Standout Papers
- Photoaffinity labeling of the beta-adrenergic receptor. (1981)
- Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit. (1981)
- Mammalian .beta.2-adrenergic receptor: purification and characterization (1984)
- Determination of the molecular size of frog and turkey erythrocyte .beta.-adrenergic receptors by radiation inactivation (1984)
- Antibodies to the beta-adrenergic receptor: attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain. (1983)
- The beta 1-adrenergic receptor of the turkey erythrocyte. Molecular heterogeneity revealed by purification and photoaffinity labeling. (1982)
- The beta-adrenergic receptor: rapid purification and covalent labeling by photoaffinity crosslinking. (1982)
- Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity. (1981)
Citation Impact
Citing Papers
Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynamin
1994
Proteins regulating Ras and its relatives
1993 StandoutNature
Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase
1991 StandoutNobel
Molecular analysis of pleckstrin: The major protein kinase c substrate of platelets
1989
G-protein-coupled Receptor Kinase Specificity for β-Arrestin Recruitment to the β2-Adrenergic Receptor Revealed by Fluorescence Resonance Energy Transfer
2006 StandoutNobel
Fluorescent Labeling of Purified β2 Adrenergic Receptor
1995 StandoutNobel
The PH domain: a common piece in the structural pathcwork of signalling proteins
1993
The β-Adrenergic Receptor Kinase (GRK2) Is Regulated by Phospholipids
1995
Feedback Inhibition of G Protein-coupled Receptor Kinase 2 (GRK2) Activity by Extracellular Signal-regulated Kinases
1999 StandoutNobel
Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism
1988
Desensitization of the isolated .beta.2-adrenergic receptor by .beta.-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms
1992 StandoutNobel
Solution structure of a pleckstrin-homology domain
1994 Nature
Protein modules and signalling networks
1995 StandoutNature
Structure of the Adrenergic and Related Receptors
1989 StandoutNobel
The G Protein-coupled Receptor Kinase 2 Is a Microtubule-associated Protein Kinase That Phosphorylates Tubulin
1998 StandoutNobel
Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor
1996 StandoutNobel
Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization
1988 StandoutNatureNobel
Phosphorylation of chick heart muscarinic cholinergic receptors by the .beta.-adrenergic receptor kinase
1989
Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid
1995 StandoutNobel
β1-Adrenergic Receptor Association with PSD-95
2000 StandoutNobel
Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES
1996 StandoutNobel
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate
1994 Nature
Protein Kinase A-mediated Phosphorylation of the β2-Adrenergic Receptor Regulates Its Coupling to Gs and Gi
2002 StandoutNobel
Catecholamine-induced desensitization of adenylate cyclase-coupled .beta.-adrenergic receptors in turkey erythrocytes: evidence for a two-step mechanism
1987
The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain
1992
Palmitoylation of the human β2-adrenergic receptor
1989 StandoutNobel
Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.
1986 StandoutNobel
Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes.
1984
The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.
1994
Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.
1986 StandoutNobel
Leukotriene C4 binding sites in the rat central nervous system
1986 Nobel
cAMP induces a rapid and reversible modification of the chemotactic receptor in Dictyostelium discoideum.
1985
Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.
1987 StandoutNobel
Rhodopsin Kinase Activity in the Mammalian Pineal Gland and Other Tissues
1984 Science
Catalytic unit of adenlyate cyclase: purification and identification by affinity crosslinking.
1985
Functional and structural characterization of the two .beta.1-adrenoceptor forms in turkey erythrocytes with molecular masses of 50 and 40 kilodaltons
1987
Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins.
1985 StandoutNobel
Cloning of a phospholipase A2-activating protein.
1991
Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.
1990 StandoutNobel
Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe.
1984 StandoutNobel
Purification and characterization of the human platelet alpha 2-adrenergic receptor.
1986 StandoutNobel
Mammalian .beta.2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system
1984 StandoutNobel
Regulation of transmembrane signaling by receptor phosphorylation
1987 StandoutNobel
Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.
