intestinal Epithelial Cells
2009
Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
2018 Standout
Cell Lineage metastability in Gfi1-deficient mouse intestinal epithelium
2010
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27 Kip1 and p57 Kip2
2008 StandoutNobel
Catalytic Asymmetric Hydrogenation of α‐CF3‐ or β‐CF3‐Substituted Acrylic Acids using Rhodium(I) Complexes with a Combination of Chiral and Achiral Ligands
2013
Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling
2009
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
2013
The Intestinal Crypt, A Prototype Stem Cell Compartment
2013
γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
2008
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny
2013
Visible light photoredox catalysis: applications in organic synthesis
2010 Standout
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
2010 StandoutNature
EMT and Dissemination Precede Pancreatic Tumor Formation
2012 Standout
Cancer Metastasis: Building a Framework
2006 Standout
Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease
2005
Human African trypanosomiasis
2009
Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling
2011
Tumor Metastasis: Molecular Insights and Evolving Paradigms
2011 Standout
Catalysis for fluorination and trifluoromethylation
2011 StandoutNature
Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells
2005
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Notch Signaling Is Required for Exocrine Regeneration After Acute Pancreatitis
2008
Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage
2009
Glutamate neurotoxicity and diseases of the nervous system
1988 Standout
New Approaches and Therapeutics Targeting Apoptosis in Disease
2005
Asymmetric Conjugate Addition to α‐Halo Enones: Dramatic Effect of Styrene on the Enantioselectivity
2006
Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke
2006
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
2016 Standout
Alzheimer's disease
2016 Standout
YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells
2007
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
2006 Nature
Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease
2011 StandoutNobel
Phosphoramidites: Privileged Ligands in Asymmetric Catalysis
2010 StandoutNobel
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
2005 Nature
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Mir-206 Regulates Pulmonary Artery Smooth Muscle Cell Proliferation and Differentiation
2012
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Origins of Stereoselectivity in Strain‐Release Allylations
2004
Transition‐Metal‐Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage
2009 Standout
Notch: Architect, Landscaper, and Guardian of the Intestine
2011 Standout
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
Kinetic resolution of donor-functionalised tertiary alcohols by Cu–H-catalysed stereoselective silylation using a strained silicon-stereogenic silane
2008
SIRT1 Regulates HIV Transcription via Tat Deacetylation
2005
Tumor Angiogenesis
2008 Standout
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Structure and function of γ-secretase
2008
Modeling Development and Disease with Organoids
2016 Standout
Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms
2006
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Fluorine in medicinal chemistry
2007 Standout
Stereoselective Organic Reactions in Water
2002 Standout
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Challenges and Opportunities for the Application of Boron Clusters in Drug Design
2016
Aggregation‐Induced Emission: The Whole Is More Brilliant than the Parts
2014 Standout
Stereocontrolled Synthesis of Tetrasubstituted Olefins
2007
An alternative metabolic pathway of amyloid precursor protein C‐terminal fragments via cathepsin B in a human neuroglioma model
2011
Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium
2008
Phenotypic characterization of human colorectal cancer stem cells
2007 Standout
Combining an amyloid‐beta (Aβ) cleaving enzyme inhibitor with a γ‐secretase modulator results in an additive reduction of Aβ production
2014
BINOL: A Versatile Chiral Reagent
2005 Standout
Deracemization of α-Aryl Hydrocoumarins via Catalytic Asymmetric Protonation of Ketene Dithioacetals
2012 StandoutNobel
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
2006 StandoutNature
Design and Implementation of New, Silicon-Based, Cross-Coupling Reactions: Importance of Silicon−Oxygen Bonds
2002
Asymmetric carbonyl addition reactions to benzyloxyaldehydes by binaphthol-titanium catalyst: Anti- vs. Syn-diastereofacial preference in anomalous nonchelation complexation
1997
γ-Cleavage Is Dependent on ζ-Cleavage during the Proteolytic Processing of Amyloid Precursor Protein within Its Transmembrane Domain
2005
Practical Methodologies for the Synthesis of Indoles
2006 Standout
Phosphine Organocatalysis
2018 Standout
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Hippo Pathway Regulation of Gastrointestinal Tissues
2014
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Self-Renewal and Cancer of the Gut: Two Sides of a Coin
2005 Science
Selected Patented Cross-Coupling Reaction Technologies
2006 Standout
Stereoselective Cyclopropanation Reactions
2003 Standout
Carbene−Alkyne−Alkene Cyclization Reactions
1996
Diastereoselective Allylation of Carbonyl Compounds and Imines: Application to the Synthesis of Natural Products
2013 Standout
Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine
2005
Kinetic Resolution of Homoaldols via Catalytic Asymmetric Transacetalization
2010 StandoutNobel
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors
2007
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development
2009
Aromatic Trifluoromethylation with Metal Complexes
2011 Standout
Recent advances in enantioselective copper-catalyzed 1,4-addition
2009 StandoutNobel
Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
2014 Standout
De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor
2019 StandoutNobel
Evaluation of Chelation Effects Operative during Diastereoselective Addition of the Allylindium Reagent to 2- and 3-Hydroxycyclohexanones in Aqueous, Organic, and Mixed Solvent Systems
1998
Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
2013 Standout
Asymmetric Conjugate Addition to α‐Halo Enones: Dramatic Effect of Styrene on the Enantioselectivity
2006
A Phosphetane Catalyzes Deoxygenative Condensation of α-Keto Esters and Carboxylic Acids via PIII/PV═O Redox Cycling
2015
Solar Synthesis: Prospects in Visible Light Photocatalysis
2014 StandoutScience
miRBase: from microRNA sequences to function
2018 Standout
Direct regulation of intestinal fate by Notch
2005
Works of Robert T. Jacobs being referenced
4-Alkylpiperidines related to SR-48968: Potent antagonists of the neurokinin-2 (NK2) receptor
1998
Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis
2013
Novel Small Molecule Inhibitors of Caspase-3 Block Cellular and Biochemical Features of Apoptosis
2003
The Mechanism of γ-Secretase
2003
Synthesis, Structure-Activity Relationships, and Pharmacological Evaluation of a Series of Fluorinated 3-Benzyl-5-Indolecarboxamides: Identification of 4-[[5-[((2R)-2-Methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methylindol-3-yl]methyl]-3methoxy-N-[(2-methylphenyl)sulfonyl]benzamide, a Potent, Orally Active Antagonist of Leukotrienes D4 and E4
1994
Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation
2004
The vinylogous anomeric effect in 3-alkyl-2-chlorocyclohexanone oximes and oxime ethers
1990
Synthesis, structure, and reactivity of an organogermanium Lewis acid
1990
Development of Novel Drugs for Human African Trypanosomiasis
2011
Defense mechanisms of arthropods. 84. Synthesis of (-)-.alpha.-necrodol and (-)-.beta.-necrodol: novel cyclopentanoid terpenes from a carrion beetle
1990
Condensation of monosubstituted isopropylidene malonates with Mannich bases
1982