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1990
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2001
Review
1995
Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates.
1986
Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division
2000
Role of arginine-tRNA in protein degradation by the ubiquitin pathway
1987 StandoutNatureNobel
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1994
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1984 Science
The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities.
1996 Nobel
Spatial resolution of fodrin proteolysis in postischemic brain.
1993
Caspase-8 and Caspase-3 Are Expressed by Different Populations of Cortical Neurons Undergoing Delayed Cell Death after Focal Stroke in the Rat
1999
Spectrin is associated with membrane-bound actin filaments in platelets and is hydrolyzed by the Ca2+-dependent protease during platelet activation
1987
Calpain Activation Contributes to Dendritic Remodeling after Brief Excitotoxic InjuryIn Vitro
1997
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1995
Calpain inhibitors as potential treatment for stroke and other neurodegenerative diseases: recent trends and developments
1998
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2003
Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosis
1998
cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase.
1991 StandoutNobel
Gene Expression Induced by Cerebral Ischemia: An Apoptotic Perspective
1997
A Family of AMPA-Selective Glutamate Receptors
1990 StandoutScienceNobel
Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.
1987 StandoutNobel
Contribution of p53-Dependent Caspase Activation to Neuronal Cell Death Declines with Neuronal Maturation
1999
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1998
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1997
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2000 Nobel
Origins of the difference in Ca2+ requirement for activation of μ- and m-calpain
2002
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
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2002
Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease
2005 Science
Reduced Ischemic Brain Injury in Interleukin-1β Converting Enzyme—Deficient Mice
1998
Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.
1993
Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage
1997
Structure and physiological function of calpains
1997
N-methyl-D-aspartate receptor-induced proteolytic conversion of postsynaptic class C L-type calcium channels in hippocampal neurons.
1996
Microtubular Proteolysis in Focal Cerebral Ischemia
1996
Design, Synthesis and Evaluation of d-Homophenylalanyl Epoxysuccinate Inhibitors of the Trypanosomal Cysteine Protease Cruzain
2000
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
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2005
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
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1996 StandoutNobel
Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis-necrosis continuum
1997
Live-cell imaging of dendritic spines by STED microscopy
2008 StandoutNobel
Apoptosis in Caspase-inhibited Neurons
2001
Delayed Antagonism of Calpain Reduces Excitotoxicity in Cultured Neurons
1995
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.
1989 StandoutNobel
Protease Inhibitors: Current Status and Future Prospects
2000
Ischemic Cell Death in Brain Neurons
1999 Standout
Axonal Self-Destruction and Neurodegeneration
2002 Science
The Calpain Hypothesis of Neurodegeneration: Evidence for a Common Cytotoxic Pathway
1997
Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat.
1996
Mitochondria and Apoptosis
1998 StandoutScience
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS
1990 StandoutScienceNobel
Somatodendritic expression of an immediate early gene is regulated by synaptic activity.
1995
Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path
1998
Investigation into the P3 Binding Domain of m-Calpain Using Photoswitchable Diazo- and Triazene-dipeptide Aldehydes: New Anticataract Agents
2007
Glutamate: A Neurotransmitter in Mammalian Brain
1984 Standout
ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX
1996
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
Selective proteasome inhibitors: modulators of antigen presentation?
1999
Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
2003 StandoutScience
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Positive regulation of mu-calpain action by polyphosphoinositides.
1992
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission
2003 StandoutNobel
Alteration of Gene Expression by Chromosome Loss in the Postnatal Mouse Brain
2003
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Transient Global Forebrain Ischemia Induces a Prolonged Expression of the Caspase-3 mRNA in Rat Hippocampal CA1 Pyramidal Neurons
1998
Purification of native p94, a muscle-specific calpain, and characterization of its autolysis
1998
Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.
1996
Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice
2004
Works of Robert Siman being referenced
Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts
1998
Potent Inhibitors of Proteasome
1995
A CBP Binding Transcriptional Repressor Produced by the PS1/ϵ-Cleavage of N-Cadherin Is Inhibited by PS1 FAD Mutations
2003
Comparison of Calpain and Caspase Activities in the Adult Rat Brain after Transient Forebrain Ischemia
2002
The ultrastructural localization of calcium‐activated protease “calpain” in rat brain
1988
A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat
1997
Enhanced Amyloidogenic Processing of the β-Amyloid Precursor Protein in Gene-targeted Mice Bearing the Swedish Familial Alzheimer's Disease Mutations and a “Humanized” Aβ Sequence
1996
Long-Term Accumulation of Amyloid-β, β-Secretase, Presenilin-1, and Caspase-3 in Damaged Axons Following Brain Trauma
2004
P2-achiral, P'-extended α-ketoamide inhibitors of calpain I
1999
Metabolism of the “Swedish” Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells
1996
Prolonged Calpain-mediated Spectrin Breakdown Occurs Regionally Following Experimental Brain Injury in the Rat
1996
A Sensitive, Continuously Recording Fluorogenic Assay for Calpain
1998
Localization of presenilin–nicastrin complexes and γ‐secretase activity to the trans‐Golgi network
2003
Modulation of Secreted β-Amyloid Precursor Protein and Amyloid β-Peptide in Brain by Cholesterol
1998
Cathepsin G: Localization in human cerebral cortex and generation of amyloidogenic fragments from the β-amyloid precursor protein
1994
Rank-Order of Potencies for Inhibition of the Secretion of Aβ40 and Aβ42 Suggests That Both Are Generated by a Single γ-Secretase
1999
Identification of a metalloprotease from Alzheimer's disease brain able to degrade the .beta.-amyloid precursor protein and generate amyloidogenic fragments
1994
Subsite requirements for peptide aldehyde inhibitors of human calpain I
1997
Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression system
1996
Potent α-ketocarbonyl and boronic ester derived inhibitors of proteasome
1996
Proteasome inhibition enhances the stability of mouse CuZn superoxide dismutase with mutations linked to familial amyotrophic lateral sclerosis
1996
Novel dipeptide aldehydes are proteasome inhibitors and block the MHC-I antigen-processing pathway.
1995
Regulation by calcium ions of glutamate receptor binding in hippocampal slices
1983
Regional distribution of soluble calcium activated proteinase activity in neonatal and adult rat brain
1985
1998
Distribution of calpain I, an enzyme associated with degenerative activity, in rat brain
1985
Increased Expression of IL-1β Converting Enzyme in Hippocampus after Ischemia: Selective Localization in Microglia
1996
Nonpeptidic inhibitors of recombinant human calpain I
1997
Evidence That Wallerian Degeneration and Localized Axon Degeneration Induced by Local Neurotrophin Deprivation Do Not Involve Caspases
2000
Potent fluoromethyl ketone inhibitors of recombinant human calpain I
1996
Brain fodrin: substrate for calpain I, an endogenous calcium-activated protease.
1984
Purification from Synaptosomal Plasma Membranes of Calpain I, a Thiol Protease Activated by Micromolar Calcium Concentrations
1983
Synthesis and Biological Activity of a Series of Potent Fluoromethyl Ketone Inhibitors of Recombinant Human Calpain I
1997
The calcium-activated protease calpain I and ischemia-induced neurodegeneration.
1996
Regulation of glutamate receptor binding by the cytoskeletal protein fodrin
1985 Nature
Xanthene derived potent nonpeptidic inhibitors of recombinant human calpain I
1996
Turnover of Amyloid β-Protein in Mouse Brain and Acute Reduction of Its Level by Phorbol Ester
1998
Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain
1994