1992 StandoutNobel
A carbene-generating photoaffinity probe for beta-adrenergic receptors
1983
Cell-free desensitization of catecholamine-sensitive adenylate cyclase. Agonist- and cAMP-promoted alterations in turkey erythrocyte beta-adrenergic receptors.
1984 StandoutNobel
Identification and characterization of a hormonally regulated form of phospholipase A2 in rat renal mesangial cells.
1988
Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution.
1986 StandoutNobel
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
1985 StandoutNobel
Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.
1985 StandoutNobel
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Translocation and Uncoupling of theβ-Adrenergic Receptor in Rat Lung after Catecholamine Promoted Desensitizationin Vivo
1984 StandoutNobel
Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils
1989
beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation.
1988 StandoutNobel
Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers
1988 Nobel
β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family
1989 StandoutScienceNobel
Identification of the subunit-binding site of alpha 2-adrenergic receptors using [3H]phenoxybenzamine.
1984 StandoutNobel
Direct Demonstration of Impaired Functionality of a Purified Desensitized β-Adrenergic Receptor in a Reconstituted System
1984 StandoutScienceNobel
Desensitization of the turkey erythrocyte beta-adrenergic receptor in a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor.
1985
Proteolysis-associated deglycosylation of .beta.1-adrenergic receptor in turkey erythrocytes and membranes
1985
The fat cell beta-adrenergic receptor. Purification and characterization of a mammalian beta 1-adrenergic receptor.
1984
Activation, desensitization, and recycling of frog erythrocyte beta-adrenergic receptors. Differential perturbation by in situ trypsinization.
1984 StandoutNobel
Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit.
1986 StandoutNobel
Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells.
1987
Direct insertion and fluorescence studies of rhodamine-labeled β-adrenergic receptors in cell membranes
1985
The regulation and cellular functions of phosphatidylcholine hydrolysis
1990
Receptor-specific mechanisms of desensitization of β-adrenergic receptor function
1984
A role for Ni in the hormonal stimulation of adenylate cyclase
1985 StandoutNatureNobel
Vasopressin induces V1 receptors to activate phosphatidylinositol- and phosphatidylcholine-specific phospholipase C and stimulates the release of arachidonic acid by at least two pathways in the smooth muscle cell line, A-10.
1988
Phorbol ester causes desensitization of gonadotropin-responsive adenylate cyclase in a murine Leydig tumor cell line.
1985
A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for .beta.-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase
1986 StandoutNobel
Structure and Regulation of G Protein-Coupled Receptors: The β2-Adrenergic Receptor as a Model
1991 StandoutNobel
Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity.
1984 StandoutNobel
Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.
1989 StandoutNobel
Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system.
1983 StandoutNobel
Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit.
1984 StandoutNobel
Pure β-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase
1983 StandoutNatureNobel
The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling.
1983 StandoutNobel
Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.
1986 StandoutNobel
Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.
1987 StandoutNobel
Reconstitution of catecholamine-stimulated guanosine triphosphatase activity
1983
Purification and characterization of the mammalian .beta.2-adrenergic receptor
1983
In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors
1992
Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.
1985 StandoutNobel
Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization
1989 StandoutNobel
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
1986 StandoutNatureNobel
Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist.
1986
Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins
1983 Nature
Functional alteration of the beta-adrenergic receptor during desensitization of mammalian adenylate cyclase by beta-agonists.
1984
The Mammalian β-Adrenergic Receptor: Structural and Functional Characterization of the Carbohydrate Moiety
1987 StandoutNobel
Functional integrity of desensitized beta-adrenergic receptors.
1983 StandoutNobel
Adenosine 3',5'-cyclic-monophosphate-dependent regulation of alpha 1-adrenergic receptor number in rabbit aortic smooth muscle cells.
1986
Genetic analysis of beta-adrenergic receptor internalization and down-regulation.
1985
Mechanism of heterologous desensitization of the adenylate cyclase system by glucagon in primary cultures of adult rat hepatocytes.
1984
Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family
1991 StandoutNobel
Mechanism of beta-adrenergic receptor kinase activation by G proteins
1993
G PROTEIN–COUPLED RECEPTOR KINASES
1998 StandoutNobel
Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase
1986 StandoutNatureNobel
Mechanisms of Membrane-Receptor Regulation
1984 StandoutNobel
The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis.
1987 StandoutNobel
Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects
1987 StandoutScienceNobel
Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.
1986 StandoutNobel
Reconstitution of catecholamine-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to the stimulatory GTP-binding protein of adenylate cyclase
1984
The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2
1993 StandoutNobel
Photoaffinity labeling of turkey erythrocyte beta-adrenergic receptors: Degradation of the Mr = 49,000 protein explains apparent heterogeneity
1984 StandoutNobel
Potentiation of alpha 1-adrenergic responses in rat liver by a cAMP-dependent mechanism.
1984
Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase. Resensitization by polyethylene glycol treatment.
1985 StandoutNobel
Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model
1985 StandoutNatureNobel
Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors
1992 StandoutScienceNobel
Purification and characterization of the beta-adrenergic receptor kinase.
1987
Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling.
1982 StandoutNobel
Receptor-mediated endocytosis.
1986
Phosphorylation of the nicotinic acetylcholine receptor by an endogenous tyrosine-specific protein kinase.
1984
β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function
1990 StandoutScienceNobel
Functional modification of the guanine nucleotide regulatory protein after desensitization of turkey erythrocytes by catecholamines
1983 StandoutNobel
Homologous desensitization of adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.
1985 StandoutNobel
Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).
1987
125I-labeled p-azidobenzylcarazolol, a photoaffinity label for the beta-adrenergic receptor. Characterization of the ligand and photoaffinity labeling of beta 1- and beta 2-adrenergic receptors.
1982 StandoutNobel
Time-dependent decreases in binding affinity of agonists for beta-adrenergic receptors of intact S49 lymphoma cells. A mechanism of desensitization.
1983
Affinity chromatography of human platelet α 2 -adrenergic receptors
1982 StandoutNobel
Purification of a high-molecular-mass form of phospholipase A2 from rat kidney activated at physiological calcium concentrations
1990
Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.
1983
Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles.
1983 StandoutNobel
Works of Robert Shorr being referenced
Molecular cloning and expression of the major protein kinase C substrate of platelets
1988 Nature
Purification, characterization, and structural properties of a single protein from rat basophilic leukemia (RBL-1) cells possessing 5-lipoxygenase and leukotriene A4 synthetase activities.
1986
Antibodies prepared to Bacillus cereus phospholipase C crossreact with a phosphatidylcholine preferring phosoholipase C in mammalian cells
1986
The beta-adrenergic receptor: rapid purification and covalent labeling by photoaffinity crosslinking.
1982 StandoutNobel
Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.
1983
The beta 1-adrenergic receptor of the turkey erythrocyte. Molecular heterogeneity revealed by purification and photoaffinity labeling.
1982 StandoutNobel
Mammalian .beta.2-adrenergic receptor: purification and characterization
1984 StandoutNobel
Biochemical characterization of phosphorylated .beta.-adrenergic receptors from catecholamine-desensitized turkey erythrocytes
1986
Photoaffinity labeling of the beta-adrenergic receptor.
1981 StandoutNobel
Antibodies to the beta-adrenergic receptor: attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain.
1983 StandoutNobel
Identification and isolation of a mammalian protein which is antigenically and functionally related to the phospholipase A2 stimulatory peptide melittin.
1987
Leukotriene C4 ([3H] - LTC4) binding to membranes isolated from a hamster smooth muscle cell line (DDTIMF2)
1984
Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit.
1981 StandoutNobel
Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity.
1981 StandoutNobel